Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIOGBU)

• Drug Name: Bosentan Drug Info
• Synonyms: Actelion; Bosentanum; Tracleer; Bosentan (INN); KS-5062; Ro 47-0203; Tracleer (TN); Bosentan [USAN:INN:BAN]; Ro 47-0203/039; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039; P-tert-Butyl-N-[6-(2-hydroxyethoxy); P-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide; 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide; 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide; 4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide; 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide; 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary arterial hypertension	BB01.0	Approved	[1]
Pulmonary hypertension	BB01	Approved	[2]
Scleroderma	4A42	Investigative	[2]

• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 104865
  ChEBI ID: CHEBI:51450
  CAS Number: CAS 147536-97-8
  TTD Drug ID: DMIOGBU
  VARIDT Drug ID: DR00288
  INTEDE Drug ID: DR0222
  ACDINA Drug ID: D00074

Molecule-Related Drug Atlas

Drug(s) Targeting Endothelin A receptor (EDNRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ambrisentan	DMD1QXW	Pulmonary arterial hypertension	BB01.0	Approved	[9]
Macitentan	DMP79A1	Cardiovascular disease	BA00-BE2Z	Approved	[10]
Sparsentan	DMMP51W	IgA nephropathy	MF8Y	Approved	[11]
LU302146	DMMJVXZ	Pulmonary hypertension	BB01	Approved	[12]
Atrasentan	DMM74PK	Diabetic nephropathy	GB61.Z	Phase 3	[13]
Clazosentan	DMQSBX4	Cerebral vasospasm	BA85.Z	Phase 3	[14]
PF-1228305	DMS1EQ7	Pulmonary hypertension	BB01	Phase 3	[15]
Darusentan	DMN8DQH	Hypotension	BA20-BA21	Phase 3	[16]
BQ-123	DM0MO8I	Pulmonary arterial hypertension	BB01.0	Phase 2	[17]
FR139317	DMEL5SV	Hypertension	BA00-BA04	Phase 2	[18]

Drug(s) Targeting Endothelin B receptor (EDNRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Macitentan	DMP79A1	Cardiovascular disease	BA00-BE2Z	Approved	[10]
BQ788	DM6KRLW	Acute kidney injury	GB60	Phase 3	[19]
PD-145065	DMWVBTQ	Hypertension	BA00-BA04	Phase 2	[20]
SPI-1620	DMNPRMC	Solid tumour/cancer	2A00-2F9Z	Phase 2	[21]
ENB003	DMK2B3S	Melanoma	2C30	Phase 1/2	[22]
J-104132	DM5E6MK	Pulmonary arterial hypertension	BB01.0	Discontinued in Phase 2	[23]
ENRASENTAN	DM05F1Z	Pulmonary arterial hypertension	BB01.0	Discontinued in Phase 2	[24]
SB-209670	DMJYW80	Arrhythmia	BC9Z	Discontinued in Phase 2	[25]
ET-1	DMA85ND	N. A.	N. A.	Phase 0	[26]
PD142893	DMFA27N	N. A.	N. A.	Terminated	[27]

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[29]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[31]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[30]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[32]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[33]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[34]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[35]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[32]

Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[30]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[39]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[33]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[35]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[40]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[35]

Drug(s) Transported By Organic anion transporting polypeptide 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[41]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[42]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[43]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[31]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[44]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[45]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[46]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[47]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[48]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[49]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[50]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[51]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[56]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[57]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[51]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[58]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[68]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[70]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[71]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[72]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[73]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[74]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[75]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[76]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[59]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[62]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[64]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[67]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[77]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[78]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[81]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[82]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[82]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[83]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[85]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[86]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[87]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[87]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[86]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[87]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[88]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[86]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[89]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[86]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[90]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[97]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[98]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[107]
Fructose	DM43AN2	Vomiting	MD90	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[97]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[110]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[111]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[112]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[113]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[114]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[115]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[116]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[117]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[118]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[119]

Drug(s) Affected By Serine/threonine-protein kinase DCLK1 (DCLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[123]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[124]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[125]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]

Drug(s) Affected By Kynurenine 3-monooxygenase (KMO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[131]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[135]

Drug(s) Affected By Carbonic anhydrase 12 (CA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[136]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[137]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]

Drug(s) Affected By All-trans-retinol dehydrogenase ADH1B (ADH1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[124]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[121]

Drug(s) Affected By Alcohol dehydrogenase 1C (ADH1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[147]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[112]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[131]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Haloperidol	DM96SE0	Delirium		Approved	[152]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[153]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[156]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]

Drug(s) Affected By Complement component C9 (C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[161]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[164]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[165]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[166]
Haloperidol	DM96SE0	Delirium		Approved	[152]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Selenium	DM25CGV	N. A.	N. A.	Approved	[168]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[169]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[177]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[179]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[190]

Drug(s) Affected By Fructose-bisphosphate aldolase B (ALDOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[191]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[131]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[193]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[121]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[176]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[195]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[196]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[197]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[198]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[200]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[201]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[202]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[201]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[204]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[207]
Selenium	DM25CGV	N. A.	N. A.	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[210]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[214]

Drug(s) Affected By Alcohol dehydrogenase 1A (ADH1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[147]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[153]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[216]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[217]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[219]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[220]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[221]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[223]

Drug(s) Affected By All-trans-retinol dehydrogenase ADH4 (ADH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[131]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[131]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[193]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[121]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[225]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[197]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[227]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[228]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[229]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]

Drug(s) Affected By Glutathione S-transferase theta-2 (GSTT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[231]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[193]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[233]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[234]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[235]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[237]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[238]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[239]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[197]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[241]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[199]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[243]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[242]

Drug(s) Affected By Microsomal glutathione S-transferase 1 (MGST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[245]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[246]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[247]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[123]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[216]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[124]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[135]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[248]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[249]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[250]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[251]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[232]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[252]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[253]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[138]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[254]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[256]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[257]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[258]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[179]

Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[260]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[261]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[263]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]

Drug(s) Affected By Tyrosine aminotransferase (TAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[266]
Miconazole	DMPMYE8	Cutaneous candidiasis	1F23.14	Approved	[267]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[268]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[269]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[121]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[270]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[271]
Methysergide	DM1EF73	Migraine	8A80	Approved	[88]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[112]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[272]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[273]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[274]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[276]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[118]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[273]

Drug(s) Affected By Macrophage mannose receptor 1 (MRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[277]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[278]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[279]
CYCLOPAMINE	DMEM2SW	Discovery agent	N.A.	Investigative	[280]

Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[281]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[282]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[233]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[163]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[283]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[284]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[285]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[286]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[288]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[289]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[291]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[292]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[293]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[286]

Drug(s) Affected By G0/G1 switch protein 2 (G0S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[175]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]

Drug(s) Affected By Sodium- and chloride-dependent GABA transporter 1 (SLC6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Tiagabine	DMKSQG0	Epilepsy	8A60-8A68	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[260]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[250]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[164]

Drug(s) Affected By Pyruvate kinase PKLR (PKLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[248]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[297]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[298]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[131]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[131]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[126]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[299]

Drug(s) Affected By Carbamoyl-phosphate synthase , mitochondrial (CPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[301]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[123]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[302]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[193]

Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[303]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[304]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[305]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[131]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[307]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[308]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[310]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[311]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[312]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[313]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[314]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[315]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[316]

Drug(s) Affected By Hepatocyte nuclear factor 4-alpha (HNF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[184]
Fructose	DM43AN2	Vomiting	MD90	Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[319]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[217]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[320]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[321]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[322]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[268]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[90]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[215]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[323]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[324]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[325]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]

Drug(s) Affected By Sulfotransferase 1E1 (SULT1E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[327]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[328]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[329]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[327]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[329]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[330]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[331]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[332]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[329]

Drug(s) Affected By Achaete-scute homolog 1 (ASCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[334]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[335]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[164]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[337]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[338]
Propanoic Acid	DM9TN2W	Discovery agent	N.A.	Investigative	[339]

Drug(s) Affected By Oxysterols receptor LXR-beta (NR1H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[341]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[342]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[342]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[302]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[342]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[343]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[344]

Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[345]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[345]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[346]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[345]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[346]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[347]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[348]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[201]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[202]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[201]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[201]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[204]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[201]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[249]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[249]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[145]

Drug(s) Affected By Complement factor H-related protein 3 (CFHR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[352]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[353]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[301]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[342]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[354]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[342]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[355]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[302]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[356]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[343]

Drug(s) Affected By Nuclear factor 1 X-type (NFIX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[232]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[358]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[299]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[218]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[359]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[361]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[123]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[362]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[363]

Drug(s) Affected By Organic solute transporter subunit alpha (SLC51A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[365]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[364]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]

Drug(s) Affected By Organic solute transporter subunit beta (SLC51B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[365]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[305]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[364]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[366]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[145]

Drug(s) Affected By Liver-expressed antimicrobial peptide 2 (LEAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[367]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[368]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[193]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[121]

Drug(s) Affected By N-acetylmuramoyl-L-alanine amidase (PGLYRP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[299]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[121]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[369]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[370]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[371]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[372]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[276]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[371]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[364]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[373]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]

Drug(s) Affected By Normal mucosa of esophagus-specific gene 1 protein (C15ORF48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[374]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[375]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[376]

Drug(s) Affected By ATP-binding cassette sub-family G member 5 (ABCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[215]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[319]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[364]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[193]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[364]

Drug(s) Affected By 2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[377]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[377]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[216]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[368]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Cytochrome P450 3A43 (CYP3A43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[153]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[379]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[380]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[381]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[164]

Drug(s) Affected By NADPH oxidase 4 (NOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[383]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[384]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[385]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[386]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[387]
ANGIOTENSIN II	DMLWQ27	Increase blood pressure	BA04	Approved	[388]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[389]
Fructose	DM43AN2	Vomiting	MD90	Approved	[390]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[391]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[392]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[346]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[393]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[145]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[393]

Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[394]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[220]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[395]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[395]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[395]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[395]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[395]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[395]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[396]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[397]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[398]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[399]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[272]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[400]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[401]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[323]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[402]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[403]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[404]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[405]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[406]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[407]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[408]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[409]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[410]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[411]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[409]

Drug(s) Affected By Coxsackievirus and adenovirus receptor (CXADR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[249]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[193]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[412]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[299]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[413]

Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[215]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[274]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[414]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[276]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[415]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[416]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[417]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[418]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[419]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[420]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[421]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[422]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[364]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[423]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[397]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endothelin A receptor (EDNRA)	TTKRD0G	EDNRA_HUMAN	Modulator	[3]
Endothelin B receptor (EDNRB)	TT3ZTGU	EDNRB_HUMAN	Modulator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 2B1 (SLCO2B1)	DTPFTEQ	SO2B1_HUMAN	Substrate	[4]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[4]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2C9 (CYP2C9) Main DME	DE5IED8	CP2C9_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)	OTINY3MW	AL8A1_HUMAN	Gene/Protein Processing	[7]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Gene/Protein Processing	[7]
Achaete-scute homolog 1 (ASCL1)	OTI4X44G	ASCL1_HUMAN	Gene/Protein Processing	[7]
Alcohol dehydrogenase 1A (ADH1A)	OTTS983E	ADH1A_HUMAN	Gene/Protein Processing	[7]
Alcohol dehydrogenase 1C (ADH1C)	OTO1DV7F	ADH1G_HUMAN	Gene/Protein Processing	[7]
All-trans-retinol dehydrogenase ADH1B (ADH1B)	OTV3TB81	ADH1B_HUMAN	Gene/Protein Processing	[7]
All-trans-retinol dehydrogenase ADH4 (ADH4)	OTKDKKNG	ADH4_HUMAN	Gene/Protein Processing	[7]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[7]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Gene/Protein Processing	[8]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Gene/Protein Processing	[8]

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