Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKPUI6)

• Drug Name: CHLORPYRIFOS Drug Info
• Synonyms: chlorpyrifos; 2921-88-2; Chlorpyriphos; Dursban; Trichlorpyrphos; Lorsban; Chlorpyrifos-ethyl; Pyrinex; Coroban; Brodan; Killmaster; Piridane; Danusban; Spannit; Lentrek; Geodinfos; Tafaban; Stipend; Bonidel; Zidil; Terial; Durmet; Equity; Suscon green; Suscon blue; suSCon; Dursban R; Dursban F; Lock-On; Dursban 4E; Dowco 179; Chlorpyriphos-ethyl; Ethyl chlorpyriphos; Dursban 10CR; Chlorpyrifos (Dursban); Detmol U.A.; Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester; Chloropyrifos; Clorpyrifos; Dhanusban; Grofo; Detmol ua

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 2730
  ChEBI ID: CHEMBL34631
  CAS Number: CAS 2921-88-2
  TTD Drug ID: DMKPUI6
  INTEDE Drug ID: DR2271

Molecule-Related Drug Atlas

Drug(s) Targeting Acetylcholinesterase (AChE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[10]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[11]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[12]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[13]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[14]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[15]
YM443	DMNZCI1	Functional dyspepsia	DD90.3	Approved	[16]
Ambenonium	DMOP0BL	Myasthenia gravis	8C6Y	Approved	[17]
Demecarium bromide	DMAYEU1	Open-angle glaucoma	9C61	Approved	[18]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[19]

Drug(s) Metabolized By Cytochrome P450 BM3 (cypBM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HY-12638	DM37KVY	N. A.	N. A.	Discontinued	[2]
Dinoterb	DM8CSOJ	N. A.	N. A.	Investigative	[2]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[21]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[22]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[23]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[24]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[25]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[26]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[25]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[21]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[27]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[33]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[34]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[40]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[47]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[51]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[54]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[55]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[58]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[59]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[61]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[62]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[64]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[65]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[69]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[75]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[81]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[76]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[82]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]

Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[84]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[86]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[87]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[88]
Methamphetamine	DMPM4SK	Anxiety		Approved	[89]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[90]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By NADH dehydrogenase iron-sulfur protein 3, mitochondrial (NDUFS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[98]

Drug(s) Affected By Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[86]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[102]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[104]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[105]

Drug(s) Affected By Cocaine esterase (CES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[106]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[107]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[110]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[112]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[113]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[116]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[117]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[118]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[117]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[119]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]

Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[123]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[124]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[125]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[126]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]

Drug(s) Affected By DNA ligase 3 (LIG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[128]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[129]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[131]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[132]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[133]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[139]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[146]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[147]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[147]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[148]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[150]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[147]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[147]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[147]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[28]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[151]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[116]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[157]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[158]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[159]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Selenium	DM25CGV	N. A.	N. A.	Approved	[162]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[163]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[164]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[27]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[170]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[171]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[172]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[176]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[179]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[180]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[181]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[182]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[183]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[184]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[185]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[186]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[187]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[188]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[189]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[190]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[188]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[194]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[195]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[194]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[196]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[197]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[202]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[203]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[204]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[27]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[206]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[207]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[208]
Haloperidol	DM96SE0	Delirium		Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[210]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[213]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[216]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[217]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[219]

Drug(s) Affected By Integrin alpha-X (ITGAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[222]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[223]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[224]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[225]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[226]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[81]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[227]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[228]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[104]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[232]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[125]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[235]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[238]
Fructose	DM43AN2	Vomiting	MD90	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[69]

Drug(s) Affected By Protein S100-P (S100P)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[241]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[242]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[243]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[244]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[146]

Drug(s) Affected By Paired box protein Pax-6 (PAX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[70]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[245]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[246]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[245]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[245]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[248]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[59]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[249]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[250]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[251]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[58]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[27]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[61]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[62]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[252]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[256]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[257]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[258]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[259]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[260]

Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[261]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[262]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[263]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[264]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[262]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[262]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[265]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[266]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[267]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[268]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[269]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[271]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[272]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[118]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[273]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[274]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[277]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Forkhead box protein G1 (FOXG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[278]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[279]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[280]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[70]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[133]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[152]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[70]

Drug(s) Affected By Reactive oxygen species modulator 1 (ROMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[282]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[283]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[284]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[286]

Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[287]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[288]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[290]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[291]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[294]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[295]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[296]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[297]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[125]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[300]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[204]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[302]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[208]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[305]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[306]

Drug(s) Affected By Hydrocephalus-inducing protein homolog (HYDIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[307]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[133]

Drug(s) Affected By Neutral cholesterol ester hydrolase 1 (NCEH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[308]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[309]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]

Drug(s) Affected By Mitofusin-1 (MFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[312]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[313]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[124]
Bortezomib	DMNO38U	Leukemia		Approved	[314]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[315]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[316]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[317]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[318]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[319]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[139]

Drug(s) Affected By CAP-Gly domain-containing linker protein 3 (CLIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[321]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[322]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[104]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[81]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[311]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[323]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[324]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[325]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[208]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[328]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[329]

Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[330]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[331]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[333]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[296]

Drug(s) Affected By PSME3-interacting protein (PSME3IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[334]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[335]

Drug(s) Affected By Chorion-specific transcription factor GCMa (GCM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[336]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[337]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[323]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[133]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[152]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[338]
T0070907	DMTKSVO	Discovery agent	N.A.	Investigative	[336]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[46]
Fructose	DM43AN2	Vomiting	MD90	Approved	[339]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[340]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[341]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[342]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[292]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[343]

Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[325]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[345]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[346]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[347]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[347]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[348]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[27]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[349]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[350]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[351]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[353]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[354]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (PPP2R3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[355]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 4 (GPAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[323]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[133]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[152]

Drug(s) Affected By DDB1- and CUL4-associated factor 12 (DCAF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[323]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[356]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[356]

Drug(s) Affected By Protein phosphatase PTC7 homolog (PPTC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[357]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[359]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[133]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]

Drug(s) Affected By Phospholipid-transporting ATPase ID (ATP8B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[360]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[361]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[280]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[360]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[133]

Drug(s) Affected By Androgen-induced gene 1 protein (AIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[362]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[104]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[363]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[364]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 8 (CHD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[365]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[133]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[356]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[366]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[356]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[285]
Chlorphrifos oxon	DMGBT68	Discovery agent	N.A.	Investigative	[367]

Drug(s) Affected By Bcl-2-interacting killer (BIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[241]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[370]

Drug(s) Affected By Formin-binding protein 4 (FNBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[356]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[308]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[125]

Drug(s) Affected By Linker for activation of T-cells family member 2 (LAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[362]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[371]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[96]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[372]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[373]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[374]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 BM3 (cypBM3) Main DME	DEMQRS9	M9TKI6_BACME	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Androgen-induced gene 1 protein (AIG1)	OTJB2UTH	AIG1_HUMAN	Drug Response	[3]
Apoptosis-associated speck-like protein containing a CARD (PYCARD)	OT67RON3	ASC_HUMAN	Gene/Protein Processing	[4]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Gene/Protein Processing	[5]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Gene/Protein Processing	[4]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[6]
Bcl-2-interacting killer (BIK)	OTTH1T3D	BIK_HUMAN	Drug Response	[3]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[4]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[7]
CAP-Gly domain-containing linker protein 3 (CLIP3)	OTGJEGIB	CLIP3_HUMAN	Gene/Protein Processing	[8]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Gene/Protein Processing	[9]

References

• [1] Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpy... Bioorg Med Chem Lett. 2006 Feb;16(3):622-7.
• [2] PEGylation of cytochrome P450 enhances its biocatalytic performance for pesticide transformation. Int J Biol Macromol. 2017 Dec;105(Pt 1):163-170.
• [3] Application of human haploid cell genetic screening model in identifying the genes required for resistance to environmental toxicants: Chlorpyrifos as a case study. J Pharmacol Toxicol Methods. 2015 Nov-Dec;76:76-82. doi: 10.1016/j.vascn.2015.08.154. Epub 2015 Aug 20.
• [4] Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells. Toxicology. 2015 Dec 2;338:37-46. doi: 10.1016/j.tox.2015.09.006. Epub 2015 Oct 3.
• [5] Organophosphate-pesticides induced survival mechanisms and APE1-mediated Nrf2 regulation in non-small-cell lung cancer cells. J Biochem Mol Toxicol. 2021 Feb;35(2):e22640. doi: 10.1002/jbt.22640. Epub 2020 Oct 20.
• [6] Impact of chlorpyrifos on human villous trophoblasts and chorionic villi. Toxicol Appl Pharmacol. 2017 Aug 15;329:26-39. doi: 10.1016/j.taap.2017.05.026. Epub 2017 May 23.
• [7] Chlorpyrifos modifies the expression of genes involved in human placental function. Reprod Toxicol. 2012 Jun;33(3):331-8. doi: 10.1016/j.reprotox.2012.01.003. Epub 2012 Jan 21.
• [8] The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes. Toxicol Sci. 2006 Sep;93(1):125-35. doi: 10.1093/toxsci/kfl046. Epub 2006 Jun 21.
• [9] Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231?cells, through cholinergic and Wnt/-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment. Food Chem Toxicol. 2021 Jun;152:112241. doi: 10.1016/j.fct.2021.112241. Epub 2021 Apr 27.
• [10] Evidence that the clinical effects of cholinesterase inhibitors are related to potency and targeting of action. Int J Clin Pract Suppl. 2002 Jun;(127):6-19.
• [11] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465).
• [12] Acetylcholinesterase activity in Corbicula fluminea Mull., as a biomarker of organophosphate pesticide pollution in Pinacanauan River, Philippines. Environ Monit Assess. 2010 Jun;165(1-4):331-40.
• [13] [From symptomatic to disease modifying therapy Recent developments in the pharmacotherapy of Alzheimer's disease]. Fortschr Neurol Psychiatr. 2009 Jun;77(6):326-33.
• [14] Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia. Brain Res. 2002 Sep 13;949(1-2):162-70.
• [15] Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet. J Sep Sci. 2009 May;32(10):1748-56.
• [16] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [17] Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology. 2008 Aug;33(9):2158-66.
• [18] The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. Vet Ophthalmol. 2003 Mar;6(1):23-5.
• [19] Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators. Chem Biol. 2003 Jun;10(6):491-502.
• [20] Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
• [21] Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40.
• [22] The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
• [23] Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
• [24] Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
• [25] Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
• [26] Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
• [27] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [28] Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
• [29] Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82.
• [30] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [31] Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):221-30. doi: 10.1016/j.taap.2014.03.023. Epub 2014 Apr 12.
• [32] Constitutive androstane/active receptor is a target of retinoic acid receptor in humans. Biochem Pharmacol. 2010 Jul 1;80(1):129-35. doi: 10.1016/j.bcp.2010.02.023. Epub 2010 Mar 6.
• [33] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [34] Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
• [35] Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. Toxicol In Vitro. 2018 Feb;46:335-349. doi: 10.1016/j.tiv.2017.09.014. Epub 2017 Sep 18.
• [36] Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
• [37] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [38] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [39] Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
• [40] Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
• [41] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [42] K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
• [43] Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
• [44] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [45] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [46] Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
• [47] Under ambient UVA exposure, pefloxacin exhibits both immunomodulatory and genotoxic effects via multiple mechanisms. J Photochem Photobiol B. 2018 Jan;178:593-605. doi: 10.1016/j.jphotobiol.2017.12.014. Epub 2017 Dec 15.
• [48] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [49] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [50] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [51] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [52] Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
• [53] Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
• [54] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [55] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [56] Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
• [57] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [58] Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
• [59] Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
• [60] Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
• [61] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [62] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
• [63] Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
• [64] Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
• [65] Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
• [66] Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
• [67] SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
• [68] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [69] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [70] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [71] Toxicogenomics-based identification of mechanisms for direct immunotoxicity. Toxicol Sci. 2013 Oct;135(2):328-46.
• [72] Differently expressed long noncoding RNAs and mRNAs in TK6 cells exposed to low dose hydroquinone. Oncotarget. 2017 Oct 4;8(56):95554-95567. doi: 10.18632/oncotarget.21481. eCollection 2017 Nov 10.
• [73] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [74] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [75] Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
• [76] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [77] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [78] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [79] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [80] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [81] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [82] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [83] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [84] Chronic Nucleoside Reverse Transcriptase Inhibitors Disrupt Mitochondrial Homeostasis and Promote Premature Endothelial Senescence. Toxicol Sci. 2019 Dec 1;172(2):445-456. doi: 10.1093/toxsci/kfz203.
• [85] Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
• [86] Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines. Toxicol In Vitro. 2022 Aug;82:105388. doi: 10.1016/j.tiv.2022.105388. Epub 2022 May 18.
• [87] Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy. Cell Chem Biol. 2017 Apr 20;24(4):471-480.e4. doi: 10.1016/j.chembiol.2017.03.005. Epub 2017 Mar 30.
• [88] Induction of parkin expression in the presence of oxidative stress. Eur J Neurosci. 2006 Sep;24(5):1366-72. doi: 10.1111/j.1460-9568.2006.04998.x.
• [89] Involvement of C/EBP-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. Toxicol Lett. 2019 Sep 15;312:11-21. doi: 10.1016/j.toxlet.2019.05.003. Epub 2019 May 3.
• [90] Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response. J Biol Chem. 2017 Sep 8;292(36):15105-15120. doi: 10.1074/jbc.M117.783175. Epub 2017 Jul 3.
• [91] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [92] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [93] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [94] The effects of quercetin on SW480 human colon carcinoma cells: a proteomic study. Nutr J. 2005 Mar 4;4:11.
• [95] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [96] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [97] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [98] Arsenic modulates posttranslational S-nitrosylation and translational proteome in keratinocytes. ScientificWorldJournal. 2014;2014:360153.
• [99] Tea polyphenols direct Bmal1-driven ameliorating of the redox imbalance and mitochondrial dysfunction in hepatocytes. Food Chem Toxicol. 2018 Dec;122:181-193.
• [100] Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. Environ Toxicol Pharmacol. 2016 Jul;45:212-21.
• [101] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [102] Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
• [103] PPAR- activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction. Toxicol Lett. 2016 Oct 17;260:8-17. doi: 10.1016/j.toxlet.2016.08.016. Epub 2016 Aug 21.
• [104] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [105] Melatonin ameliorates acute lung injury caused by paraquat poisoning by promoting PINK1 and BNIP3 expression. Toxicology. 2023 May 15;490:153506. doi: 10.1016/j.tox.2023.153506. Epub 2023 Apr 5.
• [106] Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Drug Metab Dispos. 2000 Feb;28(2):186-91.
• [107] Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway. Cancer Biol Ther. 2006 Nov;5(11):1450-6.
• [108] Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1. J Pharmacol Exp Ther. 1999 Jul;290(1):314-8.
• [109] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [110] Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors. Chem Biol Interact. 2013 Mar 25;203(1):226-30.
• [111] Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor. Toxicol Sci. 2007 Jan;95(1):13-22.
• [112] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [113] Hepatoxicity mechanism of cantharidin-induced liver LO2 cells by LC-MS metabolomics combined traditional approaches. Toxicol Lett. 2020 Oct 15;333:49-61. doi: 10.1016/j.toxlet.2020.07.024. Epub 2020 Jul 26.
• [114] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [115] Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
• [116] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [117] The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
• [118] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [119] Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
• [120] Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
• [121] Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
• [122] Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance. Toxicol Sci. 2012 Aug;128(2):387-97. doi: 10.1093/toxsci/kfs152. Epub 2012 Apr 26.
• [123] Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner. Chem Biol Interact. 2023 Sep 1;382:110642. doi: 10.1016/j.cbi.2023.110642. Epub 2023 Jul 23.
• [124] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [125] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [126] Oncoprotein SET dynamically regulates cellular stress response through nucleocytoplasmic transport in breast cancer. Cell Biol Toxicol. 2023 Aug;39(4):1795-1814. doi: 10.1007/s10565-022-09784-4. Epub 2022 Dec 19.
• [127] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [128] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [129] Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India. Eur J Cancer Prev. 2011 Mar;20(2):123-31. doi: 10.1097/cej.0b013e328341017a.
• [130] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [131] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [132] Genistein-induced changes in gene expression in Panc 1 cells at physiological concentrations of genistein. Pancreas. 2004 Aug;29(2):93-8.
• [133] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [134] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [135] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [136] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [137] Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures. Biol Pharm Bull. 2018 May 1;41(5):722-732. doi: 10.1248/bpb.b17-00913. Epub 2018 Feb 14.
• [138] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [139] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [140] Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
• [141] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [142] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [143] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [144] Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
• [145] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [146] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [147] Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
• [148] Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
• [149] Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
• [150] Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
• [151] Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
• [152] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [153] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [154] Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells. Life Sci. 2005 Sep 2;77(16):2059-70. doi: 10.1016/j.lfs.2005.04.021.
• [155] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [156] Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53. Clin Cancer Res. 2004 May 1;10(9):3179-88. doi: 10.1158/1078-0432.ccr-03-0309.
• [157] Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway. Toxicol Sci. 2017 Mar 1;156(1):252-260. doi: 10.1093/toxsci/kfw249.
• [158] Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
• [159] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [160] ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
• [161] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [162] Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
• [163] Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
• [164] Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
• [165] Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
• [166] Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
• [167] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [168] Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer. Cancer Res. 2010 Feb 15;70(4):1314-22. doi: 10.1158/0008-5472.CAN-09-3292. Epub 2010 Feb 9.
• [169] PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells. Antioxid Redox Signal. 2002 Dec;4(6):877-84. doi: 10.1089/152308602762197416.
• [170] Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
• [171] Cytokine abnormalities in a patient with eosinophilic fasciitis. Ann Allergy Asthma Immunol. 2003 Apr;90(4):452-5. doi: 10.1016/S1081-1206(10)61832-7.
• [172] Ciprofloxacin decreases survival in HT-29 cells via the induction of TGF-beta1 secretion and enhances the anti-proliferative effect of 5-fluorouracil. Br J Pharmacol. 2009 Jun;157(3):362-70. doi: 10.1111/j.1476-5381.2009.00161.x. Epub 2009 Apr 9.
• [173] Enhanced apoptosis and transforming growth factor-beta1 expression in colorectal adenomas and carcinomas after Sulindac therapy. Dis Colon Rectum. 2001 Jul;44(7):1008-15. doi: 10.1007/BF02235490.
• [174] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [175] Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution. J Biol Chem. 2014 Aug 1;289(31):21386-400. doi: 10.1074/jbc.M113.528463. Epub 2014 Jun 18.
• [176] Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
• [177] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [178] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [179] Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
• [180] Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
• [181] Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling. J Lipid Res. 2009 Sep;50(9):1814-23. doi: 10.1194/jlr.M800343-JLR200. Epub 2009 Apr 21.
• [182] Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
• [183] Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
• [184] Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
• [185] Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
• [186] Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
• [187] Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
• [188] Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
• [189] Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
• [190] Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
• [191] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [192] The psychoactive compound of Cannabis sativa, (9)-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover. Toxicology. 2015 Aug 6;334:94-103. doi: 10.1016/j.tox.2015.06.005. Epub 2015 Jun 9.
• [193] Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats. Toxicol Sci. 2011 Jun;121(2):397-407. doi: 10.1093/toxsci/kfr063. Epub 2011 Apr 6.
• [194] Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions. Mol Endocrinol. 2005 Oct;19(10):2502-16.
• [195] Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
• [196] Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation. Biochim Biophys Acta. 2005 Feb 21;1687(1-3):181-94. doi: 10.1016/j.bbalip.2004.11.017.
• [197] The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression. Toxicology. 2003 May 3;187(2-3):139-48. doi: 10.1016/s0300-483x(03)00063-5.
• [198] SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. Cancer Res. 2006 Feb 15;66(4):2279-86. doi: 10.1158/0008-5472.CAN-05-2057.
• [199] Selective activation of Src family kinases and JNK by low levels of chromium(VI). Toxicol Appl Pharmacol. 2003 Aug 1;190(3):214-23. doi: 10.1016/s0041-008x(03)00188-1.
• [200] Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 2014 Feb 1;87(3):424-34. doi: 10.1016/j.bcp.2013.11.008. Epub 2013 Nov 23.
• [201] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [202] Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
• [203] Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression. Chem Biol Interact. 2010 Jan 5;183(1):181-6. doi: 10.1016/j.cbi.2009.09.018.
• [204] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [205] miRNA expression profiling in a human stem cell-based model as a tool for developmental neurotoxicity testing. Cell Biol Toxicol. 2013 Aug;29(4):239-57. doi: 10.1007/s10565-013-9250-5. Epub 2013 Aug 1.
• [206] A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica. Tohoku J Exp Med. 2008 May;215(1):55-9. doi: 10.1620/tjem.215.55.
• [207] Aspirin-induced blockade of NF-kappaB activity restrains up-regulation of glial fibrillary acidic protein in human astroglial cells. Biochim Biophys Acta. 2006 Mar;1763(3):282-9. doi: 10.1016/j.bbamcr.2006.01.005. Epub 2006 Feb 21.
• [208] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [209] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [210] Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
• [211] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [212] Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
• [213] Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
• [214] Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
• [215] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [216] Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
• [217] Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
• [218] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [219] The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
• [220] Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid. Pediatr Blood Cancer. 2006 Apr;46(4):506-11. doi: 10.1002/pbc.20392.
• [221] Arsenic trioxide induces apoptosis of human monocytes during macrophagic differentiation through nuclear factor-kappaB-related survival pathway down-regulation. J Pharmacol Exp Ther. 2006 Jan;316(1):304-14. doi: 10.1124/jpet.105.092874. Epub 2005 Sep 20.
• [222] Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
• [223] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [224] Integrin expression on monocytes and lymphocytes in unstable angina short term effects of atorvastatin. Rom J Intern Med. 2007;45(2):193-9.
• [225] Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation. Inflamm Res. 2001 Aug;50(8):428-34. doi: 10.1007/PL00000266.
• [226] In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
• [227] Attenuation of changes in leukocyte surface markers and complement activation with heparin-coated cardiopulmonary bypass. Ann Thorac Surg. 1997 Jan;63(1):105-11. doi: 10.1016/s0003-4975(96)00743-6.
• [228] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [229] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [230] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [231] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [232] Oestrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters. Hum Reprod. 2001 May;16(5):1037-45.
• [233] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [234] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [235] Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
• [236] Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
• [237] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [238] Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
• [239] Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
• [240] S100P is selectively upregulated in tumor cell lines challenged with DNA cross-linking agents. Leuk Res. 2005 Oct;29(10):1181-90. doi: 10.1016/j.leukres.2005.03.012.
• [241] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [242] Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
• [243] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [244] Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts. Cancer Lett. 2018 Aug 28;430:1-10. doi: 10.1016/j.canlet.2018.04.043. Epub 2018 May 5.
• [245] Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reprod Toxicol. 2020 Jan;91:74-91. doi: 10.1016/j.reprotox.2019.10.004. Epub 2019 Nov 8.
• [246] hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation. Front Mol Neurosci. 2020 Jul 6;13:119. doi: 10.3389/fnmol.2020.00119. eCollection 2020.
• [247] Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. Hum Mol Genet. 2012 Sep 15;21(18):4104-14. doi: 10.1093/hmg/dds239. Epub 2012 Jun 20.
• [248] Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
• [249] A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
• [250] The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
• [251] Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
• [252] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [253] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [254] Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
• [255] Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
• [256] Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
• [257] Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
• [258] Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
• [259] Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
• [260] Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
• [261] Downregulation of glucose-6-phosphatase expression contributes to fluoxetine-induced hepatic steatosis. J Appl Toxicol. 2021 Aug;41(8):1232-1240. doi: 10.1002/jat.4109. Epub 2020 Nov 12.
• [262] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [263] Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. Arch Toxicol. 2022 Jan;96(1):195-210. doi: 10.1007/s00204-021-03177-y. Epub 2021 Oct 23.
• [264] Similarities and differences between two modes of antagonism of the thyroid hormone receptor. ACS Chem Biol. 2011 Oct 21;6(10):1096-106.
• [265] Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
• [266] Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
• [267] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [268] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [269] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [270] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [271] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [272] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [273] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [274] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [275] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [276] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [277] High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res. 2009 Oct 1;15(19):6070-8.
• [278] 5-Fluorouracil inhibits neural differentiation via Mfn1/2 reduction in human induced pluripotent stem cells. J Toxicol Sci. 2018;43(12):727-734. doi: 10.2131/jts.43.727.
• [279] Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort. Environ Pollut. 2021 Dec 1;290:118024. doi: 10.1016/j.envpol.2021.118024. Epub 2021 Aug 21.
• [280] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [281] PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
• [282] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [283] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [284] Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
• [285] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [286] Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
• [287] Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
• [288] Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
• [289] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [290] Vitamin D Counteracts an IL-23-Dependent IL-17A(+)IFN-(+) Response Driven by Urban Particulate Matter. Am J Respir Cell Mol Biol. 2017 Sep;57(3):355-366. doi: 10.1165/rcmb.2016-0409OC.
• [291] Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
• [292] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [293] Dietary flavonoids induce MLL translocations in primary human CD34+ cells. Carcinogenesis. 2007 Aug;28(8):1703-9. doi: 10.1093/carcin/bgm102. Epub 2007 Apr 29.
• [294] Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Differentiation. 2012 Nov;84(4):330-43. doi: 10.1016/j.diff.2012.07.006. Epub 2012 Aug 18.
• [295] Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression. Chem Biol Interact. 2022 Apr 1;356:109847. doi: 10.1016/j.cbi.2022.109847. Epub 2022 Feb 9.
• [296] Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci. 2007 Oct 17;27(42):11254-62. doi: 10.1523/JNEUROSCI.3272-07.2007.
• [297] The broken MLL gene is frequently located outside the inherent chromosome territory in human lymphoid cells treated with DNA topoisomerase II poison etoposide. PLoS One. 2013 Sep 25;8(9):e75871. doi: 10.1371/journal.pone.0075871. eCollection 2013.
• [298] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [299] Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. doi: 10.1097/01.ta.0000114087.46566.eb.
• [300] Glucosamine promotes osteogenic differentiation of dental pulp stem cells through modulating the level of the transforming growth factor-beta type I receptor. J Cell Physiol. 2010 Oct;225(1):140-51.
• [301] Protective effect of quercetin on hydrogen peroxide-induced tight junction disruption. Int J Toxicol. 2010 Jul;29(4):418-24. doi: 10.1177/1091581810366487. Epub 2010 May 5.
• [302] Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
• [303] Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J Nutr. 2009 May;139(5):965-74. doi: 10.3945/jn.108.100867. Epub 2009 Mar 18.
• [304] Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways. Toxicol Lett. 2020 Oct 10;332:146-154. doi: 10.1016/j.toxlet.2020.07.010. Epub 2020 Jul 16.
• [305] The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia. Clin Pharmacol Ther. 2006 Oct;80(4):375-83. doi: 10.1016/j.clpt.2006.07.002.
• [306] Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach. PLoS One. 2014 Sep 16;9(9):e107421. doi: 10.1371/journal.pone.0107421. eCollection 2014.
• [307] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [308] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [309] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [310] Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food Chem Toxicol. 2017 Dec;110:189-199. doi: 10.1016/j.fct.2017.10.031. Epub 2017 Oct 20.
• [311] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [312] Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission. Toxicol In Vitro. 2022 Apr;80:105330. doi: 10.1016/j.tiv.2022.105330. Epub 2022 Feb 11.
• [313] Melatonin prevents blood-retinal barrier breakdown and mitochondrial dysfunction in high glucose and hypoxia-induced in vitro diabetic macular edema model. Toxicol In Vitro. 2021 Sep;75:105191. doi: 10.1016/j.tiv.2021.105191. Epub 2021 May 5.
• [314] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [315] Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels. Cell Death Differ. 2000 Jun;7(6):574-86. doi: 10.1038/sj.cdd.4400688.
• [316] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [317] Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. Cancer Res. 2003 Feb 1;63(3):616-20.
• [318] Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation. 2002 Oct 27;74(8):1063-9. doi: 10.1097/00007890-200210270-00001.
• [319] Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
• [320] Down regulation of N-acetylglucosaminyltransferase V facilitates all-transretinoic acid to induce apoptosis of human hepatocarcinoma cells. Mol Cell Biochem. 2006 Mar;284(1-2):103-10. doi: 10.1007/s11010-005-9022-5. Epub 2006 Jan 13.
• [321] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [322] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [323] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [324] AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance. Cell Biol Toxicol. 2023 Oct;39(5):2165-2181. doi: 10.1007/s10565-022-09703-7. Epub 2022 Feb 28.
• [325] Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes. Toxicol Lett. 2023 Mar 1;376:39-50. doi: 10.1016/j.toxlet.2023.01.005. Epub 2023 Jan 13.
• [326] Imatinib-induced hepatotoxicity via oxidative stress and activation of NLRP3 inflammasome: an in vitro and in vivo study. Arch Toxicol. 2022 Apr;96(4):1075-1087. doi: 10.1007/s00204-022-03245-x. Epub 2022 Feb 22.
• [327] Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
• [328] Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation. Toxicology. 2021 Sep;461:152923. doi: 10.1016/j.tox.2021.152923. Epub 2021 Aug 30.
• [329] Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 Jul;37(7):863-872. doi: 10.1002/jat.3435. Epub 2017 Jan 31.
• [330] DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol Pharmacol. 2007 Mar;71(3):644-53. doi: 10.1124/mol.106.030635. Epub 2006 Oct 25.
• [331] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [332] Decarboxylases as hypothetical targets for actions of organophosphates: Molecular modeling for prediction of hidden and unexpected health threats. Food Chem Toxicol. 2022 Mar;161:112856. doi: 10.1016/j.fct.2022.112856. Epub 2022 Feb 11.
• [333] Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
• [334] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [335] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [336] Regulation of the placental BCRP transporter by PPAR gamma. J Biochem Mol Toxicol. 2017 May;31(5):10.1002/jbt.21880. doi: 10.1002/jbt.21880. Epub 2016 Nov 23.
• [337] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [338] Effects of Bisphenol A on endogenous retroviral envelopes expression and trophoblast fusion in BeWo cells. Reprod Toxicol. 2019 Oct;89:35-44. doi: 10.1016/j.reprotox.2019.07.001. Epub 2019 Jul 3.
• [339] Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
• [340] Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia. 2010 May;53(5):955-65. doi: 10.1007/s00125-010-1676-1. Epub 2010 Feb 18.
• [341] AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. J Appl Toxicol. 2017 Oct;37(10):1219-1224. doi: 10.1002/jat.3483. Epub 2017 May 29.
• [342] Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.
• [343] A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1 expression and mitochondrial biogenesis. PLoS One. 2012;7(10):e46753. doi: 10.1371/journal.pone.0046753. Epub 2012 Oct 3.
• [344] Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
• [345] Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells. Toxicology. 2015 Aug 6;334:104-10. doi: 10.1016/j.tox.2015.06.006. Epub 2015 Jun 12.
• [346] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [347] Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones. Cell Tissue Res. 2012 Aug;349(2):551-63. doi: 10.1007/s00441-012-1417-5. Epub 2012 May 13.
• [348] Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42.
• [349] ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin. Clin Pharmacol Ther. 2010 May;87(5):558-62.
• [350] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [351] Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
• [352] Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.
• [353] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [354] Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther. 2005 Jul;4(7):747-52.
• [355] Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. Int J Mol Sci. 2022 Oct 1;23(19):11620. doi: 10.3390/ijms231911620.
• [356] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [357] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [358] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [359] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [360] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [361] Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
• [362] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [363] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [364] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [365] Frequent disruption of chromodomain helicase DNA-binding protein 8 (CHD8) and functionally associated chromatin regulators in prostate cancer. Neoplasia. 2014 Dec;16(12):1018-27. doi: 10.1016/j.neo.2014.10.003.
• [366] Glyphosate-based herbicides at low doses affect canonical pathways in estrogen positive and negative breast cancer cell lines. PLoS One. 2019 Jul 11;14(7):e0219610. doi: 10.1371/journal.pone.0219610. eCollection 2019.
• [367] Gene-Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres. Environ Health Perspect. 2021 Jul;129(7):77001. doi: 10.1289/EHP8580. Epub 2021 Jul 14.
• [368] Protective effects of hepatocyte growth factor gene overexpression against hydrogen peroxide-induced apoptosis in mesenchymal stem cells. Environ Toxicol. 2019 Nov;34(11):1236-1245. doi: 10.1002/tox.22824. Epub 2019 Jul 16.
• [369] A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
• [370] Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients. J Clin Psychopharmacol. 2005 Oct;25(5):419-26. doi: 10.1097/01.jcp.0000177668.42640.fe.
• [371] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [372] NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia. Sci Rep. 2020 Jun 25;10(1):10315. doi: 10.1038/s41598-020-66223-2.
• [373] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [374] Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.