General Information of Drug (ID: DM3P6V7)

Drug Name
Furazolidone Drug Info
Synonyms
Bifuron; Corizium; Coryzium; Diafuron; Enterotoxon; Furall; Furaxon; Furaxone; Furazol; Furazolidine; Furazolidon; Furazolidona; Furazolidonum; Furazolum; Furazon; Furidon; Furovag; Furox; Furoxal; Furoxane; Furoxon; Furoxone; Furozolidine; Giardil; Giarlam; Medaron; Neftin; Nicolen; Nifulidone; Nifuran; Nifurazolidone; Nifurazolidonum; Nitrofurazolidone; Nitrofurazolidonum; Nitrofuroxon; Optazol; Ortazol; Puradin; Roptazol; Sclaventerol; Tikofuran; Topazone; Trichofuron; Tricofuron; Tricoron; Trifurox; Viofuragyn; Fiurox aerosol powder; Furoxone Liquid; Furoxone Swine Mix; NF 180 custom mix ten; F-8900; Furazolidona [INN-Spanish]; Furazolidone [INN:BAN]; Furazolidonum [INN-Latin]; Furox Aerosol Powder (Veterinary); Furoxone (TN); NF-180; Usaf ea-1; Dependal-M (TN); Furazolidone (USP/INN); N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidone; N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one; 3-(((5-Nitro-2-furanyl)methylene)amino)-2-oxazolidinone; 3-((5-Nitrofurfurylidene)amino)-2-oxazolidinone; 3-((5-Nitrofurfurylidene)amino)-2-oxazolidone; 3-((5-Nitrofurylidene)amino)-2-oxazolidone; 3-(5'-Nitrofurfuralamino)-2-oxazolidone; 3-(5-Nitrofurfurylideneamino)-2-oxazolidinone; 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone; 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone; 3-[(5-Nitrofurylidene)amino]-2-oxazolidone; 3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one; 3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone; 3-{[(5-Nitro-2-furanyl)methylene]amino}-2-oxazolidinone; 3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one; 3-{[(E)-(5-nitrofuran-2-yl)methylidene]amino}-1,3-oxazolidin-2-one; 5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine
Indication
Disease Entry ICD 11 Status REF
Diarrhea ME05.1 Approved [1]
Therapeutic Class
Antiinfective Agents
Cross-matching ID
PubChem CID
5323714
ChEBI ID
CHEBI:5195
CAS Number
CAS 67-45-8
TTD Drug ID
DM3P6V7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metronidazole DMTIVEN Abscess Approved [7]
Nitrofurantoin DM7PQIK Urinary tract infection GC08 Approved [8]
Clofazimine DMEBOFW Crohn disease DD70 Approved [9]
Hydroxystilbamidine Isethionate DMR5QS6 Blastomycosis 1F22 Approved [10]
Proflavine DMF1X5P Sepsis 1G40-1G41 Approved [11]
MGB-BP-3 DMPBTVK Clostridium infection 1A04 Phase 2 [12]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [13]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [20]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [21]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [22]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [23]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [25]
Verapamil DMA7PEW Angina pectoris BA40 Approved [26]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Selenium DM25CGV N. A. N. A. Approved [29]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [30]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Gefitinib DM15F0X Colon adenocarcinoma Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [36]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [37]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [38]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [37]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [39]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Etretinate DM2CZFA Keratosis ED56 Approved [45]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [46]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [47]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [48]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Selenium DM25CGV N. A. N. A. Approved [59]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [60]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [71]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [72]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [73]
Paclitaxel DMLB81S Breast carcinoma Approved [74]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [75]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [76]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [3]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [13]
Gefitinib DM15F0X Colon adenocarcinoma Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [80]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [85]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [88]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [89]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Gefitinib DM15F0X Colon adenocarcinoma Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [92]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [93]
Selenium DM25CGV N. A. N. A. Approved [59]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [94]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [95]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [62]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [96]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [46]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [97]
Methotrexate DM2TEOL Anterior urethra cancer Approved [98]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [84]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [103]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [105]
Gefitinib DM15F0X Colon adenocarcinoma Approved [106]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Etretinate DM2CZFA Keratosis ED56 Approved [107]
Prednisone DM2HG4X Acute asthma CA23 Approved [108]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [38]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [112]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [113]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [114]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [115]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [116]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [117]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [118]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [119]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [120]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
Gefitinib DM15F0X Colon adenocarcinoma Approved [122]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [123]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [16]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Panobinostat DM58WKG Chronic graft versus host disease Approved [125]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Verapamil DMA7PEW Angina pectoris BA40 Approved [26]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Selenium DM25CGV N. A. N. A. Approved [59]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [129]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [130]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [132]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [3]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [133]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [134]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [135]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [137]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [138]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [140]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [3]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [141]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [142]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [3]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [3]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [3]
Gefitinib DM15F0X Colon adenocarcinoma Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [143]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [143]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Deoxyribonucleic acid (Bact DNA) TTS1W4A NOUNIPROTAC Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Drug Response [3]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Drug Response [3]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [5]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [5]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [4]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Gene/Protein Processing [4]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [6]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Gene/Protein Processing [6]

References

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5 P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
6 Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
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13 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
14 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
15 Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
16 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
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20 ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006 Sep 29;281(39):28764-71. doi: 10.1074/jbc.M604392200. Epub 2006 Aug 3.
21 Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1.
22 PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma. PLoS One. 2014 Dec 22;9(12):e114583. doi: 10.1371/journal.pone.0114583. eCollection 2014.
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28 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
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30 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
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32 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
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