Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWDMJ3)

• Drug Name: OLEANOLIC_ACID Drug Info
• Synonyms: OLEANOLIC ACID; Oleanic acid; 508-02-1; Caryophyllin; Astrantiagenin C; Giganteumgenin C; Virgaureagenin B; 3beta-Hydroxyolean-12-en-28-oic acid; UNII-6SMK8R7TGJ; CCRIS 6493; (3-beta)-3-Hydroxyolean-12-en-28-oic acid; EINECS 208-081-6; NSC114945; 6SMK8R7TGJ; NSC-114945; 3-beta-Hydroxyolean-12-en-28-oic acid; CHEBI:37659; Olean-12-en-28-oic acid, 3-hydroxy-, (3beta)-; oleonolic acid; MFCD00064914

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10494
  ChEBI ID: CHEBI:37659
  CAS Number: CAS 508-02-1
  TTD Drug ID: DMWDMJ3

Molecule-Related Drug Atlas

Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[11]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[12]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[11]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[14]
Penciclovir	DMOUMDV	Herpes simplex labialis	1F00.01	Approved	[15]
Famciclovir	DMJHLSD	Meniere disease	AB31.0	Approved	[16]
Valacyclovir Hydrochloride	DM5I1CE	Herpes simplex virus infection	1F00	Approved	[11]
Foscavir	DM9KJLZ	Cytomegalovirus retinitis	9B72.00	Approved	[14]

Drug(s) Targeting PTPN1 messenger RNA (PTPN1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
TRYPAN BLUE	DM4NTMO	Ophthalmic surgery injury	PK97	Approved	[18]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[19]
ISIS 113715	DMUPD4G	Type-2 diabetes	5A11	Phase 2	[20]
ISIS-PTP1Brx	DMJGVXT	Type-2 diabetes	5A11	Phase 2	[21]
ERTIPROTAFIB	DMJXEV7	Type-2 diabetes	5A11	Terminated	[22]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[23]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[23]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[23]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[23]

Drug(s) Targeting Glycogen phosphorylase muscle form (GP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[24]
JTT-651	DMGP42Q	Type-2 diabetes	5A11	Discontinued in Phase 1	[25]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[23]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[23]
Indirubin-5-sulfonate	DM08VHZ	Discovery agent	N.A.	Investigative	[23]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[23]
Alpha-D-Glucose-6-Phosphate	DMR0EVN	Discovery agent	N.A.	Investigative	[23]
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[23]
Oleanonic acid	DMYPJC3	Discovery agent	N.A.	Investigative	[2]
Nojirimycine Tetrazole	DMYZRTB	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[27]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[27]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[27]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[28]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[29]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[30]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[31]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[32]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[33]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[34]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[37]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[38]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[40]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[41]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[42]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[43]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[44]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[47]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[48]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[49]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[50]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[58]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[59]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[62]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[71]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[72]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[72]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[34]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[74]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[77]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[78]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[79]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[80]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[81]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[82]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[82]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[83]

Drug(s) Affected By High mobility group protein B1 (HMGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[93]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[96]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[97]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[100]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[79]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[47]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[106]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[107]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[106]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[111]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[114]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[34]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[115]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[116]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[118]

Drug(s) Affected By DNA topoisomerase 1 (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[124]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[118]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[132]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[133]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[136]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[137]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[34]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[138]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[140]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[142]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[145]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[147]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[148]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[149]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[150]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[153]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[145]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[154]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[155]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[156]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[34]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[117]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[147]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[157]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[118]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[162]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[163]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[136]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[164]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[48]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[167]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[107]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[168]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[172]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[173]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[175]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[176]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[178]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[136]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[184]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[187]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[188]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[189]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[190]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[191]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[193]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[138]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[194]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[199]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[200]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[197]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[201]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[202]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[203]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[116]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[47]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[206]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[207]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[208]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[215]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[216]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[219]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[111]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[138]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[115]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[220]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[204]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[222]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[107]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[178]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[225]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]

Drug(s) Affected By Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[228]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[231]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[232]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[234]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[239]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[240]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[241]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[242]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[243]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[245]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[47]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[207]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]

Drug(s) Affected By Mitochondrial import receptor subunit TOM20 homolog (TOMM20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[246]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[247]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[250]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[251]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[252]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[253]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[254]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[257]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[258]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]

Drug(s) Affected By Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[246]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[263]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[264]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[265]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[266]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[268]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[270]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[271]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[184]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[270]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[271]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[239]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[272]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[274]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen phosphorylase muscle form (GP)	TTZHY6R	PYGM_HUMAN	Inhibitor	[2]
Herpes simplex virus DNA polymerase UL30 (HSV UL30)	TTIU7X1	DPOL_HHV11	Inhibitor	[3]
PTPN1 messenger RNA (PTPN1 mRNA)	TTELIN2	PTN1_HUMAN	Inhibitor	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[5]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Gene/Protein Processing	[5]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[6]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Gene/Protein Processing	[7]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[5]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[8]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[5]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[6]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Gene/Protein Processing	[9]

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