Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT8SZSJ6)

DOT Name Polymerase delta-interacting protein 2 (POLDIP2)
Synonyms 38 kDa DNA polymerase delta interaction protein; p38
Gene Name POLDIP2
Related Disease
Lung cancer ( )
Lung carcinoma ( )
Advanced cancer ( )
Alzheimer disease ( )
Arteriosclerosis ( )
Arthritis ( )
Atherosclerosis ( )
B-cell neoplasm ( )
Breast cancer ( )
Breast carcinoma ( )
Chronic obstructive pulmonary disease ( )
Colon cancer ( )
Colon carcinoma ( )
Congestive heart failure ( )
Diabetic kidney disease ( )
Endometriosis ( )
Glioma ( )
Head-neck squamous cell carcinoma ( )
Hepatocellular carcinoma ( )
Hyperglycemia ( )
Melanoma ( )
Myelodysplastic syndrome ( )
Myocardial infarction ( )
Neoplasm ( )
Non-insulin dependent diabetes ( )
Non-small-cell lung cancer ( )
Obesity ( )
Osteoarthritis ( )
Parkinson disease ( )
Plasma cell myeloma ( )
Pneumonia ( )
Pneumonitis ( )
Prostate cancer ( )
Prostate carcinoma ( )
Retinoblastoma ( )
Rheumatoid arthritis ( )
Cardiac failure ( )
Colorectal carcinoma ( )
leukaemia ( )
Leukemia ( )
Lung adenocarcinoma ( )
Nervous system inflammation ( )
Neuralgia ( )
Pancreatic cancer ( )
Tuberculosis ( )
Osteosarcoma ( )
Bone osteosarcoma ( )
Neuroblastoma ( )
Type-1/2 diabetes ( )
UniProt ID
PDIP2_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
PDB ID
6Z9C; 6ZLX
Pfam ID
PF04379 ; PF08755
Sequence
MAACTARRALAVGSRWWSRSLTGARWPRPLCAAAGAGAFSPASTTTTRRHLSSRNRPEGK
VLETVGVFEVPKQNGKYETGQLFLHSIFGYRGVVLFPWQARLYDRDVASAAPEKAENPAG
HGSKEVKGKTHTYYQVLIDARDCPHISQRSQTEAVTFLANHDDSRALYAIPGLDYVSHED
ILPYTSTDQVPIQHELFERFLLYDQTKAPPFVARETLRAWQEKNHPWLELSDVHRETTEN
IRVTVIPFYMGMREAQNSHVYWWRYCIRLENLDSDVVQLRERHWRIFSLSGTLETVRGRG
VVGREPVLSKEQPAFQYSSHVSLQASSGHMWGTFRFERPDGSHFDVRIPPFSLESNKDEK
TPPSGLHW
Function
Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites. May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1).

Molecular Interaction Atlas (MIA) of This DOT

49 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Lung cancer DISCM4YA Definitive Biomarker [1]
Lung carcinoma DISTR26C Definitive Biomarker [1]
Advanced cancer DISAT1Z9 Strong Altered Expression [2]
Alzheimer disease DISF8S70 Strong Biomarker [3]
Arteriosclerosis DISK5QGC Strong Altered Expression [4]
Arthritis DIST1YEL Strong Biomarker [5]
Atherosclerosis DISMN9J3 Strong Altered Expression [4]
B-cell neoplasm DISVY326 Strong Posttranslational Modification [6]
Breast cancer DIS7DPX1 Strong Altered Expression [7]
Breast carcinoma DIS2UE88 Strong Altered Expression [7]
Chronic obstructive pulmonary disease DISQCIRF Strong Altered Expression [8]
Colon cancer DISVC52G Strong Biomarker [9]
Colon carcinoma DISJYKUO Strong Biomarker [9]
Congestive heart failure DIS32MEA Strong Altered Expression [10]
Diabetic kidney disease DISJMWEY Strong Biomarker [11]
Endometriosis DISX1AG8 Strong Altered Expression [12]
Glioma DIS5RPEH Strong Altered Expression [13]
Head-neck squamous cell carcinoma DISF7P24 Strong Altered Expression [14]
Hepatocellular carcinoma DIS0J828 Strong Biomarker [15]
Hyperglycemia DIS0BZB5 Strong Biomarker [16]
Melanoma DIS1RRCY Strong Biomarker [17]
Myelodysplastic syndrome DISYHNUI Strong Biomarker [18]
Myocardial infarction DIS655KI Strong Altered Expression [19]
Neoplasm DISZKGEW Strong Posttranslational Modification [20]
Non-insulin dependent diabetes DISK1O5Z Strong Biomarker [21]
Non-small-cell lung cancer DIS5Y6R9 Strong Biomarker [22]
Obesity DIS47Y1K Strong Altered Expression [23]
Osteoarthritis DIS05URM Strong Biomarker [24]
Parkinson disease DISQVHKL Strong Biomarker [25]
Plasma cell myeloma DIS0DFZ0 Strong Biomarker [26]
Pneumonia DIS8EF3M Strong Biomarker [27]
Pneumonitis DIS88E0K Strong Biomarker [27]
Prostate cancer DISF190Y Strong Altered Expression [28]
Prostate carcinoma DISMJPLE Strong Altered Expression [28]
Retinoblastoma DISVPNPB Strong Altered Expression [29]
Rheumatoid arthritis DISTSB4J Strong Biomarker [30]
Cardiac failure DISDC067 moderate Biomarker [31]
Colorectal carcinoma DIS5PYL0 moderate Biomarker [32]
leukaemia DISS7D1V moderate Biomarker [33]
Leukemia DISNAKFL moderate Biomarker [33]
Lung adenocarcinoma DISD51WR moderate Altered Expression [1]
Nervous system inflammation DISB3X5A moderate Altered Expression [34]
Neuralgia DISWO58J moderate Altered Expression [35]
Pancreatic cancer DISJC981 moderate Biomarker [36]
Tuberculosis DIS2YIMD moderate Biomarker [37]
Osteosarcoma DISLQ7E2 Disputed Biomarker [38]
Bone osteosarcoma DIST1004 Limited Biomarker [38]
Neuroblastoma DISVZBI4 Limited Altered Expression [39]
Type-1/2 diabetes DISIUHAP Limited Altered Expression [40]
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⏷ Show the Full List of 49 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
10 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Ciclosporin DMAZJFX Approved Ciclosporin decreases the expression of Polymerase delta-interacting protein 2 (POLDIP2). [41]
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Polymerase delta-interacting protein 2 (POLDIP2). [42]
Acetaminophen DMUIE76 Approved Acetaminophen decreases the expression of Polymerase delta-interacting protein 2 (POLDIP2). [43]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate decreases the expression of Polymerase delta-interacting protein 2 (POLDIP2). [44]
Cisplatin DMRHGI9 Approved Cisplatin affects the expression of Polymerase delta-interacting protein 2 (POLDIP2). [45]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Polymerase delta-interacting protein 2 (POLDIP2). [46]
Quercetin DM3NC4M Approved Quercetin increases the expression of Polymerase delta-interacting protein 2 (POLDIP2). [47]
Arsenic trioxide DM61TA4 Approved Arsenic trioxide increases the expression of Polymerase delta-interacting protein 2 (POLDIP2). [48]
Decitabine DMQL8XJ Approved Decitabine affects the expression of Polymerase delta-interacting protein 2 (POLDIP2). [45]
Coumestrol DM40TBU Investigative Coumestrol increases the expression of Polymerase delta-interacting protein 2 (POLDIP2). [50]
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⏷ Show the Full List of 10 Drug(s)
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Coumarin DM0N8ZM Investigative Coumarin increases the phosphorylation of Polymerase delta-interacting protein 2 (POLDIP2). [49]
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References

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