Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEDGKO)

• Drug Name: dibutyl phthalate Drug Info
• Synonyms: di-n-butyl phthalate; n-butyl phthalate; nutyl phthalate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3026
  ChEBI ID: CHEBI:34687
  CAS Number: CAS 84-74-2
  TTD Drug ID: DMEDGKO
  INTEDE Drug ID: DR0481

Molecule-Related Drug Atlas

Drug(s) Targeting Transformation-sensitive protein p120 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[14]
LY3526318	DMFXNQM	Chronic low-back pain	MG30	Phase 2	[15]
HX-100	DMFRM15	Diabetic neuropathy	8C0Z	Phase 1	[16]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[17]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[18]
[3H]resolvin D1	DMFT0HU	Discovery agent	N.A.	Investigative	[19]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[20]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[21]
4-oxo-nonenal	DMPX1J9	Discovery agent	N.A.	Investigative	[22]
prostaglandin A2	DMWC4X8	Discovery agent	N.A.	Investigative	[23]

Drug(s) Metabolized By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[26]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[27]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[28]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[29]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[30]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[31]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[32]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[31]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[36]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[37]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[32]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[30]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[38]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[39]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[40]

Drug(s) Affected By Inhibin alpha chain (INHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[47]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[48]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[49]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[49]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[50]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[51]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[51]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[55]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[53]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[63]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[64]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[65]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[65]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[66]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[67]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[68]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[65]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[65]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[65]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[69]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[70]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[71]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[71]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[71]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[72]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[71]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[78]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[78]

Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[88]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[89]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[90]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[91]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[94]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[96]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[94]

Drug(s) Affected By Probetacellulin (BTC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[102]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[104]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[107]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[87]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[111]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[112]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[113]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 11 (TNFSF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[117]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[120]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[126]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[127]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[128]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[132]

Drug(s) Affected By Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[133]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[135]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]

Drug(s) Affected By Hyaluronan mediated motility receptor (HMMR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]

Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[147]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[154]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[155]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[156]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[157]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[158]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[159]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[162]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[163]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[164]
Fructose	DM43AN2	Vomiting	MD90	Approved	[165]
Ketoprofen	DMRKXPT	Bursitis		Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[167]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[168]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[169]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[174]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[78]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[176]
Selenium	DM25CGV	N. A.	N. A.	Approved	[177]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[178]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[179]

Drug(s) Affected By Alpha-fetoprotein (AFP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[181]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[180]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[135]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[188]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[157]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[188]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[192]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[194]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[200]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[201]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[202]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[203]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]

Drug(s) Affected By Thy-1 membrane glycoprotein (THY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[100]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[207]
Bortezomib	DMNO38U	Leukemia		Approved	[208]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[209]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[210]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[211]

Drug(s) Affected By Sex hormone-binding globulin (SHBG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Fructose	DM43AN2	Vomiting	MD90	Approved	[213]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[214]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[215]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[215]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[215]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[215]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[220]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[221]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[222]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[226]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[33]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[227]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[228]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[230]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[53]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[232]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[233]

Drug(s) Affected By Integrin beta-3 (ITGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[234]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[239]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[242]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[243]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[244]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[40]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[176]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[247]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[248]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[248]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[249]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[250]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[252]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[253]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[254]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[255]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[256]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[257]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[259]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[118]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[256]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[260]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[261]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[261]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[262]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[263]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Fructose	DM43AN2	Vomiting	MD90	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[269]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[270]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[127]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]

Drug(s) Affected By Integrin alpha-V (ITGAV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[274]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[260]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]

Drug(s) Affected By Thyroid peroxidase (TPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[277]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[281]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[260]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[280]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[282]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[283]
Selenium	DM25CGV	N. A.	N. A.	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[285]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[286]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[287]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[288]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[289]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[290]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[292]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[293]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[294]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[295]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[296]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[297]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[274]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[304]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[305]

Drug(s) Affected By Integrin alpha-5 (ITGA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[307]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[309]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[310]

Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[311]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[262]
Selenium	DM25CGV	N. A.	N. A.	Approved	[312]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[313]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[314]

Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[315]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[317]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[243]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[120]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[318]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[319]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[320]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[40]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[321]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[322]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[78]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[323]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[323]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[323]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[324]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[325]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[327]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[328]
Selenium	DM25CGV	N. A.	N. A.	Approved	[284]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[329]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[330]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[331]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[332]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[333]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[334]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[335]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[167]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[336]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[337]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[338]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[263]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[340]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[341]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[342]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[343]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[344]
Selenium	DM25CGV	N. A.	N. A.	Approved	[270]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[345]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[346]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[348]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Selenium	DM25CGV	N. A.	N. A.	Approved	[270]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[181]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[349]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[350]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[351]

Drug(s) Affected By Creatine kinase U-type, mitochondrial (CKMT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[352]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[354]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[354]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[354]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[355]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[262]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[356]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[357]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[358]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[359]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[267]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[118]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[360]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[361]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[363]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[364]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[237]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[366]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[367]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[269]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[263]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[270]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[127]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[370]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[371]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[372]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[374]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[375]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[376]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[377]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[378]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[379]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[380]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[381]

Drug(s) Affected By Rho-related GTP-binding protein RhoQ (RHOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[341]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[382]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[383]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[384]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[383]

Drug(s) Affected By Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[388]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[113]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[385]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[389]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[390]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[391]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[392]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[393]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[394]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[396]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[261]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[397]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[398]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[269]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[348]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[349]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[399]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[400]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[401]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[402]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[336]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[186]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[155]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[403]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[404]
Selenium	DM25CGV	N. A.	N. A.	Approved	[312]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[405]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[406]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[407]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[408]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[409]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[167]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[410]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[411]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[412]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[413]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[414]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[415]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[416]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[408]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[417]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[418]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[419]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[407]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[167]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[410]

Drug(s) Affected By Retinoic acid receptor RXR-beta (RXRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[420]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[276]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[421]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[422]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[391]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[423]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[391]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[424]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[176]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[317]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[427]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[428]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[429]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[430]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[431]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[433]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[435]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[436]
Fructose	DM43AN2	Vomiting	MD90	Approved	[437]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[438]

Drug(s) Affected By Type-1 angiotensin II receptor (AGTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[439]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[440]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Fructose	DM43AN2	Vomiting	MD90	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[442]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[443]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[444]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[445]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[341]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[446]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[447]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[448]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[336]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[449]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[450]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[451]
Selenium	DM25CGV	N. A.	N. A.	Approved	[312]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[181]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[405]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[452]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[453]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[454]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[455]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[456]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[457]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[458]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[459]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[460]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[461]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[462]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[463]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[165]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[262]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[464]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[465]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[466]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[467]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[468]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[470]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[471]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[472]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[473]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[474]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[475]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[476]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[477]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[478]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[479]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[480]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[146]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[481]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[482]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[261]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[261]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[483]

Drug(s) Affected By Retinoic acid receptor RXR-gamma (RXRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[484]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[485]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[391]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[391]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[391]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[353]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[486]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[487]
Selenium	DM25CGV	N. A.	N. A.	Approved	[312]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[181]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[488]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[489]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[490]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[491]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[492]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[493]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[494]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Selenium	DM25CGV	N. A.	N. A.	Approved	[312]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[496]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[497]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[476]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[498]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[499]

Drug(s) Affected By N-acylglucosamine 2-epimerase (RENBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[500]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[100]
Methamphetamine	DMPM4SK	Anxiety		Approved	[501]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[502]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[502]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[353]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[48]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[503]

Drug(s) Affected By Hexokinase-2 (HK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[351]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[506]

Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[507]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[508]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[341]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[274]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[308]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[509]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[482]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[510]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[511]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[512]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[513]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[514]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[515]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[516]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[517]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[518]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[519]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[473]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[520]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[521]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[522]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]

Drug(s) Affected By Forkhead box protein M1 (FOXM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[446]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[459]

Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[523]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[524]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[491]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[525]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[526]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[527]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[528]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[529]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[530]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]

Drug(s) Affected By Disks large-associated protein 5 (DLGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[261]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[261]

Drug(s) Affected By Transcription factor E2F4 (E2F4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[312]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[531]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[532]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[533]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[534]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[535]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[536]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[317]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[537]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[538]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[539]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[540]

Drug(s) Affected By Centrosomal protein of 55 kDa (CEP55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[538]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[541]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[542]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[543]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[544]

Drug(s) Affected By V-type proton ATPase subunit C 2 (ATP6V1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[545]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[101]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[546]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[547]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[548]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[549]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[550]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[551]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[152]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[552]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[553]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[554]

Drug(s) Affected By Relaxin receptor 2 (RXFP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[277]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[556]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[557]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[558]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[559]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[560]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[561]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[562]
Mestranol	DMG3F94	Contraception	QA21	Approved	[563]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[564]

Drug(s) Affected By Sodium/iodide cotransporter (SLC5A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[565]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[566]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[567]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[567]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[567]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[568]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[569]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[567]

Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[539]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[539]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[570]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[571]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[102]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[103]

Drug(s) Affected By Sororin (CDCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[513]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[541]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[572]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Selenium	DM25CGV	N. A.	N. A.	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[573]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[429]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[260]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[574]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[575]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[576]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[577]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[508]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[536]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[377]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[483]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[578]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[483]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[120]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[509]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[482]

Drug(s) Affected By Cell division cycle-associated protein 3 (CDCA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[579]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[442]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[314]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[541]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]

Drug(s) Affected By Kinesin-like protein KIF2C (KIF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[580]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[541]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]

Drug(s) Affected By Protein orai-3 (ORAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[261]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[144]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[261]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[571]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[536]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[111]

Drug(s) Affected By Kinesin-like protein KIF15 (KIF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[541]

Drug(s) Affected By Histone chaperone ASF1B (ASF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[579]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[541]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[512]

Drug(s) Affected By Histone deacetylase 6 (HDAC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[572]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[581]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[582]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[583]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[584]
Bortezomib	DMNO38U	Leukemia		Approved	[585]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[586]

Drug(s) Affected By Targeting protein for Xklp2 (TPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[541]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[134]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[543]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[587]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[311]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[588]
Selenium	DM25CGV	N. A.	N. A.	Approved	[312]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[589]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[590]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[591]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[592]

Drug(s) Affected By Cocaine esterase (CES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[591]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[593]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[588]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[433]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[594]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[595]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[276]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[596]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transformation-sensitive protein p120 (TRPA1)	TTELV3W	TRPA1_HUMAN	Activator	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 1B1 (CYP1B1) Main DME	DE9QHP6	CP1B1_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Gene/Protein Processing	[4]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Gene/Protein Processing	[5]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[7]
Alpha-fetoprotein (AFP)	OT9GG3ZI	FETA_HUMAN	Gene/Protein Processing	[8]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Gene/Protein Processing	[9]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[10]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[11]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Gene/Protein Processing	[12]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[13]

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