Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6VFO1)

Drug Name
Pregnenolone Drug Info
Synonyms Pregnenolone (schizophrenia); Neurosteroid (schizophrenia), Neuroscience; Pregnenolone (schizophrenia), Neuroscience
Indication
Disease Entry ICD 11 Status REF
Schizophrenia 6A20 Phase 4 [1]
Cross-matching ID
PubChem CID
8955
ChEBI ID
CHEBI:16581
CAS Number
CAS 145-13-1
TTD Drug ID
DM6VFO1
INTEDE Drug ID
DR1336

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Estrogen-related receptor-alpha (ESRRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rimexolone DMTAREC Arthritis FA20 Approved [10]
D-5519 DM9FAJM Asthma CA23 Phase 3 [11]
Dexamethasone palmitate DMCMT4V Choroidal neovascularization 9B76 Phase 1/2 [12]
RPR-106541 DMRGC5B Asthma CA23 Discontinued in Phase 2 [13]
Rofleponide DM6OSPQ Allergic rhinitis CA08.0 Discontinued in Phase 2 [14]
AD-121 DMB8XJM Rheumatoid arthritis FA20 Discontinued in Phase 1/2 [10]
GW-250495 DMWJZAP Asthma CA23 Discontinued in Phase 1 [10]
PLD-177 DMPHUBO Allergic rhinitis CA08.0 Terminated [10]
Steroid hormone conjugates DMOJM08 Cachexia MG20 Terminated [15]
daidzein DMRFTJX Discovery agent N.A. Investigative [16]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [19]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [34]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [36]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [37]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [38]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [39]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [40]
Capsaicin DMGMF6V Back pain ME84.Z Approved [41]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [42]
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Drug(s) Metabolized By Sulfotransferase 2A1 (SULT2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [26]
Abiraterone acetate DMANBZI Prostate cancer 2C82.0 Approved [27]
Vonoprazan DMO6315 Helicobacter infection DA42-DA63 Approved [28]
ASP-015K DMZ1UOI Psoriasis vulgaris EA90 Phase 3 [29]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [26]
BCP-13498 DM2BO9W N. A. N. A. Phase 2 [30]
daidzein DMRFTJX Discovery agent N.A. Investigative [26]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [26]
Tetramethylbutylphenol DMW9CH2 N. A. N. A. Investigative [26]
N-nonylphenol DMH3OUX N. A. N. A. Investigative [26]
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Drug(s) Metabolized By Dihydrotestosterone oxidoreductase (HSD3B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [31]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [32]
HE2100 DMCP2KH Thrombocytopenia 3B64 Discontinued in Phase 1 [6]
17alpha-hydroxypregnenolone DMT2EPG Discovery agent N.A. Investigative [4]
Drug(s) Metabolized By Beta-HSD adrenal and gonadal type (HSD3B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [31]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [32]
Norethindrone acetate DMDGCQP N. A. N. A. Approved [33]
17alpha-hydroxypregnenolone DMT2EPG Discovery agent N.A. Investigative [4]
Drug(s) Metabolized By Sulfotransferase 2B1 (SULT2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [5]
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [43]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [43]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [44]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [46]
Etidronic acid DM1XHYJ Bone Paget disease Approved [43]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [43]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [43]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [47]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [48]
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Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [50]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [8]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [54]
Estrone DM5T6US Acne vulgaris ED80 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [56]
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Drug(s) Affected By Myb-related protein A (MYBL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [49]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Panobinostat DM58WKG Chronic graft versus host disease Approved [57]
Estrone DM5T6US Acne vulgaris ED80 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [8]
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Drug(s) Affected By Protein GREB1 (GREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [8]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Testosterone DM7HUNW Hot flushes GA30 Approved [64]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [65]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [8]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [68]
Mestranol DMG3F94 Contraception QA21 Approved [8]
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Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [65]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Ethanol DMDRQZU Chronic pain MG30 Approved [74]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [75]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [76]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [77]
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Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [78]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [79]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [81]
Testosterone DM7HUNW Hot flushes GA30 Approved [81]
Pyruvic acid DM7Q41G Malnutrition 5B50-5B71 Approved [82]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [83]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [83]
ABIRATERONE DM8V75C Prostate cancer 2C82.0 Approved [84]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Estrogen-related receptor-alpha (ESRRA) TTPNQAC ERR1_HUMAN Agonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Beta-HSD adrenal and gonadal type (HSD3B2) DEN0GVQ 3BHS2_HUMAN Substrate [4]
Sulfotransferase 2A1 (SULT2A1) DE0P6LK ST2A1_HUMAN Substrate [5]
Dihydrotestosterone oxidoreductase (HSD3B1) DERDQWN 3BHS1_HUMAN Substrate [4]
Sulfotransferase 2B1 (SULT2B1) DEZBN53 ST2B1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) OT2NV3AN CP11A_HUMAN Biotransformations [6]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [7]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Gene/Protein Processing [8]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [7]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Gene/Protein Processing [8]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Gene/Protein Processing [8]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Biotransformations [9]

References

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62 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
63 Arsenic induces functional re-expression of estrogen receptor by demethylation of DNA in estrogen receptor-negative human breast cancer. PLoS One. 2012;7(4):e35957. doi: 10.1371/journal.pone.0035957. Epub 2012 Apr 27.
64 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
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67 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
68 Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals. Toxicol In Vitro. 2022 Jun;81:105348. doi: 10.1016/j.tiv.2022.105348. Epub 2022 Mar 18.
69 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
70 Use of organ culture to study the human fetal testis development: effect of retinoic acid. J Clin Endocrinol Metab. 2006 Jul;91(7):2696-703.
71 A pilot study on the transcriptional response of androgen- and insulin-related genes in peripheral blood mononuclear cells induced by testosterone administration in hypogonadal men. J Biol Regul Homeost Agents. 2011 Apr-Jun;25(2):291-4.
72 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
73 Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurol Scand Suppl. 2009;(189):14-21.
74 Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats. Toxicol Appl Pharmacol. 2018 Apr 15;345:36-47.
75 Intergenerational genetic programming mechanism and sex differences of the adrenal corticosterone synthesis dysfunction in offspring induced by prenatal ethanol exposure. Toxicol Lett. 2021 Oct 15;351:78-88. doi: 10.1016/j.toxlet.2021.08.007. Epub 2021 Aug 25.
76 Androgen receptor modulation following combination exposure to brominated flame-retardants. Sci Rep. 2018 Mar 19;8(1):4843. doi: 10.1038/s41598-018-23181-0.
77 Estrogenic endocrine disruptive components interfere with calcium handling and differentiation of human trophoblast cells. J Cell Biochem. 2003 Jul 1;89(4):755-70.
78 Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005 Aug;90(8):4858-65. doi: 10.1210/jc.2005-0330. Epub 2005 May 24.
79 Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 10;48(5):1563-75.
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