Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMME8LH)

Drug Name
Alitretinoin Drug Info
Indication
Disease Entry ICD 11 Status REF
Kaposi sarcoma 2B57 Approved [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
449171
ChEBI ID
CHEBI:50648
CAS Number
CAS 5300-03-8
TTD Drug ID
DMME8LH
VARIDT Drug ID
DR00315
INTEDE Drug ID
DR2501

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Retinoic acid receptor RXR-alpha (RXRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [10]
2-chloro-5-nitro-N-phenylbenzamide DMUGQIV Discovery agent N.A. Investigative [11]
AGN-34 DM5ECDM Discovery agent N.A. Investigative [12]
LG100754 DMEK4FY Discovery agent N.A. Investigative [13]
(5BETA)-PREGNANE-3,20-DIONE DMVQ6RN Discovery agent N.A. Investigative [11]
phytanic acid DMSZ1RB Discovery agent N.A. Investigative [14]
CD3254 DM38MU1 Discovery agent N.A. Investigative [15]
UVI3003 DM95UI1 Discovery agent N.A. Investigative [16]
Tributylstannanyl DMHN7CB Discovery agent N.A. Investigative [11]
methoprene acid DM58A0W Discovery agent N.A. Investigative [17]
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Drug(s) Targeting Retinoic acid receptor RXR-gamma (RXRG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [18]
NRX-4204 DMYXOU2 Diabetic complication 5A2Y Phase 2 [19]
IRX4204 DM9SCME Breast cancer 2C60-2C65 Phase 1 [20]
9cUAB-30 DMYKPXJ Solid tumour/cancer 2A00-2F9Z Phase 1 [21]
SR-11237 DMQG3CK Solid tumour/cancer 2A00-2F9Z Terminated [22]
AGN-34 DM5ECDM Discovery agent N.A. Investigative [12]
LG100754 DMEK4FY Discovery agent N.A. Investigative [23]
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Drug(s) Targeting Retinoic acid receptor RXR-beta (RXRB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AGN-34 DM5ECDM Discovery agent N.A. Investigative [12]
LG100754 DMEK4FY Discovery agent N.A. Investigative [23]
Drug(s) Targeting Retinoic acid receptor beta (RARB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [24]
PMID27336223-Compound-10 DMYUP6G N. A. N. A. Patented [25]
PMID27336223-Compound-8 DM460D1 N. A. N. A. Patented [25]
PMID27336223-Compound-7 DM9QM6I N. A. N. A. Patented [25]
CD666 DMC8X9Y Discovery agent N.A. Investigative [26]
AGN193109 DMC0YOE Discovery agent N.A. Investigative [27]
AC55649 DM4JNY9 Discovery agent N.A. Investigative [28]
BMS641 DMRT7G3 Discovery agent N.A. Investigative [29]
AC261066 DMSKE1I Discovery agent N.A. Investigative [28]
TTNPB DMSABD0 Discovery agent N.A. Investigative [30]
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Drug(s) Targeting Retinoic acid receptor gamma (RARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Trifarotene DMOL793 Acne vulgaris ED80 Approved [32]
Tazarotene DM8SMD1 Acne vulgaris ED80 Approved [33]
Palovarotene DMAD2OZ Fibrodysplasia ossificans progressiva FB31.1 Approved [34]
PMID27336223-Compound-13 DMSZLYD N. A. N. A. Patented [25]
PMID27336223-Compound-12 DMT4P7K N. A. N. A. Patented [25]
PMID27336223-Compound-14 DMC41MA N. A. N. A. Patented [25]
PMID27336223-Compound-11 DMBN6KU N. A. N. A. Patented [25]
PMID27336223-Compound-15 DMIYCFE N. A. N. A. Patented [25]
PMID27336223-Compound-9 DM6V13W N. A. N. A. Patented [25]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [35]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [37]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [40]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [41]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [42]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [36]
Verapamil DMA7PEW Angina pectoris BA40 Approved [43]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [46]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [47]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [48]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [49]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [50]
Capsaicin DMGMF6V Back pain ME84.Z Approved [51]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [52]
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Drug(s) Affected By Involucrin (IVL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [53]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [53]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [58]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [60]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [54]
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Drug(s) Affected By Cytochrome P450 26C1 (CYP26C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [63]
Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [65]
Testosterone enanthate DMB6871 N. A. N. A. Approved [66]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [68]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [69]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [72]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [73]
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Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [74]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [76]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [79]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Fluoxetine DM3PD2C Bipolar depression Approved [76]
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Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Etretinate DM2CZFA Keratosis ED56 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Ethanol DMDRQZU Chronic pain MG30 Approved [87]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [88]
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Drug(s) Affected By ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [91]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [92]
Bortezomib DMNO38U Leukemia Approved [93]
Omacetaxine mepesuccinate DMPU2WX Adult acute monocytic leukemia Approved [90]
Novobiocin DMRFWGK Bacterial infection 1A00-1C4Z Approved [94]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [95]
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Drug(s) Affected By Protein-arginine deiminase type-4 (PADI4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [97]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [98]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [99]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [100]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [101]
paraquat DMR8O3X Discovery agent N.A. Investigative [102]
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Drug(s) Affected By AH receptor-interacting protein (AIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [97]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
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Drug(s) Affected By Pirin (PIR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [112]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [113]
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Drug(s) Affected By Suppressor of cytokine signaling 2 (SOCS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [119]
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Drug(s) Affected By Suppressor of cytokine signaling 1 (SOCS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [120]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [122]
Lomustine DMMWSUL Brain cancer 2A00 Approved [123]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [124]
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Drug(s) Affected By Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Testosterone DM7HUNW Hot flushes GA30 Approved [126]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [128]
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Drug(s) Affected By RNA/RNP complex-1-interacting phosphatase (DUSP11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [129]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [131]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [132]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [133]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [134]
Milchsaure DM462BT Pruritus EC90 Investigative [135]
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Drug(s) Affected By Keratin, type II cytoskeletal 75 (KRT75)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [136]
Arsenic DMTL2Y1 N. A. N. A. Approved [137]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [138]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [99]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [139]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
all-trans-4-oxo-retinoic acid DMM2R1N Discovery agent N.A. Investigative [4]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [140]
Gefitinib DM15F0X Colon adenocarcinoma Approved [141]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [142]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [143]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [144]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [145]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [146]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [147]
Selenium DM25CGV N. A. N. A. Approved [148]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [149]
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Drug(s) Affected By Tissue-type plasminogen activator (PLAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [151]
Etretinate DM2CZFA Keratosis ED56 Approved [152]
Prednisone DM2HG4X Acute asthma CA23 Approved [153]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [156]
Fructose DM43AN2 Vomiting MD90 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
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Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [158]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [159]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [160]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [158]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [158]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [161]
Fluoxetine DM3PD2C Bipolar depression Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [158]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [162]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Gefitinib DM15F0X Colon adenocarcinoma Approved [164]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [165]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [166]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [165]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [167]
Selenium DM25CGV N. A. N. A. Approved [168]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [169]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [170]
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Drug(s) Affected By Keratin, type I cytoskeletal 14 (KRT14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [171]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [172]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Folic Acid DMEMBJC Colorectal carcinoma Approved [173]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [174]
Methamphetamine DMPM4SK Anxiety Approved [175]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [176]
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Drug(s) Affected By Keratin, type II cytoskeletal 6A (KRT6A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [171]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [177]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [69]
Arsenic DMTL2Y1 N. A. N. A. Approved [180]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [95]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [181]
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Drug(s) Affected By Lysosomal acid glucosylceramidase (GBA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [182]
Afegostat DMRWSKX Gaucher disease 5C56.0Y Discontinued in Phase 2 [183]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [184]
Milchsaure DM462BT Pruritus EC90 Investigative [135]
all-trans-4-oxo-retinoic acid DMM2R1N Discovery agent N.A. Investigative [4]
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Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [185]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [171]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [186]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [187]
Arsenic DMTL2Y1 N. A. N. A. Approved [188]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [189]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [190]
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Drug(s) Affected By Insulin-like growth factor I (IGF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [191]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [159]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [192]
Quercetin DM3NC4M Obesity 5B81 Approved [193]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [195]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [196]
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Drug(s) Affected By Protein S100-A8 (S100A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [197]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [198]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [197]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [199]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [197]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [197]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
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Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [201]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [202]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [203]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
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Drug(s) Affected By Fibroblast growth factor 1 (FGF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Methotrexate DM2TEOL Anterior urethra cancer Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [206]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [207]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Arsenic DMTL2Y1 N. A. N. A. Approved [137]
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Drug(s) Affected By Protein S100-A9 (S100A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [197]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [57]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [208]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
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Drug(s) Affected By Neurofilament light polypeptide (NEFL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [209]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [122]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [210]
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Drug(s) Affected By Thrombospondin-1 (THBS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [198]
Quercetin DM3NC4M Obesity 5B81 Approved [211]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [205]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [212]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
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Drug(s) Affected By Keratin, type I cytoskeletal 19 (KRT19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Selenium DM25CGV N. A. N. A. Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [213]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [112]
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Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [215]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Selenium DM25CGV N. A. N. A. Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
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Drug(s) Affected By Stromelysin-2 (MMP10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [127]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Methotrexate DM2TEOL Anterior urethra cancer Approved [205]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [198]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [205]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Haloperidol DM96SE0 Delirium Approved [216]
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Drug(s) Affected By Growth-regulated alpha protein (CXCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Selenium DM25CGV N. A. N. A. Approved [168]
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [161]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [205]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [219]
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Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [220]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [221]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [222]
Ethanol DMDRQZU Chronic pain MG30 Approved [223]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Methyldopa DM5I621 Hypertension BA00-BA04 Approved [224]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
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Drug(s) Affected By Tumor-associated calcium signal transducer 2 (TACSTD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [199]
Testosterone DM7HUNW Hot flushes GA30 Approved [225]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
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Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [189]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [226]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [216]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [227]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [229]
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Drug(s) Affected By Ornithine decarboxylase (ODC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [230]
Methotrexate DM2TEOL Anterior urethra cancer Approved [231]
Quercetin DM3NC4M Obesity 5B81 Approved [232]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [233]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Propranolol DM79NTF Angina pectoris BA40 Approved [234]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [235]
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Drug(s) Affected By Collagen alpha-1(VI) chain (COL6A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Testosterone enanthate DMB6871 N. A. N. A. Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [237]
Paclitaxel DMLB81S Breast carcinoma Approved [238]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [239]
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Drug(s) Affected By Integrin alpha-4 (ITGA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [240]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [115]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
Folic Acid DMEMBJC Colorectal carcinoma Approved [241]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [242]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [243]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [244]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [245]
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Drug(s) Affected By Keratin, type I cytoskeletal 10 (KRT10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [129]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
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Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [171]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [172]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [174]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [247]
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Drug(s) Affected By Glutamine synthetase (GLUL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [248]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [249]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Clozapine DMFC71L Schizophrenia 6A20 Approved [250]
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Drug(s) Affected By Keratin, type I cytoskeletal 15 (KRT15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [198]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [112]
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Drug(s) Affected By Filaggrin (FLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [53]
Folic Acid DMEMBJC Colorectal carcinoma Approved [251]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [60]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [57]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [190]
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Drug(s) Affected By Cornifin-B (SPRR1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [95]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [252]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [253]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
all-trans-4-oxo-retinoic acid DMM2R1N Discovery agent N.A. Investigative [4]
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Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase K (TGM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [253]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [174]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [254]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [255]
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Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [256]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [249]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [257]
Quercetin DM3NC4M Obesity 5B81 Approved [258]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [259]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [260]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [261]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
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Drug(s) Affected By Protein S100-A1 (S100A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [147]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [57]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [181]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
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Drug(s) Affected By Laminin subunit alpha-2 (LAMA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [262]
Arsenic DMTL2Y1 N. A. N. A. Approved [263]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [264]
Methotrexate DM2TEOL Anterior urethra cancer Approved [265]
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Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [266]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [267]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [268]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [269]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [270]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [271]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [272]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
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Drug(s) Affected By Collagen alpha-2(VIII) chain (COL8A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [199]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [273]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [274]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [275]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [264]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [115]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [205]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [276]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [205]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [277]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Testosterone DM7HUNW Hot flushes GA30 Approved [278]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [279]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [249]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [276]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A7 (S100A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [57]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [252]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
Milchsaure DM462BT Pruritus EC90 Investigative [135]
all-trans-4-oxo-retinoic acid DMM2R1N Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [280]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [281]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [282]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [283]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [257]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [284]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [285]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [165]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [286]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [287]
Selenium DM25CGV N. A. N. A. Approved [103]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [192]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [288]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [289]
Quercetin DM3NC4M Obesity 5B81 Approved [211]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [290]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [291]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Selenium DM25CGV N. A. N. A. Approved [103]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [198]
Quercetin DM3NC4M Obesity 5B81 Approved [292]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [93]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serpin B8 (SERPINB8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serpin B9 (SERPINB9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Quercetin DM3NC4M Obesity 5B81 Approved [293]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [294]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocarboxylate transporter 1 (SLC16A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [295]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [296]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [297]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [298]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epithelial membrane protein 1 (EMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [299]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [299]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [225]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microfibrillar-associated protein 2 (MFAP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Testosterone DM7HUNW Hot flushes GA30 Approved [225]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [210]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [300]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming protein RhoA (RHOA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [302]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [303]
Quercetin DM3NC4M Obesity 5B81 Approved [304]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [306]
Pamidronate DMB4AVP Bone Paget disease Approved [307]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [308]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [240]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [203]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [306]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neutrophil gelatinase-associated lipocalin (LCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [310]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [122]
Gentamicin DMKINJO Bacteremia 1A73 Approved [311]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid-binding protein 5 (FABP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [147]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Capsaicin DMGMF6V Back pain ME84.Z Approved [312]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [237]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [210]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [313]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [228]
Methotrexate DM2TEOL Anterior urethra cancer Approved [314]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [315]
Testosterone DM7HUNW Hot flushes GA30 Approved [225]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [316]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [53]
Selenium DM25CGV N. A. N. A. Approved [103]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [53]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [319]
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Desmocollin-1 (DSC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [161]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [187]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [189]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [323]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [324]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-24 (IL24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [165]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [165]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [165]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [165]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chromobox protein homolog 3 (CBX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [147]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Bortezomib DMNO38U Leukemia Approved [93]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 2 (EIF4EBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [225]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [326]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [327]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [328]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-10 receptor subunit alpha (IL10RA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [273]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [329]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [330]
Arsenic DMTL2Y1 N. A. N. A. Approved [137]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [331]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [264]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fas-activated serine/threonine kinase (FASTK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Testosterone DM7HUNW Hot flushes GA30 Approved [225]
Testosterone enanthate DMB6871 N. A. N. A. Approved [236]
Folic Acid DMEMBJC Colorectal carcinoma Approved [251]
Menthol DMG2KW7 Back pain ME84.Z Approved [332]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
Bortezomib DMNO38U Leukemia Approved [93]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [333]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth factor receptor-bound protein 7 (GRB7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [187]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [334]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [127]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [335]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [264]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [112]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [112]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Laminin subunit alpha-3 (LAMA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [112]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [112]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAM3C (FAM3C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [336]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [330]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [334]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [337]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [222]
Paclitaxel DMLB81S Breast carcinoma Approved [222]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [338]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [339]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [340]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [341]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase RNF5 (RNF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [334]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [342]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [103]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [343]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [344]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth/differentiation factor 15 (GDF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [345]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [346]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [347]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [297]
Quercetin DM3NC4M Obesity 5B81 Approved [293]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [349]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [233]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth/differentiation factor 2 (GDF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [350]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [344]
all-trans-4-oxo-retinoic acid DMM2R1N Discovery agent N.A. Investigative [4]
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Drug(s) Affected By Collagen alpha-1(XVII) chain (COL17A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [274]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Arsenic DMTL2Y1 N. A. N. A. Approved [137]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [351]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [352]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [353]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Laminin subunit gamma-3 (LAMC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [189]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [115]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [354]
all-trans-4-oxo-retinoic acid DMM2R1N Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [146]
Methotrexate DM2TEOL Anterior urethra cancer Approved [355]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [356]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [4]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [356]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [357]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [358]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [359]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [358]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [360]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [322]
Dolutegravir DMCZGRE Human immunodeficiency virus infection 1C62 Approved [361]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [362]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [273]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [363]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [364]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [365]
Quercetin DM3NC4M Obesity 5B81 Approved [366]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [367]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [368]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [370]
Testosterone DM7HUNW Hot flushes GA30 Approved [225]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [371]
Epinephrine DM3KJBC Acute asthma CA23 Approved [372]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [374]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [375]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [376]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [377]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [378]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [379]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [380]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [381]
Gefitinib DM15F0X Colon adenocarcinoma Approved [382]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [383]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [384]
Selenium DM25CGV N. A. N. A. Approved [103]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [192]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [385]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [386]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [215]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [387]
Gefitinib DM15F0X Colon adenocarcinoma Approved [388]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [389]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [346]
Etretinate DM2CZFA Keratosis ED56 Approved [390]
Prednisone DM2HG4X Acute asthma CA23 Approved [391]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [392]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [347]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [393]
Gefitinib DM15F0X Colon adenocarcinoma Approved [141]
Prednisone DM2HG4X Acute asthma CA23 Approved [391]
Methotrexate DM2TEOL Anterior urethra cancer Approved [394]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [395]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [396]
Fluoxetine DM3PD2C Bipolar depression Approved [397]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [398]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [399]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [400]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [401]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [402]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [403]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [404]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [405]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [403]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [406]
Estrone DM5T6US Acne vulgaris ED80 Approved [400]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Meis1 (MEIS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [54]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
Arsenic DMTL2Y1 N. A. N. A. Approved [137]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [244]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [97]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Meis2 (MEIS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Panobinostat DM58WKG Chronic graft versus host disease Approved [407]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ethanol DMDRQZU Chronic pain MG30 Approved [408]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [54]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [226]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [409]
Diazepam DM08E9O Alcohol withdrawal Approved [410]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [411]
Methotrexate DM2TEOL Anterior urethra cancer Approved [412]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [413]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [414]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [415]
Quercetin DM3NC4M Obesity 5B81 Approved [416]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [103]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [417]
Methotrexate DM2TEOL Anterior urethra cancer Approved [418]
Quercetin DM3NC4M Obesity 5B81 Approved [419]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [420]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Selenium DM25CGV N. A. N. A. Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [418]
Quercetin DM3NC4M Obesity 5B81 Approved [421]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-2(IV) chain (COL4A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [422]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [422]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Testosterone enanthate DMB6871 N. A. N. A. Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [54]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [423]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [424]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [425]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [426]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [427]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [428]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [401]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [429]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [346]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [430]
Methotrexate DM2TEOL Anterior urethra cancer Approved [431]
Epinephrine DM3KJBC Acute asthma CA23 Approved [432]
Quercetin DM3NC4M Obesity 5B81 Approved [433]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [434]
Fructose DM43AN2 Vomiting MD90 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor responder protein 1 (RARRES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [435]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [436]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [54]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [210]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [205]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [437]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein MOX-1 (MEOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [438]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [438]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [438]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [213]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [438]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [438]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [438]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatocyte nuclear factor 3-alpha (FOXA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [171]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [439]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [440]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [88]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [128]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [54]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [441]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [442]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mucin-5AC (MUC5AC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [443]
Selenium DM25CGV N. A. N. A. Approved [444]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [445]
Capsaicin DMGMF6V Back pain ME84.Z Approved [446]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [54]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [447]
Bleomycin DMNER5S Cervical cancer 2C77.0 Approved [448]
Arsenic DMTL2Y1 N. A. N. A. Approved [449]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor GATA-6 (GATA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Testosterone DM7HUNW Hot flushes GA30 Approved [225]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [450]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [54]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Indomethacin DMSC4A7 Bursitis Approved [451]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [107]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipase A and acyltransferase 4 (PLAAT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [54]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon regulatory factor 1 (IRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [212]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MHC class II transactivator (CIITA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [452]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [453]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [454]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [122]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [313]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [301]
Arsenic DMTL2Y1 N. A. N. A. Approved [455]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [454]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA binding protein fox-1 homolog 3 (RBFOX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [456]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Testosterone DM7HUNW Hot flushes GA30 Approved [225]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Arsenic DMTL2Y1 N. A. N. A. Approved [137]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [457]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [115]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [115]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [458]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [459]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [460]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [461]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [462]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [463]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 5 group A member 2 (NR5A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [465]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Arsenic DMTL2Y1 N. A. N. A. Approved [137]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [466]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-1 (SOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [213]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [467]
Arsenic DMTL2Y1 N. A. N. A. Approved [468]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [469]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [115]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [115]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [470]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [228]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [471]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [471]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [161]
Fluoxetine DM3PD2C Bipolar depression Approved [471]
Fructose DM43AN2 Vomiting MD90 Approved [472]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [471]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [347]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [473]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [162]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [474]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [475]
Selenium DM25CGV N. A. N. A. Approved [476]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [347]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [477]
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [477]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid-binding protein, brain (FABP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [213]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [478]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [479]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [115]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [480]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kallikrein-10 (KLK10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [129]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [122]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [187]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [481]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [264]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [222]
Captopril DM458UM Chronic heart failure BD1Z Approved [226]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [115]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuronal migration protein doublecortin (DCX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [482]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [467]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [483]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [484]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [465]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [485]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [486]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [487]
Quercetin DM3NC4M Obesity 5B81 Approved [293]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [488]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [489]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 6 (ABCC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzbromarone DMC3YUA Gout FA25 Approved [490]
Verapamil DMA7PEW Angina pectoris BA40 Approved [490]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [276]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [491]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [295]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [492]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [493]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [494]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [226]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [495]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [496]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [497]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [498]
Prednisone DM2HG4X Acute asthma CA23 Approved [499]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [500]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [501]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [502]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [503]
Fructose DM43AN2 Vomiting MD90 Approved [226]
Ketoprofen DMRKXPT Bursitis Approved [226]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [504]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [505]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [506]
Gefitinib DM15F0X Colon adenocarcinoma Approved [507]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [508]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [437]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [509]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [510]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [511]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [512]
Quercetin DM3NC4M Obesity 5B81 Approved [513]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [514]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [515]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [516]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein A-II (APOA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [276]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [8]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [517]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [517]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [8]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [518]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [519]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [293]
Aripiprazole DM3NUMH Bipolar I disorder Approved [520]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [521]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [522]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Ethacrynic acid DM60QMR Edema MG29 Approved [523]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [524]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [525]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [526]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [527]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [411]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [528]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [529]
Pamidronate DMB4AVP Bone Paget disease Approved [530]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [531]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [532]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [450]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A1 (ANXA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [533]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [534]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [535]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [161]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-B (S100B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Norepinephrine DMOUC09 Alopecia ED70 Approved [536]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [244]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [337]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [337]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [537]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [538]
Selenium DM25CGV N. A. N. A. Approved [103]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [539]
Quercetin DM3NC4M Obesity 5B81 Approved [540]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [7]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [541]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [542]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Clozapine DMFC71L Schizophrenia 6A20 Approved [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [543]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [498]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [544]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [545]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [546]
Prednisone DM2HG4X Acute asthma CA23 Approved [547]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [511]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [512]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [548]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-5 (IL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [509]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [544]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [545]
Prednisone DM2HG4X Acute asthma CA23 Approved [499]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [549]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [550]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [551]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [552]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [553]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [554]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-cell surface glycoprotein CD1a (CD1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [88]
Arsenic DMTL2Y1 N. A. N. A. Approved [555]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [189]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
PMID27336223-Compound-5 DM6E50A N. A. N. A. Patented [88]
24(S), 25-epoxycholesterol DMW2KI5 Discovery agent N.A. Investigative [556]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [557]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [393]
Gefitinib DM15F0X Colon adenocarcinoma Approved [558]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [389]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [538]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [365]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [559]
Methotrexate DM2TEOL Anterior urethra cancer Approved [560]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [561]
Quercetin DM3NC4M Obesity 5B81 Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleophosmin (NPM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [562]
Etretinate DM2CZFA Keratosis ED56 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [418]
Quercetin DM3NC4M Obesity 5B81 Approved [540]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [563]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [542]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lipoprotein lipase (LPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [226]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [159]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [564]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [565]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [199]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [566]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [541]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [566]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine 3-monooxygenase (TH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zonisamide DM0DTF7 Alcohol dependence 6C40.2 Approved [567]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [568]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [569]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [570]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [129]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [262]
Methamphetamine DMPM4SK Anxiety Approved [571]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [572]
Piperazine DMTY9LU Ascariasis 1F62 Approved [573]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A2 (ANXA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [319]
Quercetin DM3NC4M Obesity 5B81 Approved [533]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [574]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [575]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [576]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [535]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [577]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Synaptophysin (SYP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [538]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [482]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ethanol DMDRQZU Chronic pain MG30 Approved [578]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [579]
Methamphetamine DMPM4SK Anxiety Approved [580]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [334]
Urethane DM7NSI0 N. A. N. A. Phase 4 [581]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [582]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [368]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [165]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [165]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [165]
Methotrexate DM2TEOL Anterior urethra cancer Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [583]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [205]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A5 (ANXA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [319]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [584]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [259]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [585]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Benzatropine DMF7EXL Parkinsonian disorder Approved [216]
Clozapine DMFC71L Schizophrenia 6A20 Approved [216]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Steryl-sulfatase (STS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [205]
Tazarotene DM8SMD1 Acne vulgaris ED80 Approved [586]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
Danazol DML8KTN Menorrhagia GA20.50 Approved [587]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [205]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [588]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Gefitinib DM15F0X Colon adenocarcinoma Approved [589]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [590]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [430]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [591]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [392]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [591]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [592]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Methotrexate DM2TEOL Anterior urethra cancer Approved [593]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor alpha (RARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [594]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [112]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [112]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [112]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [595]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [596]
Ethanol DMDRQZU Chronic pain MG30 Approved [408]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [597]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [598]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [599]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [600]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [226]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Verapamil DMA7PEW Angina pectoris BA40 Approved [601]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [602]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [505]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Osteopontin (SPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [409]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [603]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [604]
Quercetin DM3NC4M Obesity 5B81 Approved [433]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [605]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [606]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [607]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated protein 2 (MAP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [147]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [608]
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [248]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [467]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cholesteryl ester transfer protein (CETP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [609]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [610]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [611]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [612]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [610]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [610]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [613]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurofilament heavy polypeptide (NEFH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [215]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [614]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [300]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [330]
Arsenic DMTL2Y1 N. A. N. A. Approved [615]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Parathyroid hormone-related protein (PTHLH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [413]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [616]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Testosterone DM7HUNW Hot flushes GA30 Approved [617]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [465]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glial fibrillary acidic protein (GFAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillin V DMKVOYF Acute otitis media AB00 Approved [226]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [226]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [618]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [619]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [620]
Testosterone DM7HUNW Hot flushes GA30 Approved [225]
Haloperidol DM96SE0 Delirium Approved [216]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Ethanol DMDRQZU Chronic pain MG30 Approved [621]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatocyte growth factor (HGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [538]
Quercetin DM3NC4M Obesity 5B81 Approved [622]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [623]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [623]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [566]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [624]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [625]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [626]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pyruvate kinase PKM (PKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [319]
Selenium DM25CGV N. A. N. A. Approved [103]
Epinephrine DM3KJBC Acute asthma CA23 Approved [627]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [248]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [628]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [541]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [186]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [542]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [162]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Clozapine DMFC71L Schizophrenia 6A20 Approved [250]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [629]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [630]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [486]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [631]
Selenium DM25CGV N. A. N. A. Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [632]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [521]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [633]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [633]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [634]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [635]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuroendocrine convertase 2 (PCSK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Liothyronine DM6IR3P Congenital hypothyroidism Approved [636]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [637]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [264]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [337]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
4-hydroxy-2-nonenal DM2LJFZ Discovery agent N.A. Investigative [538]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [63]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Platelet glycoprotein 4 (CD36)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [288]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [638]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [639]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [640]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [641]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [642]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [322]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [643]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Selenium DM25CGV N. A. N. A. Approved [644]
Methotrexate DM2TEOL Anterior urethra cancer Approved [412]
Quercetin DM3NC4M Obesity 5B81 Approved [193]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [4]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [606]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [645]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [196]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione peroxidase 2 (GPX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [338]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [346]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [276]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [646]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [647]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [320]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-2 (CDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [538]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [482]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [628]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [648]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [649]
Testosterone DM7HUNW Hot flushes GA30 Approved [650]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [209]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [651]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [454]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [652]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [653]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [654]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [655]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [656]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [657]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [658]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [659]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase B (NME2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [7]
Testosterone DM7HUNW Hot flushes GA30 Approved [225]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [660]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Capsaicin DMGMF6V Back pain ME84.Z Approved [661]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [662]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [663]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [664]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [665]
Arsenic DMTL2Y1 N. A. N. A. Approved [666]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [562]
Quercetin DM3NC4M Obesity 5B81 Approved [540]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [7]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [535]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [186]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [542]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Ethanol DMDRQZU Chronic pain MG30 Approved [621]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paired box protein Pax-6 (PAX6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [438]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [438]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [667]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [438]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [438]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [668]
Dabigatran DMDI6R4 Stroke 8B20 Approved [438]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Choline O-acetyltransferase (CHAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [482]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [669]
Methamphetamine DMPM4SK Anxiety Approved [670]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [264]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [226]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [354]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 Discovery agent N.A. Investigative [671]
Elaidoylamide DMP8VDT Discovery agent N.A. Investigative [672]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [673]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [299]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [674]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [675]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [676]
Gefitinib DM15F0X Colon adenocarcinoma Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [292]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [677]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [678]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [679]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [680]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [233]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C chemokine receptor type 7 (CCR7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [249]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [556]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [681]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [682]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [682]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [683]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [684]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [685]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [59]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [686]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [556]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [687]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [688]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [689]
Arsenic DMTL2Y1 N. A. N. A. Approved [690]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-13 (IL13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [691]
Prednisone DM2HG4X Acute asthma CA23 Approved [692]
Methotrexate DM2TEOL Anterior urethra cancer Approved [693]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [550]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [516]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [694]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [695]
Ethambutol DMR87LC Pulmonary tuberculosis 1B10.Z Approved [516]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [696]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [283]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [411]
Quercetin DM3NC4M Obesity 5B81 Approved [697]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [698]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [699]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [700]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [434]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [701]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [702]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C chemokine receptor type 2 (CCR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [217]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [703]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [704]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [642]
Ethanol DMDRQZU Chronic pain MG30 Approved [705]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [274]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [330]
Arsenic DMTL2Y1 N. A. N. A. Approved [706]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [707]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [509]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [708]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [709]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [708]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [708]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [116]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [710]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [711]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [712]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [713]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [714]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [715]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [716]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [717]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [718]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [719]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [720]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [652]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [112]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [112]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-2 (SOX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [721]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [722]
Quercetin DM3NC4M Obesity 5B81 Approved [723]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Panobinostat DM58WKG Chronic graft versus host disease Approved [115]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [724]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [725]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [726]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nestin (NES)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [215]
Quercetin DM3NC4M Obesity 5B81 Approved [727]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [482]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Testosterone enanthate DMB6871 N. A. N. A. Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Clozapine DMFC71L Schizophrenia 6A20 Approved [216]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [728]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [294]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [129]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [729]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [729]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [730]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [731]
Oxytetracycline DMOVH1M Actinomycosis Approved [732]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [474]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Selenium DM25CGV N. A. N. A. Approved [103]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [733]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [734]
Methotrexate DM2TEOL Anterior urethra cancer Approved [735]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [259]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [736]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [606]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C chemokine receptor type 3 (CCR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [704]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [737]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [738]
Indomethacin DMSC4A7 Bursitis Approved [739]
Arsenic DMTL2Y1 N. A. N. A. Approved [690]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [740]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Neural retina-specific leucine zipper protein (NRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [741]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [742]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [294]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [70]
Urethane DM7NSI0 N. A. N. A. Phase 4 [581]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [470]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [344]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [63]
TTNPB DMSABD0 Discovery agent N.A. Investigative [742]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Thyroxine 5-deiodinase (DIO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [743]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [744]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [745]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [729]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [729]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [743]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [746]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [743]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [747]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [226]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [498]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [545]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [748]
Methotrexate DM2TEOL Anterior urethra cancer Approved [749]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [750]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [550]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [552]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [751]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [752]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD83 antigen (CD83)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [735]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [709]
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [753]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [754]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [597]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [719]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Verapamil DMA7PEW Angina pectoris BA40 Approved [601]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [54]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [755]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [389]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [538]
Meloxicam DM2AR7L Arthritis FA20 Approved [756]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [392]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [757]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [758]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [759]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [162]
Gefitinib DM15F0X Colon adenocarcinoma Approved [760]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [761]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [430]
Selenium DM25CGV N. A. N. A. Approved [103]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [762]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein TGIF1 (TGIF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [763]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [212]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [764]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [466]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Long-chain fatty acid transport protein 1 (SLC27A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Testosterone DM7HUNW Hot flushes GA30 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [765]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [93]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [187]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [766]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [767]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [768]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [401]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [769]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [770]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [771]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [772]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [773]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [482]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [205]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [262]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [729]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [122]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium/iodide cotransporter (SLC5A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [728]
Quercetin DM3NC4M Obesity 5B81 Approved [774]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [775]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [776]
Tazarotene DM8SMD1 Acne vulgaris ED80 Approved [777]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [777]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [778]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [779]
Romidepsin DMT5GNL Cutaneous T-cell lymphoma 2B01 Approved [777]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [777]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Nkx-3.1 (NKX3-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [232]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [780]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [204]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [324]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [781]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [782]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [328]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [783]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dehydrogenase/reductase SDR family member 9 (DHRS9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [784]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [88]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [785]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [244]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [106]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 4F11 (CYP4F11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [108]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [786]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Ethanol DMDRQZU Chronic pain MG30 Approved [787]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [105]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [730]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [108]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [788]
Fructose DM43AN2 Vomiting MD90 Approved [472]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [789]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [790]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [194]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [791]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [792]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [792]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rab-27A (RAB27A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [109]
Leflunomide DMR8ONJ Arthritis FA20 Approved [117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [127]
Testosterone enanthate DMB6871 N. A. N. A. Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [249]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [246]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [330]
Arsenic DMTL2Y1 N. A. N. A. Approved [137]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular retinoic acid-binding protein 1 (CRABP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [147]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [464]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [178]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [682]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [682]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [793]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [252]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [335]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [480]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Retinoic acid receptor beta (RARB) TTISP28 RARB_HUMAN Agonist [2]
Retinoic acid receptor gamma (RARG) TT1Q3IE RARG_HUMAN Modulator [2]
Retinoic acid receptor RXR-alpha (RXRA) TT6PEUO RXRA_HUMAN Agonist [2]
Retinoic acid receptor RXR-beta (RXRB) TTKLV96 RXRB_HUMAN Agonist [2]
Retinoic acid receptor RXR-gamma (RXRG) TTH029C RXRG_HUMAN Agonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Gene/Protein Processing [4]
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) OT6EBDHM DHB1_HUMAN Gene/Protein Processing [5]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Gene/Protein Processing [6]
AH receptor-interacting protein (AIP) OTDJ3OSV AIP_HUMAN Gene/Protein Processing [4]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Gene/Protein Processing [4]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Gene/Protein Processing [7]
Annexin A2 (ANXA2) OTFNS0CC ANXA2_HUMAN Gene/Protein Processing [7]
Annexin A5 (ANXA5) OTZS877V ANXA5_HUMAN Gene/Protein Processing [7]
Apolipoprotein A-II (APOA2) OTQ3HGTC APOA2_HUMAN Gene/Protein Processing [8]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [9]

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134 Alteration of estrogen-regulated gene expression in human cells induced by the agricultural and horticultural herbicide glyphosate. Hum Exp Toxicol. 2007 Sep;26(9):747-52. doi: 10.1177/0960327107083453.
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735 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
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741 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
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766 Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. PLoS One. 2012;7(3):e33592. doi: 10.1371/journal.pone.0033592. Epub 2012 Mar 19.
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768 Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. PLoS One. 2012;7(4):e35895. doi: 10.1371/journal.pone.0035895. Epub 2012 Apr 23.
769 Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1533-41. doi: 10.1016/j.bbrc.2005.04.071.
770 Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin. Biochem Pharmacol. 2004 Feb 1;67(3):411-9. doi: 10.1016/j.bcp.2003.09.014.
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774 Antiproliferation and redifferentiation in thyroid cancer cell lines by polyphenol phytochemicals. J Korean Med Sci. 2011 Jul;26(7):893-9. doi: 10.3346/jkms.2011.26.7.893. Epub 2011 Jun 20.
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780 Transcriptional regulation of the homeobox gene NKX3.1 by all-trans retinoic acid in prostate cancer cells. J Cell Biochem. 2006 Dec 1;99(5):1409-19. doi: 10.1002/jcb.21020.
781 Niclosamide and Bicalutamide Combination Treatment Overcomes Enzalutamide- and Bicalutamide-Resistant Prostate Cancer. Mol Cancer Ther. 2017 Aug;16(8):1521-1530. doi: 10.1158/1535-7163.MCT-16-0912. Epub 2017 May 12.
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783 A role for DNA methylation in regulating the growth suppressor PMEPA1 gene in prostate cancer. Epigenetics. 2007 Apr-Jun;2(2):100-9.
784 Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up-regulated by retinoids and is involved in the metabolism of retinol. J Biol Chem. 2001 Jun 29;276(26):24194-202. doi: 10.1074/jbc.M100332200. Epub 2001 Apr 13.
785 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
786 Gene regulation of CYP4F11 in human keratinocyte HaCaT cells. Drug Metab Dispos. 2010 Jan;38(1):100-7. doi: 10.1124/dmd.109.029025.
787 CYP4F2 repression and a modified alpha-tocopherol (vitamin E) metabolism are two independent consequences of ethanol toxicity in human hepatocytes. Toxicol In Vitro. 2017 Apr;40:124-133.
788 Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
789 Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia. 2010 May;53(5):955-65. doi: 10.1007/s00125-010-1676-1. Epub 2010 Feb 18.
790 AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. J Appl Toxicol. 2017 Oct;37(10):1219-1224. doi: 10.1002/jat.3483. Epub 2017 May 29.
791 Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.
792 A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1 expression and mitochondrial biogenesis. PLoS One. 2012;7(10):e46753. doi: 10.1371/journal.pone.0046753. Epub 2012 Oct 3.
793 Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.