Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6CEVB)

Drug Name
all-trans-retinal Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
638015
ChEBI ID
CHEBI:17898
CAS Number
CAS 116-31-4
TTD Drug ID
DM6CEVB
INTEDE Drug ID
DR2032

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Cyclic nucleotide-gated channel alpha-2 (CNGA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
dequalinium DMXM19W Myelopathy 8B42 Clinical trial [13]
L-(cis)-diltiazem DMK07MI Discovery agent N.A. Investigative [14]
PIP3 DMJX39N Discovery agent N.A. Investigative [15]
Drug(s) Metabolized By Aldehyde dehydrogenase 1 (ALDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Decanal DMWZKLM N. A. N. A. Investigative [3]
Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [16]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [17]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [16]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [18]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [20]
Dolutegravir DMCZGRE Human immunodeficiency virus infection 1C62 Approved [21]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [16]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [22]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [23]
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Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [30]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [31]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [32]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [33]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [35]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [36]
Diazepam DM08E9O Alcohol withdrawal Approved [37]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [38]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [39]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [40]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Selenium DM25CGV N. A. N. A. Approved [49]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Gefitinib DM15F0X Colon adenocarcinoma Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [56]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [57]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [58]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [57]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Etretinate DM2CZFA Keratosis ED56 Approved [65]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [66]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [67]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [68]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [70]
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Drug(s) Affected By Amphiregulin (AREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
Estrone DM5T6US Acne vulgaris ED80 Approved [75]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [76]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [77]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [78]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Selenium DM25CGV N. A. N. A. Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [82]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [83]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [84]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [85]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
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Drug(s) Affected By Probetacellulin (BTC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [10]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [88]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [89]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [92]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [93]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [94]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [95]
Milchsaure DM462BT Pruritus EC90 Investigative [96]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [97]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [79]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [66]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [99]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [100]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [101]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [102]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [103]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [104]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [105]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [106]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [107]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [108]
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Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [110]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [111]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [113]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [117]
Verapamil DMA7PEW Angina pectoris BA40 Approved [46]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Selenium DM25CGV N. A. N. A. Approved [81]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [119]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [120]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [121]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [122]
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Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [123]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [125]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [125]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [31]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [77]
Testosterone DM7HUNW Hot flushes GA30 Approved [127]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [128]
Fructose DM43AN2 Vomiting MD90 Approved [129]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [130]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [131]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [132]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [133]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [134]
Leflunomide DMR8ONJ Arthritis FA20 Approved [135]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [134]
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Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [35]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [137]
Panobinostat DM58WKG Chronic graft versus host disease Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [139]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [77]
Testosterone DM7HUNW Hot flushes GA30 Approved [127]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [127]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [140]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [140]
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Drug(s) Affected By Epidermal retinol dehydrogenase 2 (SDR16C5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [142]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [88]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [143]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [93]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [141]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [95]
Milchsaure DM462BT Pruritus EC90 Investigative [96]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [143]
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Drug(s) Affected By Retinol dehydrogenase 12 (RDH12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [144]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [88]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [146]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [147]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [95]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [144]
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Drug(s) Affected By Retinoid isomerohydrolase (RPE65)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic DMTL2Y1 N. A. N. A. Approved [149]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [150]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [151]
Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [152]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [153]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [154]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [155]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [88]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [156]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [157]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [158]
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Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [159]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [161]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [162]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [31]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [163]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [164]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [165]
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Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [166]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [168]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [165]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [158]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [169]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [165]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [170]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [171]
Diazepam DM08E9O Alcohol withdrawal Approved [172]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [173]
Desogestrel DM27U4Y Contraception QA21 Approved [173]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [171]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [171]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [174]
Quercetin DM3NC4M Obesity 5B81 Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [176]
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Drug(s) Affected By All-trans-retinol dehydrogenase ADH1B (ADH1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [177]
Selenium DM25CGV N. A. N. A. Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [178]
Leflunomide DMR8ONJ Arthritis FA20 Approved [135]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [88]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [179]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [180]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [181]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cyclic nucleotide-gated channel alpha-2 (CNGA2) TT8SJGB CNGA2_HUMAN Inhibitor (gating inhibitor) [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Aldehyde dehydrogenase 1 (ALDH1) Main DME DE2JP1Y AL1A1_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [4]
Aldehyde dehydrogenase, mitochondrial (ALDH2) OTKJ9I3N ALDH2_HUMAN Regulation of Drug Effects [5]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Biotransformations [6]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Regulation of Drug Effects [7]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Biotransformations [8]
All-trans-retinol dehydrogenase ADH1B (ADH1B) OTV3TB81 ADH1B_HUMAN Regulation of Drug Effects [9]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Gene/Protein Processing [10]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [11]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Gene/Protein Processing [11]
Cytochrome P450 26A1 (CYP26A1) OTL1DFWV CP26A_HUMAN Gene/Protein Processing [12]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2350).
2 All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8372-7.
3 Retinoic acid biosynthesis catalyzed by retinal dehydrogenases relies on a rate-limiting conformational transition associated with substrate recognition. Chem Biol Interact. 2013 Feb 25;202(1-3):78-84.
4 Interactions of human serum albumin with retinoic acid, retinal and retinyl acetate. Biochem Pharmacol. 2007 Mar 15;73(6):901-10. doi: 10.1016/j.bcp.2006.11.023. Epub 2006 Dec 2.
5 Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver. Drug Metab Dispos. 2002 Jan;30(1):69-73. doi: 10.1124/dmd.30.1.69.
6 Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels. Chem Biol Interact. 2009 Mar 16;178(1-3):171-7. doi: 10.1016/j.cbi.2008.10.027. Epub 2008 Oct 25.
7 Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde. Chem Biol Interact. 2011 May 30;191(1-3):199-205. doi: 10.1016/j.cbi.2011.02.007. Epub 2011 Feb 15.
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