General Information of Drug (ID: DMTF7JA)

Drug Name
(E)-10-nitrooctadec-9-enoic acid Drug Info
Synonyms
10-nitrooleic acid; 10-nitro-9E-octadecenoic acid; 10-Nitro Oleic Acid; (E)-10-nitrooctadec-9-enoic acid; 10-nitroelaidic acid; 875685-46-4; UNII-1N19AGY57Y; CHEMBL561371; 1N19AGY57Y; CHEBI:86285; (9E)-10-nitrooctadecenoic acid; 10-Nitrooleate; 10-nitro-oleic acid; 10-Nitroelaidate; 88127-53-1; 9-Octadecenoic acid, 10-nitro-, (9E)-; E-10-nitrooleic acid; Oa-NO2; 10-nitro-9E-Octadecenoate; (9E)-10-Nitrooctadecenoate; 10-Nitro-9-octadecenoic acid; SCHEMBL1018141; CXA-10; (e)-10-Nitrooctadec-9-enoate; WRADPCFZZWXOTI-BMRADRMJSA-N
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
24836820
ChEBI ID
CHEBI:86285
TTD Drug ID
DMTF7JA

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [4]
AD-5075 DM1SLJ9 Type-2 diabetes 5A11 Terminated [5]
2-chloro-5-nitro-N-phenylbenzamide DMUGQIV Discovery agent N.A. Investigative [6]
L-783483 DM6OTGE Discovery agent N.A. Investigative [7]
LG100754 DMEK4FY Discovery agent N.A. Investigative [8]
L-796449 DMWTGQM Discovery agent N.A. Investigative [9]
L-165461 DMKBSGN Discovery agent N.A. Investigative [9]
AD-5061 DM5WV13 Discovery agent N.A. Investigative [10]
TZD18 DMVCHOX Discovery agent N.A. Investigative [11]
(9Z,12E)-12-nitrooctadeca-9,12-dienoic acid DM2REIN Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [12]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [13]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [12]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [16]
Testosterone DM7HUNW Hot flushes GA30 Approved [17]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [18]
Ibrutinib DMHZCPO Mantle cell lymphoma 2A85.5 Approved [19]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [20]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [21]
Gefitinib DM15F0X Colon adenocarcinoma Approved [22]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [23]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [24]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Selenium DM25CGV N. A. N. A. Approved [29]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [30]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [31]
Panobinostat DM58WKG Chronic graft versus host disease Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [38]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [39]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [39]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [40]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [42]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [45]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [46]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [47]
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Drug(s) Affected By Matrilysin (MMP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Clozapine DMFC71L Schizophrenia 6A20 Approved [56]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [57]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [58]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [60]
Verapamil DMA7PEW Angina pectoris BA40 Approved [61]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [64]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [47]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Gefitinib DM15F0X Colon adenocarcinoma Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [69]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [70]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [71]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [70]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [72]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Gefitinib DM15F0X Colon adenocarcinoma Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Selenium DM25CGV N. A. N. A. Approved [29]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [79]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [81]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [82]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [83]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [85]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [86]
Gefitinib DM15F0X Colon adenocarcinoma Approved [22]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Selenium DM25CGV N. A. N. A. Approved [89]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [90]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [94]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [96]
Leflunomide DMR8ONJ Arthritis FA20 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [98]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [100]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [101]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [102]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [85]
Gefitinib DM15F0X Colon adenocarcinoma Approved [103]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [105]
Selenium DM25CGV N. A. N. A. Approved [89]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [106]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [107]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [109]
Gefitinib DM15F0X Colon adenocarcinoma Approved [110]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Etretinate DM2CZFA Keratosis ED56 Approved [112]
Prednisone DM2HG4X Acute asthma CA23 Approved [113]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [71]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [114]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [115]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [116]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [117]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [118]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [119]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [69]
Meloxicam DM2AR7L Arthritis FA20 Approved [120]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [121]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [122]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [123]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [89]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [127]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [129]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [131]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Gefitinib DM15F0X Colon adenocarcinoma Approved [133]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [134]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [89]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [121]
Methotrexate DM2TEOL Anterior urethra cancer Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [136]
Folic Acid DMEMBJC Colorectal carcinoma Approved [137]
Methotrexate DM2TEOL Anterior urethra cancer Approved [138]
Quercetin DM3NC4M Obesity 5B81 Approved [139]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [140]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [141]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [142]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [143]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [144]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [144]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [146]
Quercetin DM3NC4M Obesity 5B81 Approved [147]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [149]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [150]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [53]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [152]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [153]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PPAR-gamma messenger RNA (PPARG mRNA) TTT2SVW PPARG_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Gene/Protein Processing [2]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [2]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [2]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [2]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [2]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Gene/Protein Processing [2]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [2]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [3]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Post-Translational Modifications [2]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Gene/Protein Processing [2]

References

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10 A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes. Eur J Pharmacol. 2004 Jul 8;495(1):17-26.
11 A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis. Endocrinology. 2004 Apr;145(4):1640-8.
12 Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct;99(2):402-15. doi: 10.1111/j.1471-4159.2006.04005.x.
13 Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKbeta. Apoptosis. 2009 Jul;14(7):913-22. doi: 10.1007/s10495-009-0367-1.
14 Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. J Immunol. 2007 Feb 15;178(4):2507-16. doi: 10.4049/jimmunol.178.4.2507.
15 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
16 Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. J Biol Chem. 2005 Dec 9;280(49):41047-56. doi: 10.1074/jbc.M503713200. Epub 2005 Sep 30.
17 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
18 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
19 Blockade of oncogenic IB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11365-70. doi: 10.1073/pnas.1411701111. Epub 2014 Jul 21.
20 Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. Endocrinology. 2005 Mar;146(3):1491-7. doi: 10.1210/en.2004-0809. Epub 2004 Nov 24.
21 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
22 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
23 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
24 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
25 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
26 Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
27 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
28 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
29 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
30 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
31 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
32 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
33 Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3). Cell Biochem Funct. 2011 Mar;29(2):87-95. doi: 10.1002/cbf.1725. Epub 2011 Feb 9.
34 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
35 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
36 Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
37 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
38 Atorvastatin affects several angiogenic mediators in human endothelial cells. Endothelium. 2005 Sep-Dec;12(5-6):233-41.
39 Dicloxacillin and erythromycin at high concentrations increase ICAM-1 expression by endothelial cells: a possible factor in the pathogenesis of infusion phlebitis. J Antimicrob Chemother. 2004 Feb;53(2):174-9. doi: 10.1093/jac/dkh056. Epub 2004 Jan 16.
40 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
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