Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM43Z1G)

• Drug Name: PMID26394986-Compound-22 Drug Info
• Cross-matching ID:
  PubChem CID: 2662
  ChEBI ID: CHEMBL41423
  CAS Number: CAS 169590-42-5
  TTD Drug ID: DM43Z1G
  ACDINA Drug ID: D00113

Molecule-Related Drug Atlas

Drug(s) Targeting Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[11]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[12]
Golotimod	DMKZN3A	Immune System disease	4A01-4B41	Phase 2	[13]
NT219	DMOYS1N	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[14]
WP-1066	DMUGHWR	Recurrent glioblastoma	2A00.00	Phase 1/2	[12]
Atiprimod	DM84YEC	Multiple myeloma	2A83	Phase 1/2	[15]
OPB-31121	DM6VGO3	Hepatocellular carcinoma	2C12.02	Phase 1/2	[16]
IMX-110	DMNHZS4	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[12]
GLG-801	DMY1CP9	Chronic lymphocytic leukaemia	2A82.0	Phase 1/2	[12]
OPB-51602	DM760FA	Solid tumour/cancer	2A00-2F9Z	Phase 1	[17]

Drug(s) Affected By Desmin (DES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[23]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[24]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[25]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[28]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[29]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[30]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[31]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[36]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[38]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[45]

Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[46]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[38]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[55]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[58]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[63]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[67]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[68]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[74]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[75]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[77]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[78]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[88]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[90]

Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[92]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[94]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[97]

Drug(s) Affected By Prostaglandin-H2 D-isomerase (PTGDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[101]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[103]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[104]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[109]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[112]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[122]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[124]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[125]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[127]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[128]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[133]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[134]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[135]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[138]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[146]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[147]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[149]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[152]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[153]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[153]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[154]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[152]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[153]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[155]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[152]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[156]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[152]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[162]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[163]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[164]

Drug(s) Affected By C-reactive protein (CRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[30]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[165]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Acalabrutinib	DM7GCVW	leukaemia	2A60-2B33	Approved	[168]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[169]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[170]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[171]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[172]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[173]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[175]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[68]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[180]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 16 (NGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[122]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[184]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[184]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Oxaprozin	DM9UB0P	Osteoarthritis	FA00-FA05	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[186]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[187]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[188]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[189]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[190]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[191]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[192]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[193]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[194]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[192]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[107]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[35]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[195]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[198]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[133]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[201]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[202]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[201]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[203]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[206]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[207]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[209]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[210]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[214]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[212]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[215]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[216]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[220]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[223]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[122]

Drug(s) Affected By Transcription factor EB (TFEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[224]
Prochlorperazine	DM53SRA	Nausea	MD90	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[229]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[231]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[233]
Fructose	DM43AN2	Vomiting	MD90	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[195]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[235]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[72]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[236]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[237]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[238]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[30]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[74]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[75]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[180]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[240]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[244]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[63]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[125]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[246]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[247]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[241]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[249]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[250]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[131]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[134]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[251]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[202]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[123]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[252]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[253]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[254]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[256]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[257]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[259]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[260]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[261]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[262]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[263]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[264]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[265]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[268]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[269]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[272]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[273]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[274]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[276]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[280]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[281]

Drug(s) Affected By Podoplanin (PDPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[282]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[283]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[104]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[122]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[122]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[284]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[285]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[133]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[287]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[288]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[289]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[290]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[293]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[294]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[295]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[198]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[296]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[297]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By FAS-associated death domain protein (FADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[298]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[59]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[302]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[113]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[303]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[287]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[304]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[305]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[306]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[196]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Signal transducer and activator of transcription 3 (STAT3)	TTH8FZW	STAT3_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[2]
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Gene/Protein Processing	[3]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Gene/Protein Processing	[3]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[4]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[5]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[6]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[7]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[8]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Protein Interaction/Cellular Processes	[9]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[10]

References

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• [4] COX-2 inhibitors block chemotherapeutic agent-induced apoptosis prior to commitment in hematopoietic cancer cells. Biochem Pharmacol. 2011 Nov 15;82(10):1277-90. doi: 10.1016/j.bcp.2011.06.028. Epub 2011 Jun 24.
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• [6] Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts. Toxicology. 2009 Apr 28;258(2-3):148-56. doi: 10.1016/j.tox.2009.01.016. Epub 2009 Jan 22.
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• [8] Failure of apoptosis and activation on NFkappaB by celecoxib and aspirin in lung cancer cell lines. Oncol Rep. 2007 Apr;17(4):823-8.
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• [17] Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies. Ann Oncol. 2015 May;26(5):998-1005.
• [18] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [19] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [20] Increased matrix proteins, collagen and transforming growth factor are early markers of hepatotoxicity in patients on long-term methotrexate therapy. J Toxicol Clin Toxicol. 1996;34(3):301-5. doi: 10.3109/15563659609013794.
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