Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTOBHZVA)

DOT Name Mas-related G-protein coupled receptor member X4 (MRGPRX4)
Synonyms Sensory neuron-specific G-protein coupled receptor 5/6
Gene Name MRGPRX4
Related Disease
Acute myelogenous leukaemia ( )
Hyperglycemia ( )
Uveal Melanoma ( )
Advanced cancer ( )
Analgesia ( )
Cardiac failure ( )
Cardiovascular disease ( )
Clear cell renal carcinoma ( )
Colorectal carcinoma ( )
Congestive heart failure ( )
Cystic fibrosis ( )
Depression ( )
Hereditary hemochromatosis ( )
Kaposi sarcoma ( )
Melanoma ( )
Metabolic disorder ( )
Multiple sclerosis ( )
Myocardial infarction ( )
Nephrogenic diabetes insipidus ( )
Non-insulin dependent diabetes ( )
Non-small-cell lung cancer ( )
Obesity ( )
Osteoarthritis ( )
Pancreatic neuroendocrine tumor ( )
Prostate cancer ( )
Prostate carcinoma ( )
Schizophrenia ( )
Thyroid gland carcinoma ( )
Thyroid gland papillary carcinoma ( )
Thyroid tumor ( )
Triple negative breast cancer ( )
Type-1/2 diabetes ( )
Autoimmune disease ( )
High blood pressure ( )
leukaemia ( )
Leukemia ( )
Small lymphocytic lymphoma ( )
Squamous cell carcinoma ( )
Parkinson disease ( )
Skin cancer ( )
Adult glioblastoma ( )
Alzheimer disease ( )
Asthma ( )
Breast cancer ( )
Breast carcinoma ( )
Carcinoma ( )
Glioblastoma multiforme ( )
Inflammatory bowel disease ( )
Osteoporosis ( )
Pancreatic cancer ( )
UniProt ID
MRGX4_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
PDB ID
7S8P
Pfam ID
PF00001
Sequence
MDPTVPVFGTKLTPINGREETPCYNQTLSFTVLTCIISLVGLTGNAVVLWLLGYRMRRNA
VSIYILNLAAADFLFLSFQIIRLPLRLINISHLIRKILVSVMTFPYFTGLSMLSAISTER
CLSVLWPIWYRCRRPTHLSAVVCVLLWGLSLLFSMLEWRFCDFLFSGADSSWCETSDFIP
VAWLIFLCVVLCVSSLVLLVRILCGSRKMPLTRLYVTILLTVLVFLLCGLPFGILGALIY
RMHLNLEVLYCHVYLVCMSLSSLNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDKPE
VDKGEGQLPEESLELSGSRLGP
Function
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins.
Tissue Specificity Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.

Molecular Interaction Atlas (MIA) of This DOT

50 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Acute myelogenous leukaemia DISCSPTN Definitive Biomarker [1]
Hyperglycemia DIS0BZB5 Definitive Genetic Variation [2]
Uveal Melanoma DISA7ZGL Definitive Genetic Variation [3]
Advanced cancer DISAT1Z9 Strong Biomarker [4]
Analgesia DISK3TVI Strong Biomarker [5]
Cardiac failure DISDC067 Strong Biomarker [6]
Cardiovascular disease DIS2IQDX Strong Biomarker [6]
Clear cell renal carcinoma DISBXRFJ Strong Biomarker [7]
Colorectal carcinoma DIS5PYL0 Strong Genetic Variation [8]
Congestive heart failure DIS32MEA Strong Biomarker [6]
Cystic fibrosis DIS2OK1Q Strong Genetic Variation [9]
Depression DIS3XJ69 Strong Biomarker [10]
Hereditary hemochromatosis DISVG5MT Strong Biomarker [11]
Kaposi sarcoma DISC1H1Z Strong Biomarker [12]
Melanoma DIS1RRCY Strong Biomarker [13]
Metabolic disorder DIS71G5H Strong Biomarker [14]
Multiple sclerosis DISB2WZI Strong Altered Expression [15]
Myocardial infarction DIS655KI Strong Altered Expression [16]
Nephrogenic diabetes insipidus DISKNSJK Strong Biomarker [17]
Non-insulin dependent diabetes DISK1O5Z Strong Biomarker [18]
Non-small-cell lung cancer DIS5Y6R9 Strong Biomarker [19]
Obesity DIS47Y1K Strong Biomarker [20]
Osteoarthritis DIS05URM Strong Genetic Variation [21]
Pancreatic neuroendocrine tumor DISDMPU0 Strong Biomarker [22]
Prostate cancer DISF190Y Strong Biomarker [23]
Prostate carcinoma DISMJPLE Strong Biomarker [23]
Schizophrenia DISSRV2N Strong Biomarker [24]
Thyroid gland carcinoma DISMNGZ0 Strong Genetic Variation [25]
Thyroid gland papillary carcinoma DIS48YMM Strong Genetic Variation [25]
Thyroid tumor DISLVKMD Strong Genetic Variation [25]
Triple negative breast cancer DISAMG6N Strong Biomarker [26]
Type-1/2 diabetes DISIUHAP Strong Biomarker [27]
Autoimmune disease DISORMTM moderate Biomarker [28]
High blood pressure DISY2OHH moderate Biomarker [29]
leukaemia DISS7D1V moderate Altered Expression [30]
Leukemia DISNAKFL moderate Altered Expression [30]
Small lymphocytic lymphoma DIS30POX moderate Biomarker [31]
Squamous cell carcinoma DISQVIFL moderate Biomarker [32]
Parkinson disease DISQVHKL Disputed Altered Expression [33]
Skin cancer DISTM18U Disputed Altered Expression [34]
Adult glioblastoma DISVP4LU Limited Biomarker [35]
Alzheimer disease DISF8S70 Limited Biomarker [36]
Asthma DISW9QNS Limited Biomarker [37]
Breast cancer DIS7DPX1 Limited Biomarker [38]
Breast carcinoma DIS2UE88 Limited Biomarker [38]
Carcinoma DISH9F1N Limited Genetic Variation [39]
Glioblastoma multiforme DISK8246 Limited Biomarker [35]
Inflammatory bowel disease DISGN23E Limited Biomarker [40]
Osteoporosis DISF2JE0 Limited Biomarker [41]
Pancreatic cancer DISJC981 Limited Biomarker [42]
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⏷ Show the Full List of 50 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Mas-related G-protein coupled receptor member X4 (MRGPRX4). [43]
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1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Leflunomide DMR8ONJ Phase 1 Trial Leflunomide increases the expression of Mas-related G-protein coupled receptor member X4 (MRGPRX4). [44]
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References

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