Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF7EXL)

• Drug Name: Benzatropine Drug Info
• Synonyms: Benzatropina; Benzatropina [INN-Spanish]; Benzatropine; Benzatropinum; Benzatropinum [INN-Latin]; Benztropinum; Cobrentin; Cogentin; Cogentine; Akitan; Cogentinol; Tropine benzohydryl ether; benztropine; (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane; 1NHL2J4X8K; 3alpha-(Diphenylmethoxy)-1alphaH,5alphaH-tropane; 3alpha-(diphenylmethoxy)tropane; 3alpha-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; 3endo-benzhydryloxytropane; 86-13-5; CHEBI:3048; HSDB 3014; NCGC00159471-02; NK 02; UNII-1NHL2J4X8K

Indication

Disease Entry	ICD 11	Status	REF
Parkinsonian disorder		Approved	[1]
Postencephalitic Parkinson disease		Approved	[2]

• Cross-matching ID:
  PubChem CID: 1201549
  ChEBI ID: CHEBI:3048
  CAS Number: CAS 86-13-5
  TTD Drug ID: DMF7EXL
  INTEDE Drug ID: DR0192

Molecule-Related Drug Atlas

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[5]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[6]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[8]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[10]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[11]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[12]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[13]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[14]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[15]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[16]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[20]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[23]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[24]

Drug(s) Affected By Syntenin-1 (SDCBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[32]

Drug(s) Affected By Importin subunit alpha-3 (KPNA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit H (EIF3H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[46]

Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[47]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[50]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]

Drug(s) Affected By Calumenin (CALU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Kinesin heavy chain isoform 5C (KIF5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[65]

Drug(s) Affected By Eukaryotic translation initiation factor 5B (EIF5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[70]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[71]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]

Drug(s) Affected By Copine-3 (CPNE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[75]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[78]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]

Drug(s) Affected By Cartilage-associated protein (CRTAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Glutaredoxin-3 (GLRX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[73]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[81]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]

Drug(s) Affected By Adenylate kinase isoenzyme 1 (AK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[89]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[89]
Anastrozole	DMNP60F	Breast cancer	2C60-2C65	Approved	[89]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[89]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[91]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[98]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[91]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[102]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[103]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[91]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[91]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[91]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[91]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[91]

Drug(s) Affected By Fatty acid-binding protein, heart (FABP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[104]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[106]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[50]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[107]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Methamphetamine	DMPM4SK	Anxiety		Approved	[109]

Drug(s) Affected By Alpha-enolase (ENO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[84]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[115]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[50]

Drug(s) Affected By Glucose-6-phosphate isomerase (GPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]

Drug(s) Affected By Tropomyosin alpha-3 chain (TPM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[119]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[121]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]

Drug(s) Affected By Protein disulfide-isomerase (P4HB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[122]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[83]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[84]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]

Drug(s) Affected By Profilin-1 (PFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[128]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Tropomyosin beta chain (TPM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[131]

Drug(s) Affected By Annexin A6 (ANXA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[132]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[138]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[135]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[139]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[140]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[91]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[91]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[47]

Drug(s) Affected By Annexin A5 (ANXA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[144]

Drug(s) Affected By U1 small nuclear ribonucleoprotein A (SNRPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Dihydropteridine reductase (QDPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]

Drug(s) Affected By 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[155]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[156]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[157]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[156]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[158]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[161]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[162]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[163]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[164]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[165]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[166]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[91]

Drug(s) Affected By Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[121]

Drug(s) Affected By Myosin-3 (MYH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[169]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[89]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[177]

Drug(s) Affected By Histidine--tRNA ligase, cytoplasmic (HARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]

Drug(s) Affected By ADP/ATP translocase 3 (SLC25A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[180]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[79]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[181]

Drug(s) Affected By Macrophage migration inhibitory factor (MIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[185]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[187]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]

Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]

Drug(s) Affected By 26S proteasome regulatory subunit 6A (PSMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[194]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Annexin A7 (ANXA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[197]

Drug(s) Affected By V-type proton ATPase subunit B, brain isoform (ATP6V1B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[199]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[200]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[197]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[201]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[202]
Methysergide	DM1EF73	Migraine	8A80	Approved	[203]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[206]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[91]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[91]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[91]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[91]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[208]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]

Drug(s) Affected By Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[210]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[78]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[58]

Drug(s) Affected By Small ribosomal subunit protein uS3 (RPS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[211]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]

Drug(s) Affected By Proteasome subunit alpha type-1 (PSMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[213]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[214]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[215]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By Microtubule-associated protein 4 (MAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By General transcription factor IIE subunit 1 (GTF2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[216]

Drug(s) Affected By Phosphatidylethanolamine-binding protein 1 (PEBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[218]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[219]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[220]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[221]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[222]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[223]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[130]

Drug(s) Affected By Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[224]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[50]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]

Drug(s) Affected By Cleavage stimulation factor subunit 2 (CSTF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[226]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[227]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[228]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[229]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[231]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[233]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]

Drug(s) Affected By Basigin (BSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[235]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]

Drug(s) Affected By Transgelin-2 (TAGLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[106]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]

Drug(s) Affected By Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]

Drug(s) Affected By Nicotinamide N-methyltransferase (NNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[63]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[240]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[242]

Drug(s) Affected By Malate dehydrogenase, cytoplasmic (MDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[243]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[113]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Bortezomib	DMNO38U	Leukemia		Approved	[73]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[78]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[244]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[29]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[247]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]

Drug(s) Affected By Small ribosomal subunit protein eS27 (RPS27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[250]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[251]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]

Drug(s) Affected By Vesicle-fusing ATPase (NSF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[224]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[81]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[252]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]

Drug(s) Affected By Serpin B4 (SERPINB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[254]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Serine--tRNA ligase, cytoplasmic (SARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[255]

Drug(s) Affected By Protein phosphatase 1F (PPM1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[257]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[258]

Drug(s) Affected By Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[259]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[71]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[260]

Drug(s) Affected By Nuclear pore complex protein Nup153 (NUP153)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 7 (PSMD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Bortezomib	DMNO38U	Leukemia		Approved	[73]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[262]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[263]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[216]

Drug(s) Affected By Succinate--CoA ligase subunit alpha, mitochondrial (SUCLG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[264]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[71]

Drug(s) Affected By Trifunctional enzyme subunit beta, mitochondrial (HADHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[264]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[181]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[265]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[266]

Drug(s) Affected By Eukaryotic translation initiation factor 6 (EIF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[267]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]

Drug(s) Affected By Breast cancer anti-estrogen resistance protein 1 (BCAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[268]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[173]

Drug(s) Affected By Protein transport protein Sec61 subunit beta (SEC61B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[59]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[269]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]

Drug(s) Affected By Actin-related protein 3 (ACTR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]

Drug(s) Affected By Small ubiquitin-related modifier 2 (SUMO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[270]

Drug(s) Affected By 26S proteasome regulatory subunit 4 (PSMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[271]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[272]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[256]
flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[125]

Drug(s) Affected By Small nuclear ribonucleoprotein Sm D2 (SNRPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[273]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[274]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[200]

Drug(s) Affected By Large ribosomal subunit protein eL8 (RPL7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[271]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[275]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[276]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[250]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[275]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[250]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[277]

Drug(s) Affected By Large ribosomal subunit protein eL30 (RPL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]

Drug(s) Affected By Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[279]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[75]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[280]

Drug(s) Affected By Small ribosomal subunit protein RACK1 (RACK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[282]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[129]

Drug(s) Affected By Dermcidin (DCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[283]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[266]

Drug(s) Affected By Enhancer of rudimentary homolog (ERH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[284]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[274]

Drug(s) Affected By Large ribosomal subunit protein eL19 (RPL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[285]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[250]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[274]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[200]

Drug(s) Affected By RNA-binding protein EWS (EWSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[287]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[288]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By 2-oxoglutarate dehydrogenase complex component E1 (OGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[291]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[271]

Drug(s) Affected By Caldesmon (CALD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[292]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[294]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]

Drug(s) Affected By Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[89]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[295]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[81]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]

Drug(s) Affected By Protein phosphatase 3 catalytic subunit alpha (PPP3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[298]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[81]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[40]

Drug(s) Affected By Nuclear cap-binding protein subunit 1 (NCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[241]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[299]

Drug(s) Affected By Mitochondrial-processing peptidase subunit alpha (PMPCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[300]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]

Drug(s) Affected By Aspartyl/asparaginyl beta-hydroxylase (ASPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[247]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[301]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[302]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[303]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[304]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[304]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[305]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[306]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[307]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[308]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[304]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8 (EPS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[310]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[91]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[91]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[91]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[159]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[91]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[176]

Drug(s) Affected By Serine/arginine-rich splicing factor 5 (SRSF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[311]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[115]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[313]

Drug(s) Affected By Transcription intermediary factor 1-beta (TRIM28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[315]

Drug(s) Affected By Inactive tyrosine-protein kinase 7 (PTK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[316]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By Dynactin subunit 2 (DCTN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[81]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[317]

Drug(s) Affected By Stromal interaction molecule 1 (STIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[215]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
USNIC ACID	DMGOURX	Discovery agent	N.A.	Investigative	[319]

Drug(s) Affected By Cullin-2 (CUL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[320]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[104]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[321]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[322]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]

Drug(s) Affected By Protein DGCR6 (DGCR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]

Drug(s) Affected By Flotillin-2 (FLOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[324]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[325]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 4 (CHD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[115]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[75]

Drug(s) Affected By Inorganic pyrophosphatase (PPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]

Drug(s) Affected By Periodic tryptophan protein 2 homolog (PWP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[327]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[327]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[328]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[45]

Drug(s) Affected By Poly(rC)-binding protein 2 (PCBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[75]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]

Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[104]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[330]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Splicing factor 3B subunit 3 (SF3B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[331]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[271]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[332]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[256]
AMINOHIPPURIC ACID	DMUN54G	Discovery agent	N.A.	Investigative	[333]

Drug(s) Affected By Splicing factor 1 (SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[334]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[70]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 1 (MAPRE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[336]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[337]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[300]

Drug(s) Affected By Disks large homolog 2 (DLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[241]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[339]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[59]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By Mitochondrial import receptor subunit TOM34 (TOMM34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[340]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]

Drug(s) Affected By Dihydropyrimidinase-related protein 2 (DPYSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[341]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[107]

Drug(s) Affected By Alpha-sarcoglycan (SGCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[267]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[323]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[256]

Drug(s) Affected By Histone H2A type 2-C (H2AC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[298]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]

Drug(s) Affected By Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[343]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[344]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[269]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]

Drug(s) Affected By Endoribonuclease LACTB2 (LACTB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]

Drug(s) Affected By Beta-actin-like protein 2 (ACTBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[298]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[178]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[257]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[250]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[345]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[346]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]

Drug(s) Affected By CD276 antigen (CD276)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[347]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[108]

Drug(s) Affected By Microtubule-associated protein 1S (MAP1S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By Leiomodin-2 (LMOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[348]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[323]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]

Drug(s) Affected By Coiled-coil domain-containing protein 121 (CCDC121)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[106]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[29]

Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[91]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[91]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[91]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[91]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[91]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[91]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]

Drug(s) Affected By Nucleoporin p54 (NUP54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[247]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By Centromere protein V (CENPV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[183]

Drug(s) Affected By Kinectin (KTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[349]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[194]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[271]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]

Drug(s) Affected By Cell division cycle and apoptosis regulator protein 1 (CCAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[350]
Bortezomib	DMNO38U	Leukemia		Approved	[351]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[352]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[75]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[351]

Drug(s) Affected By Saccharopine dehydrogenase-like oxidoreductase (SCCPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[353]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[78]

Drug(s) Affected By Paraneoplastic antigen Ma1 (PNMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]

Drug(s) Affected By PEST proteolytic signal-containing nuclear protein (PCNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[75]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]

Drug(s) Affected By Splicing regulatory glutamine/lysine-rich protein 1 (SREK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[354]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[257]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[354]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[262]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[355]

Drug(s) Affected By Nectin-2 (NECTIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[257]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]

Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[144]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[356]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[357]

Drug(s) Affected By DNA topoisomerase I, mitochondrial (TOP1MT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[183]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[340]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[358]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD12 (KCTD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[49]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[359]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[348]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]

Drug(s) Affected By Small ribosomal subunit protein mS39 (PTCD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[360]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[194]

Drug(s) Affected By PDZ and LIM domain protein 5 (PDLIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[325]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]

Drug(s) Affected By Lysophospholipid acyltransferase 7 (MBOAT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[356]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[256]

Drug(s) Affected By Tubulin-folding cofactor B (TBCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[361]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[362]

Drug(s) Affected By Proteasome subunit beta type-7 (PSMB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[363]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[364]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]

Drug(s) Affected By T-complex protein 1 subunit eta (CCT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[271]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[365]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]

Drug(s) Affected By Protein arginine N-methyltransferase 1 (PRMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[366]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[368]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Coronin-1B (CORO1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[369]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[215]

Drug(s) Affected By COP9 signalosome complex subunit 4 (COPS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[370]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]

Drug(s) Affected By Histone H2A.J (H2AJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]

Drug(s) Affected By GTP-binding protein 4 (GTPBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[70]

Drug(s) Affected By 182 kDa tankyrase-1-binding protein (TNKS1BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[298]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[371]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[345]

Drug(s) Affected By RNA cytidine acetyltransferase (NAT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Idelalisib	DM602WT	Chronic lymphocytic leukaemia	2A82.0	Approved	[372]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[372]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[70]

Drug(s) Affected By Phosducin-like protein 3 (PDCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[373]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[80]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[374]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[375]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]

Drug(s) Affected By Damage-control phosphatase ARMT1 (ARMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Obg-like ATPase 1 (OLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[376]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[371]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[332]

Drug(s) Affected By Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[377]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]

Drug(s) Affected By Very-long-chain (HACD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[378]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[379]

Drug(s) Affected By Ataxin-10 (ATXN10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[167]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[362]

Drug(s) Affected By DnaJ homolog subfamily B member 11 (DNAJB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[113]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[380]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[195]

Drug(s) Affected By Translocation protein SEC63 homolog (SEC63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Indomethacin	DMSC4A7	Bursitis		Approved	[381]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]

Drug(s) Affected By Poly(U)-binding-splicing factor PUF60 (PUF60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[382]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Nuclear pore complex protein Nup50 (NUP50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]

Drug(s) Affected By NSFL1 cofactor p47 (NSFL1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[284]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[52]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[328]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]

Drug(s) Affected By RuvB-like 2 (RUVBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[31]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[223]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit L (EIF3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[200]

Drug(s) Affected By Serine-threonine kinase receptor-associated protein (STRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[195]

Drug(s) Affected By Nucleolar complex protein 2 homolog (NOC2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[384]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By TRPM8 channel-associated factor 1 (TCAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By Talin-2 (TLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[4]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[385]
Haloperidol	DM96SE0	Delirium		Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]

Drug(s) Affected By Protocadherin gamma-A2 (PCDHGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]

Drug(s) Affected By Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[75]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By Epsin-1 (EPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[279]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[77]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[45]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[386]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[200]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[3]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein theta	OTWG7F3H	1433T_HUMAN	Gene/Protein Processing	[4]
182 kDa tankyrase-1-binding protein (TNKS1BP1)	OTBIZECQ	TB182_HUMAN	Gene/Protein Processing	[4]
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)	OTB8HCED	CN37_HUMAN	Gene/Protein Processing	[4]
2-oxoglutarate dehydrogenase complex component E1 (OGDH)	OTHGTQWF	ODO1_HUMAN	Gene/Protein Processing	[4]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7)	OT7PZZ4K	PSMD7_HUMAN	Gene/Protein Processing	[4]
26S proteasome regulatory subunit 4 (PSMC1)	OTLHD56E	PRS4_HUMAN	Gene/Protein Processing	[4]
26S proteasome regulatory subunit 6A (PSMC3)	OTSKT0JI	PRS6A_HUMAN	Gene/Protein Processing	[4]
Actin-related protein 3 (ACTR3)	OT05LJSH	ARP3_HUMAN	Gene/Protein Processing	[4]
Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2)	OTAKUO27	ACOT2_HUMAN	Gene/Protein Processing	[4]
Adenylate kinase isoenzyme 1 (AK1)	OT614AR3	KAD1_HUMAN	Gene/Protein Processing	[4]

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