Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM38CIV)

Drug Name
ELTANOLONE Drug Info
Synonyms
Pregnanolone; 3alpha-Hydroxy-5beta-pregnan-20-one; 128-20-1; Pregnanolone II; Pregnan-3alpha-ol-20-one; Eltanolona; Eltanolonum; 5beta-Pregnan-3alpha-ol-20-one; Eltanolone [INN]; SKF 6455; NSC 82867; UNII-BXO86P3XXW; Eltanolonum [INN-Latin]; Eltanolona [INN-Spanish]; Allopregnan-3 beta-ol-20-one; (3alpha,5beta)-3-hydroxypregnan-20-one; 3alpha-Hydroxy-5beta-tetrahydroprogesterone; 3alpha,5beta-Epimeric pregnanolone; Pregnanolone, (3alpha,5beta)-isomer; BXO86P3XXW
Indication
Disease Entry ICD 11 Status REF
Premenstrual syndrome GA34.40 Discontinued in Phase 3 [1]
Cross-matching ID
PubChem CID
31402
ChEBI ID
CHEBI:1712
CAS Number
CAS 128-20-1
TTD Drug ID
DM38CIV

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting GABA(A) receptor gamma-2 (GABRG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [2]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [9]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [10]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [9]
U-78875 DM2WOPX Anxiety disorder 6B00-6B0Z Discontinued in Phase 1 [11]
CGS-9896 DM39PQI N. A. N. A. Terminated [12]
CGS-17867A DMMZJY3 Alcohol dependence 6C40.2 Terminated [13]
TBPS DMFC3XP Discovery agent N.A. Investigative [14]
AMENTOFLAVONE DMLRNV2 Discovery agent N.A. Investigative [15]
Ro-15-3505 DM4NW3U Discovery agent N.A. Investigative [16]
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Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [17]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [18]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [17]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [17]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [2]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [17]
Hexobarbital DMQ314B Anaesthesia 9A78.6 Approved [17]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [9]
Meprobamate DMHM93Y Anxiety Approved [17]
Zaleplon DMGFWSM Insomnia 7A00-7A0Z Approved [19]
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Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [17]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [3]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [9]
Clonazepam DMTO13J Absence epilepsy Approved [20]
Piperazine DMTY9LU Ascariasis 1F62 Approved [21]
Alpidem DMN7Y9K Anxiety disorder 6B00-6B0Z Approved [22]
Moxidectin DMYGHX5 Onchocerciasis 1F6A Approved [23]
DP-VPA DMGOXPQ Bipolar disorder 6A60 Approved [24]
ANDROSTERONE DMITJAK N. A. N. A. Phase 3 [3]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [10]
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Drug(s) Targeting GABA(A) receptor beta-2 (GABRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [2]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [9]
Ethchlorvynol DM53IP1 Insomnia 7A00-7A0Z Approved [17]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [10]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [9]
U-78875 DM2WOPX Anxiety disorder 6B00-6B0Z Discontinued in Phase 1 [25]
CGS-9896 DM39PQI N. A. N. A. Terminated [12]
TBPS DMFC3XP Discovery agent N.A. Investigative [26]
AMENTOFLAVONE DMLRNV2 Discovery agent N.A. Investigative [15]
Ro-15-3505 DM4NW3U Discovery agent N.A. Investigative [16]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [28]
Gefitinib DM15F0X Colon adenocarcinoma Approved [29]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [30]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [32]
Selenium DM25CGV N. A. N. A. Approved [33]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [34]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [35]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [36]
Diazepam DM08E9O Alcohol withdrawal Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [38]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [36]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [42]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [43]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [36]
Diazepam DM08E9O Alcohol withdrawal Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [36]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [46]
Ethacrynic acid DM60QMR Edema MG29 Approved [44]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [36]
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Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [48]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Testosterone DM7HUNW Hot flushes GA30 Approved [50]
Dydrogesterone DMAKIDV Menstrual disorder GA20.3 Approved [43]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [51]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [52]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [53]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [43]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [54]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [54]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [36]
Diazepam DM08E9O Alcohol withdrawal Approved [5]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [55]
Desogestrel DM27U4Y Contraception QA21 Approved [55]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [36]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
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Drug(s) Affected By Aldo-keto reductase family 1 member C4 (AKR1C4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [59]
Diazepam DM08E9O Alcohol withdrawal Approved [5]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Benzbromarone DMC3YUA Gout FA25 Approved [6]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [5]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [5]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [62]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [63]
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Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [64]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [65]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [69]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [70]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [70]
ABIRATERONE DM8V75C Prostate cancer 2C82.0 Approved [71]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Inhibitor [2]
GABA(A) receptor beta-2 (GABRB2) TTZA1NY GBRB2_HUMAN Inhibitor [2]
GABA(A) receptor gamma-2 (GABRG2) TT06RH5 GBRG2_HUMAN Inhibitor [2]
Gamma-aminobutyric acid receptor (GAR) TTNJYV2 NOUNIPROTAC Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1) OTQRET2B S5A1_HUMAN Biotransformations [4]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Biotransformations [5]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Biotransformations [5]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Biotransformations [4]
Aldo-keto reductase family 1 member C4 (AKR1C4) OTW2MMOF AK1C4_HUMAN Regulation of Drug Effects [6]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Protein Interaction/Cellular Processes [7]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Biotransformations [8]

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