Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRD5SP)

• Drug Name: Fenretinide Drug Info
• Synonyms: RT-101; ST-602; SYT-101; Fenretinide (pulmonary Pseudomonas aeruginosa infections in cystic fibrosis), McGill University; LXS/4-HPR; Fenretinide (Ewing's sarcoma), Cancer Research UK; Fenretinide (ILE formulation), Children's Hospital LA; Fenretinide (intralipid emulsion formulation), Children's Hospital of Los Angeles; Fenretinide (intravenous, cancer), SciTech Development; Fenretinide (iv), Children's Hospital LA; Fenretinide (oral, AMD), Sytera; Fenretinide (soft gel capsule, AMD), ReVision Therapeutics; Fenretinide (soft gel capsule, AMD), Sirion; Fenretinide (topical, actinic keratosis and cancer), SciTech Development; N-(4-hydroxyphenyl)retinamide; Fenretinide (intravenous emulsion, lymphoma/solid tumors/pediatric neuroblastomas/pediatric leukemia), CerRx; Fenretinide (oral powder/Lym-X-Sorb, neuroblastoma), BioMolecular Products; 4-HPR

Indication

Disease Entry	ICD 11	Status	REF
Macular degeneration	9B78.3	Phase 3	[1]
Lymphoma	2A80-2A86	Phase 2	[2]
Peripheral T-cell lymphoma	2A90.C	Phase 2	[3]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
Tumour	2A00-2F9Z	Phase 1	[2]

• Cross-matching ID:
  PubChem CID: 5288209
  ChEBI ID: CHEMBL7301
  CAS Number: CAS 65646-68-6
  TTD Drug ID: DMRD5SP
  INTEDE Drug ID: DR1893

Molecule-Related Drug Atlas

Drug(s) Targeting Retinoic acid receptor (RAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[11]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[12]
Adapalene	DMX2358	Acne vulgaris	ED80	Approved	[13]
Peretinoin	DMESAZK	Hepatocellular carcinoma	2C12.02	Phase 3	[14]
13-cis-retinoic acid	DMTZ1A5	Glioma	2A00.0	Phase 3	[15]
Velac Gel	DMXHI89	Acne vulgaris	ED80	Phase 3	[16]
Amsilarotene	DMOB01U	Solid tumour/cancer	2A00-2F9Z	Phase 2	[17]
LAS-41001	DMXZ4BK	Rosacea	ED90.0	Discontinued in Preregistration	[18]
IRX-4310	DMUYQH8	Psoriasis vulgaris	EA90	Discontinued in Phase 3	[19]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[22]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[23]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[24]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[25]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[21]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[26]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[27]

Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]

Drug(s) Affected By Krueppel-like factor 7 (KLF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[44]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[45]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[46]

Drug(s) Affected By C-X-C motif chemokine 3 (CXCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[55]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[57]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[59]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[69]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[70]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[80]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[85]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[87]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[81]

Drug(s) Affected By Trefoil factor 3 (TFF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[89]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[88]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[93]

Drug(s) Affected By CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[98]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[100]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[104]

Drug(s) Affected By Retinoic acid-induced protein 3 (GPRC5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[108]

Drug(s) Affected By Semaphorin-3C (SEMA3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[112]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]

Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[113]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[113]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[114]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[114]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[120]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM33 (TRIM33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[121]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[123]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[30]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[127]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[128]

Drug(s) Affected By Regulator of G-protein signaling 5 (RGS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[33]

Drug(s) Affected By Claudin-3 (CLDN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[132]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[133]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[90]

Drug(s) Affected By Double-strand-break repair protein rad21 homolog (RAD21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[137]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[138]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[139]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[123]

Drug(s) Affected By Trafficking kinesin-binding protein 2 (TRAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[140]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[141]

Drug(s) Affected By Securin (PTTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]

Drug(s) Affected By Alpha-crystallin B chain (CRYAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[153]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[155]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Non-histone chromosomal protein HMG-17 (HMGN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[156]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[157]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[85]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[159]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[127]

Drug(s) Affected By Signal recognition particle 19 kDa protein (SRP19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[160]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[161]

Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[163]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]

Drug(s) Affected By Histone H2A.Z (H2AZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[166]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[167]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[170]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[171]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[170]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[172]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[173]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[100]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]

Drug(s) Affected By Lymphocyte function-associated antigen 3 (CD58)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]

Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[181]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[55]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[182]

Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[183]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[185]

Drug(s) Affected By NKG2-C type II integral membrane protein (KLRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[190]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[191]

Drug(s) Affected By Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[193]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]

Drug(s) Affected By Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Haloperidol	DM96SE0	Delirium		Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[195]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[198]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[197]

Drug(s) Affected By Cysteine-rich protein 2 (CRIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[199]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]

Drug(s) Affected By Apolipoprotein C-IV (APOC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[201]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[203]
GW7647	DM9RD0C	Discovery agent	N.A.	Investigative	[204]
Farnesol	DMV2X1B	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[205]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]

Drug(s) Affected By ETS-related transcription factor Elf-3 (ELF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[120]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]

Drug(s) Affected By Nucleobindin-2 (NUCB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[207]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[55]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[209]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[210]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[211]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[211]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[211]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[214]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[215]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[213]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]

Drug(s) Affected By Tumor protein D53 (TPD52L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[127]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]

Drug(s) Affected By Single-stranded DNA-binding protein 4 (SSBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[216]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[219]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[100]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[223]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[225]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[226]

Drug(s) Affected By Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[227]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[228]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[229]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[230]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD3 (KCTD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[93]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[231]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[232]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[232]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[233]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[234]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[237]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[238]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[239]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[240]

Drug(s) Affected By Acyl carrier protein, mitochondrial (NDUFAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[241]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[244]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[245]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[116]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[246]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[249]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[116]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[250]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[250]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[156]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[156]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[71]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[205]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[251]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 1 (NDUFA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[93]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[93]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[254]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[255]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[256]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[257]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[259]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[260]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[241]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]

Drug(s) Affected By Germinal-center associated nuclear protein (MCM3AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[232]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[263]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[113]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[114]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[264]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[113]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[114]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]

Drug(s) Affected By Isocitrate dehydrogenase cytoplasmic (IDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[266]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]

Drug(s) Affected By PRA1 family protein 3 (ARL6IP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[268]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[269]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[270]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[271]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[272]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[273]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[244]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[273]

Drug(s) Affected By Brain mitochondrial carrier protein 1 (SLC25A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[274]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[275]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[274]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[270]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[228]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[277]

Drug(s) Affected By Mitochondrial import receptor subunit TOM40 homolog (TOMM40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[278]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[279]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[45]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[280]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[281]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[282]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[283]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[285]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[286]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[287]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[288]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]

Drug(s) Affected By Retinol-binding protein 4 (RBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[289]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[290]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[133]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[169]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[292]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[172]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[293]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[294]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[295]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[296]
Fructose	DM43AN2	Vomiting	MD90	Approved	[297]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[299]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[300]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[302]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[303]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[253]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[304]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[51]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[253]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[307]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[308]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[310]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[287]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[313]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[316]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[317]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[318]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[319]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[320]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[321]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[322]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[323]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[322]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[324]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[325]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]

Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[327]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[328]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[93]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[217]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[329]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Glutathione peroxidase 2 (GPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[332]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[333]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]

Drug(s) Affected By Neutrophil cytosol factor 2 (NCF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[335]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[168]

Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[336]

Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[337]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[339]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[108]

Drug(s) Affected By Interleukin-4 receptor subunit alpha (IL4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[340]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[342]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[344]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[345]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[346]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[347]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[348]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[349]

Drug(s) Affected By Paired box protein Pax-6 (PAX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[350]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[350]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[351]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[350]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[350]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[352]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[350]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[353]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[354]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[356]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[357]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[358]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[359]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[360]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[362]

Drug(s) Affected By Calnexin (CANX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[268]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[363]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[364]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[118]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[365]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[354]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[366]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[367]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[368]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[353]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[297]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[356]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[357]

Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[254]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[162]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[162]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[371]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[372]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[300]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[373]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[374]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[375]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[323]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[116]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[375]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[376]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[377]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[378]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[379]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[380]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[381]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[382]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[384]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[302]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[293]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[385]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[302]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[386]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[387]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[341]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[388]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[389]
Indomethacin	DMSC4A7	Bursitis		Approved	[390]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[391]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[392]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[375]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[393]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[394]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[395]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[397]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[398]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[400]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[401]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]

Drug(s) Affected By Nuclear receptor subfamily 2 group C member 2 (NR2C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[402]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[45]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[403]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 8 (NDUFA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[404]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[263]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[407]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[401]

Drug(s) Affected By Paired mesoderm homeobox protein 1 (PRRX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[409]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Indomethacin	DMSC4A7	Bursitis		Approved	[410]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[410]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[130]

Drug(s) Affected By Growth factor receptor-bound protein 2 (GRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[412]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[407]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[388]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[413]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[416]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[417]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[418]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[419]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[420]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[421]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[421]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[422]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[423]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[421]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[421]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[421]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[421]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[424]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[321]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[426]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[427]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[257]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]

Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[429]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[208]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[430]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[388]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Histone-binding protein RBBP4 (RBBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[162]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[205]

Drug(s) Affected By TP53-binding protein 1 (TP53BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[431]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[432]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[62]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[433]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[434]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[435]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]

Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[436]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[437]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[177]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[438]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[388]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[439]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[440]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[257]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[441]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[442]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[443]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[445]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[446]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[447]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[321]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[448]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[449]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[450]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[451]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[118]

Drug(s) Affected By Cyclin-dependent kinase 5 activator 1 (CDK5R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[452]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[409]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[453]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[454]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[455]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[279]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[455]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[456]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[384]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[457]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[34]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[386]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[459]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[460]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[461]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[462]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[463]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[464]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[465]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[466]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[205]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[467]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[468]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[404]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[469]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[241]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[470]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[98]
ME-344	DM6JN19	Breast cancer	2C60-2C65	Phase 1/2	[471]

Drug(s) Affected By DnaJ homolog subfamily C member 10 (DNAJC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[472]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[100]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[472]

Drug(s) Affected By Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[321]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[448]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[473]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[214]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[74]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[474]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[476]

Drug(s) Affected By BRCA1-associated RING domain protein 1 (BARD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[177]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[477]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[143]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[168]

Drug(s) Affected By Mitochondrial intermediate peptidase (MIPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[45]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By BAG family molecular chaperone regulator 1 (BAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[478]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[388]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[479]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[193]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[480]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[481]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[482]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[483]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[77]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]

Drug(s) Affected By Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[484]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[475]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[162]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[388]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[485]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]

Drug(s) Affected By Isoleucine--tRNA ligase, mitochondrial (IARS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[404]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[263]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[161]

Drug(s) Affected By RB-associated KRAB zinc finger protein (RBAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[123]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[406]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[486]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[487]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[431]

Drug(s) Affected By Mitochondrial carrier homolog 1 (MTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[488]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[203]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[161]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 13B (TNFSF13B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[478]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[177]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[436]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[490]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 16 (MED16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[109]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[469]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[491]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[60]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[172]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[173]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[174]

Drug(s) Affected By Galactosylceramide sulfotransferase (GAL3ST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[433]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[71]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[492]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor (RAR)	TTOD7B3	NOUNIPROTAC	Modulator	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C8 (CYP2C8) Main DME	DES5XRU	CP2C8_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein theta	OTWG7F3H	1433T_HUMAN	Protein Interaction/Cellular Processes	[6]
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[7]
Acyl carrier protein, mitochondrial (NDUFAB1)	OTF906UR	ACPM_HUMAN	Gene/Protein Processing	[8]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[7]
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Gene/Protein Processing	[7]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[7]
Apolipoprotein C-IV (APOC4)	OTE8ZUXY	APOC4_HUMAN	Gene/Protein Processing	[7]
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14)	OT87E7HW	B2L14_HUMAN	Gene/Protein Processing	[8]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Gene/Protein Processing	[9]
BAG family molecular chaperone regulator 1 (BAG1)	OTRQNIA4	BAG1_HUMAN	Protein Interaction/Cellular Processes	[6]

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