Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG6Q45)

Drug Name
TDZD-8 Drug Info
Synonyms
327036-89-5; 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione; GSK-3beta Inhibitor I; TDZD 8; 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-; MFCD04973552; NP 01139; AK-48153; 4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dione; 1,2,4-Thiadiazolidine-3,5-dione,2-methyl-4-(phenylmethyl)-; GSK-3 Inhibitor I; SCHEMBL139834; GTPL5977; CHEMBL284861; BDBM7781; CTK4G9152; ZINC27361; AOB6176; EX-A109; DTXSID30399590; JDSJDASOXWCHPN-UHFFFAOYSA-N; MolPort-003-844-896; HMS3229G12; A Inhibitor I, TDZD-8
Indication
Disease Entry ICD 11 Status REF
Malignant glioma 2A00.0 Patented [1]
Cross-matching ID
PubChem CID
4124851
ChEBI ID
CHEBI:147411
CAS Number
CAS 327036-89-5
TTD Drug ID
DMG6Q45

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glycogen synthase kinase-3 beta (GSK-3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AMO-02 DMJRU3A Myotonic dystrophy 8C71.0 Phase 2/3 [5]
LY2090314 DMTBFE4 Acute myeloid leukaemia 2A60 Phase 2 [1]
Lithium DMZ3OU6 Bipolar disorder 6A60 Phase 2 [6]
Tideglusib DME4LA1 Alzheimer disease 8A20 Phase 2 [7]
9-ING-41 DM57TY3 Myelofibrosis 2A20.2 Phase 2 [8]
Neu-120 DMXKOUC Parkinson disease 8A00.0 Phase 1/2 [9]
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [10]
CHIR-99021 DMB8MNU Allergic inflammation 4A80-4A85 Patented [11]
AR-A014418 DMUPN01 Ovarian cancer 2C73 Patented [12]
PMID26161698-Compound-18 DM6JVR5 N. A. N. A. Patented [13]
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Drug(s) Targeting Glycogen synthase kinase-3 alpha (GSK-3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [14]
LY2090314 DMTBFE4 Acute myeloid leukaemia 2A60 Phase 2 [1]
Lithium DMZ3OU6 Bipolar disorder 6A60 Phase 2 [6]
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [1]
CHIR-99021 DMB8MNU Allergic inflammation 4A80-4A85 Patented [1]
AR-A014418 DMUPN01 Ovarian cancer 2C73 Patented [1]
PMID27828716-Compound-21 DMO1NAR N. A. N. A. Patented [1]
Thiadiazolidindione derivative 2 DM5AUL0 N. A. N. A. Patented [1]
PMID27828716-Compound-18 DMNR6KL N. A. N. A. Patented [1]
PMID27828716-Compound-BIO-acetoxime DMUM5L6 Malignant glioma 2A00.0 Patented [1]
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Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [15]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [16]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [20]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [21]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [22]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [24]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [29]
Paclitaxel DMLB81S Breast carcinoma Approved [30]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [31]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [32]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
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Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [35]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Selenium DM25CGV N. A. N. A. Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [41]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [42]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [43]
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Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [51]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [54]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [60]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [61]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [63]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [64]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [66]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [67]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [68]
Gefitinib DM15F0X Colon adenocarcinoma Approved [69]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [72]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [64]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [73]
Paclitaxel DMLB81S Breast carcinoma Approved [74]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [75]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [63]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [65]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [66]
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Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [15]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [80]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [82]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [83]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [84]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [32]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [85]
Gefitinib DM15F0X Colon adenocarcinoma Approved [86]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [88]
Selenium DM25CGV N. A. N. A. Approved [38]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [89]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [90]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [21]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [92]
Gefitinib DM15F0X Colon adenocarcinoma Approved [93]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Etretinate DM2CZFA Keratosis ED56 Approved [95]
Prednisone DM2HG4X Acute asthma CA23 Approved [96]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [97]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [17]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Gefitinib DM15F0X Colon adenocarcinoma Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [103]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [104]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [101]
Ethacrynic acid DM60QMR Edema MG29 Approved [105]
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Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [101]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Quercetin DM3NC4M Obesity 5B81 Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [108]
Sorbitol DMAN0DE Constipation DD91.1 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [110]
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Drug(s) Affected By Cell division control protein 6 homolog (CDC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [15]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [17]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [111]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [112]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Testosterone DM7HUNW Hot flushes GA30 Approved [23]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [23]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [110]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glycogen synthase kinase-3 alpha (GSK-3A) TTRZQE3 GSK3A_HUMAN Inhibitor [1]
Glycogen synthase kinase-3 beta (GSK-3B) TTRSMW9 GSK3B_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Gene/Protein Processing [3]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Post-Translational Modifications [4]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Post-Translational Modifications [4]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Gene/Protein Processing [3]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Gene/Protein Processing [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Post-Translational Modifications [4]

References

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13 Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.
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15 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
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23 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
24 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
25 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
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27 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
28 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
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30 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
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33 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
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37 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
38 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
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42 p38 MAPK/PP2Ac/TTP pathway on the connection of TNF- and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis. 2013 Apr;34(4):818-27. doi: 10.1093/carcin/bgs409. Epub 2013 Jan 3.
43 Glycyrrhizin attenuates histamine-mediated MUC5AC upregulation, inflammatory cytokine production, and aquaporin 5 downregulation through suppressing the NF-B pathway in human nasal epithelial cells. Chem Biol Interact. 2018 Apr 1;285:21-26. doi: 10.1016/j.cbi.2018.02.010. Epub 2018 Feb 13.
44 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
45 G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
46 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
47 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
48 Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
49 Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
50 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
51 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
52 CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
53 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
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