Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAEDQG)

• Drug Name: EMODIN Drug Info
• Synonyms: emodin; 518-82-1; Emodol; Schuttgelb; Frangula emodin; Rheum emodin; Frangulic acid; 3-Methyl-1,6,8-trihydroxyanthraquinone; Archin; 1,3,8-trihydroxy-6-methylanthracene-9,10-dione; Persian Berry Lake; 1,3,8-Trihydroxy-6-methyl-9,10-anthraquinone; 6-Methyl-1,3,8-trihydroxyanthraquinone; C.I. Natural Yellow 14; 9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl-; 1,3,8-Trihydroxy-6-methylanthraquinone; 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione; 4,5,7-Trihydroxy-2-methylanthraquinone; UNII-KA46RNI6HN; C.I. 75440; NSC 622947

Indication

Disease Entry	ICD 11	Status	REF
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3220
  ChEBI ID: CHEMBL289277
  CAS Number: CAS 518-82-1
  TTD Drug ID: DMAEDQG

Molecule-Related Drug Atlas

Drug(s) Targeting Casein kinase II alpha (CSNK2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CX-4945	DMWE7B9	Coronavirus infection	1D92	Phase 2	[8]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[9]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[10]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[2]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[2]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[2]
PMID24900749C1a	DMZPUSO	Discovery agent	N.A.	Investigative	[11]
AdoC(Dpr)2AlaArg6	DM2TWSZ	Discovery agent	N.A.	Investigative	[12]
PMID22115617C2c	DMX5UKA	Discovery agent	N.A.	Investigative	[13]
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole	DM3JB6S	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Etoposide-induced protein 2.4 homolog (EI24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[20]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[21]

Drug(s) Affected By Growth arrest-specific protein 2 (GAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[17]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[26]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[27]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[42]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[45]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[46]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[49]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[52]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[64]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[69]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[70]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[72]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[74]

Drug(s) Affected By Calnexin (CANX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[76]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[70]

Drug(s) Affected By Peroxiredoxin-6 (PRDX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[82]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[87]
Haloperidol	DM96SE0	Delirium		Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[88]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[88]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[89]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[90]

Drug(s) Affected By Actin, alpha skeletal muscle (ACTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[94]

Drug(s) Affected By TNF receptor-associated factor 2 (TRAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[20]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[100]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[107]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[70]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[109]

Drug(s) Affected By Phosducin-like protein (PDCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Bortezomib	DMNO38U	Leukemia		Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[112]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[113]

Drug(s) Affected By Translation initiation factor eIF2B subunit alpha (EIF2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[114]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[118]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[115]

Drug(s) Affected By Reticulocalbin-2 (RCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[121]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[122]

Drug(s) Affected By Transcription factor E2F5 (E2F5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[123]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]

Drug(s) Affected By Tubulin-specific chaperone C (TBCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[114]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[125]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[126]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[112]

Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[130]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[132]

Drug(s) Affected By Transcription factor SPT20 homolog (SUPT20H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[126]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[135]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[136]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[91]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[137]

Drug(s) Affected By Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[139]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[118]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[137]
cycloheximide	DMGDA3C	Discovery agent	N.A.	Investigative	[141]

Drug(s) Affected By Serine/threonine-protein kinase TAO3 (TAOK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[142]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[143]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[27]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[144]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[112]

Drug(s) Affected By Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[146]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[100]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[126]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]

Drug(s) Affected By Bifunctional apoptosis regulator (BFAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[126]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[150]

Drug(s) Affected By Very-long-chain (HACD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[88]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[151]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[152]

Drug(s) Affected By SUMO-activating enzyme subunit 1 (SAE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[154]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[126]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[155]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[133]

Drug(s) Affected By BAG family molecular chaperone regulator 5 (BAG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[156]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[20]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[158]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[159]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[161]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[152]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[162]

Drug(s) Affected By Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[164]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[100]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[167]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[104]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[168]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[169]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[176]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[177]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[130]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[179]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[180]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[183]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[185]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[189]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[190]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]

Drug(s) Affected By Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[191]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[17]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[192]
7-hydroxycoumarin	DMTMNO7	Discovery agent	N.A.	Investigative	[193]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[167]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[197]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[198]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[197]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[199]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[202]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[206]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[207]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[208]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[211]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[214]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[215]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]

Drug(s) Affected By Carbonyl reductase 1 (CBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[19]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[115]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[220]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[115]

Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[225]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[227]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Fructose	DM43AN2	Vomiting	MD90	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[69]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[232]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[233]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[234]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[235]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[236]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[237]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[238]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[240]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[232]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[241]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[242]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[243]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[244]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[233]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[234]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[18]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[248]
Bortezomib	DMNO38U	Leukemia		Approved	[249]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[22]

Drug(s) Affected By L-dopachrome tautomerase (DCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[250]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[251]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[252]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[253]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[252]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[244]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[254]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[126]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[255]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[256]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[257]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[257]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[255]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[255]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Fructose	DM43AN2	Vomiting	MD90	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[263]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[264]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[265]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[167]
Selenium	DM25CGV	N. A.	N. A.	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[268]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[269]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[17]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[271]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[271]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[271]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[273]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[271]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[274]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[271]

Drug(s) Affected By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[275]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[276]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[277]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[278]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[278]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[279]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[279]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[280]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[281]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[283]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[284]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[285]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[286]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[287]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[288]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[287]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[283]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[244]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Casein kinase II alpha (CSNK2A1)	TTER6YH	CSK21_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5,6-dihydroxyindole-2-carboxylic acid oxidase	OTRK49R4	TYRP1_HUMAN	Gene/Protein Processing	[3]
Actin, alpha skeletal muscle (ACTA1)	OTOVGLPG	ACTS_HUMAN	Gene/Protein Processing	[4]
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)	OTW3GO4Y	ARK73_HUMAN	Gene/Protein Processing	[5]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Gene/Protein Processing	[5]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[5]
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)	OTGND2YZ	SIA8A_HUMAN	Gene/Protein Processing	[4]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[6]
BAG family molecular chaperone regulator 5 (BAG5)	OT0J97C6	BAG5_HUMAN	Gene/Protein Processing	[4]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Protein Interaction/Cellular Processes	[7]
Bifunctional apoptosis regulator (BFAR)	OTTBG0V7	BFAR_HUMAN	Gene/Protein Processing	[4]

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