General Information of Disease (ID: DISDRAAR)

Disease Name Substance dependence
Synonyms dependence
Definition The psychological or physiological need to take a substance in order to experience its effects or to avoid the effects of its absence.
Disease Hierarchy
:
DISDRAAR: Substance dependence
Disease Identifiers
MONDO ID
MONDO_0004938
MESH ID
D019966
UMLS CUI
C0038580
MedGen ID
20989
SNOMED CT ID
1254812006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Methamphetamine DMPM4SK Approved Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 33 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ADH1A TT5AHZ0 Limited Genetic Variation [2]
ADH7 TT3LE7P Limited Genetic Variation [3]
CHRM2 TTYEG6Q Limited Genetic Variation [4]
GABRG2 TT06RH5 Limited Genetic Variation [5]
SLC6A4 TT3ROYC Limited Genetic Variation [6]
ABCC4 TTUEAFL Strong Biomarker [7]
CD274 TT8ZLTI Strong Biomarker [7]
CFTR TTRLZHP Strong Biomarker [7]
CHRNA5 TTH2QRX Strong Biomarker [8]
CYP2D6 TTVG215 Strong Biomarker [9]
DRD2 TTEX248 Strong Biomarker [10]
DRD5 TTS2PH3 Strong Genetic Variation [11]
FHIT TTMS54D Strong Biomarker [7]
FKBP15 TT1XEQO Strong Biomarker [7]
FKBP5 TT0J5KQ Strong Biomarker [12]
GABRA2 TTBMV1G Strong Genetic Variation [13]
GRIA4 TTPJR0G Strong Biomarker [7]
GRIK2 TT0K5RG Strong Biomarker [7]
GRM5 TTHS256 Strong Biomarker [7]
GRM7 TT0I76D Strong Biomarker [7]
INSR TTCBFJO Strong Biomarker [7]
MKNK1 TTEZAUX Strong Biomarker [7]
NPY TT64REZ Strong Biomarker [14]
OPRD1 TT27RFC Strong Biomarker [7]
OPRK1 TTQW87Y Strong Genetic Variation [15]
PDE1C TTW2HRK Strong Biomarker [7]
PLA2R1 TTHKW7D Strong Biomarker [7]
PRKCE TT57MT2 Strong Biomarker [7]
PRKCH TTONI0R Strong Biomarker [7]
SLC10A2 TTPI1M5 Strong Biomarker [7]
SLC22A3 TTG2UMS Strong Biomarker [16]
SLK TT8K4DE Strong Biomarker [7]
CNR1 TT6OEDT Definitive Biomarker [17]
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⏷ Show the Full List of 33 DTT(s)
This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC2A13 DT0NSKB Strong Biomarker [7]
SLC45A2 DTNCJAT Strong Biomarker [7]
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This Disease Is Related to 3 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ADH4 DEOCWU3 Limited Genetic Variation [18]
FAAH DEUM1EX Strong Biomarker [19]
MSRA DEU2ZBY Strong Biomarker [7]
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This Disease Is Related to 81 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
COL25A1 OT7M23Z9 Limited Biomarker [20]
FAM53B OTVD7OU6 Limited Genetic Variation [21]
RGS17 OT5RVUDS Limited Genetic Variation [22]
RGS20 OT6CGYHW Limited Genetic Variation [22]
TTC12 OTDB24YV Limited Genetic Variation [23]
ABLIM1 OTHXEK3E Strong Biomarker [7]
ADARB2 OTDJKS39 Strong Biomarker [7]
AFF3 OTR0705Z Strong Biomarker [7]
AGBL4 OTOX2H61 Strong Biomarker [7]
AKAP7 OT0L3PZ6 Strong Biomarker [7]
ANKK1 OT0OM1O0 Strong Genetic Variation [24]
ANO4 OT8E2PMA Strong Biomarker [7]
APPL2 OT9S4C4K Strong Biomarker [7]
ATP1B1 OTTO6ZP4 Strong Biomarker [7]
BCAR3 OTPJ17M8 Strong Biomarker [7]
BPIFA2 OTLFSDZD Strong Biomarker [7]
C19orf18 OTY38VMO Strong Biomarker [7]
C5orf63 OTKTZVBF Strong Biomarker [7]
CADPS2 OTV1FW0M Strong Biomarker [7]
CCDC91 OTLZNXDL Strong Biomarker [7]
CDCP1 OTD7RRWK Strong Biomarker [7]
CDH13 OTD2CYM5 Strong Biomarker [7]
CERS6 OTOP4GV1 Strong Biomarker [7]
CHCHD3 OT8BDECJ Strong Biomarker [7]
CHD1L OT7CZK7C Strong Biomarker [7]
COLEC12 OTIQTK9G Strong Biomarker [7]
CSMD1 OTIVDSC4 Strong Biomarker [7]
CSMD3 OTAT75SW Strong Biomarker [7]
CSRNP3 OTOANEHZ Strong Biomarker [7]
CSRP3 OTECBJMV Strong Biomarker [7]
CTNNA3 OT9Z0P1E Strong Biomarker [7]
CXCL14 OTM189TA Strong Biomarker [7]
DDX1 OT3U8FD0 Strong Biomarker [7]
DNAH8 OTGES2OU Strong Biomarker [7]
DOCK1 OTCFV3ON Strong Biomarker [7]
DSCAM OTL7PRMK Strong Biomarker [7]
EHHADH OTBAAHL5 Strong Biomarker [7]
EIPR1 OTNQKNL3 Strong Biomarker [7]
ETV6 OTCZMG61 Strong Biomarker [7]
FAM184A OTAI8E9G Strong Biomarker [7]
FAM184B OTIHXYJC Strong Biomarker [7]
FARP1 OTL1EBTM Strong Biomarker [7]
FHOD3 OT1WUBQX Strong Biomarker [7]
FRMD4A OTJDTIK2 Strong Biomarker [7]
GBA3 OT86XWU2 Strong Biomarker [7]
HSPA12A OTFOCDD6 Strong Biomarker [7]
KLF12 OTVH4KD4 Strong Biomarker [7]
LDLRAD3 OTYAKC55 Strong Biomarker [7]
LIMCH1 OTYPC4XA Strong Biomarker [7]
LRMDA OTIPNKTU Strong Biomarker [7]
MACROD2 OTNQCHC6 Strong Biomarker [7]
MPC1 OT6DYFUO Strong Biomarker [7]
MPP7 OT3G3HTZ Strong Biomarker [7]
MYO5C OTKLOCWZ Strong Biomarker [7]
MYO6 OTJQYRC7 Strong Biomarker [7]
NME7 OTYMBK3Q Strong Biomarker [7]
NRCAM OT80HHQ2 Strong Biomarker [25]
NRXN3 OTJ0I7HJ Strong Biomarker [7]
OR51E1 OTB7Q65H Strong Biomarker [7]
PACS1 OT9TMQL3 Strong Biomarker [7]
PARVA OTLKEWRY Strong Biomarker [7]
PBX1 OTORABGO Strong Biomarker [7]
PCDH15 OTU9C2EH Strong Biomarker [7]
PDYN OTEJ6430 Strong Biomarker [26]
PIWIL1 OT7CRGZ3 Strong Biomarker [7]
PMAIP1 OTXEE550 Strong Biomarker [7]
POLR1D OTOCZQNA Strong Biomarker [7]
PPP1R1B OTSIJMQ9 Strong Biomarker [27]
PRPF4 OTK0XRQN Strong Biomarker [7]
QSOX1 OT4ZPK4P Strong Biomarker [7]
RAD51B OTCJVRMY Strong Biomarker [7]
RHBDD3 OTJ3OLC8 Strong Biomarker [7]
RTL6 OT9LG762 Strong Biomarker [7]
SAMD4A OT4MKCC8 Strong Biomarker [7]
SEMA6D OTU0UAZS Strong Biomarker [7]
SYNE1 OTSBSLUH Strong Biomarker [7]
TENM2 OTPLUYEF Strong Biomarker [7]
THSD4 OTXDBMDC Strong Biomarker [7]
TIAM2 OTPYIPT6 Strong Biomarker [7]
TMPRSS7 OTW938I4 Strong Biomarker [7]
TTC21B OTXXA87U Strong Biomarker [7]
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⏷ Show the Full List of 81 DOT(s)

References

1 Methamphetamine FDA Label
2 ADH1A variation predisposes to personality traits and substance dependence.Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):376-386. doi: 10.1002/ajmg.b.30990.
3 ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects.Am J Med Genet B Neuropsychiatr Genet. 2008 Mar 5;147B(2):179-86. doi: 10.1002/ajmg.b.30589.
4 Neural and genetic correlates of binge drinking among college women.Biol Psychol. 2014 Mar;97:43-8. doi: 10.1016/j.biopsycho.2014.01.005. Epub 2014 Feb 14.
5 Association of gamma-aminobutyric acid A receptor 2 gene (GABRA2) with alcohol use disorder.Neuropsychopharmacology. 2014 Mar;39(4):907-18. doi: 10.1038/npp.2013.291. Epub 2013 Oct 18.
6 5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder.Psychiatr Genet. 2011 Oct;21(5):240-8. doi: 10.1097/YPG.0b013e3283457c15.
7 Genome wide association for addiction: replicated results and comparisons of two analytic approaches.PLoS One. 2010 Jan 21;5(1):e8832. doi: 10.1371/journal.pone.0008832.
8 Low ethanol concentration alters CHRNA5 RNA levels during early human development. Reprod Toxicol. 2010 Nov;30(3):489-92. doi: 10.1016/j.reprotox.2010.04.011. Epub 2010 May 11.
9 Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia. Eur J Clin Pharmacol. 2006 Dec;62(12):995-1001. doi: 10.1007/s00228-006-0210-3. Epub 2006 Nov 7.
10 Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.BMC Syst Biol. 2015 Jun 5;9:25. doi: 10.1186/s12918-015-0167-x.
11 Antisociality, substance dependence, and the DRD5 gene: a preliminary study.Am J Med Genet. 2000 Oct 9;96(5):654-8. doi: 10.1002/1096-8628(20001009)96:5<654::aid-ajmg11>3.0.co;2-y.
12 The influence of FKBP5 genotype on expression of FKBP5 and other glucocorticoid-regulated genes, dependent on trauma exposure.Genes Brain Behav. 2017 Feb;16(2):223-232. doi: 10.1111/gbb.12342. Epub 2016 Oct 11.
13 GABRA2 genotype, impulsivity, and body mass.Am J Addict. 2012 Sep-Oct;21(5):404-10. doi: 10.1111/j.1521-0391.2012.00252.x.
14 Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes.Psychoneuroendocrinology. 2012 Apr;37(4):554-64. doi: 10.1016/j.psyneuen.2011.08.005. Epub 2011 Sep 13.
15 The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.Mol Psychiatry. 2008 May;13(5):531-43. doi: 10.1038/sj.mp.4002035. Epub 2007 Jul 10.
16 Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder.Alcohol Clin Exp Res. 2006 Oct;30(10):1644-9. doi: 10.1111/j.1530-0277.2006.00215.x.
17 Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis.Addict Biol. 2013 Jul;18(4):702-8. doi: 10.1111/j.1369-1600.2011.00346.x. Epub 2011 Jul 25.
18 Personality traits of agreeableness and extraversion are associated with ADH4 variation.Biol Psychiatry. 2007 Mar 1;61(5):599-608. doi: 10.1016/j.biopsych.2006.05.017. Epub 2006 Oct 25.
19 Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function.Biol Psychiatry. 2009 Jul 1;66(1):9-16. doi: 10.1016/j.biopsych.2008.10.047. Epub 2008 Dec 21.
20 Association of COL25A1 with comorbid antisocial personality disorder and substance dependence.Biol Psychiatry. 2012 Apr 15;71(8):733-40. doi: 10.1016/j.biopsych.2011.12.011. Epub 2012 Jan 31.
21 Evaluation of previous substance dependence genome-wide significant findings in a Spanish sample.Drug Alcohol Depend. 2018 Jun 1;187:358-362. doi: 10.1016/j.drugalcdep.2018.03.013. Epub 2018 Apr 16.
22 Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses.Behav Brain Funct. 2012 May 16;8:23. doi: 10.1186/1744-9081-8-23.
23 Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.Hum Mol Genet. 2006 Dec 15;15(24):3498-507. doi: 10.1093/hmg/ddl426. Epub 2006 Nov 3.
24 Who gains? Genetic and neurophysiological correlates of BMI gain upon college entry in women.Appetite. 2014 Nov;82:160-5. doi: 10.1016/j.appet.2014.07.007. Epub 2014 Jul 15.
25 NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. Neuropsychopharmacology. 2006 Mar;31(3):572-84. doi: 10.1038/sj.npp.1300855.
26 Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain.Cereb Cortex. 2018 Sep 1;28(9):3129-3142. doi: 10.1093/cercor/bhx181.
27 Association study between casein kinase 1 epsilon gene and methamphetamine dependence.Ann N Y Acad Sci. 2008 Oct;1139:43-8. doi: 10.1196/annals.1432.025.