Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME2A8X)

Drug Name
5-methoxypsoralen Drug Info
Synonyms 5-MOP
Indication
Disease Entry ICD 11 Status REF
Psoriasis vulgaris EA90 Phase 3 [1]
Cross-matching ID
PubChem CID
2355
ChEBI ID
CHEBI:18293
CAS Number
CAS 484-20-8
TTD Drug ID
DME2A8X
INTEDE Drug ID
DR1910

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [7]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [8]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [9]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [10]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [11]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [12]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [13]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [14]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [8]
Verapamil DMA7PEW Angina pectoris BA40 Approved [15]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [16]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [17]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [21]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [13]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [23]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [24]
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Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [16]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [11]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [27]
Metronidazole DMTIVEN Abscess Approved [28]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [29]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [25]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [31]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [22]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [35]
Estrone DM5T6US Acne vulgaris ED80 Approved [36]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [37]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [38]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [39]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [41]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [42]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [43]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
Estrone DM5T6US Acne vulgaris ED80 Approved [44]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [45]
Ethanol DMDRQZU Chronic pain MG30 Approved [46]
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Drug(s) Metabolized By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [47]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [22]
Estrone DM5T6US Acne vulgaris ED80 Approved [36]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [37]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [48]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [49]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [50]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [51]
Theophylline DMRJFN9 Bronchitis CA20 Approved [50]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [56]
Paclitaxel DMLB81S Breast carcinoma Approved [57]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [58]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [60]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [62]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [63]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [64]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [65]
Cepharanthine DM9Y5JB N. A. N. A. Approved [66]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [67]
Clozapine DMFC71L Schizophrenia 6A20 Approved [68]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [69]
Trifluoperazine DMKBYWI Anxiety Approved [70]
Olanzapine DMPFN6Y Bipolar depression Approved [68]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Fluoxetine DM3PD2C Bipolar depression Approved [77]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
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Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [84]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [89]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [90]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [91]
Gefitinib DM15F0X Colon adenocarcinoma Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [94]
Selenium DM25CGV N. A. N. A. Approved [95]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [96]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [97]
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Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [98]
Folic Acid DMEMBJC Colorectal carcinoma Approved [99]
Methotrexate DM2TEOL Anterior urethra cancer Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [102]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [103]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [104]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [105]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [106]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [106]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [107]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [109]
Gefitinib DM15F0X Colon adenocarcinoma Approved [110]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Etretinate DM2CZFA Keratosis ED56 Approved [113]
Prednisone DM2HG4X Acute asthma CA23 Approved [114]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [115]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [118]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [56]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [119]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [120]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [121]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [122]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [123]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [124]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [125]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [126]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [127]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [129]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [130]
Meloxicam DM2AR7L Arthritis FA20 Approved [131]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [132]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [133]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [134]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [135]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [139]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [140]
Testosterone DM7HUNW Hot flushes GA30 Approved [141]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [142]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [124]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Verapamil DMA7PEW Angina pectoris BA40 Approved [143]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [144]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [128]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Meloxicam DM2AR7L Arthritis FA20 Approved [146]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
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Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [147]
Sulfinpyrazone DMEV954 Gout FA25 Approved [148]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [149]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [151]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [152]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [104]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [153]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [154]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [155]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [130]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [156]
Methotrexate DM2TEOL Anterior urethra cancer Approved [157]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [158]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [159]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [160]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [161]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [162]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [163]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [164]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [164]
Gefitinib DM15F0X Colon adenocarcinoma Approved [165]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [166]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [167]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [168]
Methotrexate DM2TEOL Anterior urethra cancer Approved [169]
Quercetin DM3NC4M Obesity 5B81 Approved [170]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [171]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [172]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [2]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [3]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [3]
Cytochrome P450 2A6 (CYP2A6) DEJVYAZ CP2A6_HUMAN Substrate [3]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [3]
Cytochrome P450 1B1 (CYP1B1) DE9QHP6 CP1B1_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [4]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Gene/Protein Processing [5]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [5]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [4]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [4]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [6]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [4]

References

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3 Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity. PLoS One. 2013 Sep 23;8(9):e75494.
4 Bergapten induces G1 arrest and pro-apoptotic cascade in colorectal cancer cells associating with p53/p21/PTEN axis. Environ Toxicol. 2019 Mar;34(3):303-311. doi: 10.1002/tox.22685. Epub 2018 Dec 21.
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