Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5X7VY)

Drug Name
Pyrimethamine Drug Info
Synonyms
Chloridin; Chloridine; Chloridyn; Darachlor; Daraclor; Darapram; Daraprim; Daraprime; Daraprin; Diaminopyritamin; Erbaprelina; Ethylpyrimidine; Khloridin; Malacid; Malocid; Malocide; Maloprim; Pirimecidan; Pirimetamin; Pirimetamina; Primethamine; Pyremethamine; Pyrimethamin; Pyrimethaminum; Tindurin; Tindurine; Tinduring; Aventis Brand of Pyrimethamine; Glaxo Wellcome Brand of Pyrimethamine; GlaxoSmithKline Brand of Pyrimethamine; M alocid; Pirimetamina [Spanish]; Pyrimethamine Hcl; Wellcome Brand of Pyrimethamine; BW 5063; RP 4753; WR 2978; AZT + Pyrimethamine combination; BW 50-63; Daraprim (TN); EXR-101; Lactoferrin B & Pyrimethamine; Lactoferrin H & Pyrimethamine; Pirimetamina [INN-Spanish]; Pyrimethamine (Pyr); Pyrimethaminum [INN-Latin]; TCMDC-123831; TCMDC-125860; CRL-8131 & Pyrimethamine; CRL-8142 & Pyrimethamine; Fansidar (Pyrimethamine/Sulfadoxine); Pyrimethamine (JAN/USP/INN); Pyrimethamine [USAN:INN:BAN:JAN]; 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine; 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine; 5-(4'-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine; 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE; 5-(4-CHLOROPHENYL)-6-ETHYL-2,4-PYRIMIDINEDIAMINE; 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidi nediamine; 5-(4-chlorophenyl)-2,4-diamino-6-ethylpyrimidine; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine; 5-(p-chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; 5-[4-Chlorophenyl]-6-ethyl-2,4-pyrimidinediamine
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [1]
Therapeutic Class
Antimalarials
Cross-matching ID
PubChem CID
4993
ChEBI ID
CHEBI:8673
CAS Number
CAS 58-14-0
TTD Drug ID
DM5X7VY
VARIDT Drug ID
DR01272
ACDINA Drug ID
D00573

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Folate receptor alpha (FOLR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mirvetuximab soravtansine DM5S4LX Ovarian cancer 2C73 Approved [12]
EC20 DMLA1ER Ovarian cancer 2C73 Phase 3 [13]
MK-8109 DM84LO5 Ovarian cancer 2C73 Phase 3 [14]
Farletuzumab DMFLWX1 Non-small-cell lung cancer 2C25.Y Phase 3 [15]
EC-145 DM0KVJC Solid tumour/cancer 2A00-2F9Z Phase 2 [16]
FolateImmune DMB9ADM Renal cell carcinoma 2C90 Phase 2 [17]
Talotrexin DM1AB4L Solid tumour/cancer 2A00-2F9Z Phase 1/2 [18]
BMS-753493 DMDQO0S Solid tumour/cancer 2A00-2F9Z Phase 1/2 [19]
EC0489 DM8RD4T Solid tumour/cancer 2A00-2F9Z Phase 1 [20]
IMGN-853 DMR8OG2 Solid tumour/cancer 2A00-2F9Z Phase 1 [21]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [24]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [29]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [30]
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Drug(s) Transported By Multidrug and toxin extrusion protein 1 (SLC47A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [31]
Metformin DM89QE1 Colorectal carcinoma Approved [32]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [31]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [31]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [33]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [31]
Topotecan DMP6G8T Central nervous system neoplasm Approved [31]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [34]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [35]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [36]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [37]
Verapamil DMA7PEW Angina pectoris BA40 Approved [38]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [43]
Quinidine DMLPICK N. A. N. A. Approved [37]
Mebendazole DMO14SG Ascariasis 1F62 Approved [44]
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Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [46]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [8]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [47]
Capsaicin DMGMF6V Back pain ME84.Z Approved [48]
Zafirlukast DMHNQOG Asthma CA23 Approved [49]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [8]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [50]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [47]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [8]
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Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [51]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [52]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [53]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [53]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Selenium DM25CGV N. A. N. A. Approved [57]
Etretinate DM2CZFA Keratosis ED56 Approved [58]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [59]
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Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [63]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Fedratinib DM4ZBK6 Myelofibrosis 2A20.2 Approved [66]
Panobinostat DM58WKG Chronic graft versus host disease Approved [67]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [64]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [68]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Verapamil DMA7PEW Angina pectoris BA40 Approved [71]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [72]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [71]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
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Drug(s) Affected By Beta-hexosaminidase subunit beta (HEXB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [80]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [81]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [82]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [83]
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [84]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [85]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [86]
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Drug(s) Affected By Cathepsin B (CTSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [87]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [88]
Selenium DM25CGV N. A. N. A. Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [92]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [93]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [94]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [96]
Selenium DM25CGV N. A. N. A. Approved [57]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [97]
Etretinate DM2CZFA Keratosis ED56 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [100]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [101]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [102]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
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Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain G (HLA-G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [57]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [11]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [11]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [11]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [105]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [11]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [11]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [11]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [106]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [108]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [109]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [110]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [111]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [112]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [113]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [114]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [115]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [116]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [118]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [6]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Methotrexate DM2TEOL Anterior urethra cancer Approved [119]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [120]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [121]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [102]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [122]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [123]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [125]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [128]
Meloxicam DM2AR7L Arthritis FA20 Approved [129]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [130]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [131]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [132]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [133]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [134]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [135]
Gefitinib DM15F0X Colon adenocarcinoma Approved [136]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [128]
Selenium DM25CGV N. A. N. A. Approved [57]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [130]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
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Drug(s) Affected By Multidrug and toxin extrusion protein 2 (SLC47A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Verapamil DMA7PEW Angina pectoris BA40 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [139]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [140]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [141]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [141]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [41]
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Drug(s) Affected By Proton-coupled folate transporter (SLC46A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [142]
Folic Acid DMEMBJC Colorectal carcinoma Approved [143]
Methotrexate DM2TEOL Anterior urethra cancer Approved [144]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [145]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [146]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [139]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [147]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [148]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Folate receptor alpha (FOLR1) TTVC37M FOLR1_HUMAN Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [3]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Beta-hexosaminidase subunit beta (HEXB) OTROYLCR HEXB_HUMAN Protein Interaction/Cellular Processes [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [6]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [6]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [7]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [7]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Gene/Protein Processing [7]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Gene/Protein Processing [8]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Gene/Protein Processing [9]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Post-Translational Modifications [10]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Gene/Protein Processing [11]

References

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2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity. Drug Metab Dispos. 2018 May;46(5):592-599.
4 Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34.
5 Crystal structure of -hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone. J Med Chem. 2011 Mar 10;54(5):1421-9. doi: 10.1021/jm101443u. Epub 2011 Jan 25.
6 Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicol Sci. 2012 Oct;129(2):346-62. doi: 10.1093/toxsci/kfs208. Epub 2012 Jun 14.
7 Pyrimethamine induces apoptosis of melanoma cells via a caspase and cathepsin double-edged mechanism. Cancer Res. 2008 Jul 1;68(13):5291-300. doi: 10.1158/0008-5472.CAN-08-0222.
8 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
9 Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer. 2002 Feb 10;97(5):700-5.
10 Antifolate activity of pyrimethamine enhances temozolomide-induced cytotoxicity in melanoma cells. Mol Cancer Res. 2009 May;7(5):703-12. doi: 10.1158/1541-7786.MCR-08-0263. Epub 2009 May 12.
11 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
12 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
13 EP patent application no. 2822386, Folate receptor alpha binding ligands.
14 A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer. Drug Des Devel Ther. 2015; 9: 4989-4996.
15 Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer.Gynecol Oncol.2013 Jun;129(3):452-8.
16 Significance of Folate Receptor alpha and Thymidylate Synthase Protein Expression in Patients with Non-Small Cell Lung Cancer treated with Pemetrexed. J Thorac Oncol. 2013 January; 8(1): 19-30.
17 Responsiveness of the Effective Consumer Scale (EC-17). J Rheumatol. 2009 Sep;36(9):2087-91.
18 Cancer chemotherapy: targeting folic acid synthesis. Cancer Manag Res. 2010; 2: 293-301.
19 A phase I pharmacokinetic and safety analysis of epothilone folate (BMS-753493), a folate receptor targeted chemotherapeutic agent in humans with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):321-31.
20 National Cancer Institute Drug Dictionary (drug id 638649).
21 Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. Bioconjug Chem. 2010 Jan;21(1):84-92.
22 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
23 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
24 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
25 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
26 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
27 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
28 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
29 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
30 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
31 Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71.
32 Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol. 2010 Apr;298(4):F997-F1005.
33 Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine. Antimicrob Agents Chemother. 2011 Jul;55(7):3091-8.
34 Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010 Aug;334(2):651-6.
35 Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195.
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