Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNFADH)

• Drug Name: APR-246 Drug Info
• Synonyms: Eprenetapopt

Indication

Disease Entry	ICD 11	Status	REF
Ovarian cancer	2C73	Phase 2	[1]
Bladder cancer	2C94	Phase 1/2	[2]
Gastric adenocarcinoma	2B72	Phase 1/2	[2]
Esophageal cancer	2B70	Phase 1	[1]
Myelodysplastic syndrome	2A37	Phase 1	[1]
Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]

• Cross-matching ID:
  PubChem CID: 52918385
  CAS Number: CAS 5291-32-7
  TTD Drug ID: DMNFADH

Molecule-Related Drug Atlas

Drug(s) Targeting Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Contusugene ladenovec	DMN9ETB	Oral cancer	2B6E	Phase 3	[6]
QPI-1002	DMDU5Y2	Renal transplantation	NE84	Phase 3	[7]
Thymoquinone	DMVDTR2	Polycystic ovarian syndrome	5A80.1	Phase 2/3	[8]
APG-115	DMIFA0L	Prolymphocytic leukaemia	2A82.1	Phase 2	[1]
SGT-53	DMLYIPA	Pancreatic cancer	2C10	Phase 2	[9]
Ad-p53	DMJSWXL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
Kevetrin	DMFO6MH	Ovarian cancer	2C73	Phase 2	[1]
INGN-225	DMF7J6D	Head and neck cancer	2D42	Phase 2	[11]
ALT-801	DM9KL7P	Acute myeloid leukaemia	2A60	Phase 2	[12]
ISA-P53-01	DMQ5EYJ	Colorectal cancer	2B91.Z	Phase 1/2	[13]

Drug(s) Affected By RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[20]

Drug(s) Affected By Uncharacterized membrane protein C3orf80 (C3ORF80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[24]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]

Drug(s) Affected By Splicing regulator ARVCF (ARVCF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[32]

Drug(s) Affected By F-BAR domain only protein 1 (FCHO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[33]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[34]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[20]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 2 (CHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Bortezomib	DMNO38U	Leukemia		Approved	[40]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[41]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]

Drug(s) Affected By U4/U6 small nuclear ribonucleoprotein Prp4 (PRPF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[51]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[49]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[52]

Drug(s) Affected By Eukaryotic translation initiation factor 1b (EIF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[58]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Frizzled-7 (FZD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[63]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[64]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]

Drug(s) Affected By Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[77]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[78]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[31]

Drug(s) Affected By E3 SUMO-protein ligase PIAS2 (PIAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[79]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[80]

Drug(s) Affected By Transmembrane and coiled-coil domains protein 1 (TMCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[90]

Drug(s) Affected By F-box/SPRY domain-containing protein 1 (FBXO45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[20]

Drug(s) Affected By Platelet glycoprotein Ib beta chain (GP1BB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[95]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[77]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[99]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[102]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[103]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]

Drug(s) Affected By Transcription factor E3 (TFE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[37]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[47]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Drug(s) Affected By DnaJ homolog subfamily B member 2 (DNAJB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[47]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[110]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[111]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[112]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[113]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[115]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[118]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[119]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain F (HLA-F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[122]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[120]

Drug(s) Affected By ER lumen protein-retaining receptor 2 (KDELR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[126]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[127]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[128]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[129]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[130]

Drug(s) Affected By Myosin-9 (MYH9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]

Drug(s) Affected By Amiloride-sensitive sodium channel subunit alpha (SCNN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[137]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]

Drug(s) Affected By Eukaryotic translation initiation factor 1 (EIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[47]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[141]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]

Drug(s) Affected By Neutral amino acid transporter A (SLC1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[143]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[144]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[47]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[144]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[145]

Drug(s) Affected By Translocon-associated protein subunit alpha (SSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]

Drug(s) Affected By Ran GTPase-activating protein 1 (RANGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[152]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]

Drug(s) Affected By Protein PRRC2A (PRRC2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[153]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[154]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[155]

Drug(s) Affected By Smoothelin (SMTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[157]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]

Drug(s) Affected By UV excision repair protein RAD23 homolog A (RAD23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[161]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]

Drug(s) Affected By UV excision repair protein RAD23 homolog B (RAD23B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[161]
Indomethacin	DMSC4A7	Bursitis		Approved	[165]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[60]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[166]

Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[168]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]

Drug(s) Affected By Period circadian protein homolog 3 (PER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[158]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[173]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[170]

Drug(s) Affected By AP-3 complex subunit sigma-2 (AP3S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]

Drug(s) Affected By CD81 antigen (CD81)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[176]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]

Drug(s) Affected By Signal peptidase complex subunit 3 (SPCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[178]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[179]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[180]

Drug(s) Affected By DDB1- and CUL4-associated factor 7 (DCAF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]

Drug(s) Affected By Disks large homolog 4 (DLG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[33]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[183]

Drug(s) Affected By Small ribosomal subunit protein uS10m (MRPS10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[187]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[187]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[188]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[189]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[187]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[190]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[191]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[62]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[192]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[190]

Drug(s) Affected By Protein Dr1 (DR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Haloperidol	DM96SE0	Delirium		Approved	[193]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[193]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]

Drug(s) Affected By Transducin-like enhancer protein 4 (TLE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[83]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[195]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]

Drug(s) Affected By Cytoskeleton-associated protein 4 (CKAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[198]

Drug(s) Affected By Golgin subfamily A member 2 (GOLGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[200]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[33]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[201]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[77]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[129]

Drug(s) Affected By AP-1 complex subunit beta-1 (AP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[58]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]

Drug(s) Affected By HMG domain-containing protein 3 (HMGXB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[129]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[128]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[25]

Drug(s) Affected By Protein patched homolog 1 (PTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[208]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[210]

Drug(s) Affected By Trophoblast glycoprotein (TPBG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[144]

Drug(s) Affected By HUWE1-associated protein modifying stress responses 1 (HAPSTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[217]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[218]

Drug(s) Affected By Astrocytic phosphoprotein PEA-15 (PEA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[219]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[221]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[222]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[223]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[224]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[225]

Drug(s) Affected By Sister chromatid cohesion protein PDS5 homolog A (PDS5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[226]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[31]

Drug(s) Affected By Sprouty-related, EVH1 domain-containing protein 3 (SPRED3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[227]

Drug(s) Affected By Protein FAM161A (FAM161A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[228]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[50]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By Transmembrane protein 119 (TMEM119)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[230]

Drug(s) Affected By DnaJ homolog subfamily C member 21 (DNAJC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[46]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[64]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[231]

Drug(s) Affected By Meckelin (TMEM67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[233]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[234]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[142]

Drug(s) Affected By Spindlin-3 (SPIN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]

Drug(s) Affected By Ceramide-1-phosphate transfer protein (CPTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]

Drug(s) Affected By Protein GPR107 (GPR107)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[235]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]

Drug(s) Affected By Cytosolic phospholipase A2 zeta (PLA2G4F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[83]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[25]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[20]

Drug(s) Affected By DENN domain-containing protein 5A (DENND5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[236]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]

Drug(s) Affected By Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[129]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[96]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[50]

Drug(s) Affected By DENN domain-containing protein 1B (DENND1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[25]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[62]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[53]

Drug(s) Affected By RNA demethylase ALKBH5 (ALKBH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[237]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[183]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[50]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[238]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[142]

Drug(s) Affected By Interleukin-34 (IL34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[20]

Drug(s) Affected By Autophagy-related protein 9A (ATG9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[202]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[240]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[241]

Drug(s) Affected By Cadherin-24 (CDH24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[20]

Drug(s) Affected By Centrosomal protein of 57 kDa (CEP57)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]

Drug(s) Affected By Purine nucleoside phosphorylase LACC1 (LACC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[243]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]

Drug(s) Affected By Sperm-associated antigen 16 protein (SPAG16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[58]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]

Drug(s) Affected By Protein shisa-5 (SHISA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[96]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[245]

Drug(s) Affected By Cytochrome P450 4X1 (CYP4X1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[200]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[247]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[128]

Drug(s) Affected By Refilin-B (RFLNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[176]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[248]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]

Drug(s) Affected By Solute carrier family 66 member 3 (SLC66A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[25]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]

Drug(s) Affected By Procollagen galactosyltransferase 1 (COLGALT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[249]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[245]

Drug(s) Affected By Reticulophagy regulator 2 (RETREG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[245]

Drug(s) Affected By Hemicentin-2 (HMCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Indomethacin	DMSC4A7	Bursitis		Approved	[165]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[250]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[24]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[249]

Drug(s) Affected By ATP-dependent RNA helicase DDX54 (DDX54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[31]

Drug(s) Affected By Probable glutathione peroxidase 8 (GPX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[252]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[24]

Drug(s) Affected By Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[128]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]

Drug(s) Affected By Protein TMEPAI (PMEPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[137]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[47]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[47]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[253]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]

Drug(s) Affected By Protein shisa-4 (SHISA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[20]

Drug(s) Affected By OTU domain-containing protein 5 (OTUD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[254]

Drug(s) Affected By Protein N-terminal glutamine amidohydrolase (NTAQ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[129]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[255]

Drug(s) Affected By RNA-binding protein 41 (RBM41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[256]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[49]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[49]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[142]

Drug(s) Affected By Calponin-2 (CNN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]

Drug(s) Affected By Retinoic acid receptor responder protein 2 (RARRES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[258]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[259]

Drug(s) Affected By A-kinase anchor protein 9 (AKAP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[260]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[261]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]

Drug(s) Affected By Nucleolar protein 10 (NOL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[194]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]

Drug(s) Affected By Tubulin-specific chaperone D (TBCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Bortezomib	DMNO38U	Leukemia		Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Deoxyhypusine hydroxylase (DOHH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[57]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[53]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Spindlin interactor and repressor of chromatin-binding protein (SPINDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[31]

Drug(s) Affected By Single-stranded DNA-binding protein 4 (SSBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[262]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]

Drug(s) Affected By Caspase recruitment domain-containing protein 10 (CARD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[83]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[263]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[264]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF26 (RNF26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[236]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[236]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]

Drug(s) Affected By Tripartite motif-containing protein 5 (TRIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[194]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[129]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Talin rod domain-containing protein 1 (TLNRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[265]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[266]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[245]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[49]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[267]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[268]

Drug(s) Affected By Pleckstrin homology domain-containing family A member 4 (PLEKHA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[42]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[34]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Protein bicaudal C homolog 1 (BICC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[265]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[230]
Nitrobenzanthrone	DMN6L70	N. A.	N. A.	Investigative	[269]

Drug(s) Affected By Vasculin-like protein 1 (GPBP1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[128]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]

Drug(s) Affected By RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SSU72)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Anillin (ANLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[270]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]

Drug(s) Affected By Midasin (MDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[271]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]

Drug(s) Affected By Protein eva-1 homolog B (EVA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[226]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]

Drug(s) Affected By Protein AATF (AATF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[272]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[273]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[274]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[31]

Drug(s) Affected By Short coiled-coil protein (SCOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]

Drug(s) Affected By F-box/LRR-repeat protein 4 (FBXL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[217]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[142]

Drug(s) Affected By Histone chaperone ASF1A (ASF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[275]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[68]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[127]

Drug(s) Affected By Tudor and KH domain-containing protein (TDRKH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[59]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[267]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Malignant fibrous histiocytoma-amplified sequence 1 (MFHAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[23]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[25]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF115 (RNF115)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[16]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[146]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cellular tumor antigen p53 (TP53)	TT7SBF5	P53_HUMAN	Stimulator	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein gamma	OTYQTMPI	1433G_HUMAN	Gene/Protein Processing	[5]
A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10)	OTNJ9VSU	ATS10_HUMAN	Gene/Protein Processing	[5]
A-kinase anchor protein 9 (AKAP9)	OT7Z2YRP	AKAP9_HUMAN	Gene/Protein Processing	[5]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A)	OTE2KVZV	SCNNA_HUMAN	Gene/Protein Processing	[5]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Gene/Protein Processing	[5]
AP-1 complex subunit beta-1 (AP1B1)	OTY0K84R	AP1B1_HUMAN	Gene/Protein Processing	[5]
AP-3 complex subunit sigma-2 (AP3S2)	OTN8P9OE	AP3S2_HUMAN	Gene/Protein Processing	[5]
Astrocytic phosphoprotein PEA-15 (PEA15)	OTKCKTSX	PEA15_HUMAN	Gene/Protein Processing	[5]
ATP-dependent RNA helicase DDX54 (DDX54)	OTVOJU6G	DDX54_HUMAN	Gene/Protein Processing	[5]
Autophagy-related protein 9A (ATG9A)	OTAZWZH7	ATG9A_HUMAN	Gene/Protein Processing	[5]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] ClinicalTrials.gov (NCT04383938) Phase 1/2 Study of APR-246 in Combination With Pembrolizumab in Subjects With Solid Tumor Malignancies. U.S. National Institutes of Health.
• [3] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030246)
• [4] APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell Death Dis. 2013 Oct 24;4:e881.
• [5] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [6] A review of contusugene ladenovec (Advexin) p53 therapy. Curr Opin Mol Ther. 2009 Feb;11(1):54-61.
• [7] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [8] Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197.
• [9] Transferrin receptor targeting nanomedicine delivering wild-type p53 gene sensitizes pancreatic cancer to gemcitabine therapy. Cancer Gene Ther. 2013 Apr;20(4):222-8.
• [10] Assessment of p53 gene transfer and biological activities in a clinical study of adenovirus-p53 gene therapy for recurrent ovarian cancer. Cancer Gene Ther. 2003 Mar;10(3):224-38.
• [11] INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect. Expert Opin Biol Ther. 2010 Jun;10(6):983-91.
• [12] Phase I trial of ALT-801, an interleukin-2/T-cell receptor fusion protein targeting p53 (aa264-272)/HLA-A*0201 complex, in patients with advanced malignancies. Clin Cancer Res. 2011 Dec 15;17(24):7765-75.
• [13] WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting.
• [14] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [15] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [16] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [17] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [18] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [19] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [20] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [21] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [22] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [23] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [24] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [25] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [26] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [27] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [28] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [29] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [30] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [31] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [32] Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism. Hepatology. 2017 Aug;66(2):432-448. doi: 10.1002/hep.29033. Epub 2017 Jun 16.
• [33] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [34] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [35] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [36] Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic. Oncotarget. 2015 Aug 28;6(25):21493-506. doi: 10.18632/oncotarget.4085.
• [37] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [38] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [39] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [40] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [41] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [42] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [43] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [44] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [45] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [46] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [47] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [48] Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
• [49] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [50] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [51] Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. Sci Rep. 2019 Jan 24;9(1):675.
• [52] Arachidonic acid-induced gene expression in colon cancer cells. Carcinogenesis. 2006 Oct;27(10):1950-60.
• [53] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [54] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [55] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [56] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [57] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [58] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [59] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [60] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [61] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [62] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [63] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [64] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [65] DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
• [66] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [67] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [68] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [69] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [70] Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
• [71] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [72] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [73] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [74] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [75] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [76] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [77] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [78] ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79.
• [79] Glyphosate-based herbicides at low doses affect canonical pathways in estrogen positive and negative breast cancer cell lines. PLoS One. 2019 Jul 11;14(7):e0219610. doi: 10.1371/journal.pone.0219610. eCollection 2019.
• [80] Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
• [81] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [82] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [83] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [84] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [85] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [86] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [87] Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017 May 16;37(11):e00079-17. doi: 10.1128/MCB.00079-17. Print 2017 Jun 1.
• [88] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [89] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [90] Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett. 2005 Jul 4;579(17):3651-9. doi: 10.1016/j.febslet.2005.05.056.
• [91] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [92] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [93] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [94] Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire. Reprod Toxicol. 2017 Oct;73:184-195. doi: 10.1016/j.reprotox.2017.07.023. Epub 2017 Aug 6.
• [95] Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
• [96] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [97] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [98] Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
• [99] Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
• [100] Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
• [101] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [102] Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
• [103] Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
• [104] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [105] The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
• [106] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [107] Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
• [108] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [109] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [110] Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
• [111] Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
• [112] A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
• [113] The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
• [114] Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
• [115] Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
• [116] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [117] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [118] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [119] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
• [120] Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
• [121] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [122] Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2010 Oct 15;401(2):245-50. doi: 10.1016/j.bbrc.2010.09.039. Epub 2010 Sep 16.
• [123] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [124] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [125] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [126] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [127] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [128] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [129] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [130] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [131] Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
• [132] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [133] Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
• [134] Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15;1731(1):48-56. doi: 10.1016/j.bbaexp.2005.08.006. Epub 2005 Sep 1.
• [135] Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
• [136] Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney. Hypertension. 2005 Oct;46(4):787-98. doi: 10.1161/01.HYP.0000184362.61744.c1. Epub 2005 Sep 19.
• [137] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [138] Epithelial sodium channel in a human trophoblast cell line (BeWo). J Membr Biol. 2008 Jun;223(3):127-39. doi: 10.1007/s00232-008-9119-3. Epub 2008 Jul 30.
• [139] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [140] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [141] Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
• [142] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [143] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [144] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [145] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [146] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [147] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [148] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [149] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [150] Influence of Iron on Cytotoxicity and Gene Expression Profiles Induced by Arsenic in HepG2 Cells. Int J Environ Res Public Health. 2019 Nov 14;16(22):4484. doi: 10.3390/ijerph16224484.
• [151] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [152] Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine. Chin Med J (Engl). 2007 Sep 20;120(18):1626-31.
• [153] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [154] Association of MHC region SNPs with irritant susceptibility in healthcare workers. J Immunotoxicol. 2016 Sep;13(5):738-44. doi: 10.3109/1547691X.2016.1173135. Epub 2016 Jun 3.
• [155] Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
• [156] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [157] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [158] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [159] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [160] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [161] Cisplatin transiently up-regulates hHR23 expression through enhanced translational efficiency in A549 adenocarcinoma cells. Toxicol Lett. 2011 Sep 10;205(3):341-50. doi: 10.1016/j.toxlet.2011.06.028. Epub 2011 Jul 2.
• [162] Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
• [163] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [164] In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
• [165] Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
• [166] Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols. Mol Cancer. 2004 Apr 26;3:11.
• [167] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [168] A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
• [169] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [170] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [171] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [172] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [173] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [174] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [175] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [176] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [177] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [178] Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides. J Biol Chem. 2018 Apr 13;293(15):5600-5612.
• [179] Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
• [180] Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells. Oncogene. 2006 Nov 23;25(55):7311-23.
• [181] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [182] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [183] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [184] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [185] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [186] NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11.
• [187] A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
• [188] Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
• [189] Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
• [190] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [191] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [192] Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
• [193] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [194] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [195] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [196] Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
• [197] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [198] Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
• [199] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [200] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [201] Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy. 2018;14(8):1435-1455. doi: 10.1080/15548627.2018.1474314. Epub 2018 Jul 20.
• [202] Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
• [203] Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
• [204] Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 2016 Oct;5(10):2899-2908.
• [205] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [206] Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One. 2011;6(11):e27306. doi: 10.1371/journal.pone.0027306. Epub 2011 Nov 8.
• [207] Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation. PLoS One. 2013 Jul 8;8(7):e69466. doi: 10.1371/journal.pone.0069466. Print 2013.
• [208] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [209] PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients. Br J Cancer. 2008 Oct 21;99(8):1276-84. doi: 10.1038/sj.bjc.6604665.
• [210] A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
• [211] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [212] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [213] Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
• [214] Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
• [215] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [216] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [217] Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
• [218] Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
• [219] Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
• [220] eNOS activation mediated by AMPK after stimulation of endothelial cells with histamine or thrombin is dependent on LKB1. Biochim Biophys Acta. 2011 Feb;1813(2):322-31. doi: 10.1016/j.bbamcr.2010.12.001. Epub 2010 Dec 9.
• [221] 2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways. Biochem Pharmacol. 2012 Dec 15;84(12):1604-16. doi: 10.1016/j.bcp.2012.09.022. Epub 2012 Oct 5.
• [222] Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells. J Biochem Mol Toxicol. 2020 Oct;34(10):e22547. doi: 10.1002/jbt.22547. Epub 2020 Jun 26.
• [223] Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. Nat Med. 2015 May;21(5):498-505. doi: 10.1038/nm.3821. Epub 2015 Apr 6.
• [224] Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models. Clin Cancer Res. 2012 Dec 15;18(24):6771-83. doi: 10.1158/1078-0432.CCR-12-2347. Epub 2012 Nov 7.
• [225] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [226] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [227] Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
• [228] Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
• [229] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [230] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [231] The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. BMC Med Genomics. 2008 Oct 10;1:49.
• [232] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [233] Linking site-specific loss of histone acetylation to repression of gene expression by the mycotoxin ochratoxin A. Arch Toxicol. 2018 Feb;92(2):995-1014.
• [234] Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.
• [235] Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
• [236] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [237] Role of N6-methyladenosine RNA modification in the imbalanced inflammatory homeostasis of arsenic-induced skin lesions. Environ Toxicol. 2022 Aug;37(8):1831-1839. doi: 10.1002/tox.23530. Epub 2022 Apr 1.
• [238] Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
• [239] Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells. Toxins (Basel). 2023 Feb 9;15(2):140. doi: 10.3390/toxins15020140.
• [240] Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
• [241] Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. Int J Mol Sci. 2022 Oct 1;23(19):11620. doi: 10.3390/ijms231911620.
• [242] [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
• [243] RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
• [244] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [245] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [246] Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
• [247] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [248] PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
• [249] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [250] Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
• [251] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [252] Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4. J Biol Chem. 2008 Nov 14;283(46):31378-84. doi: 10.1074/jbc.M803384200. Epub 2008 Sep 16.
• [253] Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
• [254] Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
• [255] Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
• [256] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [257] The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
• [258] Bisphenol A and its derivatives decrease expression of chemerin, which reverses its stimulatory action in ovarian cancer cells. Toxicol Lett. 2018 Jul;291:61-69. doi: 10.1016/j.toxlet.2018.04.004. Epub 2018 Apr 10.
• [259] Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
• [260] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [261] Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population. Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1367-75. doi: 10.1158/1055-9965.EPI-06-0106.
• [262] Regulation of lipocalin-2 gene by the cancer chemopreventive retinoid 4-HPR. Int J Cancer. 2006 Oct 1;119(7):1599-606.
• [263] Estrogen regulation of apoptosis in osteoblasts. Physiol Behav. 2010 Feb 9;99(2):181-5. doi: 10.1016/j.physbeh.2009.04.025. Epub 2009 May 5.
• [264] Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid. Toxicology. 2010 Jan 31;268(1-2):31-9.
• [265] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [266] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [267] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
• [268] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [269] 3-Nitrobenzanthrone promotes malignant transformation in human lung epithelial cells through the epiregulin-signaling pathway. Cell Biol Toxicol. 2022 Oct;38(5):865-887. doi: 10.1007/s10565-021-09612-1. Epub 2021 May 25.
• [270] Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
• [271] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [272] Poly(ADP-ribosyl)ation of Apoptosis Antagonizing Transcription Factor Involved in Hydroquinone-Induced DNA Damage Response. Biomed Environ Sci. 2016 Jan;29(1):80-4. doi: 10.3967/bes2016.008.
• [273] Phosphoproteomics reveals resveratrol-dependent inhibition of Akt/mTORC1/S6K1 signaling. J Proteome Res. 2014 Dec 5;13(12):5734-42. doi: 10.1021/pr500714a. Epub 2014 Oct 29.
• [274] Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4. Oncol Rep. 2017 Nov;38(5):2705-2716. doi: 10.3892/or.2017.5989. Epub 2017 Sep 22.
• [275] Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.