Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR87LC)

Drug Name
Ethambutol Drug Info
Synonyms
Aethambutolum; Diambutol; EMB; Etambutol; Etambutolo; Ethambutolum; Etibi; Miambutol; Myambutol; Purderal; Servambutol; Tibutol; Etambutolo [DCIT]; CL 40881 (dihydrochloride); D-Ethambutol; Etambutol [INN-Spanish]; Ethambutol & EEP; Ethambutol & Propolis; Ethambutol (INN); Ethambutol [INN:BAN]; Ethambutol, meso form; Ethambutol, racemic mixture; Ethambutolum [INN-Latin]; Myambutol (TN); Myambutol (dihydrochloride); Servambutol (TN); Ethambutol, (-)-isomer; D,N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine; D-N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine; D-2,2'-(Ethylenediimino)bis(1-butanol); D-2,2'-(Ethylenediimino)di-1-butanol; (+)-(S,S)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (+)-2,2'-(Ethylenediimino)di-1-butanol; (+)-N,N'-Bis(1-(hydroxymethyl)propyl)ethylenediamine; (+)-S,S-Ethambutol; (+)-ethambutol; (-)-(R,R)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (2'S)-2,2'-[Ethane-1,2-diyldi(imino)]dibutan-1-ol; (2R)-2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol; (2R)-2-[2-[[(2R)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol; (2S)-2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol; (2S)-2-[2-[[(2R)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol; (2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol; (2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol; (R)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol; (S,R)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (S,S)-ethambutol; 2,2'-(1,2-Ethylenediimino)-di-1-butanol; 2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol; 2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol
Indication
Disease Entry ICD 11 Status REF
Pulmonary tuberculosis 1B10.Z Approved [1]
Therapeutic Class
Antitubercular Agents
Cross-matching ID
PubChem CID
14052
ChEBI ID
CHEBI:4877
CAS Number
CAS 74-55-5
TTD Drug ID
DMR87LC
ACDINA Drug ID
D00252

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [7]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [7]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [7]
Capsaicin DMGMF6V Back pain ME84.Z Approved [8]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [9]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [10]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [11]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [12]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [13]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [14]
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Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fomepizole DM6VOWQ Athylene glycol or methanol poisoning NE61 Approved [15]
Ademetionine DMYQDBO Hepatic fibrosis DB93.0 Approved [16]
Theophylline DMRJFN9 Bronchitis CA20 Approved [14]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [17]
Ethanol DMDRQZU Chronic pain MG30 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [14]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [22]
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Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [24]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [25]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [27]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [28]
Capsaicin DMGMF6V Back pain ME84.Z Approved [8]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [29]
Quinidine DMLPICK N. A. N. A. Approved [30]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [31]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [32]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [22]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [33]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [34]
Capsaicin DMGMF6V Back pain ME84.Z Approved [8]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [29]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [10]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [29]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [22]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [14]
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Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [3]
Diazepam DM08E9O Alcohol withdrawal Approved [3]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Selenium DM25CGV N. A. N. A. Approved [36]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [3]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [3]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [3]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [3]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [3]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [3]
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Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [37]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [38]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [39]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [42]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [45]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [6]
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Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [4]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [47]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [4]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [51]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [52]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [53]
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Drug(s) Affected By Granzyme B (GZMB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [6]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [58]
Menthol DMG2KW7 Back pain ME84.Z Approved [59]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [60]
Bortezomib DMNO38U Leukemia Approved [61]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [62]
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [14]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [63]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [64]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [67]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [68]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [71]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
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Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [4]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [4]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [73]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [74]
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Drug(s) Affected By Interleukin-13 (IL13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Prednisone DM2HG4X Acute asthma CA23 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [6]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [80]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [78]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [81]
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Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [4]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [4]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [4]
Amikacin DM5PDRB Bacteremia 1A73 Approved [4]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [4]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [4]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
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Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [83]
Diazepam DM08E9O Alcohol withdrawal Approved [3]
Dantrolene DM1D8XY Hyperthermia MG26 Approved [3]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [3]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [3]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [3]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [3]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [3]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [3]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [3]
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Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [4]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [4]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [86]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Fluoxetine DM3PD2C Bipolar depression Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mycobacterium Arabinosyltransferase C (MycB embC) TT1Q8GP EMBC_MYCTU Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Gene/Protein Processing [3]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [4]
Bone morphogenetic protein 6 (BMP6) OT9WN536 BMP6_HUMAN Gene/Protein Processing [4]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Gene/Protein Processing [4]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [5]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [5]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Gene/Protein Processing [5]
Cytochrome P450 2E1 (CYP2E1) OTHQ17JG CP2E1_HUMAN Gene/Protein Processing [5]
Granzyme B (GZMB) OTPPVIRS GRAB_HUMAN Protein Interaction/Cellular Processes [6]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [4]

References

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