Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5I621)

Drug Name
Methyldopa Drug Info
Synonyms
AMD; Aldometil; Aldomin; Alphamethyldopa; Baypresol; Becanta; Dopamet; Dopamethyperpax; Dopatec; Dopegit; Dopegyt; Dopergit; Grospisk; Hyperpax; Hypolag; Medomet; Medopa; Medopal; Medopren; Methoplain; Methyldopum; Metildopa; Novomedopa; Presinol; Presolisin; Sedometil; Sembrina; Alpha medopa; Methyl dopa; Methyldopa anhydrous; Aldoril D30; Aldoril D50; Bayer 1440 L; LT00847269; MK 351; Aldomet (TN); Aldoril (TN); Alpha-Methyl dopa; Alpha-Methyldihydroxyphenylalanine; Alpha-Methyldopa; Apo-Methyldopa; Dopamet (TN); Dopegyt (TN); L-Methyl Dopa; L-Methyldopa; METHYL DOPA (SEE ALSO METHYL DOPA SESQUIHYDRATE); MK-351; Methyldopa (INN); Methyldopa (anhydrous); Methyldopum [INN-Latin]; Metildopa [INN-Spanish]; Mk. b51; Nr.C 2294; Nu-Medopa; Alpha-Methyldopa (VAN); L-alpha-Methyl DOPA; L-alpha-Methyldopa; Methyl-L-dopa; Aldoril, Dopamet, Dopegyt, Methyldopa; L-(alpha-Md); Methyldopa (L,-); Alpha-Methyl-L-3,4-dihydroxyphenylalanine; L-alpha-Methyl-3,4-dihydroxyphenylalanine; L-3-(3,4-Dihydroxyphenyl)-2-methylalanine; Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine; Alpha-Methyl-beta-(3,4-dihydroxyphenyl)-L-alanine; L(-)-beta-(3,4-Dihydroxyphenyl)-alpha-methylalanine; L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic acid; L-(-)-3-(3,4-Dihydroxyphenyl)-2-methylalanine; L-(-)-alpha-Methyl-beta-(3,4-dihydroxyphenyl)alanine; (-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-Alanine Sesqui-Hydrate; (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid; (S)-(-)-alpha-Methyldopa; 3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE; 3-Hydroxy-.alpha.-methyl-L-tyrosine; 3-Hydroxy-alpha-methyl-L-tyrosine
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
38853
ChEBI ID
CHEBI:61058
CAS Number
CAS 555-30-6
TTD Drug ID
DM5I621
VARIDT Drug ID
DR00596
INTEDE Drug ID
DR1051
ACDINA Drug ID
D00417

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Dopamine D2 receptor (D2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [9]
Haloperidol DM96SE0 Delirium Approved [10]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [11]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [12]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [13]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [14]
Quetiapine DM1N62C Anorexia nervosa cachexia 6B80 Approved [15]
Pimozide DMW83TP Schizophrenia 6A20 Approved [16]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [17]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [19]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [26]
Verapamil DMA7PEW Angina pectoris BA40 Approved [27]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [28]
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Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [32]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [33]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [34]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [35]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [36]
Epinephrine DM3KJBC Acute asthma CA23 Approved [37]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [38]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [40]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [41]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [42]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [43]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [44]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [45]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [46]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [47]
Propranolol DM79NTF Angina pectoris BA40 Approved [48]
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Drug(s) Metabolized By Thiopurine methyltransferase (TPMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [50]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [51]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [52]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [53]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [54]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [55]
Epinephrine DM3KJBC Acute asthma CA23 Approved [56]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [57]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [58]
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Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [59]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [60]
Thiotepa DMIZKOP Breast cancer 2C60-2C65 Approved [61]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [62]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [63]
Ethacrynic acid DM60QMR Edema MG29 Approved [64]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
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Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [69]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [71]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [71]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [72]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Selenium DM25CGV N. A. N. A. Approved [75]
Etretinate DM2CZFA Keratosis ED56 Approved [76]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [77]
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Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [69]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [78]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [79]
Ethanol DMDRQZU Chronic pain MG30 Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [82]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [83]
Testosterone enanthate DMB6871 N. A. N. A. Approved [84]
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Drug(s) Affected By Prolactin (PRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [85]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [88]
Methotrexate DM2TEOL Anterior urethra cancer Approved [89]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [90]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [91]
Aripiprazole DM3NUMH Bipolar I disorder Approved [92]
Fluoxetine DM3PD2C Bipolar depression Approved [93]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [94]
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Drug(s) Affected By Catechol O-methyltransferase (COMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [6]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [6]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [6]
Modafinil DMYILBE Malignant glioma 2A00.0 Approved [95]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [6]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [99]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Agonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [3]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [3]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Substrate [4]
Thiopurine methyltransferase (TPMT) DEFQ8VO TPMT_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Biotransformations [6]
Glutathione S-transferase A1 (GSTA1) OTA7K5XA GSTA1_HUMAN Gene/Protein Processing [7]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Gene/Protein Processing [7]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Gene/Protein Processing [7]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Gene/Protein Processing [8]

References

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