Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD4BFY)

• Drug Name: SPERMINE Drug Info
• Synonyms: spermine; 71-44-3; neuridine; musculamine; gerontine; Spermin; 4,9-Diaza-1,12-dodecanediamine; Diaminopropyltetramethylenediamine; N,N'-Bis(3-aminopropyl)-1,4-butanediamine; Spermine, puriss; N,N'-Bis(3-aminopropyl)butane-1,4-diamine; 1,4-Butanediamine, N,N'-bis(3-aminopropyl)-; 1,4-Bis(aminopropyl)butanediamine; 4,9-Diazadodecamethylenediamine; 4,9-Diazadodecane-1,12-diamine; N1,N1'-(Butane-1,4-diyl)bis(propane-1,3-diamine); UNII-2FZ7Y3VOQX; 1,4-Bis(aminopropyl) butanediamine; Spermine Derivative; 1,4-Diaminobutane, N,N'-bis
• Cross-matching ID:
  PubChem CID: 1103
  ChEBI ID: CHEBI:15746
  CAS Number: CAS 71-44-3
  TTD Drug ID: DMD4BFY
  VARIDT Drug ID: DR01249
  INTEDE Drug ID: DR1505

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase VI (CA-VI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[11]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[12]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[14]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
SAR566658	DM6Q295	Solid tumour/cancer	2A00-2F9Z	Phase 2	[16]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[14]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[14]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[17]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2A (NMDAR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[18]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[19]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[20]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[21]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[22]
DIZOCILPINE	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[23]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[24]
L-698532	DMO9HM7	Neurological disorder	6B60	Terminated	[25]
L-695902	DMT1DNS	N. A.	N. A.	Terminated	[22]
L-701324	DMAIJSX	Cerebrovascular ischaemia	8B1Z	Terminated	[25]

Drug(s) Targeting Carbonic anhydrase XIV (CA-XIV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[26]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[1]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[14]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[13]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[14]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[14]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[17]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[13]

Drug(s) Targeting Carbonic anhydrase (CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[27]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[12]
Quinethazone	DMWCOSR	Hypertension	BA00-BA04	Approved	[28]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[14]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[13]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[29]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[14]
PMID30074415-Compound-21	DM3NPOU	N. A.	N. A.	Patented	[30]

Drug(s) Targeting Carbonic anhydrase IV (CA-IV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[11]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[31]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[32]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[14]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[13]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
Sodium pyruvate	DMST6A3	Asthma	CA23	Phase 1/2	[33]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[29]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[14]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 1 (NMDAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[34]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[35]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[36]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[19]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[20]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[37]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[22]
DIZOCILPINE	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[23]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[24]
L-698532	DMO9HM7	Neurological disorder	6B60	Terminated	[25]

Drug(s) Targeting Carbonic anhydrase IX (CA-IX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[13]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[14]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[13]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[15]
INDISULAM	DM9SX6Y	Lymphoma	2A80-2A86	Phase 2	[38]
Girentuximab I-124	DMG3O2Z	Renal cell carcinoma	2C90	Phase 2	[39]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[40]
BAY 79-4620	DM14XQN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[41]
90Y-cG250	DMJR6TC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[14]

Drug(s) Transported By MFS-type transporter SLC18B1 (SLC18B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spermidine	DMVJNFI	Plaque psoriasis	EA90.0	Phase 3	[3]

Drug(s) Metabolized By Putrescine acetyltransferase (SSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spermidine	DMVJNFI	Plaque psoriasis	EA90.0	Phase 3	[43]
N1-(2-aminoethyl)ethane-1,2-diamine	DM6HM5S	Discovery agent	N.A.	Investigative	[4]
Ethylene diamine	DMBULX4	Tuberculosis	1B10-1B1Z	Investigative	[4]
Propandiamine	DMQ9USH	N. A.	N. A.	Investigative	[4]

Drug(s) Affected By Spermine oxidase (SMOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[44]
Selenium	DM25CGV	N. A.	N. A.	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[44]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Mestranol	DMG3F94	Contraception	QA21	Approved	[44]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Indomethacin	DMSC4A7	Bursitis		Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[59]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[60]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[67]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[68]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[65]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[69]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[70]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[71]
Terbutaline	DMD4381	Asthma	CA23	Approved	[72]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[73]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[78]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[79]

Drug(s) Affected By Beta-1 adrenergic receptor (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[80]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[83]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[84]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[85]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[87]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[90]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[93]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[94]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[95]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[99]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[106]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[1]
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]
Carbonic anhydrase VI (CA-VI)	TTCFSPE	CAH6_HUMAN	Inhibitor	[1]
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[1]
Glutamate receptor ionotropic NMDA 1 (NMDAR1)	TTLD29N	NMDZ1_HUMAN	Inhibitor	[2]
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	TTKJEMQ	NMDE1_HUMAN	Inhibitor	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
MFS-type transporter SLC18B1 (SLC18B1)	DTOFXP5	S18B1_HUMAN	Substrate	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Putrescine acetyltransferase (SSAT1)	DEMWO83	SAT1_HUMAN	Substrate	[4]
Spermine oxidase (SMOX)	DEOH5V3	SMOX_HUMAN	Substrate	[5]
Polyamine oxidase (PAOX)	DEW7V0G	PAOX_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[7]
Beta-1 adrenergic receptor (ADRB1)	OTQBWN4U	ADRB1_HUMAN	Protein Interaction/Cellular Processes	[8]
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Protein Interaction/Cellular Processes	[8]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Protein Interaction/Cellular Processes	[7]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Gene/Protein Processing	[9]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Gene/Protein Processing	[9]
Spermine oxidase (SMOX)	OT11E62Y	SMOX_HUMAN	Biotransformations	[10]

References

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