Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB4AVP)

Drug Name
Pamidronate Drug Info
Synonyms
AHPrBP; Amidronate; Aminomux; Aminopropanehydroxydiphosphonate; Aredia; Ribodroat; Acide pamidronique; Acido pamidronico; Acidum pamidronicum; Aminohydroxypropylidene diphosphonate; Novartis brand of pamidronate disodium salt; PAMIDRONATE DISODIUM; PAMIDRONIC ACID; Pamidronate calcium; Pamidronate monosodium; Bisphosphonate 6; Acide pamidronique [INN-French]; Acido pamidronico [INN-Spanish]; Acidum pamidronicum [INN-Latin]; Pamidronic acid (INN); Pamidronic acid [INN:BAN]; Ribodroat (TN); Amino-1-hydroxypropane-1,1-diphosphonate; (3-AMINO-1-HYDROXY-1-PHOSPHONO-PROPYL)PHOSPHONIC ACID; (3-Amino-1-hydroxypropylidene)bisphosphonic acid; (3-Amino-1-hydroxypropylidene)diphosphonic acid; (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid; (3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid); (3-amino-1-hydroxypropylidene)-1,1-biphosphonate; (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate; 1-hydroxy-3-aminopropane-1,1-diphosphonic acid; 3-Amino-1-hydroxypropylidene-1,1-diphosphonate
Indication
Disease Entry ICD 11 Status REF
Bone Paget disease Approved [1]
Hypercalcaemia 5B91.0 Approved [2]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
4674
ChEBI ID
CHEBI:7903
CAS Number
CAS 40391-99-9
TTD Drug ID
DMB4AVP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Geranyltranstransferase (FDPS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [10]
Minodronate DM50PMY Osteoporosis FB83.0 Approved [11]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [10]
Alendronate DMY2KX9 Bone Paget disease Approved [10]
Incadronate DM3DSVJ Hypercalcaemia 5B91.0 Approved [12]
Risedronate DM5FLTY Bone Paget disease Approved [13]
NERIDRONIC ACID DMMPG5V Bone disease FC0Z Approved [14]
Zarnestra DMF30HL Acute myeloid leukaemia 2A60 Phase 3 [15]
GERANYLGERANYL DIPHOSPHATE DMJZ0AM Discovery agent N.A. Investigative [16]
ISOPENTENYL PYROPHOSPHATE DMTU05Y Discovery agent N.A. Investigative [16]
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Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [17]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [18]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [21]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [22]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [23]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [24]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [25]
Testosterone DM7HUNW Hot flushes GA30 Approved [26]
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Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [27]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [32]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [33]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [36]
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Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [17]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [41]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [32]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [33]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [42]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [43]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [46]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [47]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [50]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
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Drug(s) Affected By Beta-2-microglobulin (B2M)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [56]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [59]
Folic Acid DMEMBJC Colorectal carcinoma Approved [60]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [61]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Panobinostat DM58WKG Chronic graft versus host disease Approved [70]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [71]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [72]
Fructose DM43AN2 Vomiting MD90 Approved [17]
Ketoprofen DMRKXPT Bursitis Approved [17]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [74]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [75]
Gefitinib DM15F0X Colon adenocarcinoma Approved [76]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
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Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [17]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Diazepam DM08E9O Alcohol withdrawal Approved [78]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [81]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Gefitinib DM15F0X Colon adenocarcinoma Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [87]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [88]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [89]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [88]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [90]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [93]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [94]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [95]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [96]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [17]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [97]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [98]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [74]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [99]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [100]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [101]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [102]
Paclitaxel DMLB81S Breast carcinoma Approved [103]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [104]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [105]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [17]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [74]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [106]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [108]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [109]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [110]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [111]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [112]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [113]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [114]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [115]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [116]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [117]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [118]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [98]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [87]
Meloxicam DM2AR7L Arthritis FA20 Approved [121]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [122]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [123]
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Drug(s) Affected By Transforming protein RhoA (RHOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [125]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [129]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [130]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
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Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [132]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [133]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [136]
Minodronate DM50PMY Osteoporosis FB83.0 Approved [137]
Risedronate DM5FLTY Bone Paget disease Approved [138]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [139]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
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Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Testosterone DM7HUNW Hot flushes GA30 Approved [26]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [59]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [146]
Paclitaxel DMLB81S Breast carcinoma Approved [147]
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Drug(s) Affected By Fibroblast growth factor 23 (FGF23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [148]
Arsenic DMTL2Y1 N. A. N. A. Approved [149]
Phosphate DMUXQG7 Constipation DD91.1 Approved [150]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [148]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [151]
Glycerol-2-Phosphate DM0J5KF Discovery agent N.A. Investigative [150]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [152]
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Drug(s) Affected By Bcl-2-interacting killer (BIK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [155]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [156]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [157]
Leflunomide DMR8ONJ Arthritis FA20 Approved [158]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [159]
Clozapine DMFC71L Schizophrenia 6A20 Approved [160]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Geranyltranstransferase (FDPS) TTIKWV4 FPPS_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) OTG7J4BP PPBT_HUMAN Gene/Protein Processing [4]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [5]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Drug Response [6]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Gene/Protein Processing [4]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [7]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [7]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Gene/Protein Processing [8]
Fibroblast growth factor 23 (FGF23) OTZT523D FGF23_HUMAN Gene/Protein Processing [9]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [4]

References

1 Pamidronate FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7259).
3 Detection of nonsterol isoprenoids by HPLC-MS/MS. Anal Biochem. 2008 Dec 1;383(1):18-24.
4 Pamidronate increases markers of bone formation in patients with multiple myeloma in plateau phase under interferon-alpha treatment. Calcif Tissue Int. 2001 May;68(5):285-90.
5 Bisphosphonates induce apoptosis in human breast cancer cell lines. Br J Cancer. 2000 Apr;82(8):1459-68. doi: 10.1054/bjoc.1999.1131.
6 Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik. Oncogene. 2005 Nov 10;24(49):7369-80. doi: 10.1038/sj.onc.1208890.
7 Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma. J Hepatol. 2006 Jan;44(1):142-50. doi: 10.1016/j.jhep.2005.09.022. Epub 2005 Nov 9.
8 Expression profile and synthesis of different collagen types I, II, III, and V of human gingival fibroblasts, osteoblasts, and SaOS-2 cells after bisphosphonate treatment. Clin Oral Investig. 2010 Feb;14(1):51-8. doi: 10.1007/s00784-009-0312-2. Epub 2009 Jul 14.
9 The role of fibroblast growth factor 23 for hypophosphatemia and abnormal regulation of vitamin D metabolism in patients with McCune-Albright syndrome. J Bone Miner Metab. 2005;23(3):231-7. doi: 10.1007/s00774-004-0589-9.
10 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
11 Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem. 2010 May 13;53(9):3454-64.
12 Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42.
13 Activity of bisphosphonates against Trypanosoma brucei rhodesiense. J Med Chem. 2002 Jul 4;45(14):2904-14.
14 Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95.
15 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
16 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
17 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
18 C-Reactive protein levels over time and cardiovascular risk in HIV-infected individuals suppressed on an indinavir-based regimen: AIDS Clinical Trials Group 5056s. AIDS. 2004 Dec 3;18(18):2434-7.
19 Simvastatin combined with ramipril treatment in hypercholesterolemic patients. Hypertension. 2004 Aug;44(2):180-5. doi: 10.1161/01.HYP.0000133310.42762.25. Epub 2004 Jun 7.
20 The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007 Feb 28;557(2-3):221-9.
21 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
22 Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Sci Immunol. 2020 Jun 5;5(48):eabd0110. doi: 10.1126/sciimmunol.abd0110. Epub 2020 Jun 5.
23 The influence of alclofenac treatment on acute-phase proteins, plasma tryptophan, and erythrocyte sedimentation rate in patients with rheumatoid arthritis. Curr Med Res Opin. 1975;3(5):286-97. doi: 10.1185/03007997509114779.
24 Intractable insomnia after cessation of treatment with thalidomide. Gastroenterology. 2001 May;120(6):1567-8. doi: 10.1053/gast.2001.24495.
25 Effects of hormone treatment on hemostasis variables. Climacteric. 2007 Oct;10 Suppl 2:32-7. doi: 10.1080/13697130701598548.
26 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
27 20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines. Anticancer Res. 1999 May-Jun;19(3A):1689-97.
28 Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK. Environ Toxicol. 2020 Dec;35(12):1318-1325. doi: 10.1002/tox.22996. Epub 2020 Jul 13.
29 Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
30 The effect of simvastatin on the proliferation and differentiation of human bone marrow stromal cells. J Korean Med Sci. 2005 Jun;20(3):438-44. doi: 10.3346/jkms.2005.20.3.438.
31 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
32 Glucosamine promotes osteogenic differentiation of dental pulp stem cells through modulating the level of the transforming growth factor-beta type I receptor. J Cell Physiol. 2010 Oct;225(1):140-51.
33 A highly potent 26,27-Hexafluoro-1a,25-dihydroxyvitamin D3 on calcification in SV40-transformed human fetal osteoblastic cells. Calcif Tissue Int. 2002 Jun;70(6):488-95.
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