General Information of Disease (ID: DISF2JE0)

Disease Name Osteoporosis
Synonyms
osteoporosis, involutional; fracture, hip, susceptibility to; osteoporosis, susceptibility to; bone mineral density variation QTL, osteoporosis; osteoporosis, postmenopausal, susceptibility; osteoporosis, postmenopausal
Disease Class FB83: Low bone mass disorder
Definition
A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).
Disease Hierarchy
DISGSZ65: Bone resorption
DISEOED3: Osteogenesis imperfecta and a reduction of bone mineral density.
DISO7RI8: Metabolic bone disease
DISF2JE0: Osteoporosis
ICD Code
ICD-11
ICD-11: FB83.0
ICD-10
ICD-10: M85.8
ICD-9
ICD-9: 733.9
Expand ICD-11
'FB83.0
Expand ICD-10
'M85.8
Expand ICD-9
733.9
Disease Identifiers
MONDO ID
MONDO_0005298
MESH ID
D010024
UMLS CUI
C0029456
OMIM ID
166710
MedGen ID
14535
HPO ID
HP:0000939
SNOMED CT ID
64859006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 23 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Alendronate DMY2KX9 Approved Small molecular drug [1]
Calcium DM250F6 Approved Small molecular drug [2]
Cenestin DMXQS7K Approved Small molecular drug [2]
Cholecalciferol DMGU74E Approved Small molecular drug [3]
Denosumab DMNI0KO Approved Antibody [4]
Ergocalciferol DMHO0AR Approved Small molecular drug [5]
Etidronate Disodium DMAWJIN Approved Small molecular drug [2]
Ibandronate DM0QZBN Approved Small molecular drug [6]
Ipriflavone DM0IO13 Approved Small molecular drug [2]
Lasofoxifene DMHA18P Approved Small molecular drug [7]
Minodronate DM50PMY Approved Small molecular drug [2]
Nandrolone DMFWKG1 Approved Small molecular drug [8]
Phytonadione DM8HDOL Approved Small molecular drug [9]
Raloxifene DMDKF3M Approved Small molecular drug [2]
Rhpth DM3XX5X Approved NA [2]
Risedronate DM5FLTY Approved Small molecular drug [10]
Salmon Calcitonin DMEWUPF Approved Small molecular drug [11]
Sodium Fluoride F-18 DMQRN2Q Approved Small molecular drug [2]
Strontium ranelate DMC5S1Z Approved Small molecular drug [2]
Teriparatide DMMC45B Approved Peptide [12]
Testosterone DM7HUNW Approved Small molecular drug [13]
Tiludronic acid DM2C2OO Approved Small molecular drug [14]
Zoledronate DMIXC7G Approved Small molecular drug [15]
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⏷ Show the Full List of 23 Drug(s)
This Disease is Treated as An Indication in 27 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CT-064 DMR6UL8 NDA filed Small molecular drug [16]
BA-058 DMPV6B2 Phase 3 NA [17]
Odanacatib DM1EO3G Phase 3 Small molecular drug [18]
S-06911 DMAYTIH Phase 3 NA [19]
Blosozumab DMHXJIR Phase 2 Monoclonal antibody [20]
CP-533536 DMZEJLB Phase 2 Small molecular drug [21]
DP-001 DMYYLC0 Phase 2 Small molecular drug [22]
ES-1 DMXR8MW Phase 2 NA [23]
GSK768974 DMIEXUM Phase 2 NA [24]
LY2541546 DMTVU2Q Phase 2 Antibody [20]
MK-0773 DM2CJB4 Phase 2 Small molecular drug [25]
MK-5442 DMHTIGU Phase 2 NA [26]
NPSP-795 DM3DQXG Phase 2 NA [27]
Ostabolin-C DMBVI6E Phase 2 NA [28]
STX-140 DMJK5CT Phase 2 Small molecular drug [29]
TRK-530 DMRC5RX Phase 2 NA [30]
UNI-PH (1-34) DM8LBUK Phase 2 NA [31]
BPX-501 DMIMA4V Phase 1/2 NA [32]
ALX-0141 DMBGI74 Phase 1 NA [33]
AMG 167 DMUETI2 Phase 1 NA [34]
ATF-936 DMWGKHZ Phase 1 NA [35]
AXT-914 DM7ZU3B Phase 1 NA [36]
CHF-4227 DMTE18G Phase 1 Small molecular drug [37]
Parathyroid hormone analog DMA4OWW Phase 1 NA [38]
PF-04840082 DMDSCQG Phase 1 NA [39]
RAD-140 DMNVDI2 Phase 1 Small molecular drug [40]
SAN-134 DMWU71N Phase 1 NA [41]
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⏷ Show the Full List of 27 Drug(s)
This Disease is Treated as An Indication in 4 Patented Agent(s)
Drug Name Drug ID Highest Status Drug Type REF
N,N-methylenebis-2-phenylacetamide and benzenesulfonamide derivative 1 DMEXPAU Patented Small molecular drug [42]
N,N-methylenebis-2-phenylacetamide and benzenesulfonamide derivative 2 DMD4CU5 Patented Small molecular drug [42]
N,N-methylenebis-2-phenylacetamide and benzenesulfonamide derivative 3 DMM78VS Patented Small molecular drug [42]
PMID27998201-Compound-10 DMVXTIL Patented Small molecular drug [43]
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This Disease is Treated as An Indication in 25 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Balicatib DM06JTL Discontinued in Phase 2 Small molecular drug [44]
EB-1053 DMJ2ZFV Discontinued in Phase 2 Small molecular drug [45]
NPS-2143 DMQPXLF Discontinued in Phase 2 Small molecular drug [46]
ONO-5334 DMWS7C2 Discontinued in Phase 2 NA [47]
Relacatib DMLJEFH Discontinued in Phase 2 Small molecular drug [48]
Ronacaleret DM10ZJP Discontinued in Phase 2 Small molecular drug [49]
Semparatide DMLK605 Discontinued in Phase 2 NA [50]
SERM-3339 DMSLP2O Discontinued in Phase 2 NA [51]
TAK-778 DMWR3WR Discontinued in Phase 2 NA [52]
TJN-135 DMF24AN Discontinued in Phase 2 NA [53]
WY-47766 DM7VCDZ Discontinued in Phase 2 NA [54]
LGD2941 DM9LEGU Discontinued in Phase 1 Small molecular drug [55]
MIV-701 DM23KBM Discontinued in Phase 1 NA [56]
R-1164 DMZI1BQ Discontinued in Phase 1 NA [57]
SB-267268 DMIBFAV Discontinued in Phase 1 Small molecular drug [58]
SB-273005 DMV7M1H Discontinued in Phase 1 NA [59]
AP-23588 DMXLJBA Terminated NA [63]
AP22408 DM5B72D Terminated Small molecular drug [64]
BAY-39-9624 DMPUG18 Terminated NA [65]
BAY-50-9062 DMAKXN3 Terminated NA [66]
Daniplestim DMHJAD4 Terminated NA [67]
DW-1350 DM3L0T1 Terminated Small molecular drug [68]
EL-715 DMZTC9D Terminated NA [69]
L-748415 DMPMV7P Terminated Small molecular drug [70]
SUN-E3001 DMAM3OH Terminated NA [71]
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⏷ Show the Full List of 25 Drug(s)
This Disease is Treated as An Indication in 4 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
BN-DF-037 DMFNLE6 Preclinical NA [60]
FR167356 DMF53Z7 Preclinical NA [61]
GW-2592X DMNAT5V Preclinical NA [61]
OCT-1547 DM7LBQ9 Preclinical NA [62]
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This Disease is Treated as An Indication in 21 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
BB-PTH 1-84 DM85AJ4 Investigative NA [72]
BC-6213 DMERB3D Investigative NA [73]
BT-101 DMJ0458 Investigative NA [73]
Diphyllin DM4S7PS Investigative Small molecular drug [73]
Follistatin DMZEH87 Investigative NA [74]
HU-433 DMPLG4R Investigative NA [75]
Human embryonic stem cell-derived osteoblasts DMKRJXX Investigative NA [73]
MBC-31 DMLOZFU Investigative NA [73]
NaQuinate DMS5V9J Investigative NA [73]
NP-05 DMMOLXO Investigative NA [73]
OB-14 DM3IVZ6 Investigative NA [73]
Peniel-3000 DMVA93W Investigative NA [73]
POD-003 DMDULZ8 Investigative NA [73]
PTH-CBD DM3P73L Investigative NA [73]
SNG-8006 DMCT02Q Investigative NA [76]
SOM-0420 DMD85Q2 Investigative NA [73]
TA-104 DMZ10KE Investigative NA [73]
TAK-075 DMLOAZB Investigative Small molecular drug [77]
TG-B DMTAHQA Investigative NA [73]
TZ-101sm DMYR2TZ Investigative NA [73]
ZP-2307 DM8WRAU Investigative NA [72]
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⏷ Show the Full List of 21 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 185 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CALCR TTLWS2O No Known Unknown [78]
AHSG TTKF4WV Limited Genetic Variation [79]
ALOX12 TT12ABZ Limited Genetic Variation [80]
ALPL TTMR5UV Limited Genetic Variation [81]
ANXA2 TT4YANI Limited Biomarker [82]
ARHGEF3 TT1R5DZ Limited Genetic Variation [83]
ARSA TTYQANR Limited Genetic Variation [84]
ASRGL1 TT4WT91 Limited Altered Expression [85]
CA2 TTANPDJ Limited Biomarker [86]
CNR2 TTMSFAW Limited Biomarker [87]
CSF1 TT0IQER Limited Altered Expression [88]
CXXC5 TTVS4C3 Limited Biomarker [89]
DDR2 TTU98HG Limited Biomarker [90]
DPEP1 TTYUENF Limited Genetic Variation [91]
ESR2 TTOM3J0 Limited Genetic Variation [92]
FDPS TTIKWV4 Limited Genetic Variation [93]
FES TTLBY21 Limited Genetic Variation [94]
GAPDH TTUGSWA Limited Biomarker [95]
GPER1 TTDSB34 Limited Biomarker [96]
GPNMB TT7315J Limited Biomarker [97]
GPRC6A TTI1PRE Limited Biomarker [98]
GPX1 TTYAHBP Limited Genetic Variation [99]
GSN TTUH7OM Limited Biomarker [100]
HDAC5 TTUELN5 Limited Biomarker [101]
HSD11B2 TT9H85R Limited Biomarker [102]
IDUA TT0IUKX Limited Genetic Variation [103]
IL32 TTD4G7L Limited Biomarker [104]
IL6 TTT1V78 Limited Altered Expression [105]
ITGA1 TTPERWV Limited Biomarker [106]
LPAR3 TTE2YJR Limited Biomarker [98]
LTF TTSZDQU Limited Therapeutic [107]
MALT1 TTCI81G Limited Biomarker [108]
MAS1 TTOISYB Limited Altered Expression [109]
MRGPRX1 TTIX6PK Limited Biomarker [98]
NAMPT TTD1WIG Limited Biomarker [110]
NELL1 TT7H4BF Limited Altered Expression [111]
NOTCH2 TT82FVD Limited Genetic Variation [112]
OXER1 TT7WBSV Limited Biomarker [98]
P2RX7 TT473XN Limited Genetic Variation [113]
PTH1R TTFPD47 Limited Biomarker [114]
PTN TTA9EJK Limited Biomarker [115]
QPCT TTJ7YTV Limited Biomarker [116]
RBP4 TT0C8BY Limited Altered Expression [117]
SFRP4 TTX8I1Y Limited Genetic Variation [118]
SLC12A3 TTP362L Limited Biomarker [119]
TPH1 TTZSJHV Limited Biomarker [120]
GH1 TTT3YKH moderate Biomarker [121]
ACE2 TTUI5H7 Strong Biomarker [122]
ACTG1 TTGAZF9 Strong Biomarker [123]
ADCY5 TTN64VU Strong Biomarker [124]
ADRA1A TTNGILX Strong Biomarker [114]
ADRA1D TT34BHT Strong Genetic Variation [125]
ADRA2B TTWM4TY Strong Biomarker [114]
AGER TTMO9HF Strong Altered Expression [126]
AGRP TT4DE1O Strong Genetic Variation [127]
AMD1 TTBFROQ Strong Genetic Variation [128]
ANPEP TTPHMWB Strong Biomarker [129]
ANTXR2 TTOD34I Strong Biomarker [130]
AR TTKPW01 Strong Biomarker [131]
ASIC2 TTVMWLP Strong Biomarker [132]
ATIC TT9NVXQ Strong Biomarker [123]
ATP4A TTF1QVM Strong Biomarker [133]
BACH1 TT2ME4S Strong Biomarker [134]
BAX TTQ57WJ Strong Altered Expression [135]
BMP1 TT0L58T Strong Altered Expression [85]
BMP2 TTP3IGX Strong Biomarker [136]
BMP2K TT32VXH Strong Genetic Variation [137]
BRD2 TTDP48B Strong Altered Expression [138]
BRS3 TTKYEPM Strong Biomarker [114]
CALCR TTLWS2O Strong Biomarker [139]
CAMKK2 TTV298Y Strong Biomarker [140]
CBS TTVZJ7G Strong Biomarker [141]
CIT TT3BKTU Strong Biomarker [142]
CLCF1 TTI6V13 Strong Biomarker [143]
CLCN7 TTST1AJ Strong Biomarker [144]
COASY TT4YO0Z Strong Biomarker [145]
COL1A2 TTUABC1 Strong Biomarker [146]
CPE TTXPWO6 Strong Biomarker [147]
CRBN TTDKGTC Strong Biomarker [148]
CRY2 TTAO58M Strong Genetic Variation [149]
CSF1R TT7MRDV Strong Biomarker [150]
CTH TTLQUZS Strong Biomarker [141]
CXCR6 TT2BVUA Strong Biomarker [114]
CYP17A1 TTRA5BZ Strong Biomarker [151]
CYP24A1 TT82UI1 Strong Biomarker [152]
DAAM2 TTN0Z6H Strong Biomarker [153]
DEPTOR TTLYP6D Strong Altered Expression [154]
DKK1 TTE3RAC Strong Biomarker [155]
DOT1L TTSZ8T1 Strong Biomarker [156]
ESRRA TTPNQAC Strong Genetic Variation [157]
FGF23 TT2IZ4K Strong Altered Expression [158]
FKBP10 TT4P8O2 Strong Biomarker [159]
FNDC1 TTQJCV8 Strong Altered Expression [160]
FSHR TTZFDBT Strong Biomarker [161]
FYN TT2B9KF Strong Biomarker [162]
GATA4 TT1VDN2 Strong Biomarker [163]
GGCX TT76OLR Strong Biomarker [164]
GJA4 TTQO1VY Strong Biomarker [165]
GLB1 TTNGJPH Strong Genetic Variation [166]
GLO1 TTV9A7R Strong Biomarker [167]
GPR39 TTTPCNU Strong Biomarker [168]
GPR55 TTNET8J Strong Biomarker [169]
HAMP TTRV5YJ Strong Biomarker [170]
HDAC4 TTTQGH8 Strong Altered Expression [171]
HSD11B1 TTN7BL9 Strong Biomarker [172]
HSD17B1 TTIWB6L Strong Biomarker [173]
HSD17B2 TT0PT1R Strong Biomarker [174]
HSPG2 TT5UM29 Strong Biomarker [175]
IGF2 TTE8WGO Strong Biomarker [176]
IL20 TTNZMY2 Strong Biomarker [177]
IRAK3 TTBPJOK Strong Biomarker [178]
IRS1 TTAJSQ0 Strong Biomarker [179]
IRS2 TTF95B8 Strong Biomarker [180]
KDM4A TTZHPB8 Strong Biomarker [181]
KDM5A TTIG67W Strong Biomarker [182]
KDM7A TT0NYMP Strong Biomarker [183]
LCT TTA0OSE Strong Genetic Variation [184]
LEP TTBJEZ5 Strong Biomarker [185]
LGMN TTPTWV5 Strong Biomarker [186]
LGR4 TTY6C71 Strong Altered Expression [187]
LPAR2 TTB7Y8I Strong Biomarker [114]
LTB4R TTN53ZF Strong Biomarker [188]
MAPK14 TTQBR95 Strong Biomarker [189]
MARK3 TT3DCYJ Strong Genetic Variation [190]
MCM6 TTQGKSD Strong Genetic Variation [191]
MGLL TTZ963I Strong Biomarker [123]
MMP17 TTVSZKN Strong Altered Expression [192]
MSTN TTM8I2X Strong Biomarker [193]
MTNR1B TT32JK8 Strong Genetic Variation [149]
NSD1 TTTSJ3H Strong Biomarker [140]
OSCAR TT71Q5Y Strong Biomarker [194]
PAH TTGSVH2 Strong Biomarker [195]
PCNA TTLG1PD Strong Biomarker [135]
PCSK7 TTD30LY Strong Biomarker [196]
PHGDH TT8DRCK Strong Altered Expression [197]
PKM TT4LOT8 Strong Biomarker [123]
PKN3 TTW3P4R Strong Biomarker [198]
PNP TTMCF1Y Strong Biomarker [123]
POMC TT21AKM Strong Biomarker [199]
PRKAR1A TTNAHEX Strong Genetic Variation [200]
PTGER4 TT79WV3 Strong Therapeutic [201]
PTH TT6F7GZ Strong Biomarker [202]
PTK2B TTTEFBV Strong Biomarker [203]
PYY TTVFJLX Strong Biomarker [204]
RARG TT1Q3IE Strong Biomarker [205]
REN TTB2MXP Strong Genetic Variation [206]
RICTOR TT143WL Strong Altered Expression [207]
RPGR TTHBDA9 Strong Biomarker [208]
RSPO1 TTI9HL4 Strong Biomarker [209]
RSPO3 TT7HJTF Strong Genetic Variation [210]
RUNX2 TTD6SZ8 Strong Biomarker [211]
S1PR2 TTVSMOH Strong Biomarker [212]
SEMA3A TTVKD3S Strong Altered Expression [213]
SERPINA1 TTA7UJC Strong Genetic Variation [214]
SETD7 TTJ0FSU Strong Biomarker [215]
SIGLEC15 TTBSZPF Strong Biomarker [216]
SIRT1 TTUF2HO Strong Altered Expression [217]
SIRT6 TTUXYWF Strong Biomarker [218]
SLC11A2 TT2IS7P Strong Biomarker [219]
SLC12A1 TTS087L Strong Biomarker [220]
SLC7A1 TT4S150 Strong Biomarker [221]
SMAD3 TTHQZV7 Strong Altered Expression [222]
SMAD6 TTON5JB Strong Genetic Variation [223]
SMAD9 TTX8EBV Strong Biomarker [224]
SMPD1 TTJTM88 Strong Biomarker [225]
SOST TTYRO4F Strong Biomarker [226]
SP1 TTZEP6S Strong Biomarker [227]
SPRY1 TT0PSN6 Strong Biomarker [228]
SPTBN1 TTS9BDA Strong Genetic Variation [210]
SSTR4 TTAE1BR Strong Biomarker [114]
SVIL TTBLQS5 Strong Genetic Variation [229]
TACR3 TTBPGLU Strong Biomarker [230]
TLN1 TTQSMFG Strong Biomarker [123]
TNFRSF11A TT3K9S2 Strong Biomarker [231]
TRPV1 TTMI6F5 Strong Biomarker [232]
TTK TTP7EGM Strong Biomarker [233]
TTR TTPOYU7 Strong Altered Expression [234]
VANGL1 TT18WJB Strong Biomarker [235]
VKORC1 TTEUC8H Strong Genetic Variation [236]
WNT5A TTKG7F8 Strong Biomarker [237]
WRN TT2H5WQ Strong Biomarker [238]
WWP1 TTBWMKT Strong Biomarker [239]
FOS TTOM5AU Definitive Genetic Variation [240]
MMP1 TTMX39J Definitive Genetic Variation [241]
SPARC TTBQFM7 Definitive Genetic Variation [242]
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⏷ Show the Full List of 185 DTT(s)
This Disease Is Related to 8 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCC6 DT582KR Strong Biomarker [243]
ATP12A DT5NLZA Strong Biomarker [133]
SLC22A11 DT06JWZ Strong Genetic Variation [244]
SLC25A20 DTQOUM4 Strong Biomarker [86]
SLC26A2 DTFSLX5 Strong Biomarker [245]
SLC34A1 DT42EWA Strong Genetic Variation [246]
SLC41A1 DTB37ZE Strong Biomarker [247]
SLC51A DTMEQ32 Strong Biomarker [248]
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⏷ Show the Full List of 8 DTP(s)
This Disease Is Related to 9 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
NAT10 DEZV4AP Limited Altered Expression [85]
UGT2B17 DEAZDL8 Limited Genetic Variation [249]
ACP5 DESITDW Strong Biomarker [250]
AKR1C4 DEAJN47 Strong Genetic Variation [251]
CHST3 DEQIZP2 Strong Biomarker [252]
CYP1A1 DE6OQ3W Strong Biomarker [253]
CYP27B1 DE3FYEM Strong Altered Expression [254]
PARK7 DEPOVCH Strong Biomarker [123]
SULT2A1 DE0P6LK Strong Biomarker [255]
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⏷ Show the Full List of 9 DME(s)
This Disease Is Related to 252 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CALCR OTOVDJ7S No Known Unknown [78]
ACAD8 OT3JI5GB Limited Biomarker [256]
ALPP OTZU4G9W Limited Altered Expression [85]
AMH OT5FH4BD Limited Genetic Variation [94]
ANKH OTCN25R5 Limited Genetic Variation [257]
ATP6V1H OTX17GQ9 Limited Genetic Variation [258]
ATRNL1 OTY5JUX2 Limited Altered Expression [85]
BHLHE40 OTITX14U Limited Altered Expression [259]
CA10 OTC3N1F6 Limited Biomarker [260]
CCDC170 OTNQOJ6S Limited Genetic Variation [261]
CCL27 OTUZYC61 Limited Altered Expression [85]
CRTAP OT53H5U6 Limited Genetic Variation [83]
DDOST OT39PDMS Limited Biomarker [262]
FOXA1 OTEBY0TD Limited Genetic Variation [263]
FZD4 OTGLZIE0 Limited Biomarker [98]
GALNT3 OT7M67WT Limited Altered Expression [264]
GC OTWS63BY Limited Biomarker [265]
GDF11 OTOSNMND Limited Biomarker [266]
GPR151 OT7EACU6 Limited Biomarker [98]
HIVEP3 OTM3QT3L Limited Biomarker [267]
KAT2A OTN0W2SW Limited Altered Expression [268]
MACF1 OTVIHD77 Limited Biomarker [269]
MCF2L OTEURA8N Limited Biomarker [262]
MEPE OTXJRUW0 Limited Biomarker [270]
MOK OTQK7M9V Limited Altered Expression [126]
MRGPRX3 OTRKCCDS Limited Biomarker [98]
MRGPRX4 OTOBHZVA Limited Biomarker [98]
MYOG OTPLJKFA Limited Biomarker [271]
NFATC1 OT4TMERS Limited Biomarker [272]
P4HB OTTYNYPF Limited Altered Expression [273]
PDLIM3 OTVXQC81 Limited Altered Expression [85]
PIR OT8ALXHU Limited Biomarker [274]
PLK3 OT19CT2Z Limited Genetic Variation [275]
PTRH1 OTOAOS93 Limited Biomarker [276]
RAPGEF5 OT53VS75 Limited Biomarker [277]
RETN OTW5Z1NH Limited Biomarker [278]
RPS5 OTPSWQRS Limited Biomarker [279]
S100P OTJCXNJG Limited Genetic Variation [280]
SALL1 OTYYZGLH Limited Biomarker [281]
SATB2 OT2W80XC Limited Biomarker [282]
SBDS OTHDCCIB Limited Genetic Variation [283]
SLPI OTUNFUU8 Limited Altered Expression [85]
SQOR OTTLD0KB Limited Biomarker [284]
THSD4 OTXDBMDC Limited Genetic Variation [242]
TPM4 OTN4YLYR Limited Biomarker [285]
TRAF3 OT5TQBGV Limited Biomarker [286]
TSPAN5 OTHCCHHV Limited Biomarker [280]
IGSF23 OTORIW79 Disputed Biomarker [287]
OSTM1 OTKNJDH7 Disputed Biomarker [288]
COL1A1 OTI31178 moderate Biomarker [159]
SGMS2 OT3NHO99 moderate Genetic Variation [289]
ABI1 OT5H4M62 Strong Biomarker [290]
ACE OTDF1964 Strong Biomarker [133]
ADCY6 OTFOY4WW Strong Biomarker [291]
AEBP1 OTBI1RZ6 Strong Genetic Variation [292]
AGBL2 OTCX9987 Strong Biomarker [293]
AKAP11 OT7E2FVD Strong Biomarker [294]
ALDH7A1 OTV57BZD Strong Biomarker [295]
AMFR OTQRX7LC Strong Biomarker [296]
ATP6 OTPHOGLX Strong Genetic Variation [297]
ATP6V1G1 OTBT1O58 Strong Biomarker [298]
BICD2 OTVJ03NZ Strong Biomarker [299]
BMP15 OT2G3YR1 Strong Genetic Variation [300]
BMP3 OTCTI0UW Strong Biomarker [301]
BMPR1B OTGFN0OD Strong Genetic Variation [242]
BRCC3 OTK0ZN7Y Strong Altered Expression [302]
C1QTNF3 OTOJMWW0 Strong Genetic Variation [303]
C1QTNF4 OTHD4Y9D Strong Altered Expression [304]
CA8 OT9Y8GA8 Strong Genetic Variation [305]
CAP1 OTYM8A2N Strong Biomarker [123]
CAV3 OTWSFDB4 Strong Altered Expression [306]
CBFB OTIAC6W4 Strong Biomarker [307]
CCT2 OTW1VV4E Strong Biomarker [123]
CDX2 OTCG4TSY Strong Biomarker [308]
CER1 OTTAJJ63 Strong Genetic Variation [309]
CHAD OT7PF813 Strong Biomarker [310]
CIITA OTRJNZFO Strong Biomarker [311]
CILK1 OTWOYEYP Strong Biomarker [312]
CLC OTYMYR85 Strong Biomarker [220]
CLCN5 OT9YXZSO Strong Biomarker [220]
CLEC11A OT9KBH7C Strong Biomarker [313]
COL4A4 OT9G0MCT Strong Biomarker [314]
COL9A3 OTCUJOEK Strong Biomarker [315]
CPT1A OTI862QH Strong Genetic Variation [316]
CRX OTH435SV Strong Biomarker [208]
CST5 OTHJXNJG Strong Altered Expression [317]
CTHRC1 OTV88X2G Strong Biomarker [318]
CTSZ OTSCX2LL Strong Biomarker [319]
CXXC1 OTO10D1N Strong Genetic Variation [320]
DBP OTE0W7LN Strong Genetic Variation [321]
DCAF13 OTQQ0QXT Strong Genetic Variation [322]
DCAF6 OT3EYK1J Strong Biomarker [300]
DGCR2 OTEGL17Z Strong Biomarker [315]
DLX5 OTEEFBEU Strong Biomarker [323]
DNASE1L3 OTEUIMC2 Strong Biomarker [324]
DNM3 OTDMUGCR Strong Genetic Variation [190]
DOCK5 OT63I0CL Strong Biomarker [325]
DOK6 OTX55OIF Strong Genetic Variation [326]
DRAM1 OTIJTXEN Strong Altered Expression [327]
DSPP OT1TYNDN Strong Biomarker [328]
DUSP14 OTGODFCR Strong Biomarker [329]
EIF3K OTGTKVGO Strong Biomarker [330]
ELAVL2 OT6EJ8MQ Strong Altered Expression [302]
ENO1 OTB1KWJS Strong Biomarker [123]
EXT1 OTRPALJK Strong Genetic Variation [331]
FANCC OTTIDM3P Strong Biomarker [332]
FGA OTMIHY80 Strong Biomarker [123]
FGB OT6RKLI9 Strong Biomarker [123]
FLCN OTVM78XM Strong Genetic Variation [333]
FLII OT7G9JG6 Strong Biomarker [334]
FRZB OTTO3DPY Strong Genetic Variation [118]
GBP1 OTUM7RPJ Strong Altered Expression [335]
GFI1 OT9HB9H8 Strong Biomarker [336]
GGPS1 OTVEHG28 Strong Genetic Variation [337]
GNAS OTMH8BKJ Strong Biomarker [338]
GOLGA6A OTHU9MRX Strong Biomarker [339]
GOLM1 OTOZSV6O Strong Biomarker [340]
GORAB OTP65YD7 Strong Genetic Variation [341]
GPATCH1 OTQRDBY6 Strong Genetic Variation [210]
GPC6 OTNJBESF Strong Biomarker [342]
GPD2 OTV232Y7 Strong Biomarker [123]
GPLD1 OTUUQOVY Strong Biomarker [343]
GPR42 OTEB0ROY Strong Biomarker [114]
GREM2 OTE91EWT Strong Biomarker [344]
GSTM3 OTLA2WJT Strong Genetic Variation [345]
GTF2B OTAH5NSO Strong Genetic Variation [346]
HAP1 OT6SG0JQ Strong Biomarker [347]
HBM OT8WB3RL Strong Biomarker [224]
HFE OTDD93KB Strong Genetic Variation [348]
HIRA OTON40EJ Strong Biomarker [299]
HJV OT4235J2 Strong Genetic Variation [349]
HNRNPL OT0DJX74 Strong Biomarker [350]
ID4 OTPMJ39I Strong Biomarker [351]
IDH2 OTTQA4PB Strong Biomarker [123]
IFIT1 OTXOQDSG Strong Biomarker [159]
IFIT2 OTI4EOAR Strong Biomarker [159]
IFITM5 OTLP5QEJ Strong Biomarker [352]
IFNGR1 OTCTQBWW Strong Biomarker [353]
IFRD1 OT4SQMLQ Strong Biomarker [354]
IL17B OTS86H50 Strong Biomarker [177]
IL34 OTZ15VVK Strong Biomarker [355]
IL6R OTCQL07Z Strong Biomarker [356]
INSL3 OT7KUNTE Strong Genetic Variation [357]
IREB2 OT747D24 Strong Biomarker [358]
IRF2 OTAZRUW3 Strong Biomarker [359]
KAT8 OT5LPQTR Strong Genetic Variation [360]
KCNH6 OTQ52G7V Strong Biomarker [361]
KDM4B OT5P1UPY Strong Biomarker [362]
KL OTD4VWU6 Strong Biomarker [363]
KLF10 OT4F4UGS Strong Altered Expression [364]
KREMEN2 OTS0BTXC Strong Biomarker [159]
LGR6 OTPZ1PWR Strong Biomarker [365]
LRP4 OTO4M459 Strong Genetic Variation [366]
LRRK1 OTCQMOIX Strong Biomarker [367]
MAB21L2 OTZM5VMX Strong Altered Expression [88]
MAFB OTH2N3T8 Strong Genetic Variation [368]
MAP9 OTZD5099 Strong Biomarker [369]
MARCHF11 OTODNSYN Strong Biomarker [370]
MECOM OTP983W8 Strong Genetic Variation [371]
MEN1 OTN6U6V0 Strong Biomarker [372]
METTL21C OTEMLDE6 Strong Genetic Variation [373]
METTL3 OTSXP1M3 Strong Altered Expression [374]
MGME1 OTC5LPXX Strong Biomarker [375]
MGP OTZWU3FU Strong Biomarker [376]
MIER1 OTT0UJAS Strong Genetic Variation [377]
MLPH OT7ADCXL Strong Biomarker [378]
MRPL49 OTN5PNSP Strong Biomarker [379]
MT1G OTAV1OCR Strong Biomarker [380]
NDUFAB1 OTF906UR Strong Biomarker [381]
NIPA2 OT4NEBNO Strong Biomarker [382]
NKRF OTUVY0P6 Strong Biomarker [383]
NNAT OTNRLO7G Strong Biomarker [384]
NOG OTGRHHPG Strong Altered Expression [385]
NOX1 OTZPJQCC Strong Biomarker [386]
NPNT OTFZAO1G Strong Altered Expression [387]
NRIP1 OTIZOJQV Strong Genetic Variation [388]
OGN OTKP5S4L Strong Biomarker [389]
OR2AG1 OTEITRP4 Strong Biomarker [390]
OSBPL1A OTQ33OQV Strong Genetic Variation [326]
OXA1L OTS0BFRD Strong Genetic Variation [391]
OXCT1 OT536PE7 Strong Biomarker [123]
PADI1 OT13WAQX Strong Altered Expression [273]
PDIA2 OTC2WMXS Strong Altered Expression [273]
PDLIM4 OT23LZYY Strong Genetic Variation [392]
PFN1 OTHTGA1H Strong Biomarker [393]
PGLS OTO6C0IQ Strong Biomarker [123]
PHF20 OTCBVH5P Strong Biomarker [299]
PIEZO1 OTBG1FU4 Strong Biomarker [394]
PIP5K1B OT8JQ1F7 Strong Biomarker [395]
PLEK OTB73XXA Strong Biomarker [123]
PLEKHA1 OT66PF24 Strong Biomarker [147]
PLEKHO1 OTMVUQ9W Strong Biomarker [396]
PLIN2 OTRXJ9UN Strong Altered Expression [397]
PLS3 OTYBM4PK Strong Biomarker [398]
PLXNA3 OTMZIBVG Strong Biomarker [399]
PPBP OT1FHGQS Strong Biomarker [400]
PRDM6 OTKY12D9 Strong Genetic Variation [190]
PRDX3 OTLB2WEU Strong Biomarker [123]
PROP1 OT8GF6N8 Strong Genetic Variation [401]
PSMA2 OTJRT2ZL Strong Biomarker [123]
PSMA5 OT38E6Y1 Strong Biomarker [123]
PTHLH OTI1JF13 Strong Biomarker [402]
PTPRF OTH5KF2D Strong Biomarker [403]
PUM1 OTTMWP8L Strong Genetic Variation [190]
RAB31 OTMLXQZ0 Strong Genetic Variation [229]
RAB7B OT60A0E9 Strong Biomarker [123]
RAN OT2TER5M Strong Biomarker [404]
RAP1A OT5RH6TI Strong Biomarker [291]
RCBTB1 OTAYELI8 Strong Biomarker [339]
RMND1 OT7I6RBT Strong Biomarker [261]
RPL29 OTUFIBJL Strong Biomarker [405]
RPL31 OTV9E1OE Strong Genetic Variation [316]
RPLP0 OT3XKD6Y Strong Biomarker [406]
RSU1 OTO5GHT1 Strong Biomarker [123]
RUNX1T1 OT30DED5 Strong Genetic Variation [251]
RXFP2 OT7SAT9U Strong Genetic Variation [357]
SAMD4A OT4MKCC8 Strong Biomarker [407]
SEM1 OTASLBM1 Strong Genetic Variation [408]
SEPTIN4 OTD16B30 Strong Biomarker [409]
SH3PXD2B OTAOMCDJ Strong Genetic Variation [410]
SLIT3 OTU8MKEU Strong Biomarker [411]
SMAD5 OTQNSVCQ Strong Biomarker [412]
SMURF1 OT5UIZR8 Strong Altered Expression [413]
SMURF2 OT3TRVL7 Strong Biomarker [414]
SNX10 OT05B7BT Strong Altered Expression [415]
SOX6 OTT0W0LE Strong Genetic Variation [416]
SOX9 OTVDJFGN Strong Biomarker [417]
SPI1 OTVCA1D0 Strong Biomarker [418]
SRM OT4N5MDP Strong Genetic Variation [419]
SRY OT516T6D Strong Altered Expression [420]
ST3GAL4 OTNENJZQ Strong Biomarker [421]
STARD3 OTSTC5B5 Strong Biomarker [422]
STK24 OTGUHOIL Strong Altered Expression [423]
STOM OTC8R6EH Strong Biomarker [424]
STRA6 OT2IDF27 Strong Altered Expression [378]
SUFU OT0IRYG1 Strong Altered Expression [135]
SYN2 OTK0DEGH Strong Biomarker [425]
TBC1D8 OT2011SS Strong Genetic Variation [326]
TESMIN OTZ5UILU Strong Genetic Variation [316]
THSD7A OT7249HH Strong Genetic Variation [426]
TM7SF2 OTILU5S7 Strong Biomarker [427]
TMCO1 OTSME34W Strong Biomarker [428]
TMEM135 OT63ZT3X Strong Genetic Variation [210]
TMEM64 OTO9IDFD Strong Biomarker [429]
TNFAIP8L2 OTII0RM0 Strong Biomarker [430]
TPI1 OT14KP4B Strong Biomarker [123]
TRAF4 OTJLRVMC Strong Biomarker [431]
TRIM16 OTLRXYOZ Strong Biomarker [432]
TRIO OT71X1AK Strong Genetic Variation [433]
TRPS1 OT7XPPEL Strong Genetic Variation [190]
TSC22D3 OT03UM03 Strong Altered Expression [434]
SMS OT8JYKNH Definitive Genetic Variation [419]
------------------------------------------------------------------------------------
⏷ Show the Full List of 252 DOT(s)

References

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89 Discovery of a small-molecule inhibitor of Dvl-CXXC5 interaction by computational approaches.J Comput Aided Mol Des. 2018 May;32(5):643-655. doi: 10.1007/s10822-018-0118-x. Epub 2018 Apr 7.
90 Genetic analysis identifies DDR2 as a novel gene affecting bone mineral density and osteoporotic fractures in Chinese population.PLoS One. 2015 Feb 6;10(2):e0117102. doi: 10.1371/journal.pone.0117102. eCollection 2015.
91 Technetium-99 Conjugated with Methylene Diphosphonate Ameliorates Glucocorticoid Induced Osteoporosis by Inhibiting Osteoclastogenesis.Biomed Res Int. 2018 Oct 14;2018:7902760. doi: 10.1155/2018/7902760. eCollection 2018.
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96 Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.Sci Rep. 2019 May 6;9(1):6991. doi: 10.1038/s41598-019-43518-7.
97 miR-26b modulates OA induced BMSC osteogenesis through regulating GSK3/-catenin pathway.Exp Mol Pathol. 2019 Apr;107:158-164. doi: 10.1016/j.yexmp.2019.02.003. Epub 2019 Feb 13.
98 Wnt5a/FZD4 Mediates the Mechanical Stretch-Induced Osteogenic Differentiation of Bone Mesenchymal Stem Cells.Cell Physiol Biochem. 2018;48(1):215-226. doi: 10.1159/000491721. Epub 2018 Jul 13.
99 The antioxidant enzyme GPX1 gene polymorphisms are associated with low BMD and increased bone turnover markers.Dis Markers. 2010;29(2):71-80. doi: 10.3233/DMA-2010-0728.
100 Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women.PLoS One. 2018 May 22;13(5):e0197732. doi: 10.1371/journal.pone.0197732. eCollection 2018.
101 MicroRNA variants as genetic determinants of bone mass.Bone. 2016 Mar;84:57-68. doi: 10.1016/j.bone.2015.12.016. Epub 2015 Dec 23.
102 Effects of 17-HSD2 inhibition in bones on osteoporosis based on an animal rat model.J Steroid Biochem Mol Biol. 2019 Sep;192:105405. doi: 10.1016/j.jsbmb.2019.105405. Epub 2019 Jun 8.
103 Associations of IDUA and PTCH1 with Bone Mineral Density, Bone Turnover Markers, and Fractures in Chinese Elderly Patients with Osteoporosis.Dis Markers. 2019 Jun 2;2019:9503762. doi: 10.1155/2019/9503762. eCollection 2019.
104 Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis.Immune Netw. 2018 Jun 9;18(3):e20. doi: 10.4110/in.2018.18.e20. eCollection 2018 Jun.
105 Association of pro-inflammatory cytokines with QCT-measured bone mineral density and its gender difference in a Chinese population - a pilot study.Endokrynol Pol. 2019;70(3):248-254. doi: 10.5603/EP.a2019.0014. Epub 2019 Mar 7.
106 Impact of common variation in bone-related genes on type 2 diabetes and related traits.Diabetes. 2012 Aug;61(8):2176-86. doi: 10.2337/db11-1515. Epub 2012 Jun 14.
107 Iron loading: a risk factor for osteoporosis.Biometals. 2006 Dec;19(6):633-5. doi: 10.1007/s10534-006-9000-8. Epub 2006 Apr 29.
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110 Nicotinamide phosphoribosyltransferase inhibits receptor activator of nuclear factor-B ligand-induced osteoclast differentiation invitro.Mol Med Rep. 2017 Feb;15(2):784-792. doi: 10.3892/mmr.2016.6069. Epub 2016 Dec 23.
111 Inactivation of Nell-1 in Chondrocytes Significantly Impedes Appendicular Skeletogenesis.J Bone Miner Res. 2019 Mar;34(3):533-546. doi: 10.1002/jbmr.3615. Epub 2018 Dec 14.
112 The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor .J Biol Chem. 2019 Sep 27;294(39):14203-14214. doi: 10.1074/jbc.RA119.009824. Epub 2019 Aug 1.
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114 Structure and dynamics of the active human parathyroid hormone receptor-1.Science. 2019 Apr 12;364(6436):148-153. doi: 10.1126/science.aav7942.
115 -1227C>T polymorphism in the pleiotrophin gene promoter influences bone mineral density in postmenopausal women.Mol Genet Metab. 2011 May;103(1):76-80. doi: 10.1016/j.ymgme.2011.01.017. Epub 2011 Feb 3.
116 Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD.Int J Chron Obstruct Pulmon Dis. 2015 Sep 4;10:1809-17. doi: 10.2147/COPD.S91576. eCollection 2015.
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133 Prevalence and predictors of inappropriate prescribing according to the Screening Tool of Older People's Prescriptions and Screening Tool to Alert to Right Treatment version? criteria in older patients discharged from geriatric and internal medicine wards: A prospective observational multicenter study.Geriatr Gerontol Int. 2019 Jan;19(1):5-11. doi: 10.1111/ggi.13542. Epub 2018 Oct 11.
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136 Strontium enhances BMP-2 mediated bone regeneration in a femoral murine bone defect model.J Biomed Mater Res B Appl Biomater. 2020 Jan;108(1):174-182. doi: 10.1002/jbm.b.34376. Epub 2019 Apr 5.
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138 FSH-metabolic circuitry and menopause.J Mol Endocrinol. 2019 Oct;63(3):R73-R80. doi: 10.1530/JME-19-0152.
139 Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms.Biochem Pharmacol. 2018 Feb;148:111-129. doi: 10.1016/j.bcp.2017.12.016. Epub 2017 Dec 23.
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145 Overexpressed miR-196a accelerates osteogenic differentiation in osteoporotic mice via GNAS-dependent Hedgehog signaling pathway.J Cell Biochem. 2019 Dec;120(12):19422-19431. doi: 10.1002/jcb.29166. Epub 2019 Aug 26.
146 Bone turnover: Biology and assessment tools.Best Pract Res Clin Endocrinol Metab. 2018 Oct;32(5):725-738. doi: 10.1016/j.beem.2018.05.003. Epub 2018 May 26.
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148 Cereblon (CRBN) deletion reverses streptozotocin induced diabetic osteoporosis in mice.Biochem Biophys Res Commun. 2018 Feb 12;496(3):967-974. doi: 10.1016/j.bbrc.2018.01.095. Epub 2018 Jan 17.
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150 Colony-stimulating factor 1 receptor inhibition prevents against lipopolysaccharide -induced osteoporosis by inhibiting osteoclast formation.Biomed Pharmacother. 2019 Jul;115:108916. doi: 10.1016/j.biopha.2019.108916. Epub 2019 May 1.
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160 Rutin suppresses FNDC1 expression in bone marrow mesenchymal stem cells to inhibit postmenopausal osteoporosis.Am J Transl Res. 2019 Oct 15;11(10):6680-6690. eCollection 2019.
161 Discovery of small molecule binders of human FSHR(TMD) with novel structural scaffolds by integrating structural bioinformatics and machine learning algorithms.J Mol Graph Model. 2019 Jun;89:156-166. doi: 10.1016/j.jmgm.2019.02.001. Epub 2019 Mar 5.
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163 Acetylation of GATA4 on Lysine Residue K313 Promotes Osteoblastic Cells Growth.Cell Physiol Biochem. 2018;46(1):269-278. doi: 10.1159/000488428. Epub 2018 Mar 22.
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165 Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men.Int J Mol Med. 2007 May;19(5):791-801.
166 Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures.J Bone Miner Res. 2004 Jan;19(1):42-7. doi: 10.1359/JBMR.0301207.
167 Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H(2)O(2) and entailing Glyoxalase 1-dependent MG-H1 accumulation leading to TG2-mediated NF-kB desensitization: Implication for smokers-related osteoporosis.Free Radic Biol Med. 2018 Mar;117:6-17. doi: 10.1016/j.freeradbiomed.2018.01.017. Epub 2018 Jan 31.
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170 Lowering iron level protects against bone loss in focally irradiated and contralateral femurs through distinct mechanisms.Bone. 2019 Mar;120:50-60. doi: 10.1016/j.bone.2018.10.005. Epub 2018 Oct 7.
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175 Perlecan/Hspg2 deficiency impairs bone's calcium signaling and associated transcriptome in response to mechanical loading.Bone. 2020 Feb;131:115078. doi: 10.1016/j.bone.2019.115078. Epub 2019 Nov 9.
176 Preptin promotes proliferation and osteogenesis of MC3T3-E1 cells by upregulating -catenin expression.IUBMB Life. 2019 Jul;71(7):854-862. doi: 10.1002/iub.2016. Epub 2019 Feb 6.
177 IL-20 bone diseases involvement and therapeutic target potential.J Biomed Sci. 2018 Apr 24;25(1):38. doi: 10.1186/s12929-018-0439-z.
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181 Histone demethylase KDM4A regulates adipogenic and osteogenic differentiation via epigenetic regulation of C/EBP and canonical Wnt signaling.Cell Mol Life Sci. 2020 Jun;77(12):2407-2421. doi: 10.1007/s00018-019-03289-w. Epub 2019 Sep 12.
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184 Adult lactose intolerance, calcium intake, bone metabolism and bone density in German-Turkish immigrants.J Bone Miner Metab. 2020 May;38(3):378-384. doi: 10.1007/s00774-019-01070-4. Epub 2019 Dec 4.
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186 Mammalian legumain - A lysosomal cysteine protease with extracellular functions?.Biochimie. 2019 Nov;166:77-83. doi: 10.1016/j.biochi.2019.06.002. Epub 2019 Jun 7.
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189 Inhibition of Osteoclastogenesis by Thioredoxin-Interacting Protein-Derived Peptide (TN13).J Clin Med. 2019 Mar 29;8(4):431. doi: 10.3390/jcm8040431.
190 Identification of Novel Potentially Pleiotropic Variants Associated With Osteoporosis and Obesity Using the cFDR Method.J Clin Endocrinol Metab. 2018 Jan 1;103(1):125-138. doi: 10.1210/jc.2017-01531.
191 Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: a Mendelian randomization study.Eur J Clin Nutr. 2017 Aug;71(8):1008-1012. doi: 10.1038/ejcn.2017.8. Epub 2017 Feb 22.
192 miRNA?7a regulates arthritis via PPAR invivo and invitro.Mol Med Rep. 2018 Apr;17(4):5454-5462. doi: 10.3892/mmr.2018.8531. Epub 2018 Jan 31.
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195 Association between polycyclic aromatic hydrocarbons and osteoporosis: data from NHANES, 2005-2014.Arch Osteoporos. 2018 Oct 17;13(1):112. doi: 10.1007/s11657-018-0527-4.
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203 Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2/Anoikis Signaling.Endocrinology. 2019 Jul 1;160(7):1659-1673. doi: 10.1210/en.2019-00237.
204 Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment.Front Endocrinol (Lausanne). 2019 Feb 26;10:75. doi: 10.3389/fendo.2019.00075. eCollection 2019.
205 Drug therapy targeting pyrophosphate slows the ossification of spinal ligaments in twy mice.J Orthop Res. 2018 Apr;36(4):1256-1261. doi: 10.1002/jor.23743. Epub 2017 Oct 9.
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265 Serum Proteomic Analysis Reveals Vitamin D-Binding Protein (VDBP) as a Potential Biomarker for Low Bone Mineral Density in Mexican Postmenopausal Women.Nutrients. 2019 Nov 21;11(12):2853. doi: 10.3390/nu11122853.
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269 Microtubule actin crosslinking factor 1 (MACF1) knockdown inhibits RANKL-induced osteoclastogenesis via Akt/GSK3/NFATc1 signalling pathway.Mol Cell Endocrinol. 2019 Aug 20;494:110494. doi: 10.1016/j.mce.2019.110494. Epub 2019 Jun 28.
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277 Degree of hypercalcemia correlates with parathyroidectomy but not with symptoms.Am J Surg. 2019 Mar;217(3):437-440. doi: 10.1016/j.amjsurg.2018.09.010. Epub 2018 Sep 21.
278 Assessment of selected adipocytokines in obese women with postmenopausal osteoporosis.Endokrynol Pol. 2019;70(6):478-483. doi: 10.5603/EP.a2019.0043. Epub 2019 Sep 30.
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280 Screening of differentially expressed genes in male idiopathic osteoporosis via RNA sequencing.Mol Med Rep. 2018 Jul;18(1):67-76. doi: 10.3892/mmr.2018.8985. Epub 2018 May 7.
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282 Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via ER-SATB2 pathway.J Cell Physiol. 2018 May;233(5):4194-4204. doi: 10.1002/jcp.26233. Epub 2017 Nov 16.
283 Shwachman-Diamond syndrome is associated with low-turnover osteoporosis.Bone. 2007 Dec;41(6):965-72. doi: 10.1016/j.bone.2007.08.035. Epub 2007 Sep 5.
284 Genetic susceptibility of postmenopausal osteoporosis on sulfide quinone reductase-like gene.Osteoporos Int. 2018 Sep;29(9):2041-2047. doi: 10.1007/s00198-018-4575-9. Epub 2018 May 31.
285 Differentially expressed proteins identified by TMT proteomics analysis in bone marrow microenvironment of osteoporotic patients.Osteoporos Int. 2019 May;30(5):1089-1098. doi: 10.1007/s00198-019-04884-0. Epub 2019 Feb 9.
286 TGF-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.Nat Commun. 2019 Jun 26;10(1):2795. doi: 10.1038/s41467-019-10677-0.
287 Osteoclastogenesis inhibition by mutated IGSF23 results in human osteopetrosis.Cell Prolif. 2019 Nov;52(6):e12693. doi: 10.1111/cpr.12693. Epub 2019 Sep 27.
288 Ostm1 Bifunctional Roles in Osteoclast Maturation: Insights From a Mouse Model Mimicking a Human OSTM1 Mutation.J Bone Miner Res. 2018 May;33(5):888-898. doi: 10.1002/jbmr.3378. Epub 2018 Feb 14.
289 Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2. JCI Insight. 2019 Apr 4;4(7):e126180. doi: 10.1172/jci.insight.126180. eCollection 2019 Apr 4.
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292 Bi-allelic AEBP1 mutations in two patients with Ehlers-Danlos syndrome.Hum Mol Genet. 2019 Jun 1;28(11):1853-1864. doi: 10.1093/hmg/ddz024.
293 Association of Low Bone Mineral Density with Anti-Citrullinated Protein Antibody Positivity and Disease Activity in Established Rheumatoid Arthritis: Findings from a US Observational Cohort.Adv Ther. 2018 Feb;35(2):232-242. doi: 10.1007/s12325-017-0657-x. Epub 2018 Jan 25.
294 Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long-Range Super-Enhancer.J Bone Miner Res. 2018 Jul;33(7):1335-1346. doi: 10.1002/jbmr.3419. Epub 2018 May 17.
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302 Gene co-expression network analysis identifies BRCC3 as a key regulator in osteogenic differentiation of osteoblasts through a -catenin signaling dependent pathway.Iran J Basic Med Sci. 2019 Feb;22(2):173-178. doi: 10.22038/IJBMS.2018.29498.7123.
303 Serum CTRP3 Level is Associated with Osteoporosis in Postmenopausal Women.Exp Clin Endocrinol Diabetes. 2018 Oct;126(9):559-563. doi: 10.1055/s-0043-124365. Epub 2018 Feb 8.
304 Ctrp4, a new adipokine, promotes the differentiation of osteoblasts.Biochem Biophys Res Commun. 2019 Apr 30;512(2):224-229. doi: 10.1016/j.bbrc.2019.03.053. Epub 2019 Mar 15.
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306 Overexpression of CAV3 facilitates bone formation via the Wnt signaling pathway in osteoporotic rats.Endocrine. 2019 Mar;63(3):639-650. doi: 10.1007/s12020-018-1803-1. Epub 2018 Nov 14.
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308 Cdx-2 polymorphism in the vitamin D receptor gene (VDR) marks VDR expression in monocyte/macrophages through VDR promoter methylation.Immunogenetics. 2018 Aug;70(8):523-532. doi: 10.1007/s00251-018-1063-5. Epub 2018 May 28.
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310 The C-terminal domain of chondroadherin: a new regulator of osteoclast motility counteracting bone loss.J Bone Miner Res. 2014 Aug;29(8):1833-46. doi: 10.1002/jbmr.2206.
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315 Low-trauma fractures and bone mineral density testing in adults with and without intellectual and developmental disabilities: a population study.Osteoporos Int. 2017 Feb;28(2):727-732. doi: 10.1007/s00198-016-3740-2. Epub 2016 Sep 9.
316 Functional relevance for associations between osteoporosis and genetic variants.PLoS One. 2017 Apr 3;12(4):e0174808. doi: 10.1371/journal.pone.0174808. eCollection 2017.
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320 Genes Regulated by Vitamin D in Bone Cells Are Positively Selected in East Asians.PLoS One. 2015 Dec 31;10(12):e0146072. doi: 10.1371/journal.pone.0146072. eCollection 2015.
321 Association of Thr420Lys polymorphism in DBP gene with fat-soluble vitamins and low radial bone mineral density in postmenopausal Thai women.Biomark Med. 2012 Feb;6(1):103-8. doi: 10.2217/bmm.11.88.
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