Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2R68E)

Drug Name

Ramipril Drug Info

Synonyms

Acovil; Altace; Carasel; Cardace; Delix; Hypren; Hytren; Lostapres; Naprix; Pramace; Quark; Ramace; Ramiprilum; Triatec; Tritace; Vesdil; Zabien; Almirall Brand of Ramipril; Astra Brand of Ramipril; AstraZeneca Brand of Ramipril; Aventis Brand of Ramipril; Aventis Pharma Brand of Ramipril; Hoechst Brand of Ramipril; Monarch Brand of Ramipril; Promed Brand of Ramipril; Ramiprilum [Latin]; HOE 498; HOE498; Altace (TN); Hoe-498; Pramace (discontinued); Tritace (TN); Ramipril (USP/INN); Ramipril [USAN:INN:BAN]; Ramipro, Tritace, Altace, Prilace, Ramipril; N-(1S-carboethoxy-3-phenylpropyl)-S-alanyl-cis,endo-2-azabicyclo[3.3.0]octane-3S-carboxylic Acid; [2s,3as,6as]-1-[(2s)-2-[[(1s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopen; [2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid; (2 S ,3 aS,6 aS)-1[(S)-N-[(S)-1-Carboxy-3-phenylpropyl] alanyl] octahydrocyclopenta [ b ]pyrrole-2-carboxylic acid, 1-ethyl ester; (2S,3aS,6aS)-1-((S)-2-((S)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanoyl) octahydrocyclopenta[b]pyrrole-2-carboxylic acid; (2S,3aS,6aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid, 1-ethyl ester; (2S,3aS,6aS)-1-((S)-N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrol-2-carbonsaeure; (2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid; (2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid; (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid (non-preferred name); (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid; (2s,3as,6as)-1((s)-n-((s)-1-carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic; (2s,3as,6as)-1-((s)-2-((s)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanoyl)-octahydrocyclopenta[b]p; (2s,3as,6as)-1-[(s)-2-((s)-1-ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-octahydro-cyclopenta[b]

Indication

Disease Entry	ICD 11	Status	REF
Acute heart failure	BD10-BD13	Approved	[1]
Chronic heart failure	BD1Z	Approved	[2]
Congestive heart failure	BD10	Approved	[3]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[4]
Stroke	8B20	Investigative	[2]

Therapeutic Class

Antihypertensive Agents

Cross-matching ID

PubChem CID: 5362129
ChEBI ID: CHEBI:8774
CAS Number: CAS 87333-19-5
TTD Drug ID: DM2R68E
VARIDT Drug ID: DR00031
INTEDE Drug ID: DR2648
ACDINA Drug ID: D00582

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[15]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[16]
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[17]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[18]
Moexipril	DM26E4B	Hypertension	BA00-BA04	Approved	[19]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[20]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[21]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[22]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[23]
Enalaprilat	DMFYAM1	Congestive heart failure	BD10	Approved	[24]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[10]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[10]
Quinapril	DMR8H31	Chronic heart failure	BD1Z	Approved	[10]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[89]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[90]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[93]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[94]
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Drug(s) Targeting HUMAN angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[6]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[25]
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Drug(s) Transported By Peptide transporter 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[26]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[27]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[28]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[29]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[30]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[31]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[32]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[27]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[29]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[29]
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Drug(s) Transported By Peptide transporter 2 (SLC15A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[26]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[33]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[34]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[35]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[36]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[33]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[37]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[26]
Aminolevulinic acid hci	DMS4BLQ	Acne vulgaris	ED80	Approved	[38]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[7]
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Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[39]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[40]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[41]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[42]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[43]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[44]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[45]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[46]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[47]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[48]
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Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[52]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[52]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[56]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[57]
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Drug(s) Affected By Platelet-derived growth factor subunit A (PDGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[61]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[66]
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Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[67]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[67]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[73]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[71]
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Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[67]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[67]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[67]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
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Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[81]
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[85]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[86]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
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Drug(s) Affected By B2 bradykinin receptor (BDKRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[101]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[102]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin-converting enzyme (ACE)	TTL69WB	ACE_HUMAN	Inhibitor	[5]
HUMAN angiotensin-converting enzyme (ACE)	TTGFNPD	ACE_HUMAN	Inhibitor	[6]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Peptide transporter 2 (SLC15A2)	DT8QKNP	S15A2_HUMAN	Substrate	[7]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[7]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Gene/Protein Processing	[8]
Angiotensin-converting enzyme (ACE)	OTDF1964	ACE_HUMAN	Drug Response	[9]
B2 bradykinin receptor (BDKRB2)	OTOA9D3W	BKRB2_HUMAN	Drug Response	[10]
Leptin (LEP)	OT5Q7ODW	LEP_HUMAN	Gene/Protein Processing	[11]
Liver carboxylesterase 1 (CES1)	OT9L0LR8	EST1_HUMAN	Biotransformations	[12]
Platelet-derived growth factor subunit A (PDGFA)	OTCMZ0W8	PDGFA_HUMAN	Gene/Protein Processing	[13]
Platelet-derived growth factor subunit B (PDGFB)	OTMFMFC3	PDGFB_HUMAN	Gene/Protein Processing	[13]
Renin (REN)	OT52GZR2	RENI_HUMAN	Gene/Protein Processing	[14]

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