Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM79F6G)

Drug Name
Adenosine triphosphate Drug Info
Synonyms
Adenylpyrophosphate; Triphosadenine; Triphosadenine (DCF); Adenosine 5'-triphosphate(4-); [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate; [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate; [[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid; 3b2q; 5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-ylmethoxy-hydroxy-phosphoryloxy-hydroxy-phosphoryl oxyphosphonic acid; 9H-purin-6-amine, 9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]
Indication
Disease Entry ICD 11 Status REF
Malnutrition 5B50-5B71 Approved [1]
Heart disease BA41-BA42 Phase 2 [2]
Bradycardia MC81.1 Discontinued in Phase 2 [3]
Therapeutic Class
Dietary supplement
Cross-matching ID
PubChem CID
5957
ChEBI ID
CHEMBL14249
CAS Number
CAS 56-65-5
TTD Drug ID
DM79F6G

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Tyrosine-protein kinase ABL1 (ABL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ponatinib DMYGJQO Acute lymphoblastic leukaemia 2A85 Approved [14]
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [15]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [16]
Saracatinib DMBLHGP Hematologic tumour 2B33.Y Phase 2 [17]
Flumatinib DM0G5O6 Chronic myelogenous leukaemia 2A20.0 Phase 2 [18]
DCC-2036 DMJKFNU Chronic myeloid leukaemia 2A20 Phase 1/2 [19]
ISIS-CRP DMQDUG4 Cardiovascular disease BA00-BE2Z Phase 1 [20]
KW-2449 DMFO7RP Acute myeloid leukaemia 2A60 Phase 1 [21]
IkT-148009 DMMJ9HY Parkinson disease 8A00.0 Phase 1 [22]
PMID27774824-Compound-Figure9Example2down DMXAV42 N. A. N. A. Patented [23]
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Drug(s) Affected By ATP-binding cassette sub-family C member 6 (ABCC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzbromarone DMC3YUA Gout FA25 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [28]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [26]
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Drug(s) Affected By Casein kinase II subunit beta (CSNK2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [36]
Capsaicin DMGMF6V Back pain ME84.Z Approved [37]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [38]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [32]
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Drug(s) Affected By Casein kinase II subunit alpha (CSNK2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [36]
Capsaicin DMGMF6V Back pain ME84.Z Approved [37]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [43]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [44]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [45]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [46]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [49]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [51]
Gefitinib DM15F0X Colon adenocarcinoma Approved [52]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [55]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [46]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [56]
Paclitaxel DMLB81S Breast carcinoma Approved [57]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [58]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [45]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [48]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [49]
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Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Selenium DM25CGV N. A. N. A. Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [63]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [69]
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Drug(s) Affected By Protein S100-A6 (S100A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Selenium DM25CGV N. A. N. A. Approved [32]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Panobinostat DM58WKG Chronic graft versus host disease Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [36]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [76]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [77]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
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Drug(s) Affected By Protein S100-P (S100P)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [83]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [84]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [88]
Estrone DM5T6US Acne vulgaris ED80 Approved [89]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [90]
Testosterone DM7HUNW Hot flushes GA30 Approved [91]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [91]
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Drug(s) Affected By Protein S100-A4 (S100A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [93]
Panobinostat DM58WKG Chronic graft versus host disease Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [94]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [97]
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Drug(s) Affected By Protein S100-A11 (S100A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Panobinostat DM58WKG Chronic graft versus host disease Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [98]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
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Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [102]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [103]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [36]
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Drug(s) Affected By Protein S100-A10 (S100A10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Panobinostat DM58WKG Chronic graft versus host disease Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Testosterone DM7HUNW Hot flushes GA30 Approved [91]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [36]
Folic Acid DMEMBJC Colorectal carcinoma Approved [106]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [38]
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Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (ENPP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [107]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [108]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [109]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [110]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [111]
lysophosphatidylcholine DMOGFVH Discovery agent N.A. Investigative [112]
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Drug(s) Affected By Pannexin-1 (PANX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Leflunomide DMR8ONJ Arthritis FA20 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [114]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [43]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [115]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [116]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [114]
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Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [119]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [108]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [43]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
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Drug(s) Affected By ATP-sensitive inward rectifier potassium channel 15 (KCNJ15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [122]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [93]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [90]
Testosterone DM7HUNW Hot flushes GA30 Approved [123]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [102]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [43]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [124]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [125]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [111]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [126]
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Drug(s) Affected By Rho-related GTP-binding protein RhoF (RHOF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [25]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [129]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [73]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [130]
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Drug(s) Affected By Brain mitochondrial carrier protein 1 (SLC25A14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [113]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [114]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [12]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [132]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [133]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [111]
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Drug(s) Affected By Kinesin heavy chain isoform 5A (KIF5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [134]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [135]
Urethane DM7NSI0 N. A. N. A. Phase 4 [136]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [111]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [137]
Lithium chloride DMHYLQ2 Discovery agent N.A. Investigative [138]
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Drug(s) Affected By Pro-neuropeptide Y (NPY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mifepristone DMGZQEF Cushing disease 5A70 Approved [59]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Panobinostat DM58WKG Chronic graft versus host disease Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [139]
Guanethidine DM9NSWT Moderate and severe hypertension BA00.Z Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [141]
Orlistat DMRJSP8 Obesity 5B81 Approved [142]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [143]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [144]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [145]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [146]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [147]
Cepharanthine DM9Y5JB N. A. N. A. Approved [148]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [149]
Clozapine DMFC71L Schizophrenia 6A20 Approved [150]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [151]
Trifluoperazine DMKBYWI Anxiety Approved [152]
Olanzapine DMPFN6Y Bipolar depression Approved [150]
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Drug(s) Affected By Potassium voltage-gated channel subfamily D member 2 (KCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [73]
Testosterone DM7HUNW Hot flushes GA30 Approved [91]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [153]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [154]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [155]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [155]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [156]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [73]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Gefitinib DM15F0X Colon adenocarcinoma Approved [158]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [159]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [160]
Etretinate DM2CZFA Keratosis ED56 Approved [161]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [41]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [162]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [163]
Quercetin DM3NC4M Obesity 5B81 Approved [164]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [165]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [166]
Fructose DM43AN2 Vomiting MD90 Approved [167]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [168]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [169]
Testosterone DM7HUNW Hot flushes GA30 Approved [91]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [91]
Haloperidol DM96SE0 Delirium Approved [170]
Leflunomide DMR8ONJ Arthritis FA20 Approved [113]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [171]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [172]
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Drug(s) Affected By Prothrombin (F2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [173]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [174]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [175]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [176]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [177]
Phytonadione DM8HDOL Bleeding disorder GA20-GA21 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Testosterone enanthate DMB6871 N. A. N. A. Approved [179]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [180]
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Drug(s) Affected By Cytochrome c oxidase subunit 3 (COX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [181]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [182]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [36]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [183]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [184]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [185]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [186]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [187]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [188]
Quercetin DM3NC4M Obesity 5B81 Approved [189]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [190]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [191]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [192]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [193]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-synuclein (SNCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Testosterone enanthate DMB6871 N. A. N. A. Approved [196]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [197]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [36]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [198]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [38]
Bortezomib DMNO38U Leukemia Approved [199]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [200]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase HCK (HCK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [98]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [96]
Testosterone enanthate DMB6871 N. A. N. A. Approved [196]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [201]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [202]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [128]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [118]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [203]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [203]
Gefitinib DM15F0X Colon adenocarcinoma Approved [204]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [59]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [205]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [206]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [189]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [208]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tyrosine-protein kinase ABL1 (ABL) TT3PJMV ABL1_HUMAN Inhibitor [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Regulation of Drug Effects [5]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Protein Interaction/Cellular Processes [6]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Biotransformations [7]
ATP-binding cassette sub-family C member 6 (ABCC6) OTZT0LKT MRP6_HUMAN Protein Interaction/Cellular Processes [8]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Biotransformations [9]
ATP-sensitive inward rectifier potassium channel 15 (KCNJ15) OTZT6EQB KCJ15_HUMAN Gene/Protein Processing [10]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Regulation of Drug Effects [11]
Brain mitochondrial carrier protein 1 (SLC25A14) OT1ZQSKS UCP5_HUMAN Biotransformations [12]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Biotransformations [9]
Casein kinase II subunit alpha (CSNK2A1) OT9T8WQM CSK21_HUMAN Protein Interaction/Cellular Processes [13]

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113 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
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