Details of Disease

General Information of Disease (ID: DISO0BY5)

Disease Name	Bronchopulmonary dysplasia
Synonyms	BPD
Disease Class	KB29: Perinatal period chronic respiratory disease
Definition	Bronchopulmonary dysplasia is a chronic respiratory disease that results from complications related to lung injury during the treatment of infant acute respiratory distress syndrome in low-birth-weight premature infants or from abnormal lung development in older infants. Clinical signs are tachypnea, tachycardia and signs of respiratory distress such as intercostal recession, grunting and nasal flaring.
Disease Hierarchy	DISQCXZX: Disorder of development or morphogenesis DISGGAGJ: Respiratory disease DISO0BY5: Bronchopulmonary dysplasia
ICD Code	ICD-11 ICD-11: KB29.0 ICD-10 ICD-10: P27.1 ICD-9 ICD-9: 770.7 Expand ICD-9 770.7
Disease Identifiers	MONDO ID MONDO_0019091 MESH ID D001997 UMLS CUI C0006287 MedGen ID 2738 Orphanet ID 70589 SNOMED CT ID 67569000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Rsv Immune Globulin	DM3FCQ9	Approved	NA	[1]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Pneumostem	DM9NJXX	Phase 2	NA	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 62 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
P2RX7	TT473XN	Limited	Biomarker	[3]
SFTPD	TTGLMU7	Limited	Biomarker	[4]
TPH2	TT3KLDP	Limited	Genetic Variation	[5]
TXN	TTZJ5U9	Limited	Altered Expression	[6]
DMD	TTWLFXU	moderate	Genetic Variation	[7]
FGF7	TTFY134	moderate	Genetic Variation	[8]
GAD1	TTKGEP3	moderate	Altered Expression	[9]
POSTN	TT8ALTZ	moderate	Altered Expression	[10]
ADCY2	TTBQ9IM	Strong	Genetic Variation	[11]
BAX	TTQ57WJ	Strong	Biomarker	[12]
BPI	TTXCSDR	Strong	Genetic Variation	[13]
BRD1	TTT09OB	Strong	Biomarker	[14]
CACNA1E	TTYRP0M	Strong	Biomarker	[15]
CASP3	TTPF2QI	Strong	Biomarker	[12]
CASP8	TT6SZNG	Strong	Biomarker	[12]
CASP9	TTB6T7O	Strong	Biomarker	[12]
CHRM2	TTYEG6Q	Strong	Biomarker	[16]
CHRNA2	TTF4E0J	Strong	Genetic Variation	[17]
CHRNA7	TTLA931	Strong	Biomarker	[18]
CLDN18	TT6PKBX	Strong	Altered Expression	[19]
CMKLR1	TT4UGZL	Strong	Genetic Variation	[20]
CRHR1	TT7EFHR	Strong	Genetic Variation	[21]
CTSG	TTQAJF1	Strong	Altered Expression	[22]
CXCL1	TTLK1RW	Strong	Biomarker	[23]
DUSP5	TTZN92A	Strong	Genetic Variation	[24]
EDN1	TTJR60Z	Strong	Biomarker	[25]
EPAS1	TTWPA54	Strong	Therapeutic	[26]
ERBB4	TTWALCO	Strong	Biomarker	[27]
FGF10	TTNPEFX	Strong	Altered Expression	[28]
FKBP5	TT0J5KQ	Strong	Genetic Variation	[29]
FPR1	TT5Y4EM	Strong	Biomarker	[30]
GABRB2	TTZA1NY	Strong	Altered Expression	[31]
GRIK2	TT0K5RG	Strong	Altered Expression	[32]
GRK3	TT5A4DX	Strong	Genetic Variation	[33]
HIF1A	TTSN6QU	Strong	Biomarker	[34]
HTR1A	TTSQIFT	Strong	Altered Expression	[35]
HTR1B	TTK8CXU	Strong	Altered Expression	[35]
HTR2C	TTWJBZ5	Strong	Biomarker	[36]
ID2	TTW8A5N	Strong	Genetic Variation	[37]
IMPA2	TTXWL6D	Strong	Genetic Variation	[38]
KCNQ2	TTPXI3S	Strong	Genetic Variation	[39]
KCNQ3	TTIVDM3	Strong	Altered Expression	[39]
LCT	TTA0OSE	Strong	Genetic Variation	[40]
MCHR1	TTX4RTB	Strong	Biomarker	[41]
MMP16	TTNP4CU	Strong	Genetic Variation	[42]
NPSR1	TTV1C0Z	Strong	Biomarker	[20]
NRN1	TTS05MJ	Strong	Biomarker	[43]
P2RX1	TTJW7B3	Strong	Biomarker	[3]
P2RX3	TT2THBD	Strong	Biomarker	[3]
P2RX4	TT1NLOA	Strong	Biomarker	[3]
P2RY1	TTA93TL	Strong	Biomarker	[3]
P2RY2	TTOZHQC	Strong	Biomarker	[3]
PDE10A	TTJW4LU	Strong	Biomarker	[44]
PLOD2	TT8MEUD	Strong	Altered Expression	[45]
SCGB1A1	TTONPVW	Strong	Biomarker	[46]
SELL	TT2IYXF	Strong	Genetic Variation	[47]
SLC18A2	TTNZRI3	Strong	Biomarker	[48]
TIRAP	TTKU0LS	Strong	Genetic Variation	[49]
TLR5	TTCXP8J	Strong	Genetic Variation	[50]
TLR6	TTWRI8V	Strong	Genetic Variation	[51]
TPH1	TTZSJHV	Strong	Genetic Variation	[52]
TXNRD1	TTR7UJ3	Strong	Biomarker	[53]
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⏷ Show the Full List of 62 DTT(s)

This Disease Is Related to 4 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCA3	DT2T6VQ	Strong	Biomarker	[54]
CACNG2	DTRL7OG	Strong	Altered Expression	[55]
SLC14A2	DT8QC7K	Strong	Genetic Variation	[56]
SLC18A1	DTM953D	Strong	Genetic Variation	[48]
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This Disease Is Related to 3 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP1A1	DE6OQ3W	moderate	Biomarker	[57]
DDAH1	DEY0TQC	Strong	Genetic Variation	[58]
GSTZ1	DEQPEMB	Strong	Genetic Variation	[59]
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This Disease Is Related to 65 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SPOCK2	OTXSVTSA	Limited	Biomarker	[60]
TENM4	OT91K3FC	Limited	Genetic Variation	[61]
AGBL1	OT8NQLH0	moderate	Genetic Variation	[7]
CTNNA3	OT9Z0P1E	moderate	Genetic Variation	[62]
DISC1	OT43AW4H	moderate	Genetic Variation	[63]
IL1RAPL1	OTW3T4B2	moderate	Genetic Variation	[7]
NBL1	OTT37U4O	moderate	Genetic Variation	[64]
RAB40B	OTCA9ZF5	moderate	Genetic Variation	[65]
SFTPB	OTOHS07E	moderate	Biomarker	[66]
SFTPC	OTIZJD09	moderate	Altered Expression	[28]
AIMP1	OTTA5C3U	Strong	Altered Expression	[67]
BID	OTOSHSHU	Strong	Biomarker	[12]
BOC	OTXBCY9W	Strong	Biomarker	[68]
CACNA2D4	OTVYNX7N	Strong	Genetic Variation	[69]
CALB2	OTSNMCG9	Strong	Biomarker	[70]
CAMK2A	OTJGX19T	Strong	Biomarker	[15]
CAP2	OTC1WFNO	Strong	Biomarker	[71]
CCL13	OTNX0JD0	Strong	Genetic Variation	[72]
CCL24	OT9LGHV0	Strong	Biomarker	[72]
CCN5	OTADU8JJ	Strong	Biomarker	[73]
CENPJ	OTZCQZN5	Strong	Biomarker	[74]
CEP85L	OTSHJFOT	Strong	Biomarker	[11]
CRISPLD2	OTVSFHTL	Strong	Biomarker	[75]
DDAH2	OT8Q40G2	Strong	Biomarker	[58]
DDT	OTF5HTYL	Strong	Genetic Variation	[76]
DGKH	OTYNPJ4B	Strong	Biomarker	[77]
DYM	OTQ670WI	Strong	Biomarker	[78]
EML2	OTRX2NTA	Strong	Altered Expression	[67]
EML5	OT0EFCPB	Strong	Altered Expression	[67]
ETNPPL	OTSXO9P6	Strong	Altered Expression	[79]
FOXF2	OTV20NGX	Strong	Altered Expression	[80]
GPC1	OTQKRSSV	Strong	Biomarker	[81]
IL18BP	OTW0LRYZ	Strong	Biomarker	[82]
INTU	OTXB13E6	Strong	Biomarker	[83]
IPO13	OT887N3O	Strong	Genetic Variation	[84]
KANK4	OT5WC0Q8	Strong	Biomarker	[71]
LLGL1	OTAIQSXZ	Strong	Biomarker	[75]
LMAN2L	OTJ9FAWS	Strong	Biomarker	[85]
LOXL1	OTA0NEJU	Strong	Biomarker	[86]
MIXL1	OT584VOQ	Strong	Biomarker	[87]
MPPE1	OTINBJVE	Strong	Genetic Variation	[88]
MSC	OTBRPZL5	Strong	Biomarker	[89]
MZB1	OT071TET	Strong	Genetic Variation	[90]
NIF3L1	OT4MP90J	Strong	Genetic Variation	[13]
OPN1LW	OTFNUZ7O	Strong	Genetic Variation	[91]
P2RX2	OT0LF34A	Strong	Biomarker	[3]
P2RX5	OTLBR20R	Strong	Biomarker	[3]
P2RX6	OT1FNTXA	Strong	Biomarker	[3]
PC	OT6O0V51	Strong	Biomarker	[92]
PLA2G10	OTRZ2L5A	Strong	Altered Expression	[93]
PLOD3	OTT00T7Q	Strong	Altered Expression	[45]
PRSS2	OTOMVUWL	Strong	Altered Expression	[94]
PTBP2	OTF4S7NE	Strong	Genetic Variation	[95]
SCGB3A2	OTB63PHR	Strong	Biomarker	[96]
SCN4B	OT3JSUWO	Strong	Altered Expression	[9]
SERPINB1	OT5RDUFO	Strong	Biomarker	[97]
SFTPA1	OT87XL1U	Strong	Genetic Variation	[47]
SFTPA2	OT6SFOMU	Strong	Biomarker	[98]
SHANK1	OTK8PV0S	Strong	Genetic Variation	[99]
SHANK2	OTSQTPFQ	Strong	Genetic Variation	[99]
SIPA1	OTXY5RXC	Strong	Genetic Variation	[47]
SUMO2	OT1Y5IKN	Strong	Biomarker	[100]
SYNJ1	OTTE02XC	Strong	Biomarker	[101]
TNFAIP6	OT1SLUZH	Strong	Altered Expression	[102]
TSPAN8	OT1F68WQ	Strong	Genetic Variation	[103]
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⏷ Show the Full List of 65 DOT(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Associations between depression severity and purinergic receptor P2RX7 gene polymorphisms.J Affect Disord. 2013 Aug 15;150(1):104-9. doi: 10.1016/j.jad.2013.02.033. Epub 2013 Apr 18.
4	Serum surfactant protein D as a marker for bronchopulmonary dysplasia.J Matern Fetal Neonatal Med. 2019 Mar;32(5):815-819. doi: 10.1080/14767058.2017.1392506. Epub 2017 Oct 26.
5	Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population.Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:97-100. doi: 10.1016/j.pnpbp.2014.08.008. Epub 2014 Aug 21.
6	Thioredoxin-1 Protects Bone Marrow-Derived Mesenchymal Stromal Cells from Hyperoxia-Induced Injury In Vitro.Oxid Med Cell Longev. 2018 Jan 21;2018:1023025. doi: 10.1155/2018/1023025. eCollection 2018.
7	Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia.Am J Respir Crit Care Med. 2011 Nov 15;184(10):1164-70. doi: 10.1164/rccm.201103-0548OC. Epub 2011 Aug 11.
8	Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?.Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L248-L252. doi: 10.1152/ajplung.00140.2018. Epub 2018 May 3.
9	Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree.PLoS One. 2015 Nov 10;10(11):e0142693. doi: 10.1371/journal.pone.0142693. eCollection 2015.
10	Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication.PLoS One. 2012;7(2):e31336. doi: 10.1371/journal.pone.0031336. Epub 2012 Feb 17.
11	Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis.Biol Psychiatry. 2017 Nov 1;82(9):634-641. doi: 10.1016/j.biopsych.2016.08.040. Epub 2016 Oct 18.
12	Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1 and p53 pathways.Respir Physiol Neurobiol. 2016 Jan;220:81-7. doi: 10.1016/j.resp.2015.09.011. Epub 2015 Sep 30.
13	Linkage and candidate gene analysis of 14q22-24 in bipolar disorder: support for GCHI as a novel susceptibility gene.Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):75-80. doi: 10.1002/ajmg.b.30192.
14	Support of association between BRD1 and both schizophrenia and bipolar affective disorder.Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):582-591. doi: 10.1002/ajmg.b.31023.
15	Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder.J Psychiatr Res. 2019 Aug;115:165-175. doi: 10.1016/j.jpsychires.2019.05.024. Epub 2019 May 25.
16	The Role of Muscarinic Receptors in the Pathophysiology of Mood Disorders: A Potential Novel Treatment?.Curr Neuropharmacol. 2015;13(6):739-49. doi: 10.2174/1570159x13666150612230045.
17	No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) and bipolar I disorder.Psychiatry Res. 2005 Jun 30;135(3):171-7. doi: 10.1016/j.psychres.2005.04.004.
18	Genes Involved in Neurodevelopment, Neuroplasticity, and Bipolar Disorder: CACNA1C, CHRNA1, and MAPK1.Neuropsychobiology. 2016;74(3):159-168. doi: 10.1159/000468543. Epub 2017 May 12.
19	Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice.Am J Respir Cell Mol Biol. 2014 Oct;51(4):550-8. doi: 10.1165/rcmb.2013-0456OC.
20	A new mouse model for mania shares genetic correlates with human bipolar disorder.PLoS One. 2012;7(6):e38128. doi: 10.1371/journal.pone.0038128. Epub 2012 Jun 4.
21	Correction: Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia.Pediatr Res. 2019 Apr;85(5):731. doi: 10.1038/s41390-019-0314-y.
22	Foxm1 regulates resolution of hyperoxic lung injury in newborns.Am J Respir Cell Mol Biol. 2015 May;52(5):611-21. doi: 10.1165/rcmb.2014-0091OC.
23	[Anti-inflammatory effects of erythropoietin on hyperoxia-induced bronchopulmonary dysplasia in newborn rats].Zhonghua Er Ke Za Zhi. 2009 Jun;47(6):446-51.
24	Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia.Pediatr Res. 2020 Jan;87(1):81-87. doi: 10.1038/s41390-019-0502-9. Epub 2019 Jul 22.
25	Identification of two nuclear factor of activated T-cells (NFAT)-response elements in the 5'-upstream regulatory region of the ET-1 promoter.J Biol Chem. 2010 Sep 10;285(37):28520-8. doi: 10.1074/jbc.M110.153189. Epub 2010 Jul 20.
26	Sildenafil alleviates bronchopulmonary dysplasia in neonatal rats by activating the hypoxia-inducible factor signaling pathway.Am J Respir Cell Mol Biol. 2013 Jan;48(1):105-13. doi: 10.1165/rcmb.2012-0043OC. Epub 2012 Oct 11.
27	ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines.Elife. 2018 Sep 4;7:e39907. doi: 10.7554/eLife.39907.
28	Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.Hum Mol Genet. 2019 May 1;28(9):1429-1444. doi: 10.1093/hmg/ddy439.
29	FKBP5 gene variants and borderline personality disorder.J Affect Disord. 2019 Apr 1;248:26-28. doi: 10.1016/j.jad.2019.01.025. Epub 2019 Jan 27.
30	Intratracheal transplantation of mesenchymal stem cells attenuates hyperoxia-induced lung injury by down-regulating, but not direct inhibiting formyl peptide receptor 1 in the newborn mice.PLoS One. 2018 Oct 24;13(10):e0206311. doi: 10.1371/journal.pone.0206311. eCollection 2018.
31	Epigenetic regulation on GABRB2 isoforms expression: developmental variations and disruptions in psychotic disorders.Schizophr Res. 2012 Feb;134(2-3):260-6. doi: 10.1016/j.schres.2011.11.029. Epub 2011 Dec 27.
32	Deregulation of the A-to-I RNA editing mechanism in psychiatric disorders.Hum Mol Genet. 2012 Jan 15;21(2):311-21. doi: 10.1093/hmg/ddr461. Epub 2011 Oct 7.
33	Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation.Psychiatr Genet. 2007 Dec;17(6):315-22. doi: 10.1097/YPG.0b013e3282efeeb4.
34	Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia.J Immunol. 2017 May 15;198(10):3815-3822. doi: 10.4049/jimmunol.1700014. Epub 2017 Apr 5.
35	Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia.Biol Psychiatry. 2004 Feb 1;55(3):225-33. doi: 10.1016/j.biopsych.2003.09.017.
36	Serotonin 2c receptor RNA editing in major depression and suicide.World J Biol Psychiatry. 2013 Dec;14(8):590-601. doi: 10.3109/15622975.2011.630406. Epub 2012 Mar 9.
37	Meta-analysis of ACE gene I/D polymorphism and bipolar disorder susceptibility.Nord J Psychiatry. 2011 Sep;65(4):276-82. doi: 10.3109/08039488.2011.555564. Epub 2011 Feb 11.
38	Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder.Prog Neuropsychopharmacol Biol Psychiatry. 2010 Dec 1;34(8):1515-9. doi: 10.1016/j.pnpbp.2010.08.015. Epub 2010 Aug 26.
39	DNA methylation and expression of KCNQ3 in bipolar disorder.Bipolar Disord. 2015 Mar;17(2):150-9. doi: 10.1111/bdi.12230. Epub 2014 Jul 11.
40	Factors associated with development of early and late pulmonary hypertension in preterm infants with bronchopulmonary dysplasia.J Perinatol. 2020 Jan;40(1):138-148. doi: 10.1038/s41372-019-0549-9. Epub 2019 Nov 13.
41	Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia.Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141B(5):524-33. doi: 10.1002/ajmg.b.30335.
42	Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.PLoS One. 2008 Sep 11;3(9):e3188. doi: 10.1371/journal.pone.0003188.
43	Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning.World J Biol Psychiatry. 2016;17(2):129-39. doi: 10.3109/15622975.2015.1093658. Epub 2015 Dec 24.
44	Genetic association of cyclic AMP signaling genes with bipolar disorder.Transl Psychiatry. 2012 Oct 2;2(10):e169. doi: 10.1038/tp.2012.92.
45	Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia.Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L246-59. doi: 10.1152/ajplung.00109.2013. Epub 2013 Nov 27.
46	Clara Cell Protein Expression in Mechanically Ventilated Term and Preterm Infants with Respiratory Distress Syndrome and at Risk of Bronchopulmonary Dysplasia: A Pilot Study.Can Respir J. 2017;2017:8074678. doi: 10.1155/2017/8074678. Epub 2017 Apr 11.
47	Dysplasia: a review.Pediatr Pulmonol. 2007 Oct;42(10):952-61. doi: 10.1002/ppul.20689.
48	Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder.Neuropsychopharmacology. 2006 Dec;31(12):2739-47. doi: 10.1038/sj.npp.1301196. Epub 2006 Aug 23.
49	A TLR5 (g.1174C?T) variant that encodes a stop codon (R392X) is associated with bronchopulmonary dysplasia.Pediatr Pulmonol. 2012 May;47(5):460-8. doi: 10.1002/ppul.21568. Epub 2011 Nov 4.
50	Association of TLR polymorphisms with bronchopulmonary dysplasia.Gene. 2016 Oct 30;592(1):23-28. doi: 10.1016/j.gene.2016.07.049. Epub 2016 Jul 25.
51	Single nucleotide polymorphism in toll-like receptor 6 is associated with a decreased risk for ureaplasma respiratory tract colonization and bronchopulmonary dysplasia in preterm infants.Pediatr Infect Dis J. 2013 Aug;32(8):898-904. doi: 10.1097/INF.0b013e31828fc693.
52	Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese.Arch Gen Psychiatry. 2007 Sep;64(9):1015-24. doi: 10.1001/archpsyc.64.9.1015.
53	Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia.Oxid Med Cell Longev. 2019 Jan 21;2019:7945983. doi: 10.1155/2019/7945983. eCollection 2019.
54	Cerebropulmonary dysgenetic syndrome.Exp Mol Pathol. 2008 Oct;85(2):112-6. doi: 10.1016/j.yexmp.2008.04.006. Epub 2008 May 28.
55	Stargazin involvement with bipolar disorder and response to lithium treatment. Pharmacogenet Genomics. 2008 May;18(5):403-12.
56	Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder.Mol Psychiatry. 2003 May;8(5):546-57. doi: 10.1038/sj.mp.4001268.
57	Hyperoxia-mediated transcriptional activation of cytochrome P4501A1 (CYP1A1) and decreased susceptibility to oxygen-mediated lung injury in newborn mice.Biochem Biophys Res Commun. 2018 Jan 1;495(1):408-413. doi: 10.1016/j.bbrc.2017.10.166. Epub 2017 Oct 31.
58	A single nucleotide polymorphism in the dimethylarginine dimethylaminohydrolase gene is associated with lower risk of pulmonary hypertension in bronchopulmonary dysplasia.Acta Paediatr. 2016 Apr;105(4):e170-5. doi: 10.1111/apa.13296. Epub 2016 Jan 11.
59	Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder.Psychiatry Res. 2012 Jun 30;198(1):166-8. doi: 10.1016/j.psychres.2011.09.002. Epub 2012 Feb 27.
60	Angiogenesis-related genes may be a more important factor than matrix metalloproteinases in bronchopulmonary dysplasia development.Oncotarget. 2017 Mar 21;8(12):18670-18679. doi: 10.18632/oncotarget.14722.
61	Replication of previous genome-wide association studies of psychiatric diseases in a large schizophrenia case-control sample from Spain.Schizophr Res. 2014 Oct;159(1):107-13. doi: 10.1016/j.schres.2014.07.004. Epub 2014 Aug 12.
62	A genome-wide association study (GWAS) for bronchopulmonary dysplasia.Pediatrics. 2013 Aug;132(2):290-7. doi: 10.1542/peds.2013-0533. Epub 2013 Jul 29.
63	DISC1 in adult ADHD patients: an association study in two European samples.Am J Med Genet B Neuropsychiatr Genet. 2013 Apr;162B(3):227-34. doi: 10.1002/ajmg.b.32136. Epub 2013 Feb 6.
64	Ancestry and genetic associations with bronchopulmonary dysplasia in preterm infants.Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L858-L869. doi: 10.1152/ajplung.00073.2018. Epub 2018 Aug 16.
65	Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases.Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):50-3. doi: 10.1002/ajmg.b.30113.
66	Surfactant status and respiratory outcome in premature infants receiving late surfactant treatment.Pediatr Res. 2019 Feb;85(3):305-311. doi: 10.1038/s41390-018-0144-3. Epub 2018 Aug 15.
67	Potential role for antiangiogenic proteins in the evolution of bronchopulmonary dysplasia.Antioxid Redox Signal. 2004 Feb;6(1):137-45. doi: 10.1089/152308604771978444.
68	Lipoxin A4 reduces hyperoxia-induced lung injury in neonatal rats through PINK1 signaling pathway.Int Immunopharmacol. 2019 Aug;73:414-423. doi: 10.1016/j.intimp.2019.05.046. Epub 2019 May 29.
69	Identification of a CACNA2D4 deletion in late onset bipolar disorder patients and implications for the involvement of voltage-dependent calcium channels in psychiatric disorders.Am J Med Genet B Neuropsychiatr Genet. 2012 Jun;159B(4):465-75. doi: 10.1002/ajmg.b.32053. Epub 2012 Apr 9.
70	GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders.Int J Neuropsychopharmacol. 2011 Jul;14(6):721-34. doi: 10.1017/S1461145710001616.
71	A linkage and exome study implicates rare variants of KANK4 and CAP2 in bipolar disorder in a multiplex family.Bipolar Disord. 2020 Feb;22(1):70-78. doi: 10.1111/bdi.12815. Epub 2019 Aug 21.
72	Increased serum Th2 chemokine levels are associated with bronchopulmonary dysplasia in premature infants.Eur J Pediatr. 2019 Jan;178(1):81-87. doi: 10.1007/s00431-018-3266-z. Epub 2018 Oct 15.
73	CCN5 in alveolar epithelial proliferation and differentiation during neonatal lung oxygen injury.J Cell Commun Signal. 2018 Mar;12(1):217-229. doi: 10.1007/s12079-017-0443-1. Epub 2018 Jan 18.
74	A modified physiologic test for bronchopulmonary dysplasia: a clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies?.Ital J Pediatr. 2019 Jan 4;45(1):2. doi: 10.1186/s13052-018-0582-x.
75	LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts.Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L391-402. doi: 10.1152/ajplung.00119.2014. Epub 2014 Dec 5.
76	Plasma Levels of Macrophage Migration Inhibitory Factor and d-Dopachrome Tautomerase Show a Highly Specific Profile in Early Life.Front Immunol. 2017 Jan 25;8:26. doi: 10.3389/fimmu.2017.00026. eCollection 2017.
77	Expressional profile of the diacylglycerol kinase eta gene DGKH.Eur Arch Psychiatry Clin Neurosci. 2017 Aug;267(5):445-454. doi: 10.1007/s00406-016-0695-4. Epub 2016 Apr 16.
78	Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway.J Clin Invest. 2009 Sep;119(9):2538-49. doi: 10.1172/JCI38079. Epub 2009 Aug 17.
79	Shared gene expression alterations in schizophrenia and bipolar disorder.Biol Psychiatry. 2008 Jul 15;64(2):89-97. doi: 10.1016/j.biopsych.2007.11.010. Epub 2008 Jan 11.
80	Gene Expression Signatures Point to a Male Sex-Specific Lung Mesenchymal Cell PDGF Receptor Signaling Defect in Infants Developing Bronchopulmonary Dysplasia.Sci Rep. 2018 Nov 20;8(1):17070. doi: 10.1038/s41598-018-35256-z.
81	Glypican-1 and glycoprotein 2 bearing extracellular vesicles do not discern pancreatic cancer from benign pancreatic diseases.Oncotarget. 2019 Feb 1;10(10):1045-1055. doi: 10.18632/oncotarget.26620. eCollection 2019 Feb 1.
82	Bipolar disorder moderates associations between linoleic acid and markers of inflammation.J Psychiatr Res. 2017 Feb;85:29-36. doi: 10.1016/j.jpsychires.2016.10.021. Epub 2016 Oct 27.
83	Neurocognitive impairment in unaffected siblings of youth with bipolar disorder.Psychol Med. 2009 Aug;39(8):1253-63. doi: 10.1017/S0033291708004832. Epub 2008 Dec 11.
84	The impact of glucocorticoid polymorphisms on markers of neonatal respiratory disease after antenatal betamethasone administration.Am J Obstet Gynecol. 2013 Mar;208(3):215.e1-6. doi: 10.1016/j.ajog.2012.12.031. Epub 2013 Jan 4.
85	Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism.Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:157-62. doi: 10.1016/j.pnpbp.2014.05.017. Epub 2014 Jun 8.
86	Lysyl oxidase activity is dysregulated during impaired alveolarization of mouse and human lungs.Am J Respir Crit Care Med. 2009 Dec 15;180(12):1239-52. doi: 10.1164/rccm.200902-0215OC. Epub 2009 Sep 24.
87	Molecular identification of bacteria in tracheal aspirate fluid from mechanically ventilated preterm infants.PLoS One. 2011;6(10):e25959. doi: 10.1371/journal.pone.0025959. Epub 2011 Oct 10.
88	Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder.Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 5;153B(3):830-6. doi: 10.1002/ajmg.b.31042.
89	Timing of erythropoietin modified mesenchymal stromal cell transplantation for the treatment of experimental bronchopulmonary dysplasia.J Cell Mol Med. 2018 Nov;22(11):5759-5763. doi: 10.1111/jcmm.13843. Epub 2018 Aug 30.
90	Association analysis of the pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) gene in bipolar disorder.Psychiatr Genet. 2008 Apr;18(2):53-8. doi: 10.1097/YPG.0b013e3282f60320.
91	Early red cell transfusion is associated with development of severe retinopathy of prematurity.J Perinatol. 2019 Mar;39(3):393-400. doi: 10.1038/s41372-018-0274-9. Epub 2018 Nov 20.
92	Refining anti-inflammatory therapy strategies for bronchopulmonary dysplasia.J Cell Mol Med. 2017 Jun;21(6):1128-1138. doi: 10.1111/jcmm.13044. Epub 2016 Dec 13.
93	Cord blood Clara cell protein CC16 predicts the development of bronchopulmonary dysplasia.Eur J Pediatr. 2008 Nov;167(11):1305-12. doi: 10.1007/s00431-008-0713-2. Epub 2008 Jun 3.
94	Pulmonary trypsin-2 in the development of bronchopulmonary dysplasia in preterm infants.Pediatrics. 2003 Sep;112(3 Pt 1):570-7. doi: 10.1542/peds.112.3.570.
95	Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates.J Perinatol. 2012 May;32(5):349-55. doi: 10.1038/jp.2011.104. Epub 2011 Sep 29.
96	Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways.Am J Respir Crit Care Med. 2002 Dec 1;166(11):1498-509. doi: 10.1164/rccm.200204-285OC. Epub 2002 Aug 1.
97	SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia.Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L619-27. doi: 10.1152/ajplung.00507.2005. Epub 2006 Apr 14.
98	Data mining and multiparameter analysis of lung surfactant protein genes in bronchopulmonary dysplasia.Hum Mol Genet. 2004 Jun 1;13(11):1095-104. doi: 10.1093/hmg/ddh132. Epub 2004 Apr 21.
99	Reduced Efficacy of d-Amphetamine and 3,4-Methylenedioxymethamphetamine in Inducing Hyperactivity in Mice Lacking the Postsynaptic Scaffolding Protein SHANK1.Front Mol Neurosci. 2018 Nov 16;11:419. doi: 10.3389/fnmol.2018.00419. eCollection 2018.
100	Attenuated SUMOylation of sirtuin 1 in premature neonates with bronchopulmonary dysplasia.Mol Med Rep. 2018 Jan;17(1):1283-1288. doi: 10.3892/mmr.2017.8012. Epub 2017 Nov 8.
101	Mutation analysis of SYNJ1: a possible candidate gene for chromosome 21q22-linked bipolar disorder.Mol Psychiatry. 2001 Jul;6(4):387-95. doi: 10.1038/sj.mp.4000871.
102	TNF-stimulated protein 6 (TSG-6) reduces lung inflammation in an experimental model of bronchopulmonary dysplasia.Pediatr Res. 2019 Feb;85(3):390-397. doi: 10.1038/s41390-018-0250-2. Epub 2018 Dec 11.
103	Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia.Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):967-72. doi: 10.1002/ajmg.b.31057.