Details of Disease

General Information of Disease (ID: DISSYMBS)

Disease Name Behcet disease
Synonyms
Behcet's disease; BD; Behets disease; Behet's disease; Adamantiades-Behcet disease; Behet-Adamantiades syndrome; Behet's syndrome; Bechet syndrome; silk road disease; Behet's syndrome; Behcet's syndrome; triple symptom complex; Morbus Behet's syndrome; Behet disease; Behcet syndrome; Behet syndrome; Behcet disease
Disease Class 4A62: Behcet disease
Definition A chronic, relapsing, multisystemic vasculitis characterized by mucocutaneous lesions, as well as articular, vascular, ocular and central nervous system manifestations.
Disease Hierarchy
DIS6SVEE: Syndromic disease
DIS2TMQU: Skin vascular disease
DISSYMBS: Behcet disease
ICD Code
ICD-11
ICD-11: 4A62
Disease Identifiers
MONDO ID
MONDO_0007191
MESH ID
D001528
UMLS CUI
C0004943
OMIM ID
109650
MedGen ID
2568
Orphanet ID
117
SNOMED CT ID
310701003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Retigabine DMGNYIH Approved Small molecular drug [1]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Interferon-alpha lozenge DM8YF01 Phase 2 NA [2]
PRTX-100 DMF2XCC Phase 1/2 NA [3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 75 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CCR3 TTD3XFU Limited Genetic Variation [4]
IL12B TTGW72V Limited Altered Expression [5]
NOD2 TTYPUHA Limited Genetic Variation [6]
AHR TT037IE moderate Altered Expression [7]
ERAP1 TT60XFL moderate Biomarker [8]
ACLY TT0Z6Y2 Strong Altered Expression [9]
APOA1 TT5S8DR Strong Biomarker [10]
APOB TTN1IE2 Strong Biomarker [10]
APOH TT2OUI9 Strong Altered Expression [11]
ATP4A TTF1QVM Strong Biomarker [12]
BLK TTNDSC3 Strong Altered Expression [5]
C3AR1 TTI6B3F Strong Altered Expression [13]
CAT TTPS279 Strong Biomarker [10]
CCR1 TTC24WT Strong Altered Expression [14]
CCR5 TTJIH8Q Strong Genetic Variation [15]
CD209 TTBXIM9 Strong Biomarker [16]
CD28 TTQ13FT Strong Biomarker [17]
CD83 TTT9MRQ Strong Biomarker [18]
CR2 TT0HUN7 Strong Genetic Variation [19]
CTSG TTQAJF1 Strong Biomarker [20]
FAS TT7LTUJ Strong SusceptibilityMutation [21]
FCGR3A TTIFOC0 Strong Genetic Variation [22]
GRIA2 TTWM461 Strong Altered Expression [23]
HLA-G TTLKFB3 Strong Genetic Variation [24]
HSPD1 TT9HL5R Strong Biomarker [25]
HTR2C TTWJBZ5 Strong Genetic Variation [26]
ICAM1 TTA1L39 Strong Genetic Variation [27]
IL12A TTRTK6Y Strong Biomarker [28]
IL17F TT2B6PS Strong Biomarker [29]
IL19 TT87RWS Strong Genetic Variation [4]
IL20 TTNZMY2 Strong Altered Expression [30]
IL23A TTC1GLB Strong Altered Expression [31]
IL33 TT5MD4P Strong Altered Expression [32]
IL37 TTQTX98 Strong Altered Expression [33]
IL9 TT0JTFD Strong Altered Expression [34]
IRF8 TTHUBNK Strong Altered Expression [35]
ITGAL TT48WR6 Strong Genetic Variation [36]
ITGB2 TTIJWR7 Strong Altered Expression [37]
JAK1 TT6DM01 Strong Biomarker [38]
KLRC1 TTC4IMS Strong Biomarker [39]
LIMK2 TTASMD8 Strong Genetic Variation [40]
LTA TTP73TM Strong Genetic Variation [41]
MBL2 TTMQDZ5 Strong Genetic Variation [42]
PRKCQ TT1MS7X Strong Biomarker [43]
QPCT TTJ7YTV Strong Genetic Variation [44]
REL TT1ZCTH Strong Genetic Variation [43]
RORC TTGV6LY Strong Altered Expression [45]
SERPINE1 TTTO43N Strong Genetic Variation [46]
SLC25A1 TTTD730 Strong Altered Expression [9]
TEP1 TTQGAVX Strong Biomarker [47]
TLR7 TTRJ1K4 Strong Genetic Variation [48]
TNFAIP3 TT5W0IO Strong Genetic Variation [49]
TNFRSF13C TT7NJSE Strong Altered Expression [50]
TNFRSF1A TTG043C Strong Biomarker [6]
TNFSF12 TTBTDM1 Strong Altered Expression [51]
TXK TT8M1DP Strong Altered Expression [52]
VEGFB TTPJQHE Strong Altered Expression [53]
CA4 TTZHA0O Definitive Genetic Variation [54]
CEBPB TTUI35N Definitive Genetic Variation [55]
CPB2 TTP18AY Definitive Altered Expression [56]
ERAP2 TTVGS1C Definitive Biomarker [57]
GAS6 TT69QD2 Definitive Biomarker [58]
HNRNPA2B1 TT8UPW6 Definitive Biomarker [59]
IL15RA TTGN89I Definitive Altered Expression [60]
IL1R1 TTWOTEA Definitive Genetic Variation [61]
LAMP1 TTC214J Definitive Altered Expression [62]
MVK TT5DFHW Definitive Biomarker [63]
NOD1 TTYSRXM Definitive Biomarker [64]
PTPN2 TTY8PUS Definitive Genetic Variation [65]
SELL TT2IYXF Definitive Biomarker [66]
SELPLG TTS5K8U Definitive Genetic Variation [67]
TAP1 TT7JZI8 Definitive Genetic Variation [68]
TIRAP TTKU0LS Definitive Genetic Variation [69]
TNFSF4 TTBW580 Definitive Biomarker [70]
TSLP TTHMW3T Definitive Altered Expression [71]
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⏷ Show the Full List of 75 DTT(s)
This Disease Is Related to 5 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ATP12A DT5NLZA Strong Biomarker [12]
SLC11A1 DT650XW Strong Biomarker [72]
SLC22A4 DT2EG60 Strong Biomarker [73]
SLC22A5 DT3HUVD Strong Biomarker [73]
SLC35A1 DTVZIRG Strong Biomarker [74]
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This Disease Is Related to 2 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
DHCR7 DEL7GFA Limited Genetic Variation [75]
UBASH3B DE10BJ5 Strong Genetic Variation [76]
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This Disease Is Related to 93 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
IKBKG OTNWJWSD Limited Genetic Variation [77]
MICB OTS2DVDW Limited Genetic Variation [78]
PSTPIP1 OT4PGEAB Limited Genetic Variation [79]
ADA2 OTGCV24S Strong Altered Expression [5]
ADARB1 OTGKSZEV Strong Altered Expression [80]
ADO OTRLGQ7V Strong Biomarker [55]
ARMC9 OT0MZER2 Strong Biomarker [81]
ATG10 OTVRPC5X Strong Genetic Variation [82]
C4A OTXMOYXU Strong SusceptibilityMutation [83]
C4BPA OTHNH6Y8 Strong Biomarker [84]
C4BPB OTJ70B0K Strong Biomarker [84]
CAPS OTC9GZ2M Strong Biomarker [85]
CASP14 OTKY93H9 Strong Altered Expression [86]
CCHCR1 OT22C116 Strong Genetic Variation [78]
CCL13 OTNX0JD0 Strong Altered Expression [87]
CDSN OTQW4HV6 Strong Genetic Variation [78]
CEBPD OTNBIPMY Strong Altered Expression [88]
CIITA OTRJNZFO Strong Biomarker [64]
CLEC16A OTLGV5SV Strong Genetic Variation [89]
CLEC7A OTRTBH27 Strong Biomarker [16]
CNTN5 OTWU5FLZ Strong Genetic Variation [28]
CORT OTX3GUHB Strong Biomarker [74]
CPLX1 OT7UIGTP Strong Biomarker [90]
CTDP1 OTHHFW17 Strong Biomarker [91]
CXCL6 OTFTCQ4O Strong Altered Expression [92]
CYCS OTBFALJD Strong Biomarker [93]
DAOA OT7NFEO6 Strong Biomarker [94]
DEFA1 OT5N1B9B Strong Genetic Variation [95]
DEFB104A OTLQZR6K Strong Genetic Variation [96]
DISC1 OT43AW4H Strong Biomarker [97]
ENHO OT91QASK Strong Altered Expression [98]
ENO1 OTB1KWJS Strong Biomarker [99]
ETFB OT6Q6FBD Strong Biomarker [100]
FCRL3 OTIFXFWL Strong Genetic Variation [101]
FUT2 OTLXM6WI Strong Genetic Variation [102]
GAL3ST1 OTSFFZRD Strong Biomarker [74]
GATM OTIJ4Z11 Strong Genetic Variation [103]
GCHFR OTEOT8GI Strong Altered Expression [104]
GEMIN2 OT4L6TLL Strong Altered Expression [105]
GP2 OTB6TMGY Strong Biomarker [106]
HLA-C OTV38BUJ Strong Biomarker [107]
HLA-F OT76CM19 Strong Biomarker [108]
HSPA14 OTZCA5LK Strong Biomarker [25]
HSPA6 OTH4S7WB Strong Altered Expression [109]
IFI16 OT4SPU0U Strong Genetic Variation [110]
IFNL2 OT4BMJF7 Strong Biomarker [111]
IL12RB1 OTM1IJO2 Strong Biomarker [112]
INTS4 OT5JQ913 Strong Genetic Variation [72]
ITGAX OTOGIMHE Strong Altered Expression [36]
KIDINS220 OTLBH2MA Strong Genetic Variation [113]
KLRC4 OTXOSGIB Strong Genetic Variation [42]
MEFV OTRJ6S6K Strong Genetic Variation [6]
NAALADL2 OT2HOGPQ Strong Altered Expression [114]
NCOA5 OTOGWTWB Strong Genetic Variation [115]
NDEL1 OTAGFML5 Strong Altered Expression [116]
NDUFB2 OT4717TF Strong Genetic Variation [117]
NEFM OT8VCBNF Strong Biomarker [118]
NEIL1 OTHBU5DJ Strong Genetic Variation [40]
ORM2 OTRJGZP8 Strong Genetic Variation [106]
PADI1 OT13WAQX Strong Biomarker [119]
PANX1 OTXPEDOK Strong Altered Expression [86]
PDGFRL OTJPRECT Strong Genetic Variation [120]
PDIA2 OTC2WMXS Strong Biomarker [119]
PIAS1 OTZVAHZI Strong Genetic Variation [121]
PROZ OTI3TXBE Strong Altered Expression [122]
PRPF40A OT6EXJZN Strong Biomarker [123]
PRSS21 OT8ZYC7G Strong Altered Expression [124]
PSORS1C1 OT9HK436 Strong Biomarker [125]
RNF39 OTUQA9JT Strong Biomarker [126]
SAG OTDNS3ZQ Strong Altered Expression [127]
SCAF11 OTX59D0X Strong Altered Expression [105]
STAT4 OTAK3VFR Strong Genetic Variation [128]
SUMO4 OT9B447E Strong Genetic Variation [129]
TFCP2L1 OT7QIJ0X Strong Genetic Variation [78]
TRAF3IP2 OTLLZERL Strong Genetic Variation [130]
TRAF5 OTSBTLO0 Strong Genetic Variation [130]
TRIM39 OTESLVP9 Strong Biomarker [126]
CCDC180 OT4AL3LW Definitive Genetic Variation [131]
CPQ OTTNZNLD Definitive Genetic Variation [128]
CPVL OTOJL31C Definitive Genetic Variation [131]
FCN2 OTTHJBKZ Definitive Altered Expression [104]
FLNB OTPCOYL6 Definitive Biomarker [68]
HLA-DPB1 OTW8JHU2 Definitive Genetic Variation [132]
HLA-E OTX1CTFB Definitive Genetic Variation [133]
IL26 OT2WYCW4 Definitive Biomarker [134]
KIR3DS1 OTJWIO4T Definitive Genetic Variation [135]
MIB1 OT5C404P Definitive Genetic Variation [136]
NXF1 OTEFHXG6 Definitive Biomarker [68]
PIEZO1 OTBG1FU4 Definitive Genetic Variation [136]
SEC14L2 OTJST64D Definitive Biomarker [68]
TAP2 OTWSYFI7 Definitive Genetic Variation [68]
TG OT3ELHIJ Definitive Biomarker [137]
TGFBR3 OTQOOUC4 Definitive Genetic Variation [138]
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⏷ Show the Full List of 93 DOT(s)

References

1 Clinical pipeline report, company report or official report of GlaxoSmithKline.
2 Clinical pipeline report, company report or official report of Amarillo Biosciences.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Genome-wide association analysis identifies new susceptibility loci for Behet's disease and epistasis between HLA-B*51 and ERAP1.Nat Genet. 2013 Feb;45(2):202-7. doi: 10.1038/ng.2520. Epub 2013 Jan 6.
5 Genetics of vasculitis.Curr Opin Rheumatol. 2015 Jan;27(1):10-7. doi: 10.1097/BOR.0000000000000124.
6 Behet's disease and genetic interactions between HLA-B*51 and variants in genes of autoinflammatory syndromes.Sci Rep. 2019 Feb 26;9(1):2777. doi: 10.1038/s41598-019-39113-5.
7 Macrophages from Behcet's Disease Patients Express Decreased Level of Aryl Hydrocarbon Receptor (AHR) mRNA.Iran J Allergy Asthma Immunol. 2017 Oct;16(5):418-424.
8 From structure to function for the characterization of ERAP1 active site in Behet syndrome. A novel polymorphism associated with known gene variations.Mol Immunol. 2020 Jan;117:155-159. doi: 10.1016/j.molimm.2019.11.005. Epub 2019 Nov 29.
9 New Insights into Behet's Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation.Mediators Inflamm. 2018 Jun 28;2018:1419352. doi: 10.1155/2018/1419352. eCollection 2018.
10 The evaluation of autoantibodies against oxidatively modified low-density lipoprotein (LDL), susceptibility of LDL to oxidation, serum lipids and lipid hydroperoxide levels, total antioxidant status, antioxidant enzyme activities, and endothelial dysfunction in patients with Behet's disease.Clin Biochem. 2002 May;35(3):217-24. doi: 10.1016/s0009-9120(02)00290-4.
11 Behet's disease with vascular involvement: the contribution of anticardiolipin antibodies and thrombomodulin.Adv Exp Med Biol. 2003;528:395-8. doi: 10.1007/0-306-48382-3_81.
12 Upper gastrointestinal hemorrhage and thoracic aortic aneurysm rupture as presenting signs of Behet disease: A case report.Medicine (Baltimore). 2019 Oct;98(41):e17455. doi: 10.1097/MD.0000000000017455.
13 Increased Complement 3a Receptor is Associated with Behcet's disease and Vogt-Koyanagi-Harada disease.Sci Rep. 2017 Nov 14;7(1):15579. doi: 10.1038/s41598-017-15740-8.
14 The role of CCR1 and therapeutic effects of anti-CCL3 antibody in herpes simplex virus-induced Behet's disease mouse model.Immunology. 2019 Nov;158(3):206-218. doi: 10.1111/imm.13102. Epub 2019 Sep 8.
15 Association of CCR532 and Behet's disease: new data from a case-control study in the Spanish population and meta-analysis.Clin Exp Rheumatol. 2015 Nov-Dec;33(6 Suppl 94):S96-100. Epub 2015 Sep 22.
16 The Correlation of CD206, CD209, and Disease Severity in Behet's Disease with Arthritis.Mediators Inflamm. 2017;2017:7539529. doi: 10.1155/2017/7539529. Epub 2017 Mar 9.
17 The association of CTLA-4 and CD28 gene polymorphisms with idiopathic ischemic stroke in the paediatric population.Int J Immunogenet. 2009 Apr;36(2):113-8. doi: 10.1111/j.1744-313X.2009.00833.x.
18 Inhibition of CD83 Alleviates Systemic Inflammation in Herpes Simplex Virus Type 1-Induced Behet's Disease Model Mouse.Mediators Inflamm. 2019 Sep 9;2019:5761392. doi: 10.1155/2019/5761392. eCollection 2019.
19 Applying T-cell receptor excision circles and immunoglobulin -deleting recombination excision circles to patients with primary immunodeficiency diseases.Ann Med. 2014 Nov;46(7):555-65. doi: 10.3109/07853890.2014.941920. Epub 2014 Aug 11.
20 Serum anti-lysozyme is associated with disease activity of Behet's disease.Int J Rheum Dis. 2017 Feb;20(2):261-268. doi: 10.1111/1756-185X.12832. Epub 2016 Feb 18.
21 FAS Gene Copy Numbers are Associated with Susceptibility to Behet Disease and VKH Syndrome in Han Chinese.Hum Mutat. 2015 Nov;36(11):1064-9. doi: 10.1002/humu.22829. Epub 2015 Aug 3.
22 Analysis of the association between Fc receptor family gene polymorphisms and ocular Behet's disease in Han Chinese.Sci Rep. 2018 Mar 19;8(1):4850. doi: 10.1038/s41598-018-23222-8.
23 Classification of Visual Cortex Plasticity Phenotypes following Treatment for Amblyopia.Neural Plast. 2019 Sep 3;2019:2564018. doi: 10.1155/2019/2564018. eCollection 2019.
24 HLA-G 14 bp insertion/deletion polymorphism and its association with sHLA-G levels in Behet's disease Tunisian patients.Hum Immunol. 2016 Jan;77(1):90-95. doi: 10.1016/j.humimm.2015.10.016. Epub 2015 Oct 28.
25 Evaluation of the relationship between salivary concentration of anti-heat shock protein immunoglobulin and clinical manifestations of Behet's disease.Scand J Rheumatol. 2017 Sep;46(5):381-387. doi: 10.1080/03009742.2016.1249942. Epub 2017 Feb 14.
26 Further evidence supporting the association between 5HTR2C gene and bipolar disorder.Psychiatry Res. 2010 Dec 30;180(2-3):151-2. doi: 10.1016/j.psychres.2009.12.006. Epub 2010 May 21.
27 Intercellular adhesion molecule-1 polymorphisms, K469E and G261R and susceptibility to vasculitis and rheumatoid arthritis: a meta-analysis.Cell Mol Biol (Noisy-le-grand). 2016 Oct 31;62(12):84-90. doi: 10.14715/cmb/2016.62.12.15.
28 Genetic Analysis with the Immunochip Platform in Behet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci.PLoS One. 2016 Aug 22;11(8):e0161305. doi: 10.1371/journal.pone.0161305. eCollection 2016.
29 Genetic variations of IL17F and IL23A show associations with Behet's disease and Vogt-Koyanagi-Harada syndrome.Ophthalmology. 2015 Mar;122(3):518-23. doi: 10.1016/j.ophtha.2014.09.025. Epub 2014 Nov 15.
30 The importance of serum interleukin-20 levels in patients with Behet's disease.Adv Clin Exp Med. 2018 Oct;27(10):1391-1395. doi: 10.17219/acem/70523.
31 Correlation between IL-17A/F, IL-23, IL-35 and IL-12/-23 (p40) levels in peripheral blood lymphocyte cultures and disease activity in Behcet's patients.Clin Rheumatol. 2018 Oct;37(10):2797-2804. doi: 10.1007/s10067-018-4049-7. Epub 2018 Mar 20.
32 Interleukin-33 gene expression and rs1342326 polymorphism in Behet's disease.Immunol Lett. 2019 Aug;212:120-124. doi: 10.1016/j.imlet.2018.11.005. Epub 2018 Nov 14.
33 Serum interleukin-37 level and interleukin-37 gene polymorphism in patients with Behet disease.Clin Rheumatol. 2019 Feb;38(2):495-502. doi: 10.1007/s10067-018-4288-7. Epub 2018 Sep 18.
34 Th 9 cells in Behet disease: Possible involvement of IL-9 in pulmonary manifestations.Immunol Lett. 2019 Jul;211:3-12. doi: 10.1016/j.imlet.2019.05.004. Epub 2019 May 7.
35 Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease.Sci Rep. 2017 Apr 21;7(1):1007. doi: 10.1038/s41598-017-01249-7.
36 CD11c is upregulated in CD8+ T cells of patients with Behet's disease.Clin Exp Rheumatol. 2016 Sep-Oct;34(6 Suppl 102):S86-S91. Epub 2016 Jun 16.
37 Soluble CD40L is associated with increased oxidative burst and neutrophil extracellular trap release in Behet's disease.Arthritis Res Ther. 2017 Oct 19;19(1):235. doi: 10.1186/s13075-017-1443-5.
38 Lack of association of TNFAIP3 and JAK1 with Behet's disease in the European population.Clin Exp Rheumatol. 2015 Nov-Dec;33(6 Suppl 94):S36-9. Epub 2015 May 25.
39 Association of CD94/NKG2A, CD94/NKG2C, and its ligand HLA-E polymorphisms with Behcet's disease.Tissue Antigens. 2007 Oct;70(4):307-13. doi: 10.1111/j.1399-0039.2007.00907.x.
40 Whole Exome Sequencing Identifies Rare Protein-Coding Variants in Behet's Disease.Arthritis Rheumatol. 2016 May;68(5):1272-80. doi: 10.1002/art.39545.
41 Tumor necrosis factor gene polymorphisms in Tunisian patients with Behcet's disease.Hum Immunol. 2007 Mar;68(3):201-5. doi: 10.1016/j.humimm.2006.12.006. Epub 2007 Jan 5.
42 Genetic polymorphisms of C-type lectin receptors in Behcet's disease in a Chinese Han population.Sci Rep. 2017 Jul 13;7(1):5348. doi: 10.1038/s41598-017-05877-x.
43 Genetic Variation in the REL Gene Increases Risk of Behcet's Disease in a Chinese Han Population but That of PRKCQ Does Not.PLoS One. 2016 Jan 19;11(1):e0147350. doi: 10.1371/journal.pone.0147350. eCollection 2016.
44 The critical region for Behet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping.Am J Hum Genet. 1999 May;64(5):1406-10. doi: 10.1086/302364.
45 Skewed TGF/Smad signalling pathway in T cells in patients with Behet's disease.Clin Exp Rheumatol. 2012 May-Jun;30(3 Suppl 72):S35-9. Epub 2012 Sep 25.
46 Factor V Leiden mutation and PAI-1 gene 4G/5G genotype in thrombotic patients with Behcet's disease.Blood Coagul Fibrinolysis. 2003 Feb;14(2):121-4. doi: 10.1097/00001721-200302000-00001.
47 Patterns of persistence with pharmacological treatment among patients with current depressive episode and their impact on long-term outcome: a naturalistic study with 5-year follow-up.Patient Prefer Adherence. 2018 May 3;12:681-693. doi: 10.2147/PPA.S160767. eCollection 2018.
48 Association Between Copy Number Variations of TLR7 and Ocular Behet's Disease in a Chinese Han Population.Invest Ophthalmol Vis Sci. 2015 Feb 3;56(3):1517-23. doi: 10.1167/iovs.14-15030.
49 Pseudodominance of autoinflammatory disease in a single Turkish family explained by co-inheritance of haploinsufficiency of A20 and familial Mediterranean fever.Clin Exp Rheumatol. 2019 Nov-Dec;37 Suppl 121(6):89-92. Epub 2019 Jul 15.
50 Serum BAFF levels and skin mRNA expression in patients with Behet's disease.Clin Exp Rheumatol. 2008 Jul-Aug;26(4 Suppl 50):S64-71.
51 Local Cytokine Expression Profiling in Patients with Specific Autoimmune Uveitic Entities.Ocul Immunol Inflamm. 2020 Apr 2;28(3):453-462. doi: 10.1080/09273948.2019.1604974. Epub 2019 Jun 4.
52 Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease.Clin Med Res. 2006 Jun;4(2):147-51. doi: 10.3121/cmr.4.2.147.
53 The Evaluation of the Relationship between sTREM-1, VEGF-B, and VEGF Gene Expression Levels with Disease Activity of Behet's Patients.Dis Markers. 2018 Oct 21;2018:2649392. doi: 10.1155/2018/2649392. eCollection 2018.
54 Carrier of R14W in carbonic anhydrase IV presents Bothnia dystrophy phenotype caused by two allelic mutations in RLBP1. Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3172-7. doi: 10.1167/iovs.07-1664. Epub 2008 Mar 14.
55 Association of LACC1, CEBPB-PTPN1, RIPK2 and ADO-EGR2 with ocular Behcet's disease in a Chinese Han population.Br J Ophthalmol. 2018 Sep;102(9):1308-1314. doi: 10.1136/bjophthalmol-2017-311753. Epub 2018 Jun 15.
56 Fibrinolytic inhibitor levels and polymorphisms in Behet disease and their association with thrombosis.Br J Haematol. 2008 May;141(5):716-9. doi: 10.1111/j.1365-2141.2008.07078.x. Epub 2008 Mar 12.
57 Redundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behcet's Disease-associated HLA-B*51 Peptidome.Mol Cell Proteomics. 2019 Aug;18(8):1491-1510. doi: 10.1074/mcp.RA119.001515. Epub 2019 May 15.
58 Analysis of receptor tyrosine kinase genetics identifies two novel risk loci in GAS6 and PROS1 in Behet's disease.Sci Rep. 2016 May 25;6:26662. doi: 10.1038/srep26662.
59 Cilostazol inhibits the expression of hnRNP A2/B1 and cytokines in human dermal microvascular endothelial cells.Clin Exp Rheumatol. 2017 Nov-Dec;35 Suppl 108(6):60-66. Epub 2017 Aug 28.
60 Frequencies of IL-15R+ cells in patients with Behet's disease and the effects of overexpressing IL-15R+ on disease symptoms in mice.Cytokine. 2018 Oct;110:257-266. doi: 10.1016/j.cyto.2018.01.010. Epub 2018 Feb 1.
61 Interleukin-1-related genes polymorphisms in Turkish patients with Behet disease: a meta-analysis.Mod Rheumatol. 2014 Mar;24(2):321-6. doi: 10.3109/14397595.2013.844304. Epub 2013 Nov 5.
62 Higher Frequencies of Lymphocytes Expressing the Natural Killer Group 2D Receptor in Patients With Behet Disease.Front Immunol. 2018 Sep 25;9:2157. doi: 10.3389/fimmu.2018.02157. eCollection 2018.
63 Mevalonate kinase gene mutations and their clinical correlations in Behet's disease.Int J Rheum Dis. 2014 May;17(4):435-43. doi: 10.1111/1756-185X.12243. Epub 2014 Jan 11.
64 Genetic Variations of NLR family genes in Behcet's Disease.Sci Rep. 2016 Feb 1;6:20098. doi: 10.1038/srep20098.
65 Association of genetic variations in PTPN2 and CD122 with ocular Behcet's disease.Br J Ophthalmol. 2018 Jul;102(7):996-1002. doi: 10.1136/bjophthalmol-2017-310820. Epub 2018 Mar 3.
66 Differences in Expression of Human Leukocyte Antigen Class II Subtypes and T Cell Subsets in Behet's Disease with Arthritis.Int J Mol Sci. 2019 Oct 11;20(20):5044. doi: 10.3390/ijms20205044.
67 The association between P selectin glycoprotein ligand 1 gene variable number of tandem repeats polymorphism and risk of thrombosis in Behet's disease.Int J Rheum Dis. 2018 Dec;21(12):2175-2179. doi: 10.1111/1756-185X.13151. Epub 2017 Aug 14.
68 Association of transporter associated with antigen processing genes with Behet's disease in Japanese.Autoimmunity. 2003 May;36(3):161-5. doi: 10.1080/0891693031000098805.
69 TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in Behet's disease patients in two ethnic cohorts.Clin Exp Rheumatol. 2013 May-Jun;31(3 Suppl 77):54-6. Epub 2013 Sep 9.
70 Associations between TNFSF4, TNFSF8 and TNFSF15 and Behet's disease but not VKH syndrome in Han Chinese.Oncotarget. 2017 Oct 23;8(62):105037-105046. doi: 10.18632/oncotarget.22064. eCollection 2017 Dec 1.
71 Elevated expression of TSLP and IL-33 in Behet's disease skin lesions: IL-37 alleviate inflammatory effect of TSLP.Clin Immunol. 2018 Jul;192:14-19. doi: 10.1016/j.clim.2018.03.016. Epub 2018 Apr 6.
72 Genetic susceptibility to Behet's syndrome is associated with NRAMP1 (SLC11A1) polymorphism in Turkish patients.Rheumatol Int. 2009 May;29(7):787-91. doi: 10.1007/s00296-008-0763-9. Epub 2008 Nov 8.
73 Genetic variants in the JAK1 gene confer higher risk of Behcet's disease with ocular involvement in Han Chinese.Hum Genet. 2013 Sep;132(9):1049-58. doi: 10.1007/s00439-013-1312-5. Epub 2013 May 15.
74 Serum Cortistatin Levels in Patients with Ocular Active and Ocular Inactive Behet Disease.Ocul Immunol Inflamm. 2020 May 18;28(4):601-605. doi: 10.1080/09273948.2019.1610461. Epub 2019 Jul 17.
75 Polymorphisms in genetics of vitamin D metabolism confer susceptibility to ocular Behet disease in a Chinese Han population.Am J Ophthalmol. 2014 Feb;157(2):488-494.e6. doi: 10.1016/j.ajo.2013.10.010. Epub 2013 Nov 1.
76 Ubiquitin Associated and SH3 Domain Containing B (UBASH3B) Gene Association with Behcet's Disease in Iranian Population.Curr Eye Res. 2019 Feb;44(2):200-205. doi: 10.1080/02713683.2018.1524913. Epub 2018 Oct 22.
77 Transplantation from a symptomatic carrier sister restores host defenses but does not prevent colitis in NEMO deficiency.Clin Immunol. 2016 Mar;164:52-6. doi: 10.1016/j.clim.2016.01.010. Epub 2016 Jan 23.
78 Identification of a susceptibility locus in STAT4 for Behet's disease in Han Chinese in a genome-wide association study.Arthritis Rheum. 2012 Dec;64(12):4104-13. doi: 10.1002/art.37708.
79 Mutational profile of rare variants in inflammasome-related genes in Behet disease: A Next Generation Sequencing approach.Sci Rep. 2017 Aug 16;7(1):8453. doi: 10.1038/s41598-017-09164-7.
80 Serum and erythrocyte adenosine deaminase activities in patients with Behet's disease.Int J Dermatol. 2006 Sep;45(9):1053-6. doi: 10.1111/j.1365-4632.2006.02892.x.
81 Frequent immune response to a melanocyte specific protein KU-MEL-1 in patients with Vogt-Koyanagi-Harada disease.Br J Ophthalmol. 2006 Jun;90(6):773-7. doi: 10.1136/bjo.2005.086520. Epub 2006 Feb 15.
82 Association of ATG5 Gene Polymorphisms With Behet's Disease and ATG10 Gene Polymorphisms With VKH Syndrome in a Chinese Han Population.Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8280-7. doi: 10.1167/iovs.15-18035.
83 Copy number variations of complement component C4 are associated with Behet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.Arthritis Rheum. 2013 Nov;65(11):2963-70. doi: 10.1002/art.38116.
84 C4 binding protein deficiency in a patient with atypical Behet's disease.J Rheumatol. 1987 Feb;14(1):135-8.
85 Autoinflammatory syndromes.Clin Exp Rheumatol. 2006 Jan-Feb;24(1 Suppl 40):S79-85.
86 Low levels of pannexin-1 in Behet's syndrome.Int J Rheum Dis. 2019 Aug;22(8):1474-1478. doi: 10.1111/1756-185X.13614. Epub 2019 Jun 18.
87 The CC chemokines CCL8, CCL13 and CCL20 are local inflammatory biomarkers of HLA-B27-associated uveitis.Acta Ophthalmol. 2019 Feb;97(1):e122-e128. doi: 10.1111/aos.13835. Epub 2018 Sep 21.
88 Transcription Factors Regulating Inflammatory Cytokine Production Are Differentially Expressed in Peripheral Blood Mononuclear Cells of Behet Disease Depending on Disease Activity.Ann Dermatol. 2017 Apr;29(2):173-179. doi: 10.5021/ad.2017.29.2.173. Epub 2017 Mar 24.
89 A variant of CLEC16A gene confers protection for Vogt-Koyanagi-Harada syndrome but not for Behcet's disease in a Chinese Han population.Exp Eye Res. 2015 Mar;132:225-30. doi: 10.1016/j.exer.2015.01.004. Epub 2015 Jan 7.
90 Increased complexin-1 and decreased miR-185 expression levels in Behet's disease with and without neurological involvement.Neurol Sci. 2016 Mar;37(3):411-6. doi: 10.1007/s10072-015-2419-3. Epub 2015 Nov 14.
91 Identification of Novel Biomarkers for Behcet Disease Diagnosis Using Human Proteome Microarray Approach.Mol Cell Proteomics. 2017 Feb;16(2):147-156. doi: 10.1074/mcp.M116.061002. Epub 2016 Oct 24.
92 Synovial angiostatic non-ELR CXC chemokines in inflammatory arthritides: does CXCL4 designate chronicity of synovitis?.Rheumatol Int. 2007 Aug;27(10):969-73. doi: 10.1007/s00296-007-0317-6. Epub 2007 Jan 31.
93 Long term follow-up of Behet's syndrome patients treated with cyclophosphamide.Rheumatology (Oxford). 2020 Sep 1;59(9):2264-2271. doi: 10.1093/rheumatology/kez598.
94 DAOA variants on diagnosis and response to treatment in patients with major depressive disorder and bipolar disorder.J Int Med Res. 2012;40(1):258-65. doi: 10.1177/147323001204000126.
95 Correlation of DEFA1 gene copy number variation with intestinal involvement in Behcet's disease.J Korean Med Sci. 2012 Jan;27(1):107-9. doi: 10.3346/jkms.2012.27.1.107. Epub 2011 Dec 19.
96 Copy number variation of -defensin genes in Behet's disease.Clin Exp Rheumatol. 2011 Jul-Aug;29(4 Suppl 67):S20-3. Epub 2011 Sep 27.
97 Primary cilia formation is diminished in schizophrenia and bipolar disorder: A possible marker for these psychiatric diseases.Schizophr Res. 2018 May;195:412-420. doi: 10.1016/j.schres.2017.08.055. Epub 2017 Sep 18.
98 Serum adropin level and ENHO gene expression in systemic sclerosis.Clin Rheumatol. 2016 Jun;35(6):1535-40. doi: 10.1007/s10067-016-3266-1. Epub 2016 Apr 15.
99 Anti-alpha-enolase antibodies in Behet's disease: a marker of mucocutaneous and articular disease activity?.Clin Exp Rheumatol. 2018 Nov-Dec;36(6 Suppl 115):28-32. Epub 2018 Feb 7.
100 Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behet's Disease.PLoS One. 2015 Apr 27;10(4):e0124760. doi: 10.1371/journal.pone.0124760. eCollection 2015.
101 Single Nucleotide Polymorphisms of FCRL3 in Iranian Patients with Behcet's Disease.Iran J Public Health. 2019 Jun;48(6):1133-1139.
102 FUT2: filling the gap between genes and environment in Behet's disease?.Ann Rheum Dis. 2015 Mar;74(3):618-24. doi: 10.1136/annrheumdis-2013-204475. Epub 2013 Dec 10.
103 SUMO4 gene polymorphisms in Chinese Han patients with Behcet's disease.Clin Immunol. 2008 Oct;129(1):170-5. doi: 10.1016/j.clim.2008.06.006. Epub 2008 Jul 26.
104 Increased expression of interleukin-23 p19 mRNA in erythema nodosum-like lesions of Behet's disease.Br J Dermatol. 2008 Mar;158(3):505-11. doi: 10.1111/j.1365-2133.2007.08403.x. Epub 2008 Jan 17.
105 Identification and characterization of the carboxy-terminal region of Sip-1, a novel autoantigen in Behet's disease.Arthritis Res Ther. 2006;8(3):R71. doi: 10.1186/ar1940. Epub 2006 Apr 12.
106 Antibodies against glycoprotein 2 display diagnostic advantages over ASCA in distinguishing CD from intestinal tuberculosis and intestinal Behet's disease.Clin Transl Gastroenterol. 2018 Feb 15;9(2):e133. doi: 10.1038/ctg.2018.1.
107 How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins.Front Immunol. 2018 Oct 30;9:2463. doi: 10.3389/fimmu.2018.02463. eCollection 2018.
108 Behet disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated cytotoxicity.Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8867-72. doi: 10.1073/pnas.1406575111. Epub 2014 May 12.
109 Heat shock protein family A member 6 combined with clinical characteristics for the differential diagnosis of intestinal Behet's disease.J Dig Dis. 2018 Jun;19(6):350-358. doi: 10.1111/1751-2980.12613.
110 Variants of the IFI16 gene affecting the levels of expression of mRNA are associated with susceptibility to Behet disease.J Rheumatol. 2015 Apr;42(4):695-701. doi: 10.3899/jrheum.140949. Epub 2015 Feb 1.
111 Interleukin-28A promotes IFN- production by peripheral blood mononuclear cells from patients with Behet's disease.Cell Immunol. 2014 Jul;290(1):116-9. doi: 10.1016/j.cellimm.2014.06.003. Epub 2014 Jun 18.
112 Genetic variations of IL-12B, IL-12R1, IL-12R2 in Behcet's disease and VKH syndrome.PLoS One. 2014 May 23;9(5):e98373. doi: 10.1371/journal.pone.0098373. eCollection 2014.
113 Analyses of functional IL10 and TNF- genotypes in Behet's syndrome.Mol Biol Rep. 2010 Oct;37(7):3637-41. doi: 10.1007/s11033-010-0015-4. Epub 2010 Feb 27.
114 Identification of genetic susceptibility loci for intestinal Behet's disease.Sci Rep. 2017 Jan 3;7:39850. doi: 10.1038/srep39850.
115 Clinical significance of NCOA5 gene rs2903908 polymorphism in Behet's disease.EXCLI J. 2017 May 4;16:609-617. doi: 10.17179/excli2017-189. eCollection 2017.
116 Gene expression alterations related to mania and psychosis in peripheral blood of patients with a first episode of psychosis.Transl Psychiatry. 2016 Oct 4;6(10):e908. doi: 10.1038/tp.2016.159.
117 Associations between interferon regulatory factor-1 polymorphisms and Behet's disease.Hum Immunol. 2007 Sep;68(9):770-8. doi: 10.1016/j.humimm.2007.06.002. Epub 2007 Jul 17.
118 Behet Disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial HSP-65, a putative trigger.J Autoimmun. 2017 Nov;84:87-96. doi: 10.1016/j.jaut.2017.08.002. Epub 2017 Aug 24.
119 One-Year Developmental Outcomes for Infants of Mothers With Bipolar Disorder.J Clin Psychiatry. 2017 Sep-Oct;78(8):1083-1090. doi: 10.4088/JCP.15m10535.
120 Genetic variant on PDGFRL associated with Behet disease in Chinese Han populations.Hum Mutat. 2013 Jan;34(1):74-8. doi: 10.1002/humu.22208. Epub 2012 Oct 11.
121 PIAS genes as disease markers in bipolar disorder.J Cell Biochem. 2019 Aug;120(8):12937-12942. doi: 10.1002/jcb.28564. Epub 2019 Mar 12.
122 Decreased protein Z concentrations complicating the hypercoagulable state of Behet's disease.Clin Appl Thromb Hemost. 2003 Jul;9(3):259-63. doi: 10.1177/107602960300900312.
123 Association of HYPA haplotype in the mannose-binding lectin gene-2 with Behet's disease.Tissue Antigens. 2005 Mar;65(3):260-5. doi: 10.1111/j.1399-0039.2005.00363.x.
124 Interaction between temperature and sublethal infection with the amphibian chytrid fungus impacts a susceptible frog species.Sci Rep. 2019 Jan 14;9(1):83. doi: 10.1038/s41598-018-35874-7.
125 Identification of multiple independent susceptibility loci in the HLA region in Behet's disease.Nat Genet. 2013 Mar;45(3):319-24. doi: 10.1038/ng.2551. Epub 2013 Feb 10.
126 TRIM39 and RNF39 are associated with Behet's disease independently of HLA-B?1 and -A?6.Biochem Biophys Res Commun. 2010 Oct 29;401(4):533-7. doi: 10.1016/j.bbrc.2010.09.088. Epub 2010 Sep 27.
127 S-antigen specific T helper type 1 response is present in Behcet's disease.Mol Vis. 2008 Aug 7;14:1456-64.
128 Behet's disease: An immunogenetic perspective.J Cell Physiol. 2019 Jun;234(6):8055-8074. doi: 10.1002/jcp.27576. Epub 2018 Oct 20.
129 Uveitis genetics.Exp Eye Res. 2020 Jan;190:107853. doi: 10.1016/j.exer.2019.107853. Epub 2019 Oct 25.
130 TRAF5 and TRAF3IP2 gene polymorphisms are associated with Behet's disease and Vogt-Koyanagi-Harada syndrome: a case-control study.PLoS One. 2014 Jan 8;9(1):e84214. doi: 10.1371/journal.pone.0084214. eCollection 2014.
131 Replication study confirms the association between UBAC2 and Behet's disease in two independent Chinese sets of patients and controls.Arthritis Res Ther. 2012 Mar 29;14(2):R70. doi: 10.1186/ar3789.
132 HLA class I and II typing of the patients with Behet's disease in Saudi Arabia.Tissue Antigens. 1999 Sep;54(3):273-7. doi: 10.1034/j.1399-0039.1999.540308.x.
133 HLA-E*0101 and HLA-G*010101 reduce the risk of Behcet's disease.Tissue Antigens. 2007 Feb;69(2):139-44. doi: 10.1111/j.1399-0039.2006.00742.x.
134 Cytokine Signatures in Mucocutaneous and Ocular Behet's Disease.Front Immunol. 2017 Feb 27;8:200. doi: 10.3389/fimmu.2017.00200. eCollection 2017.
135 KIR3DL1/S1 Allotypes Contribute Differentially to the Development of Behet Disease.J Immunol. 2019 Sep 15;203(6):1629-1635. doi: 10.4049/jimmunol.1801178. Epub 2019 Aug 12.
136 Analysis of microsatellite polymorphism around the HLA-B locus in Iranian patients with Behet's disease.Tissue Antigens. 2002 Nov;60(5):396-9. doi: 10.1034/j.1399-0039.2002.600506.x.
137 Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis.J Formos Med Assoc. 2018 Aug;117(8):691-696. doi: 10.1016/j.jfma.2018.03.015. Epub 2018 Apr 10.
138 Association analysis of TGFBR3 gene with Behet's disease and idiopathic intermediate uveitis in a Caucasian population.Br J Ophthalmol. 2015 May;99(5):696-9. doi: 10.1136/bjophthalmol-2014-306198. Epub 2015 Feb 12.