Details of Disease

General Information of Disease (ID: DISLSNBJ)

Disease Name Knee osteoarthritis
Disease Class FA01: Knee osteoarthritis
Definition
Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
Disease Hierarchy
DIS05URM: Osteoarthritis
DISLSNBJ: Knee osteoarthritis
ICD Code
ICD-11
ICD-11: FA01
ICD-10
ICD-10: M15-M19, M47
ICD-9
ICD-9: 715
Expand ICD-9
715
Disease Identifiers
MONDO ID
MONDO_0005416
MESH ID
D020370
UMLS CUI
C0409959
OMIM ID
612401
MedGen ID
98371
HPO ID
HP:0005086
SNOMED CT ID
239873007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Diclofenac DMPIHLS Approved Small molecular drug [1]
Lumiracoxib DM1S4AG Approved Small molecular drug [2]
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This Disease is Treated as An Indication in 13 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
AXS-02 DMNJ6R1 Phase 3 NA [3]
CNTX-4975 DMB4JPG Phase 3 NA [4]
HP-5000 DMEHESA Phase 3 NA [5]
TLC599 DMGZXIQ Phase 3 NA [6]
Tonogenchoncel-L DM5SO15 Phase 3 Cell therapy [7]
JointStem DMW3YKM Phase 2/3 Cell therapy [8]
DHACM DMP32N8 Phase 2 Cell therapy [9]
LNA043 DMDHVK8 Phase 2 NA [10]
SI-613 DMRKC3V Phase 2 NA [11]
UBX0101 DM9YQVJ Phase 2 NA [12]
XT-150 DMCYM9Q Phase 2 Gene therapy [13]
3VM1001 DMRSXGD Phase 1/2 NA [14]
Zofin DMN9W53 Phase 1/2 NA [15]
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⏷ Show the Full List of 13 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 50 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
GRK5 TTTCXO0 Limited Altered Expression [16]
IL1A TTPM6HI moderate Biomarker [17]
MMP13 TTHY57M moderate Genetic Variation [18]
TGFA TTTLQFR moderate Genetic Variation [19]
WWP2 TT6TU05 moderate Genetic Variation [20]
ACLY TT0Z6Y2 Strong Biomarker [21]
ACR TTAHE2N Strong Biomarker [22]
ADIPOQ TTXKA7D Strong Genetic Variation [23]
BAX TTQ57WJ Strong Therapeutic [24]
BDKRB2 TTGY8IW Strong Altered Expression [25]
CD36 TTPJMCU Strong Biomarker [26]
CFP TTLA0VS Strong Biomarker [27]
DDR2 TTU98HG Strong Altered Expression [28]
DKK1 TTE3RAC Strong Biomarker [29]
DOT1L TTSZ8T1 Strong Genetic Variation [30]
FGF18 TT6ICRA Strong Genetic Variation [19]
FTO TTFW3BT Strong Genetic Variation [19]
GLA TTIS03D Strong Biomarker [31]
GREM1 TTOUZN5 Strong Biomarker [29]
HDAC7 TTMUEK1 Strong Altered Expression [32]
IL17F TT2B6PS Strong Genetic Variation [33]
IL4 TTLGTKB Strong Biomarker [34]
MMP1 TTMX39J Strong Genetic Variation [35]
MMP3 TTUZ2L5 Strong Biomarker [36]
PCSK6 TT75LN9 Strong Genetic Variation [37]
PDE3B TTN34SQ Strong Biomarker [38]
PDZK1 TTDTBLM Strong Genetic Variation [39]
PEPD TTLZXI0 Strong Altered Expression [40]
PLIN1 TTIV27N Strong Biomarker [41]
PRG4 TTSKF4V Strong Biomarker [42]
PTGES TTYLQ8V Strong Altered Expression [43]
RHOB TT6LPFO Strong Biomarker [44]
SIK1 TT1H6LC Strong Biomarker [45]
SLC14A1 TTWVJU1 Strong Biomarker [46]
SLC6A5 TTI0138 Strong Altered Expression [47]
SMAD3 TTHQZV7 Strong Genetic Variation [48]
SOST TTYRO4F Strong Altered Expression [49]
TNFRSF11B TT2CJ75 Strong Genetic Variation [50]
TNFRSF17 TTZ3P4W Strong Genetic Variation [51]
USP8 TT1J07C Strong Genetic Variation [19]
ADAMTS4 TTYG6BU Definitive Genetic Variation [52]
ADAMTS5 TTXSU2Y Definitive Genetic Variation [52]
ADCYAP1 TTW4LYC Definitive Biomarker [53]
BPI TTXCSDR Definitive Genetic Variation [54]
CCL11 TTCF05Y Definitive Altered Expression [55]
CCL20 TT2XAZY Definitive Biomarker [56]
FABP4 TTHWMFZ Definitive Altered Expression [57]
IL1R1 TTWOTEA Definitive Genetic Variation [58]
LBP TTVQJLY Definitive Genetic Variation [59]
NLRP1 TTQX29T Definitive Biomarker [60]
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⏷ Show the Full List of 50 DTT(s)
This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCB6 DTF9Y2V Strong Biomarker [61]
SLC26A2 DTFSLX5 Strong Genetic Variation [62]
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This Disease Is Related to 3 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
GMDS DE8K7F3 moderate Biomarker [63]
ACP5 DESITDW Strong Biomarker [64]
ALDH1A2 DEKN1H4 Strong Genetic Variation [65]
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This Disease Is Related to 77 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ANKRD6 OTM86B04 Limited Genetic Variation [66]
ASPN OTYJM80N Limited Biomarker [67]
BTNL2 OTTTEMZA Limited Genetic Variation [68]
CHADL OT4TQF2I Limited Genetic Variation [20]
COMP OTS2FPMI Limited Biomarker [69]
MAGI1 OTMV4ASV Limited Genetic Variation [66]
RETN OTW5Z1NH Limited Genetic Variation [70]
THBS4 OTA1T9KK Limited Altered Expression [71]
ADAM12 OTZKOTDB moderate Genetic Variation [72]
ENHO OT91QASK moderate Biomarker [73]
SULF1 OTJCNCO0 moderate Biomarker [74]
ADAMTS3 OT2U6VF5 Strong Biomarker [75]
ADAMTS9 OTV3Q0DS Strong Genetic Variation [76]
AGAP1 OTVX8835 Strong Genetic Variation [77]
AKNA OTQ6E2C8 Strong Genetic Variation [78]
AP3B1 OTYTIH5Q Strong Genetic Variation [19]
BAG6 OT4Z0S2U Strong Genetic Variation [79]
BCL9 OTRBIPR4 Strong Biomarker [80]
BGLAP OTK1YLWQ Strong Biomarker [81]
BTNL8 OTRQT8CK Strong Genetic Variation [77]
BUD31 OTN3HZYF Strong Genetic Variation [82]
C4BPA OTHNH6Y8 Strong Biomarker [61]
CARD14 OTADQHOV Strong Biomarker [61]
CCDC33 OTOIFZ4R Strong Genetic Variation [19]
CDAN1 OTCVZRG6 Strong Altered Expression [83]
CIRBP OTXWTPBL Strong Biomarker [84]
CLEC11A OT9KBH7C Strong Genetic Variation [85]
COL11A1 OTB0DRMS Strong Genetic Variation [19]
CORO7 OTG7MEAJ Strong Genetic Variation [86]
CRADD OT02TZ4S Strong Genetic Variation [19]
CTRL OTB6NA5O Strong Biomarker [87]
DYNC1I1 OTFX1KCG Strong Genetic Variation [19]
EEF1A1 OT00THXS Strong Biomarker [88]
EIF3K OTGTKVGO Strong Biomarker [89]
ERG OTOTX9VU Strong Genetic Variation [19]
FOXK1 OTLZGS7J Strong Altered Expression [90]
GDF6 OTERXWJU Strong Biomarker [91]
GLIS3 OTBC960E Strong Genetic Variation [19]
GLT8D1 OTG14TPO Strong Genetic Variation [19]
GNL3 OTILGYO4 Strong Biomarker [92]
GSDMD OTH39BKI Strong Biomarker [93]
GTF3A OTVROUVQ Strong Altered Expression [57]
HLA-DPB1 OTW8JHU2 Strong Genetic Variation [19]
IL34 OTZ15VVK Strong Altered Expression [94]
ITIH1 OTSXJGQF Strong Genetic Variation [19]
KALRN OT8WRCBH Strong Genetic Variation [95]
KDM5D OTEKG0KD Strong Biomarker [96]
KIAA1217 OTRMK3PU Strong Genetic Variation [77]
LTBP1 OTR7Q75L Strong Genetic Variation [19]
MAP2K6 OTK13JKC Strong Genetic Variation [77]
MZB1 OT071TET Strong Biomarker [53]
NFAT5 OTKIE59S Strong Genetic Variation [19]
NME8 OT4RULP5 Strong Genetic Variation [44]
NT5DC2 OTPDRGGN Strong Genetic Variation [77]
PAPSS2 OTDLEXPN Strong Genetic Variation [62]
PCDHGA12 OT3JJI7L Strong Biomarker [97]
PENK OT8P3HMP Strong Therapeutic [98]
PI3 OT47MTC3 Strong Biomarker [99]
PRDX2 OTLWCY9T Strong Biomarker [61]
PTPN5 OT2H1KDK Strong Biomarker [100]
R3HDM2 OTMJ3S6J Strong Genetic Variation [39]
SAMSN1 OT7N88T1 Strong Biomarker [101]
SBNO1 OTNX3RL0 Strong Genetic Variation [19]
SDC4 OTKUVUGZ Strong Biomarker [102]
SLBP OTVYYQRT Strong Genetic Variation [19]
SMG6 OTRCEJQL Strong Genetic Variation [19]
SPCS1 OTUHQ4UC Strong Genetic Variation [92]
SUPT3H OT7B6FRO Strong Genetic Variation [19]
TCP1 OT1MGUX9 Strong Genetic Variation [103]
TENT5A OTSYF511 Strong Biomarker [79]
TGFBR3 OTQOOUC4 Strong Genetic Variation [77]
THRSP OTKYE01L Strong Biomarker [104]
TNFAIP6 OT1SLUZH Strong Altered Expression [38]
ADAMTS14 OTFJ1PDB Definitive Genetic Variation [105]
LCTL OTN36T21 Definitive Genetic Variation [106]
MGP OTZWU3FU Definitive Genetic Variation [107]
PITX1 OTA0UN4C Definitive Genetic Variation [108]
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⏷ Show the Full List of 77 DOT(s)

References

1 Diclofenac FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2897).
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 ClinicalTrials.gov (NCT03660943) A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain. U.S. National Institutes of Health.
5 ClinicalTrials.gov (NCT04683627) A 12-Week, Randomized, Double-blind, Placebo-controlled, Parallel-group Phase 3 Study to Evaluate the Efficacy and Safety of HP-5000 Topical System (Patch) in Subjects With Osteoarthritis Pain of the Knee. U.S.National Institutes of Health.
6 ClinicalTrials.gov (NCT04123561) A Phase 3, Randomized, Double-blind, Placebo- and Active-controlled Study to Evaluate the Efficacy and Safety of TLC599 in Patients With Osteoarthritis of the Knee. U.S.National Institutes of Health.
7 ClinicalTrials.gov (NCT03383471) The Efficacy and Safety of Invossa K Injection in Patients Diagnosed With Knee Osteoarthritis. U.S. National Institutes of Health.
8 ClinicalTrials.gov (NCT04368806) A 48-Weeks, Phase 2b/3a, Double-Blind, Randomized, Placebo Controlled, Multi-center, Superiority Study to Evaluate the Efficacy and Safety of JointStem, Autologous Adipose Tissue Derived Mesenchymal Stem Cells in Patients Diagnosed as Knee Osteoarthritis. U.S.National Institutes of Health.
9 ClinicalTrials.gov (NCT03485157) A Phase 2B, Prospective, Double-blinded, Randomized Controlled Trial of the Micronized Dehydrated Human Amnion Chorion Membrane Injection as Compared to Saline Placebo Injection in the Treatment of Osteoarthritis of the Knee. U.S.National Institutes of Health.
10 ClinicalTrials.gov (NCT04864392) A 5-year, Randomized, Double-blind, Placebo-controlled, Multi-center Study Assessing the Efficacy, Safety, and Tolerability of Intra-articular Regimens of LNA043 Versus Placebo in Patients With Symptomatic Knee Osteoarthritis. U.S.National Institutes of Health.
11 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036809)
12 ClinicalTrials.gov (NCT04129944) A Study to Assess the Safety and Efficacy of a Single Dose of UBX0101 in Patients With Osteoarthritis of the Knee. U.S. National Institutes of Health.
13 ClinicalTrials.gov (NCT04124042) A Double-Blind, Placebo-Controlled Assessment of the Tolerability and Efficacy of XT-150 for the Treatment of Moderate to Severe Pain Due to Osteoarthritis of the Knee. U.S.National Institutes of Health.
14 ClinicalTrials.gov (NCT03142178) 3VM for Treatment of Chronic Osteoarthritis Knee Pain. U.S. National Institutes of Health.
15 Clinical pipeline report, company report or official report of Organicell
16 GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-B Signaling.Arthritis Rheumatol. 2020 Apr;72(4):620-631. doi: 10.1002/art.41152. Epub 2020 Mar 5.
17 A Phase II Trial of Lutikizumab, an Anti-Interleukin-1/ Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis.Arthritis Rheumatol. 2019 Jul;71(7):1056-1069. doi: 10.1002/art.40840. Epub 2019 Jun 7.
18 Association of IL-6, IL-8, MMP-13 gene polymorphisms with knee osteoarthritis susceptibility in the Chinese Han population.Biosci Rep. 2019 Feb 1;39(2):BSR20181346. doi: 10.1042/BSR20181346. Print 2019 Feb 28.
19 Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. Nat Genet. 2019 Feb;51(2):230-236.
20 Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.Nat Genet. 2018 Dec;50(12):1681-1687. doi: 10.1038/s41588-018-0247-0. Epub 2018 Oct 29.
21 Radiographic Osteoarthritis Prevalence Over Ten Years After Anterior Cruciate Ligament Reconstruction.Int J Sports Med. 2019 Oct;40(11):683-695. doi: 10.1055/a-0902-8539. Epub 2019 Aug 12.
22 The association of plasma fatty acids with hand and knee osteoarthritis: the NEO study.Osteoarthritis Cartilage. 2020 Feb;28(2):223-230. doi: 10.1016/j.joca.2019.10.002. Epub 2019 Oct 16.
23 Association between ADIPOQ gene variants and knee osteoarthritis in a Chinese population.Biosci Rep. 2019 Mar 1;39(3):BSR20182104. doi: 10.1042/BSR20182104. Print 2019 Mar 29.
24 Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees.Arthritis Rheum. 2010 May;62(5):1393-402. doi: 10.1002/art.27357.
25 BDKRB2 +9/-9bp polymorphisms influence BDKRB2 expression levels and NO production in knee osteoarthritis.Exp Biol Med (Maywood). 2017 Feb;242(4):422-428. doi: 10.1177/1535370215625471. Epub 2016 Jul 24.
26 The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli.J Immunol. 2009 Apr 15;182(8):5024-31. doi: 10.4049/jimmunol.0803603.
27 A comparison of clinical- and patient-reported outcomes of the cemented ATTUNE and PFC sigma fixed bearing cruciate sacrificing knee systems in patients who underwent total knee replacement with both prostheses in opposite knees.J Orthop Surg Res. 2018 Mar 15;13(1):54. doi: 10.1186/s13018-018-0757-6.
28 Allogeneic adipose-derived stem cell transplantation on knee osteoarthritis rats and its effect on MMP-13 and DDR2.Exp Ther Med. 2019 Jul;18(1):99-104. doi: 10.3892/etm.2019.7554. Epub 2019 May 8.
29 The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity.Cartilage. 2021 Oct;12(4):496-504. doi: 10.1177/1947603519841676. Epub 2019 Apr 4.
30 Association between single nucleotide polymorphisms of DOT1L gene and risk of knee osteoarthritis in a Chinese Han population.Cell Biochem Biophys. 2014 Dec;70(3):1677-82. doi: 10.1007/s12013-014-0112-4.
31 Cross-cultural adaptation and implementation of Good Life with osteoarthritis in Denmark (GLA:D?: group education and exercise for hip and knee osteoarthritis is feasible in Canada.Osteoarthritis Cartilage. 2018 Feb;26(2):211-219. doi: 10.1016/j.joca.2017.11.005. Epub 2017 Nov 13.
32 Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis.Mod Rheumatol. 2010 Feb;20(1):11-7. doi: 10.1007/s10165-009-0224-7. Epub 2009 Sep 26.
33 Correlation between Interleukin-17 gene polymorphism and osteoarthritis susceptibility in Han Chinese population.BMC Med Genet. 2019 Jan 18;20(1):20. doi: 10.1186/s12881-018-0736-0.
34 Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis.J Clin Med. 2019 Oct 5;8(10):1631. doi: 10.3390/jcm8101631.
35 The association between MMP-1 gene rs1799750 polymorphism and knee osteoarthritis risk.Biosci Rep. 2018 Sep 19;38(5):BSR20181257. doi: 10.1042/BSR20181257. Print 2018 Oct 31.
36 Cartilage oligomeric protein, matrix metalloproteinase-3, and Coll2-1 as serum biomarkers in knee osteoarthritis: a cross-sectional study.Rheumatol Int. 2018 May;38(5):821-830. doi: 10.1007/s00296-017-3887-y. Epub 2017 Nov 21.
37 A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.Ann Rheum Dis. 2012 Jun;71(6):1042-8. doi: 10.1136/annrheumdis-2011-200300. Epub 2012 Mar 22.
38 Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments.Osteoarthritis Cartilage. 2015 Apr;23(4):571-80. doi: 10.1016/j.joca.2014.12.020. Epub 2015 Jan 7.
39 Common gene variants interactions related to uric acid transport are associated with knee osteoarthritis susceptibility.Connect Tissue Res. 2019 May;60(3):219-229. doi: 10.1080/03008207.2018.1483359. Epub 2018 Jul 11.
40 Increased oxidative stress and its relation with collagen metabolism in knee osteoarthritis.Rheumatol Int. 2007 Feb;27(4):339-44. doi: 10.1007/s00296-006-0247-8. Epub 2006 Nov 10.
41 Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis.Arthritis Res Ther. 2017 Dec 1;19(1):264. doi: 10.1186/s13075-017-1473-z.
42 Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilage.J Orthop Res. 2007 Jul;25(7):873-83. doi: 10.1002/jor.20344.
43 Regulation of calcitonin gene-related peptide expression through the COX-2/mPGES-1/PGE2 pathway in the infrapatellar fat pad in knee osteoarthritis.Lipids Health Dis. 2018 Sep 11;17(1):215. doi: 10.1186/s12944-018-0864-8.
44 Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis.Arthritis Res Ther. 2008;10(3):R54. doi: 10.1186/ar2423. Epub 2008 May 10.
45 Performance of distinct knee osteoarthritis classification criteria in the ELSA-Brasil musculoskeletal study.Clin Rheumatol. 2019 Mar;38(3):793-802. doi: 10.1007/s10067-018-4347-0. Epub 2018 Oct 31.
46 Cartilage Subsurface Changes to Magnetic Resonance Imaging UTE-T2* 2 Years After Anterior Cruciate Ligament Reconstruction Correlate With Walking Mechanics Associated With Knee Osteoarthritis.Am J Sports Med. 2018 Mar;46(3):565-572. doi: 10.1177/0363546517743969. Epub 2018 Jan 2.
47 Spinal Cord Glycine Transporter 2 Mediates Bilateral ST35 Acupoints Sensitization in Rats with Knee Osteoarthritis.Evid Based Complement Alternat Med. 2019 Feb 7;2019:7493286. doi: 10.1155/2019/7493286. eCollection 2019.
48 The polymorphism of SMAD3 rs1065080 is associated with increased risk for knee osteoarthritis.Mol Biol Rep. 2019 Aug;46(4):4501-4505. doi: 10.1007/s11033-019-04905-5. Epub 2019 Jun 10.
49 Association between serum and synovial fluid Dickkopf-1 levels with radiographic severity in primary knee osteoarthritis patients.Clin Rheumatol. 2017 Aug;36(8):1865-1872. doi: 10.1007/s10067-017-3640-7. Epub 2017 Apr 27.
50 Association of OPG gene polymorphisms with the risk of knee osteoarthritis among Chinese people.Mol Genet Genomic Med. 2019 Jun;7(6):e662. doi: 10.1002/mgg3.662. Epub 2019 Apr 11.
51 Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study.Trials. 2019 Apr 11;20(1):214. doi: 10.1186/s13063-019-3327-2.
52 Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population.Genet Mol Res. 2016 Aug 19;15(3). doi: 10.4238/gmr.15038264.
53 The synovial fluid neuropeptide PACAP may act as a protective factor during disease progression of primary knee osteoarthritis and is increased following hyaluronic acid injection.Innate Immun. 2019 May;25(4):255-264. doi: 10.1177/1753425919839125. Epub 2019 Apr 1.
54 Safety and efficacy of duloxetine in Japanese patients with chronic knee pain due to osteoarthritis: an open-label, long-term, Phase III extension study.J Pain Res. 2018 Jul 31;11:1391-1403. doi: 10.2147/JPR.S171395. eCollection 2018.
55 Synovial Fluid Eotaxin-1 Levels May Reflect Disease Progression in Primary Knee Osteoarthritis Among Elderly Han Chinese: A Cross-Sectional Study.Cartilage. 2019 Oct;10(4):408-416. doi: 10.1177/1947603518764280. Epub 2018 Mar 22.
56 Relationship between serum and synovial fluid CCL20 concentrations with disease severity in primary knee osteoarthritis.J Musculoskelet Neuronal Interact. 2019 Sep 1;19(3):326-332.
57 Effects of ultrasound therapy on the synovial fluid proteome in a rabbit surgery-induced model of knee osteoarthritis.Biomed Eng Online. 2019 Feb 22;18(1):18. doi: 10.1186/s12938-019-0637-2.
58 IL1R1 gene polymorphisms are associated with knee osteoarthritis risk in the Chinese Han population.Oncotarget. 2017 Jan 17;8(3):4228-4233. doi: 10.18632/oncotarget.13935.
59 Physical Therapists' Ability to Distinguish Between Inflammatory and Noninflammatory Arthritis and to Appropriately Refer Patients to a Rheumatologist.Arthritis Care Res (Hoboken). 2020 Dec;72(12):1747-1754. doi: 10.1002/acr.24081. Epub 2020 Nov 6.
60 Increased HIF-1 in Knee Osteoarthritis Aggravate Synovial Fibrosis via Fibroblast-Like Synoviocyte Pyroptosis.Oxid Med Cell Longev. 2019 Jan 10;2019:6326517. doi: 10.1155/2019/6326517. eCollection 2019.
61 The use of cellular matrix in symptomatic knee osteoarthritis.Bosn J Basic Med Sci. 2020 May 1;20(2):271-274. doi: 10.17305/bjbms.2019.4205.
62 Identification of sequence polymorphisms in two sulfation-related genes, PAPSS2 and SLC26A2, and an association analysis with knee osteoarthritis.J Hum Genet. 2001;46(9):538-43. doi: 10.1007/s100380170036.
63 Inferring distinct mechanisms in the absence of subjective differences: Placebo and centrally acting analgesic underlie unique brain adaptations.Hum Brain Mapp. 2018 May;39(5):2210-2223. doi: 10.1002/hbm.23999. Epub 2018 Feb 7.
64 Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA.Osteoarthritis Cartilage. 2017 Jun;25(6):858-865. doi: 10.1016/j.joca.2017.01.002. Epub 2017 Jan 10.
65 The rs4238326 polymorphism in ALDH1A2 gene potentially associated with non-post traumatic knee osteoarthritis susceptibility: a two-stage population-based study.Osteoarthritis Cartilage. 2017 Jul;25(7):1062-1067. doi: 10.1016/j.joca.2017.01.003. Epub 2017 Jan 12.
66 Genetic Determinants of Radiographic Knee Osteoarthritis in African Americans.J Rheumatol. 2017 Nov;44(11):1652-1658. doi: 10.3899/jrheum.161488. Epub 2017 Sep 15.
67 Identifying the role of ASPN and COMP genes in knee osteoarthritis development.J Orthop Surg Res. 2019 Oct 29;14(1):337. doi: 10.1186/s13018-019-1391-7.
68 New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.PLoS One. 2010 Mar 18;5(3):e9723. doi: 10.1371/journal.pone.0009723.
69 COMP in the Infrapatellar Fat Pad-Results of a Prospective Histological, Immunohistological, and Biochemical Case-Control Study.J Orthop Res. 2020 Apr;38(4):747-758. doi: 10.1002/jor.24514. Epub 2019 Nov 17.
70 Role of resistin genetic variations in knee osteoarthritis pathogenesis, a cross sectional study.Mol Biol Rep. 2019 Jun;46(3):2657-2663. doi: 10.1007/s11033-019-04673-2. Epub 2019 Mar 22.
71 The Expression of Thrombospondin-4 Correlates with Disease Severity in Osteoarthritic Knee Cartilage.Int J Mol Sci. 2019 Jan 21;20(2):447. doi: 10.3390/ijms20020447.
72 Association between ADAM12 Single-Nucleotide Polymorphisms and Knee Osteoarthritis: A Meta-Analysis.Biomed Res Int. 2017;2017:5398181. doi: 10.1155/2017/5398181. Epub 2017 Aug 8.
73 A novel biomarker in patients with knee osteoarthritis: adropin.Clin Rheumatol. 2018 Aug;37(8):2179-2186. doi: 10.1007/s10067-018-4052-z. Epub 2018 Mar 16.
74 Suppression of cartilage degeneration by intra-articular injection of heparan sulfate 6-O endosulfatase in a mouse osteoarthritis model.Histol Histopathol. 2017 Jul;32(7):725-733. doi: 10.14670/HH-11-838. Epub 2016 Nov 3.
75 Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages.Genet Mol Res. 2014 Nov 14;13(4):9642-9. doi: 10.4238/2014.November.14.9.
76 Relationship between cytosine-adenine repeat polymorphism of ADAMTS9 gene and clinical and radiologic severity of knee osteoarthritis.Int J Rheum Dis. 2018 Apr;21(4):821-827. doi: 10.1111/1756-185X.12849. Epub 2016 May 27.
77 Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.Nat Genet. 2018 Apr;50(4):549-558. doi: 10.1038/s41588-018-0079-y. Epub 2018 Mar 20.
78 The association of AKNA gene polymorphisms with knee osteoarthritis suggests the relevance of this immune response regulator in the disease genetic susceptibility.Mol Biol Rep. 2018 Apr;45(2):151-161. doi: 10.1007/s11033-018-4148-1. Epub 2018 Jan 24.
79 Susceptibility to large-joint osteoarthritis (hip and knee) is associated with BAG6 rs3117582 SNP and the VNTR polymorphism in the second exon of the FAM46A gene on chromosome 6.J Orthop Res. 2015 Jan;33(1):56-62. doi: 10.1002/jor.22738. Epub 2014 Sep 18.
80 Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study.Osteoporos Int. 2010 Jan;21(1):109-18. doi: 10.1007/s00198-009-0931-0. Epub 2009 Apr 17.
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