Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKPUI6)

• Drug Name: CHLORPYRIFOS Drug Info
• Synonyms: chlorpyrifos; 2921-88-2; Chlorpyriphos; Dursban; Trichlorpyrphos; Lorsban; Chlorpyrifos-ethyl; Pyrinex; Coroban; Brodan; Killmaster; Piridane; Danusban; Spannit; Lentrek; Geodinfos; Tafaban; Stipend; Bonidel; Zidil; Terial; Durmet; Equity; Suscon green; Suscon blue; suSCon; Dursban R; Dursban F; Lock-On; Dursban 4E; Dowco 179; Chlorpyriphos-ethyl; Ethyl chlorpyriphos; Dursban 10CR; Chlorpyrifos (Dursban); Detmol U.A.; Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester; Chloropyrifos; Clorpyrifos; Dhanusban; Grofo; Detmol ua

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 2730
  ChEBI ID: CHEBI:34631
  CAS Number: CAS 2921-88-2
  TTD Drug ID: DMKPUI6
  INTEDE Drug ID: DR2271

Molecule-Related Drug Atlas

Drug(s) Targeting Acetylcholinesterase (AChE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[13]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[14]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[15]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[16]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[17]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[18]
YM443	DMNZCI1	Functional dyspepsia	DD90.3	Approved	[19]
Ambenonium	DMOP0BL	Myasthenia gravis	8C6Y	Approved	[20]
Demecarium bromide	DMAYEU1	Open-angle glaucoma	9C61	Approved	[21]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[22]

Drug(s) Metabolized By Cytochrome P450 BM3 (cypBM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HY-12638	DM37KVY	N. A.	N. A.	Discontinued	[2]
Dinoterb	DM8CSOJ	N. A.	N. A.	Investigative	[2]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[24]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[27]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[28]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[29]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[30]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[31]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[32]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[35]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[35]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[36]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[37]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[41]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[42]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[43]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[44]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[29]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[30]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[45]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[30]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[42]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[46]

Drug(s) Affected By Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[47]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[48]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[49]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[50]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[46]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[51]
Ethopropazine	DM0N3L7	Parkinson disease	8A00.0	Approved	[48]
Dimenhydrinate	DM264B3	Meniere disease	AB31.0	Approved	[52]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[53]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[52]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[56]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[57]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[58]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[59]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[60]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[61]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[62]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[63]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[64]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[65]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[66]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[74]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[75]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[78]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[79]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[82]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[83]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[86]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[89]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[90]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[93]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[94]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[46]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[78]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[46]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[42]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[98]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[99]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[100]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[102]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[103]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[104]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[110]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[116]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[117]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Ketoprofen	DMRKXPT	Bursitis		Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[128]
Haloperidol	DM96SE0	Delirium		Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[130]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[131]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[133]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[63]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[139]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[144]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[147]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]

Drug(s) Affected By Annexin A5 (ANXA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[151]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[156]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[156]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[157]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[160]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[163]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[164]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[167]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[168]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[170]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[172]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[173]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[174]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[175]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[178]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[181]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[183]

Drug(s) Affected By Galectin-1 (LGALS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[188]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[191]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[192]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[194]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[195]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[196]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[197]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[199]

Drug(s) Affected By N-arachidonyl glycine receptor (GPR18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[181]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[181]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[181]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[208]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[212]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[213]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[3]

Drug(s) Affected By 2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[3]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[206]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[214]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[215]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[216]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[217]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[106]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[224]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[224]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[225]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]

Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[227]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[228]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[229]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[230]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[231]
Methamphetamine	DMPM4SK	Anxiety		Approved	[232]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[233]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]

Drug(s) Affected By NADH dehydrogenase iron-sulfur protein 3, mitochondrial (NDUFS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[237]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[238]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]

Drug(s) Affected By Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[229]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[244]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[246]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[247]

Drug(s) Affected By Cocaine esterase (CES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[248]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[249]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[250]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[251]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[253]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[254]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[255]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[256]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[250]
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[257]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[258]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[248]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[260]

Drug(s) Affected By N-glycosylase/DNA lyase (OGG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[263]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[264]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[265]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[266]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[267]

Drug(s) Affected By DNA polymerase beta (POLB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[269]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[270]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[46]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[271]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[272]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[273]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[172]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[275]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[276]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[275]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[277]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[279]

Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[280]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[281]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[282]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[284]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Indomethacin	DMSC4A7	Bursitis		Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[286]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[152]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[289]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[290]

Drug(s) Affected By DNA ligase 3 (LIG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[291]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[269]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[294]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[297]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[298]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[299]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[301]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]

Drug(s) Affected By Glutathione S-transferase A4 (GSTA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[302]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[246]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[303]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[224]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[298]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[306]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[307]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[307]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[308]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[310]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[307]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[307]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[307]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[84]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[311]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[312]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[172]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[317]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[300]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[318]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[319]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[320]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[321]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[322]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[323]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
Selenium	DM25CGV	N. A.	N. A.	Approved	[324]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[325]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[326]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[304]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[329]
Selenium	DM25CGV	N. A.	N. A.	Approved	[330]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[331]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[332]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[333]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[334]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[336]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[338]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[339]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[340]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[341]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[342]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[343]
Fructose	DM43AN2	Vomiting	MD90	Approved	[46]
Ketoprofen	DMRKXPT	Bursitis		Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[344]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[160]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[345]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[346]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[348]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[217]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[349]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[350]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[351]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[355]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[356]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[357]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[106]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[358]
Selenium	DM25CGV	N. A.	N. A.	Approved	[142]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[359]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[360]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[361]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[362]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[321]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[366]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[367]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[364]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[368]

Drug(s) Affected By Platelet-derived growth factor subunit A (PDGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[369]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[370]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[211]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[371]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[372]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[374]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[375]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[376]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[377]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[378]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[379]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[380]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[381]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[54]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[382]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[383]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[384]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[152]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[385]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[386]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[387]

Drug(s) Affected By Arginase-1 (ARG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[259]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[388]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[389]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[338]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[390]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[391]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[392]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[393]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[351]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[352]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[394]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[46]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[395]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[396]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[397]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[398]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[400]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[401]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[401]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[401]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[29]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[402]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[45]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[403]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[404]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[405]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[46]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[304]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[406]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[407]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[408]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[409]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[410]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[411]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[412]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[143]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[413]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[63]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[414]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[348]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[358]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[415]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[416]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[417]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[418]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[419]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[420]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[421]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[422]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[423]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[424]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zonisamide	DM0DTF7	Alcohol dependence	6C40.2	Approved	[425]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[426]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[427]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[428]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[429]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[430]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[431]
Methamphetamine	DMPM4SK	Anxiety		Approved	[432]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[433]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[435]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[436]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[437]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[438]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[439]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[440]

Drug(s) Affected By Muscarinic acetylcholine receptor M2 (CHRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylscopolamine	DM5VWOB	Peptic ulcer	DA61	Approved	[441]
Gallamine Triethiodide	DMPO0MS	Stabilize muscle contraction	FB3Z	Approved	[441]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[442]
Omadacycline	DMR2J95	Acute bacterial skin infection	1C41	Approved	[443]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[444]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[445]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[446]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[447]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[448]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[449]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[450]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[451]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[452]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[453]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[454]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[452]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[455]
Selenium	DM25CGV	N. A.	N. A.	Approved	[324]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[456]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[457]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[458]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[459]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[460]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[461]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[462]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[463]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[43]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[464]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[35]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[465]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[466]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[467]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[468]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[469]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[470]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[471]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[471]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[472]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[306]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[473]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[474]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[475]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[476]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[475]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[477]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[478]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[479]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[479]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[479]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[480]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[481]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[416]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[482]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[483]
Selenium	DM25CGV	N. A.	N. A.	Approved	[484]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[485]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[486]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[487]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[488]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[489]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[490]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[160]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[491]

Drug(s) Affected By Breakpoint cluster region protein (BCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[492]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[493]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[494]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[495]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[496]
Bortezomib	DMNO38U	Leukemia		Approved	[497]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[498]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[499]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[500]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[501]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[502]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[503]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[504]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[506]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[507]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[508]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[509]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[510]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[511]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[511]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Neural cell adhesion molecule 1 (NCAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[512]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[513]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[514]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[293]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[515]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[516]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[46]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[517]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[518]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[519]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[520]
Haloperidol	DM96SE0	Delirium		Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[521]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[522]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[523]
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[524]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[525]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[526]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[220]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[527]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[503]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[528]

Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[531]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[532]
Haloperidol	DM96SE0	Delirium		Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[512]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[533]

Drug(s) Affected By Histidine decarboxylase (HDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[534]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[535]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[536]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[536]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[537]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[211]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[537]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[538]

Drug(s) Affected By Myeloid cell surface antigen CD33 (CD33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[539]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[246]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]
Tesmilifene	DMPB36I	Breast cancer	2C60-2C65	Discontinued in Phase 2	[540]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[541]

Drug(s) Affected By Integrin alpha-X (ITGAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[542]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[543]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[544]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[532]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[545]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[546]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[547]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[224]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[224]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[548]

Drug(s) Affected By Aromatic-L-amino-acid decarboxylase (DDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[549]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[537]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[429]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[216]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[550]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[44]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[551]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[552]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[553]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[554]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[555]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[556]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[557]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[558]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[559]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[152]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[560]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[561]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[246]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[562]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[563]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[349]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[391]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[564]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[565]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[566]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[567]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[568]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[569]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[570]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[571]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[572]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[573]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[572]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[574]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[575]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[576]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[520]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[577]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[578]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[579]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[580]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[89]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[558]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[578]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[581]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[582]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[583]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[585]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[586]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[491]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[362]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[319]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[587]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[588]
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[331]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[589]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[590]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[591]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[592]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[593]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[594]
Fructose	DM43AN2	Vomiting	MD90	Approved	[595]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[590]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[181]

Drug(s) Affected By Protein S100-P (S100P)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[596]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[185]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[597]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[259]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[598]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[306]

Drug(s) Affected By Paired box protein Pax-6 (PAX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[599]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[211]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[599]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[600]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[599]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[599]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[601]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[599]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[602]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[158]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[603]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[604]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[605]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[157]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[160]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[161]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[357]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[606]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[358]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[607]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[535]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[608]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[609]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[610]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[334]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[611]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[612]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[613]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[614]
Fructose	DM43AN2	Vomiting	MD90	Approved	[615]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[616]

Drug(s) Affected By Nitric oxide synthase 1 (NOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[590]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[617]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[618]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[147]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[254]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[619]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[620]
Bortezomib	DMNO38U	Leukemia		Approved	[621]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[622]

Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[623]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[624]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[624]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[625]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[619]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[626]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[627]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[628]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[272]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[629]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[459]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[630]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[631]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[632]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[633]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[634]

Drug(s) Affected By Interleukin-13 (IL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[635]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[636]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[637]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[638]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[356]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[639]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[640]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[638]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[356]

Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[641]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[206]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[642]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[643]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[206]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[206]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[214]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[644]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[645]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[646]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[647]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[648]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[649]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[90]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[650]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[651]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[652]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[653]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[654]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[655]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[594]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[656]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[657]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[658]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[256]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[500]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[659]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[587]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[660]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[661]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[276]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[179]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[414]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[348]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[662]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[663]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[664]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[414]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[414]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[665]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[473]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[666]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[667]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[349]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[668]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[669]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[668]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[329]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[668]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[208]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[670]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[671]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[672]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[375]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[673]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[674]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[675]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[676]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[677]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[678]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[679]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[504]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[680]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[681]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[192]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[682]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[683]
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[684]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[685]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[679]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[686]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[687]

Drug(s) Affected By Forkhead box protein G1 (FOXG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[688]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[689]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[690]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[211]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[691]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[312]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[211]

Drug(s) Affected By Reactive oxygen species modulator 1 (ROMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[561]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[692]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[693]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[694]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[695]

Drug(s) Affected By Hepcidin (HAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[415]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[696]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[697]
Papaverine	DMCA9QP	Brain ischaemia	8B1Z	Approved	[697]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[698]

Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[312]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[699]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[700]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[701]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[702]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[561]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[703]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[704]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[215]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[705]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[706]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[706]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[707]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[708]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[373]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[709]

Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[710]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[669]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[504]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[711]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[712]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[561]

Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[499]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[619]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[713]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[269]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[714]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[715]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[183]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[253]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[716]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[717]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[718]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]

Drug(s) Affected By Glutamate decarboxylase 2 (GAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[537]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[234]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[537]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[537]
Chlorphrifos oxon	DMGBT68	Discovery agent	N.A.	Investigative	[537]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[537]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[719]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[486]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[678]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[490]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[590]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[111]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[587]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[272]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[720]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[276]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[272]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[721]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[609]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[722]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[511]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[723]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[511]

Drug(s) Affected By Serum paraoxonase/arylesterase 2 (PON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[724]
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[725]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[726]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[78]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[700]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[727]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[298]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[511]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[511]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[728]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[135]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[729]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[730]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[731]

Drug(s) Affected By Interleukin-17A (IL17A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[352]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[569]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[732]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[733]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[734]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[735]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[736]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[737]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[738]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[739]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[740]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[741]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[520]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[742]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[532]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[743]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[744]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[745]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[746]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[746]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[747]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[748]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[749]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[593]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[205]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[750]

Drug(s) Affected By Hydrocephalus-inducing protein homolog (HYDIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[495]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]

Drug(s) Affected By Neutral cholesterol ester hydrolase 1 (NCEH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[561]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[533]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[751]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]

Drug(s) Affected By Mitofusin-1 (MFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[582]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[429]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[752]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[753]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[282]
Bortezomib	DMNO38U	Leukemia		Approved	[497]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[754]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[755]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[756]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[757]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[758]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[759]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[760]
Mestranol	DMG3F94	Contraception	QA21	Approved	[761]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[762]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[763]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[678]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[764]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[765]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[766]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[767]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[680]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[299]

Drug(s) Affected By CAP-Gly domain-containing linker protein 3 (CLIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[335]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[624]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[768]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[246]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[224]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[429]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[769]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[624]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[770]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[771]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[772]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[773]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[774]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[520]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[775]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[721]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[609]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[520]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[776]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[777]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[778]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[779]

Drug(s) Affected By Glutamate decarboxylase 1 (GAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[780]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[537]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[781]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[717]

Drug(s) Affected By PSME3-interacting protein (PSME3IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[782]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[783]

Drug(s) Affected By Solute carrier family 40 member 1 (SLC40A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[784]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[785]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[786]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[787]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[215]

Drug(s) Affected By Chorion-specific transcription factor GCMa (GCM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[473]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[788]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[789]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[769]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[312]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[790]
T0070907	DMTKSVO	Discovery agent	N.A.	Investigative	[788]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[116]
Fructose	DM43AN2	Vomiting	MD90	Approved	[791]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[792]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[771]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[793]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[794]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[794]

Drug(s) Affected By Annexin A10 (ANXA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[795]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[796]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[312]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[797]

Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[608]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[609]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[561]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[798]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[619]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[799]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[799]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[800]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[46]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[801]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[802]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[803]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[804]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[784]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[805]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (PPP2R3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[541]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 4 (GPAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[769]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[312]

Drug(s) Affected By DDB1- and CUL4-associated factor 12 (DCAF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[769]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[806]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[806]

Drug(s) Affected By Protein phosphatase PTC7 homolog (PPTC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[795]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[807]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[808]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[809]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[810]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[811]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[812]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[813]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[814]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[211]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[815]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[650]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[809]

Drug(s) Affected By Apolipoprotein E (APOE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[816]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[817]
Selenium	DM25CGV	N. A.	N. A.	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[504]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[560]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[818]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[819]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[30]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[43]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[29]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[820]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[30]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[821]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[43]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[30]

Drug(s) Affected By Phospholipid-transporting ATPase ID (ATP8B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[561]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[822]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[823]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[690]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[822]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]

Drug(s) Affected By Androgen-induced gene 1 protein (AIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[246]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[224]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[824]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 8 (CHD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[253]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[825]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[806]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[826]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[806]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[203]
Chlorphrifos oxon	DMGBT68	Discovery agent	N.A.	Investigative	[827]

Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[471]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[37]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[828]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[829]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[830]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[831]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[832]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[833]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]

Drug(s) Affected By Bcl-2-interacting killer (BIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[834]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[835]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[781]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[608]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[561]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[836]

Drug(s) Affected By Formin-binding protein 4 (FNBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[806]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[533]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[246]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]

Drug(s) Affected By Linker for activation of T-cells family member 2 (LAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[785]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[246]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[239]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[837]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[796]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[838]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 BM3 (cypBM3) Main DME	DEMQRS9	M9TKI6_BACME	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)	OTINY3MW	AL8A1_HUMAN	Gene/Protein Processing	[3]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[4]
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[5]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Gene/Protein Processing	[6]
Androgen-induced gene 1 protein (AIG1)	OTJB2UTH	AIG1_HUMAN	Drug Response	[7]
Annexin A10 (ANXA10)	OTA8LWSL	ANX10_HUMAN	Gene/Protein Processing	[8]
Annexin A5 (ANXA5)	OTZS877V	ANXA5_HUMAN	Protein Interaction/Cellular Processes	[9]
Apolipoprotein E (APOE)	OTFOWL2H	APOE_HUMAN	Drug Response	[10]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[11]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[12]

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