Details of Disease

General Information of Disease (ID: DISXJUAF)

Disease Name Gallbladder cancer
Synonyms
localised malignant gallbladder neoplasm; localized malignant gallbladder neoplasm; tumour of the gallbladder; tumor of the gallbladder; gallbladder neoplasm; malignant tumour of gallbladder; malignant gall bladder neoplasm; malignant neoplasm of the gallbladder; malignant neoplasm of gall bladder; gall bladder cancer; malignant gallbladder tumor; malignant tumor of the gallbladder; malignant gallbladder neoplasm; malignant tumour of the gallbladder; cancer of gall bladder; malignant neoplasm of gallbladder; gallbladder Ca; malignant gallbladder tumour; malignant tumor of gallbladder
Definition A malignant neoplasm involving the gall bladder
Disease Hierarchy
:
DISAT1Z9: Advanced cancer
DIS3AOQ7: Aerodigestive tract cancer
DISXJUAF: Gallbladder cancer
Disease Identifiers
MONDO ID
MONDO_0005411
MESH ID
D005706
UMLS CUI
C0153452
MedGen ID
57784
SNOMED CT ID
363353009

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 39 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ADRA2A TTWG9A4 Limited Genetic Variation [1]
ADRB3 TTMXGCW Limited Biomarker [2]
DKK2 TTST5KX Limited Genetic Variation [3]
GOT1 TTU507L Limited Genetic Variation [4]
HDGF TTKGV26 Limited Biomarker [5]
HTATIP2 TTC6IX5 Limited Altered Expression [6]
IMP3 TTEJA2R Limited Biomarker [7]
PRKCE TT57MT2 Limited Biomarker [8]
RNASEL TT7V0K4 Limited Genetic Variation [9]
ST8SIA4 TTDP8YM Limited Genetic Variation [10]
STOML2 TTOI329 Limited Altered Expression [11]
CLDN18 TT6PKBX Disputed Altered Expression [12]
EIF5A2 TTH53G9 Disputed Biomarker [13]
ERBB2 TTR5TV4 Disputed Biomarker [14]
NEK7 TTJ5SWP Disputed Biomarker [15]
PBRM1 TTH8ZRL Disputed Biomarker [16]
PKLR TT31N4S Disputed Biomarker [17]
BIRC3 TTAIWZN moderate Biomarker [18]
CETP TTFQAYR moderate Biomarker [19]
SPOCK1 TTF23RE moderate Biomarker [20]
TPT1 TT3PTB6 moderate Biomarker [21]
CCK TT90CMU Strong Biomarker [22]
CEACAM5 TTY6DTE Strong Biomarker [23]
CLIC1 TT8KZG6 Strong Biomarker [24]
DDR2 TTU98HG Strong Biomarker [25]
ERBB4 TTWALCO Strong Biomarker [26]
KEAP1 TT3Z6Y9 Strong Biomarker [27]
KRAS TTM8FR7 Strong Genetic Variation [28]
OGG1 TTRU01G Strong Genetic Variation [29]
OLFM4 TTK1CX7 Strong Altered Expression [30]
SERPINB5 TT1KW50 Strong Altered Expression [31]
UCHL1 TTX9IFP Strong Biomarker [32]
VEGFD TTOM5H4 Strong Biomarker [33]
CCKAR TTCG0AL Definitive Altered Expression [34]
ERBB3 TTSINU2 Definitive Biomarker [35]
PSCA TT9T4AV Definitive Altered Expression [36]
RALBP1 TTVSRUA Definitive Biomarker [37]
RIPK1 TTVJHX8 Definitive Biomarker [37]
SGCB TTEDCQ0 Definitive Biomarker [38]
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⏷ Show the Full List of 39 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC25A22 DTJCWP8 Strong Altered Expression [39]
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This Disease Is Related to 6 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
HSD17B7 DEDMWFX Limited Altered Expression [40]
CYP39A1 DEEG96X Disputed Biomarker [19]
CYP7B1 DE36TMY Disputed Biomarker [19]
SULT2B1 DEZBN53 Disputed Altered Expression [19]
CYP7A1 DEDZRQ1 Strong Genetic Variation [41]
GSTM1 DEYZEJA Definitive Genetic Variation [42]
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⏷ Show the Full List of 6 DME(s)
This Disease Is Related to 69 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CIB2 OT9ZJX1I Limited Biomarker [43]
CIZ1 OT3UKHPI Limited Biomarker [44]
CPEB4 OTW1SCZW Limited Biomarker [45]
EIF3D OTDOMP80 Limited Biomarker [46]
EMP3 OTODMJ1D Limited Altered Expression [47]
FKTN OTQ9GCXL Limited Biomarker [48]
FLNC OT3F8J6Y Limited Biomarker [49]
FOXL1 OT89XFPN Limited Altered Expression [50]
GCNT2 OTRUIMC4 Limited Genetic Variation [4]
GNL3 OTILGYO4 Limited Altered Expression [51]
HIPK3 OT4WYQM2 Limited Biomarker [52]
HLTF OTRX2OSF Limited Biomarker [49]
MPG OTAHW80B Limited Biomarker [53]
MYBL2 OTZ3JX8Q Limited Biomarker [54]
NEDD4L OT1B19RU Limited Altered Expression [55]
NLK OT2LETFS Limited Biomarker [56]
PCBP1 OTHN0TD7 Limited Biomarker [57]
PHLPP1 OTIFXW8D Limited Altered Expression [58]
PPP1R10 OT7GE3BN Limited Altered Expression [59]
PSAP OTUOEKY7 Limited Biomarker [60]
RNF125 OTBD1Q3X Limited Altered Expression [61]
SCAMP1 OTFS4IKJ Limited Biomarker [62]
SKAP2 OTSF44KP Limited Altered Expression [40]
SYTL2 OTUIOWKL Limited Altered Expression [11]
TCF12 OTZVONNU Limited Biomarker [63]
TMPRSS4 OTCCGY2K Limited Altered Expression [64]
TP53BP2 OTOWJ2Y4 Limited Altered Expression [65]
TPD52 OTPKSK43 Limited Biomarker [66]
TPTE2 OTR3K733 Limited Biomarker [67]
TRIM31 OT7VW6RP Limited Biomarker [68]
TRO OTRZQMU8 Limited Altered Expression [69]
ACTR3 OT05LJSH Disputed Altered Expression [70]
APOBEC3A OTYO6F5P Disputed Altered Expression [70]
CREBRF OT2GK1HI Disputed Biomarker [71]
ELP5 OTW5R7YD Disputed Biomarker [72]
MBD1 OTD19VO6 Disputed Altered Expression [22]
MUC5B OTPW6K5C Disputed Biomarker [12]
NSUN2 OTZCNM33 Disputed Altered Expression [73]
PA2G4 OT7IG7HT Disputed Biomarker [74]
PLEK2 OTUBWUUK Disputed Biomarker [75]
RPL6 OTRU71O4 Disputed Biomarker [73]
RRN3 OTKGOZ49 Disputed Altered Expression [74]
TENM3 OTWY13GR Disputed Biomarker [76]
TENM4 OT91K3FC Disputed Genetic Variation [76]
CNTN4 OTULXVE0 moderate Genetic Variation [77]
DCAF1 OT3ZDVOE moderate Biomarker [78]
KRR1 OTCMJ3K3 moderate Biomarker [37]
RPAIN OTBMXAYK moderate Biomarker [78]
ABI3BP OTW8DN50 Strong Altered Expression [79]
ALDH1A3 OT1C9NKQ Strong Biomarker [80]
ATAD1 OTJ02XFL Strong Genetic Variation [81]
ATP5F1B OTLFZUQK Strong Biomarker [82]
CCNL2 OT0NIKYM Strong Biomarker [83]
CCNQ OT183N7L Strong Biomarker [83]
CDK10 OTKP7TTR Strong Biomarker [83]
CDO1 OTLG1P77 Strong Biomarker [84]
CDX2 OTCG4TSY Strong Genetic Variation [85]
EIF6 OTEXMUED Strong Biomarker [86]
IFITM1 OTECO1G8 Strong Biomarker [25]
PPIG OTZ8BTTM Strong Biomarker [87]
SFN OTLJCZ1U Strong Altered Expression [88]
SSBP2 OTYG1G80 Strong Posttranslational Modification [89]
STOM OTC8R6EH Strong Altered Expression [11]
ABCG8 OTIJ76XW Definitive Genetic Variation [90]
AKT1S1 OT4JHN4Y Definitive Biomarker [91]
CROCC OTVNOZSM Definitive Altered Expression [92]
DCC OT2C1SHW Definitive Biomarker [48]
E2F7 OTWW358N Definitive Biomarker [93]
KPNA2 OTU7FOE6 Definitive Altered Expression [93]
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⏷ Show the Full List of 69 DOT(s)

References

1 Association of adrenergic receptor gene polymorphisms in gallbladder cancer susceptibility in a North Indian population.J Cancer Res Clin Oncol. 2014 May;140(5):725-35. doi: 10.1007/s00432-014-1621-7. Epub 2014 Feb 21.
2 A Multiple Interaction Analysis Reveals ADRB3 as a Potential Candidate for Gallbladder Cancer Predisposition via a Complex Interaction with Other Candidate Gene Variations.Int J Mol Sci. 2015 Nov 25;16(12):28038-49. doi: 10.3390/ijms161226077.
3 Association of Wnt signaling pathway genetic variants in gallbladder cancer susceptibility and survival.Tumour Biol. 2016 Jun;37(6):8083-95. doi: 10.1007/s13277-015-4728-9. Epub 2015 Dec 29.
4 Association of genetic variants of cancer stem cell gene CD44 haplotypes with gallbladder cancer susceptibility in North Indian population.Tumour Biol. 2014 Mar;35(3):2583-9. doi: 10.1007/s13277-013-1340-8. Epub 2013 Nov 5.
5 Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion.Med Oncol. 2013;30(2):587. doi: 10.1007/s12032-013-0587-7. Epub 2013 Apr 23.
6 MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder.Mol Med Rep. 2016 Nov;14(5):4581-4592. doi: 10.3892/mmr.2016.5851. Epub 2016 Oct 13.
7 IMP2/IGF2BP2 expression, but not IMP1 and IMP3, predicts poor outcome in patients and high tumor growth rate in xenograft models of gallbladder cancer.Oncotarget. 2017 Sep 21;8(52):89736-89745. doi: 10.18632/oncotarget.21116. eCollection 2017 Oct 27.
8 miR-218-5p restores sensitivity to gemcitabine through PRKCE/MDR1 axis in gallbladder cancer.Cell Death Dis. 2017 May 11;8(5):e2770. doi: 10.1038/cddis.2017.178.
9 Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.Cancer Res. 2008 Aug 1;68(15):6442-52. doi: 10.1158/0008-5472.CAN-08-0444.
10 Cholecystokinin receptor A gene polymorphism in gallstone disease and gallbladder cancer.J Gastroenterol Hepatol. 2008 Jun;23(6):970-5. doi: 10.1111/j.1440-1746.2007.05170.x. Epub 2007 Oct 11.
11 Enhanced SLP-2 promotes invasion and metastasis by regulating Wnt/-catenin signal pathway in colorectal cancer and predicts poor prognosis.Pathol Res Pract. 2019 Jan;215(1):57-67. doi: 10.1016/j.prp.2018.10.018. Epub 2018 Oct 24.
12 Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma.Histopathology. 2019 Mar;74(4):597-607. doi: 10.1111/his.13797. Epub 2019 Jan 28.
13 Overexpression of EIF5A2 is associated with poor survival and aggressive tumor biology in gallbladder cancer.Histol Histopathol. 2020 Jun;35(6):579-587. doi: 10.14670/HH-18-186. Epub 2019 Nov 20.
14 Pretreatment with Gemcitabine/5-Fluorouracil Enhances the Cytotoxicity of Trastuzumab to HER2-Negative Human Gallbladder Cancer Cells In Vitro and In Vivo.Biomed Res Int. 2019 Mar 25;2019:9205851. doi: 10.1155/2019/9205851. eCollection 2019.
15 Downregulation of NIMA-related kinase-7 inhibits cell proliferation by inducing cell cycle arrest in human retinoblastoma cells.Exp Ther Med. 2018 Feb;15(2):1360-1366. doi: 10.3892/etm.2017.5558. Epub 2017 Nov 23.
16 Patterns of gene mutations in bile duct cancers: is it time to overcome the anatomical classification?.HPB (Oxford). 2019 Dec;21(12):1648-1655. doi: 10.1016/j.hpb.2019.04.002. Epub 2019 May 20.
17 Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression.Mol Cancer. 2019 Oct 17;18(1):145. doi: 10.1186/s12943-019-1078-z.
18 cIAP1 promotes proliferation and migration and prevents apoptosis in gallbladder cancer in vitro.Biosci Rep. 2019 Apr 12;39(4):BSR20182266. doi: 10.1042/BSR20182266. Print 2019 Apr 30.
19 Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response.Cell Cycle. 2019 Dec;18(23):3337-3350. doi: 10.1080/15384101.2019.1676581. Epub 2019 Oct 10.
20 Identification of messenger and long noncoding RNAs associated with gallbladder cancer via gene expression profile analysis.J Cell Biochem. 2019 Dec;120(12):19377-19387. doi: 10.1002/jcb.28953. Epub 2019 Sep 9.
21 Correction to: Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer.J Exp Clin Cancer Res. 2019 Sep 3;38(1):385. doi: 10.1186/s13046-019-1378-6.
22 MBD1 promotes the malignant behavior of gallbladder cancer cells and induces chemotherapeutic resistance to gemcitabine.Cancer Cell Int. 2019 Sep 9;19:232. doi: 10.1186/s12935-019-0948-1. eCollection 2019.
23 Scoring System to Predict pt2 in Gallbladder Cancer Based on Carcinoembryonic Antigen and Tumor Diameter.Scand J Surg. 2020 Dec;109(4):301-308. doi: 10.1177/1457496919866016. Epub 2019 Jul 29.
24 Effect of CLIC1 gene silencing on proliferation, migration, invasion and apoptosis of human gallbladder cancer cells.J Cell Mol Med. 2018 May;22(5):2569-2579. doi: 10.1111/jcmm.13499. Epub 2018 Mar 8.
25 DDR2 and IFITM1 Are Prognostic Markers in Gallbladder Squamous Cell/Adenosquamous Carcinomas and Adenocarcinomas.Pathol Oncol Res. 2019 Jan;25(1):157-167. doi: 10.1007/s12253-017-0314-3. Epub 2017 Oct 17.
26 Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway.Nat Genet. 2014 Aug;46(8):872-6. doi: 10.1038/ng.3030. Epub 2014 Jul 6.
27 aPKC promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1.Redox Biol. 2019 Apr;22:101149. doi: 10.1016/j.redox.2019.101149. Epub 2019 Feb 21.
28 IL-33 overexpression in gallbladder cancers associated with pancreatobiliary maljunction.Histopathology. 2019 Sep;75(3):365-375. doi: 10.1111/his.13863. Epub 2019 Jul 2.
29 Gallbladder cancer predisposition: a multigenic approach to DNA-repair, apoptotic and inflammatory pathway genes.PLoS One. 2011 Jan 21;6(1):e16449. doi: 10.1371/journal.pone.0016449.
30 Olfactomedin-4 in digestive diseases: A mini-review.World J Gastroenterol. 2018 May 7;24(17):1881-1887. doi: 10.3748/wjg.v24.i17.1881.
31 Significance of methylation status of MASPIN gene and its protein expression in prognosis of gallbladder cancer.Asia Pac J Clin Oncol. 2019 Oct;15(5):e120-e125. doi: 10.1111/ajco.13129. Epub 2019 Feb 10.
32 Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.Cancer Sci. 2006 Nov;97(11):1205-10. doi: 10.1111/j.1349-7006.2006.00320.x. Epub 2006 Sep 12.
33 TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway.BMC Cancer. 2016 Mar 19;16:240. doi: 10.1186/s12885-016-2259-4.
34 Differential expression of cholecystokinin A receptor in gallbladder cancer in the young and elderly suggests two subsets of the same disease?.Biomed Res Int. 2014;2014:625695. doi: 10.1155/2014/625695. Epub 2014 Jun 15.
35 The HER3 pathway as a potential target for inhibition in patients with biliary tract cancers.PLoS One. 2018 Oct 18;13(10):e0206007. doi: 10.1371/journal.pone.0206007. eCollection 2018.
36 Down-regulation of Immune-related Genes by PSCA in Gallbladder Cancer Cells Implanted into Mice.Anticancer Res. 2015 May;35(5):2619-25.
37 Receptorinteracting serine/threonineprotein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer.Oncol Rep. 2019 Dec;42(6):2435-2449. doi: 10.3892/or.2019.7331. Epub 2019 Sep 23.
38 JAK2 tyrosine kinase inhibitor AG490 suppresses cell growth and invasion of gallbladder cancer cells via inhibition of JAK2/STAT3 signaling.J Biol Regul Homeost Agents. 2017 Jan-Mar;31(1):51-58.
39 SLC25A22 promotes proliferation and metastasis by activating MAPK/ERK pathway in gallbladder cancer.Cancer Cell Int. 2019 Feb 14;19:33. doi: 10.1186/s12935-019-0746-9. eCollection 2019.
40 UHRF1 depletion suppresses growth of gallbladder cancer cells through induction of apoptosis and cell cycle arrest.Oncol Rep. 2014 Jun;31(6):2635-43. doi: 10.3892/or.2014.3145. Epub 2014 Apr 23.
41 CYP7A1 (-204 A>C; rs3808607 and -469 T>C; rs3824260) promoter polymorphisms and risk of gallbladder cancer in North Indian population.Metabolism. 2010 Jun;59(6):767-73. doi: 10.1016/j.metabol.2009.09.021. Epub 2009 Dec 16.
42 Role of Glutathione-S-Transferases in Gallbladder Cancer and Cholelithiasis Susceptibility and Meta-Analysis.Nutr Cancer. 2020;72(6):984-991. doi: 10.1080/01635581.2019.1661503. Epub 2019 Nov 22.
43 Expression of p21(Wafl/Cip1), p57(Kip2) and HER2/neu in patients with gallbladder cancer.Anticancer Res. 2007 May-Jun;27(3B):1679-84.
44 CIZ1 promoted the growth and migration of gallbladder cancer cells.Tumour Biol. 2015 Apr;36(4):2583-91. doi: 10.1007/s13277-014-2876-y. Epub 2014 Nov 28.
45 MicroRNA-29c-5p suppresses gallbladder carcinoma progression by directly targeting CPEB4 and inhibiting the MAPK pathway.Cell Death Differ. 2017 Mar;24(3):445-457. doi: 10.1038/cdd.2016.146. Epub 2017 Jan 6.
46 EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway.Cell Death Dis. 2017 Jun 8;8(6):e2868. doi: 10.1038/cddis.2017.263.
47 RETRACTED: EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway.Cancer Lett. 2018 Aug 28;430:97-108. doi: 10.1016/j.canlet.2018.05.022. Epub 2018 May 17.
48 Sequential occurrence of preneoplastic lesions and accumulation of loss of heterozygosity in patients with gallbladder stones suggest causal association with gallbladder cancer.Ann Surg. 2014 Dec;260(6):1073-80. doi: 10.1097/SLA.0000000000000495.
49 Epigenetic profiling of gallbladder cancer and gall stone diseases: Evaluation of role of tumour associated genes.Gene. 2016 Feb 1;576(2 Pt 2):743-52. doi: 10.1016/j.gene.2015.10.004. Epub 2015 Oct 8.
50 Forkhead box L1 is frequently downregulated in gallbladder cancer and inhibits cell growth through apoptosis induction by mitochondrial dysfunction.PLoS One. 2014 Jul 10;9(7):e102084. doi: 10.1371/journal.pone.0102084. eCollection 2014.
51 Significance of epithelial growth factor in the epithelial-mesenchymal transition of human gallbladder cancer cells.Cancer Sci. 2012 Jun;103(6):1165-71. doi: 10.1111/j.1349-7006.2012.02264.x. Epub 2012 Apr 3.
52 Circular RNA HIPK3 promotes gallbladder cancer cell growth by sponging microRNA-124.Biochem Biophys Res Commun. 2018 Sep 5;503(2):863-869. doi: 10.1016/j.bbrc.2018.06.088. Epub 2018 Aug 2.
53 Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer.Oncotarget. 2017 Apr 18;8(16):26169-26184. doi: 10.18632/oncotarget.15410.
54 MYBL2 is a Potential Prognostic Marker that Promotes Cell Proliferation in Gallbladder Cancer.Cell Physiol Biochem. 2017;41(5):2117-2131. doi: 10.1159/000475454. Epub 2017 Apr 17.
55 Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.Int J Exp Pathol. 2011 Apr;92(2):79-86. doi: 10.1111/j.1365-2613.2010.00740.x. Epub 2010 Oct 5.
56 NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells.Mol Cell Biochem. 2012 Oct;369(1-2):27-33. doi: 10.1007/s11010-012-1365-0. Epub 2012 Jun 24.
57 PCBP1 is an important mediator of TGF--induced epithelial to mesenchymal transition in gall bladder cancer cell line GBC-SD.Mol Biol Rep. 2014 Aug;41(8):5519-24. doi: 10.1007/s11033-014-3428-7. Epub 2014 Jun 3.
58 SNORA74B gene silencing inhibits gallbladder cancer cells by inducing PHLPP and suppressing Akt/mTOR signaling.Oncotarget. 2017 Mar 21;8(12):19980-19996. doi: 10.18632/oncotarget.15301.
59 miR-34 is associated with poor prognosis of patients with gallbladder cancer through regulating telomere length in tumor stem cells.Tumour Biol. 2014 Feb;35(2):1503-10. doi: 10.1007/s13277-013-1207-z.
60 Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics.Biochem Biophys Res Commun. 2014 Apr 18;446(4):863-9. doi: 10.1016/j.bbrc.2014.03.017. Epub 2014 Mar 20.
61 Ring finger protein 125, as a potential highly aggressive and unfavorable prognostic biomarker, promotes the invasion and metastasis of human gallbladder cancers via activating the TGF- 1-SMAD3-ID1 signaling pathway.Oncotarget. 2017 Jul 25;8(30):49897-49914. doi: 10.18632/oncotarget.18180.
62 Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells.Tumour Biol. 2013 Oct;34(5):2731-9. doi: 10.1007/s13277-013-0825-9. Epub 2013 May 8.
63 HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer.Oncotarget. 2016 May 31;7(22):32754-64. doi: 10.18632/oncotarget.8740.
64 Clinical implication of TMPRSS4 expression in human gallbladder cancer.Tumour Biol. 2014 Jun;35(6):5481-6. doi: 10.1007/s13277-014-1716-4. Epub 2014 Feb 15.
65 Downregulation of ASPP2 promotes gallbladder cancer metastasis and macrophage recruitment via aPKC-/GLI1 pathway.Cell Death Dis. 2018 Nov 2;9(11):1115. doi: 10.1038/s41419-018-1145-1.
66 Global methylation profiling to identify epigenetic signature of gallbladder cancer and gallstone disease.Tumour Biol. 2016 Nov;37(11):14687-14699. doi: 10.1007/s13277-016-5355-9. Epub 2016 Sep 14.
67 Downregulation of TPTE2P1 Inhibits Migration and Invasion of Gallbladder Cancer Cells.Chem Biol Drug Des. 2015 Oct;86(4):656-62. doi: 10.1111/cbdd.12533. Epub 2015 May 11.
68 Knockdown of TRIM31 suppresses proliferation and invasion of gallbladder cancer cells by down-regulating MMP2/9 through the PI3K/Akt signaling pathway.Biomed Pharmacother. 2018 Jul;103:1272-1278. doi: 10.1016/j.biopha.2018.04.120. Epub 2018 May 7.
69 Enhanced expression of trophinin promotes invasive and metastatic potential of human gallbladder cancer cells.J Cancer Res Clin Oncol. 2009 Apr;135(4):581-90. doi: 10.1007/s00432-008-0492-1. Epub 2008 Oct 10.
70 CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinomas of gallbladder.Cancer Invest. 2013 Feb;31(2):132-9. doi: 10.3109/07357907.2012.756113. Epub 2013 Jan 15.
71 MicroRNA-181b blocks gensenoside Rg3-mediated tumor suppression of gallbladder carcinoma by promoting autophagy flux via CREBRF/CREB3 pathway.Am J Transl Res. 2019 Sep 15;11(9):5776-5787. eCollection 2019.
72 Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer.Nat Commun. 2019 Dec 2;10(1):5492. doi: 10.1038/s41467-019-13420-x.
73 NOP2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL6 in gallbladder carcinoma.Cancer Sci. 2019 Nov;110(11):3510-3519. doi: 10.1111/cas.14190. Epub 2019 Sep 23.
74 Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription.Mol Cancer. 2019 Nov 21;18(1):166. doi: 10.1186/s12943-019-1098-8.
75 PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.J Exp Clin Cancer Res. 2019 Jun 10;38(1):247. doi: 10.1186/s13046-019-1250-8.
76 Laparoscopy versus laparotomy approach of a radical resection for gallbladder cancer: a retrospective comparative study.Surg Endosc. 2020 Jul;34(7):2926-2938. doi: 10.1007/s00464-019-07075-4. Epub 2019 Aug 28.
77 A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population.J Hum Genet. 2012 Apr;57(4):235-7. doi: 10.1038/jhg.2012.9. Epub 2012 Feb 9.
78 Expression of the RIP-1 gene and its role in growth and invasion of human gallbladder carcinoma.Cell Physiol Biochem. 2014;34(4):1152-65. doi: 10.1159/000366328. Epub 2014 Sep 22.
79 Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells.J Exp Clin Cancer Res. 2019 Jun 7;38(1):244. doi: 10.1186/s13046-019-1237-5.
80 Positive ALDH1A3 and negative GPX3 expressions are biomarkers for poor prognosis of gallbladder cancer.Dis Markers. 2013;35(3):163-72. doi: 10.1155/2013/187043. Epub 2013 Aug 25.
81 Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population.Eur J Cancer Prev. 2008 Apr;17(2):77-81. doi: 10.1097/CEJ.0b013e3282b6fdd2.
82 ATP5b and 2-microglobulin are predictive markers for the prognosis of patients with gallbladder cancer.J Mol Histol. 2015 Feb;46(1):57-65. doi: 10.1007/s10735-014-9597-9. Epub 2014 Oct 14.
83 miR-433 accelerates acquired chemoresistance of gallbladder cancer cells by targeting cyclin M.Oncol Lett. 2018 Mar;15(3):3305-3312. doi: 10.3892/ol.2017.7708. Epub 2017 Dec 28.
84 Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease.PLoS One. 2017 Nov 21;12(11):e0188178. doi: 10.1371/journal.pone.0188178. eCollection 2017.
85 Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma.J Cancer Res Clin Oncol. 2006 Dec;132(12):805-10. doi: 10.1007/s00432-006-0129-1. Epub 2006 Jun 23.
86 Eukaryotic translation initiation factor 6 overexpression plays a major role in the translational control of gallbladder cancer.J Cancer Res Clin Oncol. 2019 Nov;145(11):2699-2711. doi: 10.1007/s00432-019-03030-x. Epub 2019 Oct 4.
87 A multigenic approach to evaluate genetic variants of PLCE1, LXRs, MMPs, TIMP, and CYP genes in gallbladder cancer predisposition.Tumour Biol. 2014 Sep;35(9):8597-606. doi: 10.1007/s13277-014-2094-7. Epub 2014 May 27.
88 Role of stratifin (14-3-3 sigma) in adenocarcinoma of gallbladder: A novel prognostic biomarker.Surg Oncol. 2020 Mar;32:57-62. doi: 10.1016/j.suronc.2019.10.022. Epub 2019 Nov 2.
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