Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRD5SP)

• Drug Name: Fenretinide Drug Info
• Synonyms: RT-101; ST-602; SYT-101; Fenretinide (pulmonary Pseudomonas aeruginosa infections in cystic fibrosis), McGill University; LXS/4-HPR; Fenretinide (Ewing's sarcoma), Cancer Research UK; Fenretinide (ILE formulation), Children's Hospital LA; Fenretinide (intralipid emulsion formulation), Children's Hospital of Los Angeles; Fenretinide (intravenous, cancer), SciTech Development; Fenretinide (iv), Children's Hospital LA; Fenretinide (oral, AMD), Sytera; Fenretinide (soft gel capsule, AMD), ReVision Therapeutics; Fenretinide (soft gel capsule, AMD), Sirion; Fenretinide (topical, actinic keratosis and cancer), SciTech Development; N-(4-hydroxyphenyl)retinamide; Fenretinide (intravenous emulsion, lymphoma/solid tumors/pediatric neuroblastomas/pediatric leukemia), CerRx; Fenretinide (oral powder/Lym-X-Sorb, neuroblastoma), BioMolecular Products; 4-HPR

Indication

Disease Entry	ICD 11	Status	REF
Macular degeneration	9B78.3	Phase 3	[1]
Lymphoma	2A80-2A86	Phase 2	[2]
Peripheral T-cell lymphoma	2A90.C	Phase 2	[3]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
Tumour	2A00-2F9Z	Phase 1	[2]

• Cross-matching ID:
  PubChem CID: 5288209
  ChEBI ID: CHEBI:42588
  CAS Number: CAS 65646-68-6
  TTD Drug ID: DMRD5SP
  INTEDE Drug ID: DR1893

Molecule-Related Drug Atlas

Drug(s) Targeting Retinoic acid receptor (RAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[12]
Adapalene	DMX2358	Acne vulgaris	ED80	Approved	[13]
Peretinoin	DMESAZK	Hepatocellular carcinoma	2C12.02	Phase 3	[14]
13-cis-retinoic acid	DMTZ1A5	Glioma	2A00.0	Phase 3	[15]
Velac Gel	DMXHI89	Acne vulgaris	ED80	Phase 3	[16]
Amsilarotene	DMOB01U	Solid tumour/cancer	2A00-2F9Z	Phase 2	[17]
LAS-41001	DMXZ4BK	Rosacea	ED90.0	Discontinued in Preregistration	[18]
IRX-4310	DMUYQH8	Psoriasis vulgaris	EA90	Discontinued in Phase 3	[19]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[22]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[23]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[24]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[25]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[21]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[26]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[27]

Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[28]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[33]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[28]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[34]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[35]

Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]

Drug(s) Affected By Krueppel-like factor 7 (KLF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[47]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[52]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[53]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[54]

Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[63]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[65]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[76]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]

Drug(s) Affected By Interferon regulatory factor 1 (IRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[82]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By Bone morphogenetic protein 2 (BMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]

Drug(s) Affected By Aminopeptidase N (ANPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[101]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[104]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[105]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[106]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[107]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[113]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]

Drug(s) Affected By C-X-C motif chemokine 3 (CXCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[122]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[123]

Drug(s) Affected By Hematopoietic progenitor cell antigen CD34 (CD34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[104]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[124]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[128]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[129]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[130]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[131]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[132]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[134]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[135]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[136]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[140]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[142]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[144]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[61]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[149]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[153]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[157]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[162]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[158]

Drug(s) Affected By Trefoil factor 3 (TFF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[164]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[165]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[163]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[168]

Drug(s) Affected By CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[172]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[174]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[175]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[178]

Drug(s) Affected By Retinoic acid-induced protein 3 (GPRC5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]

Drug(s) Affected By Semaphorin-3C (SEMA3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[185]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[190]

Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[191]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[192]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[191]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[192]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[192]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[185]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[196]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM33 (TRIM33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[56]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[198]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[38]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[200]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[201]

Drug(s) Affected By Claudin-4 (CLDN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[202]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[203]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[203]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]

Drug(s) Affected By Regulator of G-protein signaling 5 (RGS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[41]

Drug(s) Affected By Claudin-3 (CLDN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[209]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[49]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[210]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[165]

Drug(s) Affected By Double-strand-break repair protein rad21 homolog (RAD21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[214]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[215]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[216]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[198]

Drug(s) Affected By Trafficking kinesin-binding protein 2 (TRAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[218]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[218]

Drug(s) Affected By Securin (PTTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[224]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]

Drug(s) Affected By Alpha-crystallin B chain (CRYAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[227]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[229]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]

Drug(s) Affected By Non-histone chromosomal protein HMG-17 (HMGN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[231]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[232]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[234]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[235]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[236]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[237]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[161]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[200]

Drug(s) Affected By Signal recognition particle 19 kDa protein (SRP19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[240]

Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[242]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]

Drug(s) Affected By Histone H2A.Z (H2AZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[246]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[247]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[250]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[249]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Selenium	DM25CGV	N. A.	N. A.	Approved	[234]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[252]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[253]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[254]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[255]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[256]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[257]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[174]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]

Drug(s) Affected By Lymphocyte function-associated antigen 3 (CD58)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[261]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By Alanine--glyoxylate aminotransferase (AGXT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[59]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[53]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[264]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[59]

Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[266]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[123]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[267]

Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[268]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[270]

Drug(s) Affected By NKG2-C type II integral membrane protein (KLRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[271]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[272]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[274]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[275]

Drug(s) Affected By Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[276]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]

Drug(s) Affected By Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Haloperidol	DM96SE0	Delirium		Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[278]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[279]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[280]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[279]

Drug(s) Affected By Cysteine-rich protein 2 (CRIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Bortezomib	DMNO38U	Leukemia		Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[281]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]

Drug(s) Affected By Apolipoprotein C-IV (APOC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[282]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[283]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[284]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[272]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[285]
GW7647	DM9RD0C	Discovery agent	N.A.	Investigative	[286]
Farnesol	DMV2X1B	Discovery agent	N.A.	Investigative	[286]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[287]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[288]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]

Drug(s) Affected By ETS-related transcription factor Elf-3 (ELF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[196]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By Neutrophil gelatinase-associated lipocalin (LCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[289]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[290]

Drug(s) Affected By Nucleobindin-2 (NUCB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[291]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[123]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[293]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[294]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[295]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[296]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[297]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[295]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[295]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[298]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[297]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[295]

Drug(s) Affected By Tumor protein D53 (TPD52L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[200]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[200]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[200]

Drug(s) Affected By Single-stranded DNA-binding protein 4 (SSBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[299]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[300]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[272]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[301]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[302]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[303]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[304]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[174]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[305]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[307]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[308]

Drug(s) Affected By Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[309]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[310]
Bortezomib	DMNO38U	Leukemia		Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[311]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[312]

Drug(s) Affected By Heat shock protein beta-8 (HSPB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[313]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[274]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[230]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD3 (KCTD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[247]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[168]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[37]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[315]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[315]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[316]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[317]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[319]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[320]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[321]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[322]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[323]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[324]
Haloperidol	DM96SE0	Delirium		Approved	[325]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[326]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[329]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[332]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[334]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[335]
Selenium	DM25CGV	N. A.	N. A.	Approved	[336]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[338]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[341]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[325]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[343]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[344]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[345]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[346]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[347]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[348]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[257]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-2 (RPS6KA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[293]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[351]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[352]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[230]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[353]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[354]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[355]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[356]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[357]

Drug(s) Affected By Acyl carrier protein, mitochondrial (NDUFAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[358]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[359]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[360]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[361]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[185]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[362]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Selenium	DM25CGV	N. A.	N. A.	Approved	[364]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[185]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[365]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[365]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[55]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[287]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[366]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 1 (NDUFA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[168]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[168]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[368]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[369]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[371]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[372]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[373]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[358]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[374]

Drug(s) Affected By Germinal-center associated nuclear protein (MCM3AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[375]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[272]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[315]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[376]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[191]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[192]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[377]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[191]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[192]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[47]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[175]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[82]

Drug(s) Affected By Isocitrate dehydrogenase cytoplasmic (IDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[378]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[247]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]

Drug(s) Affected By PRA1 family protein 3 (ARL6IP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[379]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[380]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[358]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[381]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[382]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[359]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[384]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[360]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[384]

Drug(s) Affected By Brain mitochondrial carrier protein 1 (SLC25A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[385]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[386]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[385]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[272]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[381]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[310]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[388]

Drug(s) Affected By Mitochondrial import receptor subunit TOM40 homolog (TOMM40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[389]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[390]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[53]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[391]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[392]

Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[386]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[325]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[393]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[394]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[82]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[378]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[395]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[396]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[397]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[398]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[399]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[400]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[401]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[402]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[403]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[404]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[234]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[405]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[406]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[407]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]

Drug(s) Affected By Retinol-binding protein 4 (RBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[408]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[409]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[210]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[410]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[411]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[413]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[414]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[415]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[416]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[417]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[418]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[419]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[420]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[421]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[422]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[423]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[424]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[425]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[256]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[426]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[427]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[428]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[429]
Fructose	DM43AN2	Vomiting	MD90	Approved	[325]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[430]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[431]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[433]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[434]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[326]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[435]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[436]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[437]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[326]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[438]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[326]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[378]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[439]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[440]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[346]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[406]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[442]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[443]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[444]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[237]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[445]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[446]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[247]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[447]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[409]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[448]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[353]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]
Selenium	DM25CGV	N. A.	N. A.	Approved	[450]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[451]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[452]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[453]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[454]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[455]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[456]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[457]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[456]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[458]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[459]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[460]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[326]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[461]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[200]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[200]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[200]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[462]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[293]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[463]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[464]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[465]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[466]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[325]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[467]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[468]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[469]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[470]

Drug(s) Affected By Microtubule-associated protein tau (MAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[345]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[471]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[472]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[292]

Drug(s) Affected By Retinoic acid receptor beta (RARB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[326]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[473]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[474]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[293]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[475]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[476]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[326]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[345]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[477]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[393]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[144]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[478]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[479]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[480]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[481]

Drug(s) Affected By Retinoic acid receptor gamma (RARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[482]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[483]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[293]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[484]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[485]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[390]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[486]

Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[487]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[488]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[489]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[173]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[355]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[356]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[490]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[491]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[492]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[493]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[168]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[300]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[494]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[239]

Drug(s) Affected By Glutathione peroxidase 2 (GPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[488]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[343]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[495]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[496]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[174]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[47]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[497]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[498]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[499]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[500]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[501]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[502]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[200]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[503]

Drug(s) Affected By Neutrophil cytosol factor 2 (NCF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[505]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[247]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[506]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[232]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[253]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[442]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[507]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]

Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[175]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[508]

Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[509]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[510]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[511]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[62]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[512]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[513]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[470]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[514]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[397]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[515]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[405]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[516]

Drug(s) Affected By Interleukin-4 receptor subunit alpha (IL4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[517]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[518]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[519]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[334]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[520]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[521]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[522]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[523]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[524]

Drug(s) Affected By Paired box protein Pax-6 (PAX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[525]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[525]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[526]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[525]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[525]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[527]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[525]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[528]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[529]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[530]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[469]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[531]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[532]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[533]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[534]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[535]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[536]

Drug(s) Affected By Calreticulin (CALR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[393]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[537]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[538]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[539]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[241]

Drug(s) Affected By Calnexin (CANX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[81]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[540]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[541]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[113]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[542]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[529]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[543]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[544]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[545]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[528]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[325]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[469]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[531]

Drug(s) Affected By Retinoic acid receptor RXR-beta (RXRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[546]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[292]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[547]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[548]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[497]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[549]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[497]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[485]

Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[393]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[241]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[241]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[551]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[552]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[553]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[554]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[555]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[556]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[557]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[558]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[559]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[560]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[327]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[561]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[235]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[562]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[457]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[185]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[563]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[565]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[413]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[566]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[567]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[568]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[569]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[570]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[571]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[572]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[573]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[574]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[575]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[576]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[577]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[562]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[578]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[579]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[411]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[580]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[581]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[582]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[583]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[430]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[584]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[433]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[426]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[585]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[433]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[586]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[587]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[588]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[589]
Indomethacin	DMSC4A7	Bursitis		Approved	[590]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[440]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[397]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[562]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[592]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[593]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[399]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[594]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[595]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[596]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[597]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[598]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[599]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]

Drug(s) Affected By Retinoic acid receptor RXR-gamma (RXRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[600]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[601]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[497]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[497]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[497]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[272]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[488]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[602]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[343]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[603]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[604]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[605]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[606]

Drug(s) Affected By Nuclear receptor subfamily 2 group C member 2 (NR2C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[607]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[374]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[53]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[608]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[272]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[301]

Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[506]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[522]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[609]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 8 (NDUFA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[381]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[301]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[610]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[376]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[611]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[313]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[612]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[599]

Drug(s) Affected By Paired mesoderm homeobox protein 1 (PRRX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[491]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[613]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Indomethacin	DMSC4A7	Bursitis		Approved	[614]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[614]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[207]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[615]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[616]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[617]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[618]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[618]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[587]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[619]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[620]

Drug(s) Affected By Growth factor receptor-bound protein 2 (GRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[621]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[622]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[612]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[588]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[623]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[624]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[625]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[626]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[627]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[628]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[629]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[630]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[631]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[631]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[632]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[633]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[631]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[631]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[631]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[631]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[634]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[634]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[635]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[636]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[411]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[113]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[637]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[463]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[571]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[467]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[326]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[638]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[441]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[254]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[457]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[416]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[639]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[455]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[640]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[634]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]

Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[641]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[642]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[292]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[643]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[588]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]

Drug(s) Affected By Histone-binding protein RBBP4 (RBBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[241]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[287]

Drug(s) Affected By TP53-binding protein 1 (TP53BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[644]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[645]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[646]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[647]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]

Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[648]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[649]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[650]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[588]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[651]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[571]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[370]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[652]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[653]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[654]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[655]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[656]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[657]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[658]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[455]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[659]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[660]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[661]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[662]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[113]

Drug(s) Affected By Cyclin-dependent kinase 5 activator 1 (CDK5R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[613]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[110]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[663]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[664]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[390]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[664]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[665]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[611]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[666]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[42]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[586]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[667]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[668]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[474]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[669]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[670]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[117]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[671]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[672]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[673]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[674]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[675]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[676]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[677]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[287]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[678]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[679]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[610]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[680]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[358]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[681]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[172]
ME-344	DM6JN19	Breast cancer	2C60-2C65	Phase 1/2	[682]

Drug(s) Affected By DnaJ homolog subfamily C member 10 (DNAJC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[683]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[174]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[683]

Drug(s) Affected By Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[272]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[455]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[659]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[684]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[151]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[685]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[686]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[687]

Drug(s) Affected By BRCA1-associated RING domain protein 1 (BARD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[688]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[220]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[247]

Drug(s) Affected By Mitochondrial intermediate peptidase (MIPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[263]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[374]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[53]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[90]

Drug(s) Affected By BAG family molecular chaperone regulator 1 (BAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[575]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[658]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[588]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[670]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[689]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[690]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[691]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[692]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[154]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[693]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[686]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[241]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[588]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[694]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[272]

Drug(s) Affected By Isoleucine--tRNA ligase, mitochondrial (IARS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[610]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[376]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[240]

Drug(s) Affected By RB-associated KRAB zinc finger protein (RBAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[374]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[198]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[301]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[313]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[695]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[696]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[644]

Drug(s) Affected By Mitochondrial carrier homolog 1 (MTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[697]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[272]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[301]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[285]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[240]

Drug(s) Affected By FAS-associated factor 1 (FAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[181]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[491]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[588]
Bortezomib	DMNO38U	Leukemia		Approved	[698]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[689]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[55]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 13B (TNFSF13B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[699]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[575]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[90]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[648]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[359]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[700]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[127]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 16 (MED16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[170]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[374]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[680]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[701]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[256]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[257]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[258]

Drug(s) Affected By Galactosylceramide sulfotransferase (GAL3ST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[645]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[55]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[375]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[128]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor (RAR)	TTOD7B3	NOUNIPROTAC	Modulator	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C8 (CYP2C8) Main DME	DES5XRU	CP2C8_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein theta	OTWG7F3H	1433T_HUMAN	Protein Interaction/Cellular Processes	[6]
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[7]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[8]
Acyl carrier protein, mitochondrial (NDUFAB1)	OTF906UR	ACPM_HUMAN	Gene/Protein Processing	[9]
Alanine--glyoxylate aminotransferase (AGXT)	OTIPTH3Q	AGT1_HUMAN	Gene/Protein Processing	[7]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[7]
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Gene/Protein Processing	[7]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[7]
Aminopeptidase N (ANPEP)	OTP3WYFD	AMPN_HUMAN	Gene/Protein Processing	[8]
Apolipoprotein C-IV (APOC4)	OTE8ZUXY	APOC4_HUMAN	Gene/Protein Processing	[7]

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