General Information of Drug (ID: DM0N19Y)

Drug Name
Chondroitin sulfate Drug Info
Synonyms
Chondritinsulfate; Chondritinsulphate; Chondroitin 4 and 6 sulfate; Chondroitin 4-sulfate; Chondroitin 6-sulfate; Chondroitin polysulfate; Chondroitin sulfate; Chondroitin sulfuric acid; Chondroitin sulfuric acids; Chondroitin sulphate; Chondroitin, CHONDROITIN SULFATES; hydrogen sulfate; Chondroitine sulfate; Chondroitinsulfate C; Chondroitinsulfuric acids; Chondron; Chonsurid; Condrosan; Condrosulf; Sodium chondroitin sulfate; Structum; Uropol S; chondroitin sulfate C; 9007-28-7; EINECS 232-696-9; Gepan; UNII-6IC1M3OG5Z
Cross-matching ID
PubChem CID
24766
CAS Number
CAS 9007-28-7
TTD Drug ID
DM0N19Y
INTEDE Drug ID
DR0317

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Patented Agent(s)
Drug(s) Metabolized By Beta-glucuronidase (GUSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MK-4827 DMLYGH4 Ovarian cancer 2C73 Phase 3 [11]
Tyropanoic acid DM91UKB N. A. N. A. Investigative [12]
Drug(s) Metabolized By Hyaluronate lyase (hyaL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hyaluronate sodium DMX8M26 Joint lubricant FA30-FA38 Approved [5]
Drug(s) Metabolized By Hyaluronoglucosaminidase (nagH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hyaluronic acid DMABXOZ N. A. N. A. Phase 4 [3]
Drug(s) Affected By Arylsulfatase B (ARSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [13]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [14]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [15]
Arsenic DMTL2Y1 N. A. N. A. Approved [16]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [17]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [19]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [20]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [21]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [22]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Panobinostat DM58WKG Chronic graft versus host disease Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [34]
Panobinostat DM58WKG Chronic graft versus host disease Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [36]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Arsenic DMTL2Y1 N. A. N. A. Approved [16]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [41]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [20]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [42]
PHENCYCLIDINE DMQBEYX Discovery agent N.A. Investigative [43]
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Drug(s) Affected By Coagulation factor XII (F12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [30]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [45]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [46]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [46]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [47]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Complement C3 (C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [57]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [53]
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Drug(s) Affected By Complement C5 (C5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [13]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [60]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [62]
Olanzapine DMPFN6Y Bipolar depression Approved [63]
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Drug(s) Affected By Plasma kallikrein (KLKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [66]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [67]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Diazepam DM08E9O Alcohol withdrawal Approved [69]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [70]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [71]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [74]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [75]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [76]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [24]
Gefitinib DM15F0X Colon adenocarcinoma Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [79]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [80]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pleiotrophin (PTN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Testosterone enanthate DMB6871 N. A. N. A. Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [13]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [85]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [86]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [32]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [87]
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Drug(s) Affected By Midkine (MDK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [92]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [61]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [93]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [36]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Testosterone DM7HUNW Hot flushes GA30 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [103]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [60]
Bortezomib DMNO38U Leukemia Approved [104]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [62]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [105]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [106]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [107]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Arylsulfatase B (ARSB) DEHKRDS ARSB_HUMAN Substrate [1]
Iduronate 2-sulfatase (IDS) DEL45C2 IDS_HUMAN Substrate [1]
N-acetyl-beta-glucosaminidase beta (HEXB) DE6AY40 HEXB_HUMAN Substrate [1]
Beta-glucuronidase (GUSB) DEP54UE BGLR_HUMAN Substrate [1]
Alpha-L-iduronidase (IDUA) DELTYX6 IDUA_HUMAN Substrate [1]
Chondroitin 6-sulfotransferase (CHST3) DEQIZP2 CHST3_HUMAN Substrate [2]
Hyaluronoglucosaminidase (nagH) DEV7UZD NAGH_CLOPE Substrate [3] , [4]
Hyaluronate lyase (hyaL) DEH31BC D1AWD4_STRM9 Substrate [5] , [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Arylsulfatase B (ARSB) OTTYDDNU ARSB_HUMAN Regulation of Drug Effects [7]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Protein Interaction/Cellular Processes [8]
Coagulation factor XII (F12) OTBFD2FU FA12_HUMAN Gene/Protein Processing [9]
Complement C3 (C3) OTCH5GS0 CO3_HUMAN Protein Interaction/Cellular Processes [9]
Complement C5 (C5) OTSL3OIC CO5_HUMAN Protein Interaction/Cellular Processes [9]
Fibroblast growth factor 10 (FGF10) OTDSATGA FGF10_HUMAN Protein Interaction/Cellular Processes [10]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Protein Interaction/Cellular Processes [10]
Midkine (MDK) OTF24HKC MK_HUMAN Protein Interaction/Cellular Processes [10]
Plasma kallikrein (KLKB1) OTGSEISX KLKB1_HUMAN Gene/Protein Processing [9]
Pleiotrophin (PTN) OTYC7M2A PTN_HUMAN Protein Interaction/Cellular Processes [10]

References

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14 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
15 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
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17 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
18 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
19 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
20 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
21 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
22 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
23 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
24 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
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26 Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
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30 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
31 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
32 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
33 Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
34 Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study. Arthritis Res Ther. 2007;9(6):R117. doi: 10.1186/ar2325.
35 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
36 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
37 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):381-8. doi: 10.1016/j.jsbmb.2006.12.054. Epub 2007 Feb 12.
38 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
39 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
40 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
41 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
42 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
43 Effects of Agricultural Organic Dusts on Human Lung-Resident Mesenchymal Stem (Stromal) Cell Function. Toxicol Sci. 2018 Apr 1;162(2):635-644. doi: 10.1093/toxsci/kfx286.
44 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
45 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
46 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
47 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
48 Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
49 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
50 The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
51 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
52 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
53 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
54 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
55 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
56 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
57 Thalidomide therapy. An open trial. Int J Dermatol. 1985 Mar;24(2):131-4. doi: 10.1111/j.1365-4362.1985.tb05400.x.
58 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
59 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
60 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
61 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
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