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Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7402).
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Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain.J Med Chem. 2019 Mar 14;62(5):2466-2484. doi: 10.1021/acs.jmedchem.8b01775. Epub 2019 Feb 20.
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Involvement of adenosine A1 receptor in electroacupuncture-mediated inhibition of astrocyte activation during neuropathic pain.Arq Neuropsiquiatr. 2018 Nov;76(11):736-742. doi: 10.1590/0004-282X20180128.
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Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior.Neuropsychopharmacology. 2019 Sep;44(10):1728-1741. doi: 10.1038/s41386-019-0423-7. Epub 2019 May 29.
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Role of ASIC3, Nav1.7 and Nav1.8 in electroacupuncture-induced analgesia in a mouse model of fibromyalgia pain.Acupunct Med. 2018 Apr;36(2):110-116. doi: 10.1136/acupmed-2016-011244. Epub 2018 Jan 17.
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Sustained relief of neuropathic pain by AAV-targeted expression of CBD3 peptide in rat dorsal root ganglion.Gene Ther. 2014 Jan;21(1):44-51. doi: 10.1038/gt.2013.56. Epub 2013 Oct 24.
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Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.Nat Neurosci. 2011 Oct 23;14(12):1569-73. doi: 10.1038/nn.2941.
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Complex formation between the vasopressin 1b receptor, -arrestin-2, and the -opioid receptor underlies morphine tolerance.Nat Neurosci. 2018 Jun;21(6):820-833. doi: 10.1038/s41593-018-0144-y. Epub 2018 Apr 30.
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Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli.Mol Brain. 2019 Oct 21;12(1):81. doi: 10.1186/s13041-019-0500-1.
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Brain mechanisms of social touch-induced analgesia in females.Pain. 2019 Sep;160(9):2072-2085. doi: 10.1097/j.pain.0000000000001599.
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Oximes short-acting CB1 receptor agonists.Bioorg Med Chem. 2018 Oct 1;26(18):4963-4970. doi: 10.1016/j.bmc.2018.08.003. Epub 2018 Aug 2.
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Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation.PLoS One. 2019 Jun 25;14(6):e0218619. doi: 10.1371/journal.pone.0218619. eCollection 2019.
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Involvement of glycine receptor 1 subunits in cannabinoid-induced analgesia.Neuropharmacology. 2018 May 1;133:224-232. doi: 10.1016/j.neuropharm.2018.01.041. Epub 2018 Feb 1.
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Genetic behavioral screen identifies an orphan anti-opioid system.Science. 2019 Sep 20;365(6459):1267-1273. doi: 10.1126/science.aau2078. Epub 2019 Aug 15.
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Positive Modulation of Angiotensin II Type 1 Receptor-Mediated Signaling by LVV-Hemorphin-7.Front Pharmacol. 2019 Oct 25;10:1258. doi: 10.3389/fphar.2019.01258. eCollection 2019.
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Deletion of the type 2 metabotropic glutamate receptor increases heroin abuse vulnerability in transgenic rats.Neuropsychopharmacology. 2018 Dec;43(13):2615-2626. doi: 10.1038/s41386-018-0231-5. Epub 2018 Oct 3.
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Supraspinal metabotropic glutamate receptor subtype 8: a switch to turn off pain.Amino Acids. 2014 Jun;46(6):1441-8. doi: 10.1007/s00726-014-1703-5. Epub 2014 Mar 13.
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HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.J Pharmacol Exp Ther. 2013 Jun;345(3):363-73. doi: 10.1124/jpet.113.203620. Epub 2013 Apr 2.
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Spinal Orexin-2 Receptors are Involved in Modulation of the Lateral Hypothalamic Stimulation-Induced Analgesia.Neurochem Res. 2019 May;44(5):1152-1158. doi: 10.1007/s11064-019-02749-w. Epub 2019 Mar 15.
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Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and post-operative analgesia, pain sensitivity, and nicotine dependence.J Pharmacol Sci. 2014;126(3):253-63. doi: 10.1254/jphs.14189fp. Epub 2014 Oct 25.
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Endogenous cannabinoid modulation of restraint stress-induced analgesia in thermal nociception.J Neurochem. 2020 Jan;152(1):92-102. doi: 10.1111/jnc.14884. Epub 2019 Oct 25.
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Genetic Influences of OPRM1, OPRD1 and COMT on Morphine Analgesia in a Multi-Modal, Multi-Tissue Human Experimental Pain Model.Basic Clin Pharmacol Toxicol. 2017 Jul;121(1):6-12. doi: 10.1111/bcpt.12757. Epub 2017 Mar 14.
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Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine.J Pharmacol Exp Ther. 2019 Nov;371(2):487-499. doi: 10.1124/jpet.118.255661. Epub 2019 Sep 6.
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Nociceptin/orphanin FQ receptor ligands and translational challenges: focus on cebranopadol as an innovative analgesic.Br J Anaesth. 2018 Nov;121(5):1105-1114. doi: 10.1016/j.bja.2018.06.024. Epub 2018 Aug 22.
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Electroacupuncture downregulates P2X3 receptor expression in dorsal root ganglia of the spinal nerve-ligated rat.Mol Pain. 2019 Jan-Dec;15:1744806919847810. doi: 10.1177/1744806919847810.
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Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray.Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10720-E10729. doi: 10.1073/pnas.1807991115. Epub 2018 Oct 22.
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Altered Gene Expression of RNF34 and PACAP Possibly Involved in Mechanism of Exercise-Induced Analgesia for Neuropathic Pain in Rats.Int J Mol Sci. 2017 Sep 13;18(9):1962. doi: 10.3390/ijms18091962.
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Characterization of New TRPM8 Modulators in Pain Perception.Int J Mol Sci. 2019 Nov 7;20(22):5544. doi: 10.3390/ijms20225544.
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Anti-nociceptive and anti-inflammatory effects of the ethanol extract of Arenga pinnata (Wurmb) Merr. fruit.J Ethnopharmacol. 2020 Feb 10;248:112349. doi: 10.1016/j.jep.2019.112349. Epub 2019 Nov 19.
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The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity.Neuron. 2014 Sep 3;83(5):1144-58. doi: 10.1016/j.neuron.2014.07.036.
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The involvement of ventral hippocampal microglial cells, but not cannabinoid CB1 receptors, in morphine-induced analgesia in rats.Acta Neurol Belg. 2020 Oct;120(5):1077-1084. doi: 10.1007/s13760-019-01144-0. Epub 2019 Apr 20.
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Association between MDR(1)/CYP3A4/OPRM(1) gene polymorphisms and the post-caesarean fentanyl analgesic effect on Chinese women.Gene. 2018 Jun 30;661:78-84. doi: 10.1016/j.gene.2018.03.081. Epub 2018 Mar 27.
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Widespread dynamic and pleiotropic expression of the melanocortin-1-receptor (MC1R) system is conserved across chick, mouse and human embryonic development.Birth Defects Res. 2018 Mar 15;110(5):443-455. doi: 10.1002/bdr2.1183. Epub 2018 Jan 8.
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Inferring distinct mechanisms in the absence of subjective differences: Placebo and centrally acting analgesic underlie unique brain adaptations.Hum Brain Mapp. 2018 May;39(5):2210-2223. doi: 10.1002/hbm.23999. Epub 2018 Feb 7.
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Influence of uridine diphosphate-glucuronyltransferase 2B7 (UGT2B7) variants on postoperative buprenorphine analgesia.Pain Pract. 2015 Jan;15(1):22-30. doi: 10.1111/papr.12152. Epub 2013 Nov 20.
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Enhanced recovery after esophageal resection.Cir Esp (Engl Ed). 2018 Aug-Sep;96(7):401-409. doi: 10.1016/j.ciresp.2018.02.010. Epub 2018 Mar 21.
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Oligomerization of MrgC11 and -opioid receptors in sensory neurons enhances morphine analgesia.Sci Signal. 2018 Jun 19;11(535):eaao3134. doi: 10.1126/scisignal.aao3134.
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Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice.Neuroreport. 2017 Dec 13;28(18):1215-1220. doi: 10.1097/WNR.0000000000000872.
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The Systemic Administration of the Chemokine CCL1 Evokes Thermal Analgesia in Mice Through the Activation of the Endocannabinoid System.Cell Mol Neurobiol. 2019 Nov;39(8):1115-1124. doi: 10.1007/s10571-019-00706-3. Epub 2019 Jun 15.
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The nicotinic 6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.Sci Transl Med. 2015 May 13;7(287):287ra72. doi: 10.1126/scitranslmed.3009986.
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Precision-guided long-acting analgesia by Gel-immobilized bupivacaine-loaded microsphere.Theranostics. 2018 May 23;8(12):3331-3347. doi: 10.7150/thno.25276. eCollection 2018.
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Impact of epidural analgesia on the systemic biomarker response after hepatic resection.Oncotarget. 2019 Jan 15;10(5):584-594. doi: 10.18632/oncotarget.26549. eCollection 2019 Jan 15.
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Dexmedetomidine in combination with morphine improves postoperative analgesia and sleep quality in elderly patients after open abdominal surgery: A pilot randomized control trial.PLoS One. 2018 Aug 14;13(8):e0202008. doi: 10.1371/journal.pone.0202008. eCollection 2018.
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Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.Addict Biol. 2019 Mar;24(2):228-238. doi: 10.1111/adb.12590. Epub 2017 Dec 21.
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Buprenorphine-Sustained Release Alters Hemodynamic Parameters in a Rat Burn Model.J Surg Res. 2018 Dec;232:154-159. doi: 10.1016/j.jss.2018.03.016. Epub 2018 Jul 5.
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Variation in postoperative narcotic prescribing after pediatric appendectomy.J Pediatr Surg. 2019 Sep;54(9):1866-1871. doi: 10.1016/j.jpedsurg.2018.11.015. Epub 2019 Feb 7.
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Heart rate variability in healthy term newborns is related to delivery mode: a prospective observational study.BMC Pregnancy Childbirth. 2018 Jun 27;18(1):264. doi: 10.1186/s12884-018-1900-4.
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Subarachnoid block with continuous TAP catheter analgesia produces less chronic pain and better functional outcome after inguinal hernioplasty: a randomized controlled observer-blinded study.Reg Anesth Pain Med. 2019 Feb;44(2):228-233. doi: 10.1136/rapm-2018-000029.
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Evaluation of ultrasound-guided transversalis fascia plane block for postoperative analgesia in cesarean section: A prospective, randomized, controlled clinical trial.J Clin Anesth. 2020 Feb;59:56-60. doi: 10.1016/j.jclinane.2019.06.025. Epub 2019 Jun 27.
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Global Gene Knockout of Kcnip3 Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats.Front Mol Neurosci. 2019 Jan 25;12:5. doi: 10.3389/fnmol.2019.00005. eCollection 2019.
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Low-dose methoxyflurane analgesia in adolescent patients with moderate-to-severe trauma pain: a subgroup analysis of the STOP! study.J Pain Res. 2019 Feb 15;12:689-700. doi: 10.2147/JPR.S188675. eCollection 2019.
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Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants.Synapse. 2016 Oct;70(10):395-407. doi: 10.1002/syn.21914. Epub 2016 Jul 12.
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Effects of hydromorphone and morphine intravenous analgesia on plasma motilin and postoperative nausea and vomiting in patients undergoing total hysterectomy.Eur Rev Med Pharmacol Sci. 2018 Sep;22(17):5697-5703. doi: 10.26355/eurrev_201809_15837.
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Intrathecal betamethasone for cancer pain: A study of its analgesic efficacy and safety.Acta Anaesthesiol Scand. 2019 May;63(5):659-667. doi: 10.1111/aas.13305. Epub 2018 Dec 7.
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SUMMIT-07: a randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain.Pain. 2019 Jun;160(6):1374-1382. doi: 10.1097/j.pain.0000000000001517.
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Analgesic activities of the mixed opioid and NPFF receptors agonist DN-9 in a mouse model of formalin-induced orofacial inflammatory pain.Peptides. 2018 Dec;110:30-39. doi: 10.1016/j.peptides.2018.10.010. Epub 2018 Nov 1.
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Central noradrenergic activity affects analgesic effect of Neuropeptide S.J Anesth. 2018 Feb;32(1):48-53. doi: 10.1007/s00540-017-2427-y. Epub 2017 Nov 11.
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Gonadotropin-inhibitory hormone mediates behavioral stress responses.Gen Comp Endocrinol. 2018 Sep 1;265:202-206. doi: 10.1016/j.ygcen.2018.03.004. Epub 2018 Mar 3.
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Calcium-binding protein, spermatid-specific 1 is expressed in human salivary glands and contains an anti-inflammatory motif.Am J Physiol Regul Integr Comp Physiol. 2015 Apr 1;308(7):R569-75. doi: 10.1152/ajpregu.00153.2014. Epub 2015 Jan 28.
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Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene.Peptides. 2018 Sep;107:10-16. doi: 10.1016/j.peptides.2018.06.010. Epub 2018 Jul 21.
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Yin-and-yang bifurcation of opioidergic circuits for descending analgesia at the midbrain of the mouse.Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11078-11083. doi: 10.1073/pnas.1806082115. Epub 2018 Oct 8.
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Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors.Neuropharmacology. 2013 Dec;75:164-71. doi: 10.1016/j.neuropharm.2013.07.012. Epub 2013 Aug 2.
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Desmetramadol Has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials.J Pain. 2019 Oct;20(10):1218-1235. doi: 10.1016/j.jpain.2019.04.005. Epub 2019 Apr 18.
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RGS9-2 Modulates Responses to Oxycodone in Pain-Free and Chronic Pain States.Neuropsychopharmacology. 2017 Jun;42(7):1548-1556. doi: 10.1038/npp.2017.4. Epub 2017 Jan 11.
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Additional benefit of local infiltration of analgesia to femoral nerve block in total knee arthroplasty: double-blind randomized control study.Knee Surg Sports Traumatol Arthrosc. 2019 Jul;27(7):2368-2374. doi: 10.1007/s00167-018-5322-7. Epub 2018 Dec 8.
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Local infiltration analgesia: a 2-year follow-up of patients undergoing total hip arthroplasty.J Anesth. 2017 Dec;31(6):837-845. doi: 10.1007/s00540-017-2403-6. Epub 2017 Aug 30.
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Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice.Mol Pain. 2019 Jan-Dec;15:1744806919845750. doi: 10.1177/1744806919845750.
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TAT-Modified -Conotoxin MVIIA for Crossing the Blood-Brain Barrier.Mar Drugs. 2019 May 12;17(5):286. doi: 10.3390/md17050286.
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The combination of opioid and neurotensin receptor agonists improves their analgesic/adverse effect ratio.Eur J Pharmacol. 2019 Apr 5;848:80-87. doi: 10.1016/j.ejphar.2019.01.048. Epub 2019 Jan 29.
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