Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEGIQ6)

• Drug Name: Nitrazepam Drug Info
• Synonyms: Alodorm; Apodorm; Benzalin; Calsamin; Calsmin; Cerson; Dormalon; Dumolid; Eatan; Epibenzalin; Epinelbon; Eunoctin; Eunoktin; Gerson; Hipnax; Hipsal; Ibrovek; Imadorm; Imeson; Imesont; Ipersed; Magadon; Megadon; Mitidin; Mogadan; Mogadon; Mogadone; Nelbon; Nelmat; Neozepam; Neuchlonic; Nitrados; Nitravet; Nitrazadon; Nitrazep; Nitrazepamum; Nitrempax; Nitrenpax; Nitrodiazepam; Noctesed; Novanox; Pacisyn; Paxisyn; Pelson; Persopit; Radedorm; Relact; Remnos; Serenade; Somitran; Somnased; Somnibel; Somnite; Sonebon; Sonnolin; Surem; Trazenin; Unisomnia; Aliud Brand of Nitrazepam; Allphar Brand of Nitrazepam; Alphapharma Brand of Nitrazepam; Alpharma Brand of Nitrazepam; Alter Brand of Nitrazepam; CSP Brand of Nitrazepam; DDSA Brand of Nitrazepam; Dermatech Brand of Nitrazepam; Desitin Brand of Nitrazepam; Dormicum Brand of Nitrazepam; Eatan N; ICN Brand of Nitrazepam; Neuraxpharm Brand of Nitrazepam; Nitrazepam AL; Norgine Brand of Nitrazepam; Pfleger Brand of Nitrazepam; Protea Brand of Nitrazepam; Rhoxalpharma Brand of Nitrazepam; Sandoz nitrazepam; Scheurich Brand of Nitrazepam; Sonebon Tofraniln A; Taurus Brandof Nitrazepam; United Drug Brand of Nitrazepam; Wernigerode Brand of Nitrazepam; LA 1; S 2000; Alodorm (TN); Apo-nitrazepam tablets BP; Apodorm (TN); Arem (TN); Benzalin (TN); Cavodan (TN); Ct-Arzneimittel Brand of Nitrazepam; Dima (TN); Dormalon (TN); Dormicum (anticonvulsant); Dormigen (TN); Dormin-5; Dormo-Puren; Dumolid (TN); Eatan N (TN); Eunoctin (TN); Hypnotex (TN); ISOPROPYLACETATE/NITRAZEPAM; Imeson (TN); Insoma (TN); Insomin (TN); Ipersed (TN); LA 1 (VAN); Mitidin (TN); Mogadan (TN); Mogadon (TN); N-Desmethylnimetazepam; Nitavan (TN); Nitepam (TN); Nitrados (TN); Nitrapan (TN); Nitravet (TN); Nitrazadon (TN); Nitrazep (TN); Nitrazepam (TN); Nitrazepam Capsules BP 1993 (TN); Nitrazepam Oral Suspension BP 1993 (TN); Nitrazepam Tablets BP 1993 (TN); Nitrazepam-10; Nitrazepam-5; Nitrazepam-neuraxpharm; Nitrazepamum [INN-Latin]; Nitrazepan (TN); Nitrazepol (TN); Nitredon (TN); Nitrosun (TN); Novanox (TN); Numbon (TN); Onirema (TN); Ormodon (TN); Pacisyn (TN); Paxadorm (TN); Pelson (TN); Pelsonfilina (TN); Protraz (TN); Radedorm (TN); Remnos (TN); Rhoxal-nitrazepam; Ro 4-5360; Ro 5-3059; Ro 53-60; Serenade (TN); Somnibel N (TN); Somnipar (TN); Somnite (TN); Sonebon (TN); Sonotrat (TN); Surem (TN); Tri (TN); Unisomnia (TN); Dormo-Puren (TN); Nitrazepam (JP15/USAN/INN); Nitrazepam [USAN:INN:BAN:JAN]; 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one; 2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-on; 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

Indication

Disease Entry	ICD 11	Status	REF
Epilepsy	8A60-8A68	Approved	[1]
Insomnia	7A00-7A0Z	Approved	[1]

• Therapeutic Class: Antianxiety Agents
• Cross-matching ID:
  PubChem CID: 4506
  ChEBI ID: CHEBI:7581
  CAS Number: CAS 146-22-5
  TTD Drug ID: DMEGIQ6
  INTEDE Drug ID: DR1166

Molecule-Related Drug Atlas

Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[2]
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[12]
Methoxyflurane	DML0RAE	Anaesthesia	9A78.6	Approved	[2]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[13]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[2]
Hexobarbital	DMQ314B	Anaesthesia	9A78.6	Approved	[2]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[14]
Meprobamate	DMHM93Y	Anxiety		Approved	[2]
Zaleplon	DMGFWSM	Insomnia	7A00-7A0Z	Approved	[15]
Ethchlorvynol	DM53IP1	Insomnia	7A00-7A0Z	Approved	[2]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[17]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[22]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[23]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[17]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[24]

Drug(s) Metabolized By Oxygen-insensitive NADPH nitroreductase B (nfsB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrofurazone	DMSM2KE	Skin burns	ME65.0	Approved	[4]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[25]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[26]
CB1954	DMVP4YK	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[4]
Nitrobenzodiazepine	DM254EW	N. A.	N. A.	Investigative	[25]
Misonidazole	DMYB0HK	N. A.	N. A.	Investigative	[27]

Drug(s) Metabolized By Nitroreductase (NTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[28]
P-nitrobenzoic acid	DMVJUOZ	N. A.	N. A.	Investigative	[28]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[6]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[32]
Mononitrophenol	DM4QO9G	N. A.	N. A.	Investigative	[6] , [7]
Nitrobenzoate	DM6FVHC	N. A.	N. A.	Investigative	[6] , [7]

Drug(s) Metabolized By Oxygen-insensitive NADPH nitroreductase A (nfsA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrofurazone	DMSM2KE	Skin burns	ME65.0	Approved	[5]
Loperamide	DMOJZQ9	Diarrhea	ME05.1	Approved	[29]
HSDB-674	DMJG4WR	N. A.	N. A.	Phase 1	[30]
CB1954	DMVP4YK	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[31]
Ornidazole	DM6QHDJ	Amoebiasis	1A36	Approved	[8]
AI3-23606	DMHMT49	N. A.	N. A.	Phase 1	[33]
2-chloro-5-nitro-N-phenylbenzamide	DMUGQIV	Discovery agent	N.A.	Investigative	[34]
Nitroimidazole	DMMY2S5	Trypanosomiasis	1D51-1F53	Investigative	[33]
CL-205086	DMB6XUY	N. A.	N. A.	Investigative	[33]

Drug(s) Affected By Aldo-keto reductase family 1 member C4 (AKR1C4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[35]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[37]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[11]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[39]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[40]
Indomethacin	DMSC4A7	Bursitis		Approved	[37]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[42]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[11]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[43]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[43]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[42]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[42]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[11]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[48]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[53]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[42]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[11]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[42]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[42]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[55]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[56]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor alpha-1 (GABRA1)	TT1MPAY	GBRA1_HUMAN	Antagonist	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[3]
Oxygen-insensitive NADPH nitroreductase B (nfsB)	DE0QLUZ	NFSB_ECOLI	Substrate	[4]
Oxygen-insensitive NADPH nitroreductase A (nfsA)	DEDPI65	NFSA_ECOLI	Substrate	[5]
Nitroreductase (NTR)	DE0K82S	A0A5K1UB29_SALTM	Substrate	[6] , [7]
Oxygen-insensitive NADPH nitroreductase A (nfsA)	DEX5D46	NFSA_SALTY	Substrate	[8]
Nitroreductase (NTR)	DEAVXGM	A0A412R9E4_9FIRM	Substrate	[9]
Nitroreductase (NTR)	DEGV7K0	A0A413TUJ8_9BACT	Substrate	[10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[11]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[11]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[11]
Aldo-keto reductase family 1 member C4 (AKR1C4)	OTW2MMOF	AK1C4_HUMAN	Gene/Protein Processing	[11]

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