Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5FSJA)

Drug Name

Glimepiride Drug Info

Synonyms

Amarel; Amaryl; Endial; Glimepirid; Glimepirida; Glimepiridum; Glimepride; Glimer; Glymepirid; Roname; Solosa; Glimepirida [Spanish]; Glimepiridum [Latin]; Sandoz glimepiride; HOE 490; Amaryl (TN); Hoe-490; Novo-glimepiride; PMS-glimepiride; Ratio-glimepiride; Amaryl, Glista OD, Glimepiride; Glimepiride [USAN:BAN:INN]; Glimepiride (JAN/USP/INN); 1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea; 1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea; 3-ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide; 3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro; 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide; 64598P

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Approved	[1]

Therapeutic Class

Hypoglycemic Agents

Cross-matching ID

PubChem CID: 3476
ChEBI ID: CHEBI:5383
CAS Number: CAS 261361-60-8
TTD Drug ID: DM5FSJA
VARIDT Drug ID: DR00158
INTEDE Drug ID: DR0777
ACDINA Drug ID: D00302

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DME

DOT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting ATP-binding cassette transporter C9 (ABCC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[9]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[10]
Nicorandil	DMIYJFV	Angina pectoris	BA40	Approved	[11]
BTS-67582	DM54K2P	Diabetic complication	5A2Y	Discontinued in Phase 2	[12]
KRN-2391	DMZ1SEW	Angina pectoris	BA40	Discontinued in Phase 2	[13]
CCX915	DMHMST3	Multiple sclerosis	8A40	Discontinued in Phase 1	[14]
BMS-191095	DMKFXTD	Angina pectoris	BA40	Discontinued in Phase 1	[15]
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Drug(s) Targeting ATP-binding cassette transporter C8 (ABCC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[16]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[9]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[10]
Acetohexamide	DMR6N7H	Diabetic complication	5A2Y	Approved	[17]
Gliclazide	DMN6QO5	Diabetic complication	5A2Y	Approved	[18]
NN-414	DMRJEXM	Type-1 diabetes	5A10	Phase 1	[19]
HBR-985	DMKDBFL	Discovery agent	N.A.	Investigative	[20]
NS-11757	DM98VMZ	Atrial fibrillation	BC81.3	Investigative	[21]
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Drug(s) Transported By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[22]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[3]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[3]
Taurocholic Acid	DM2LZ8F	Type-2 diabetes	5A11	Phase 1/2	[23]
Sodium taurocholate	DM3GO0J	Type-2 diabetes	5A11	Phase 1/2	[22]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[3]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[3]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[33]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[7]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[3]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[34]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[7]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[35]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[7]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[36]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[24]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[29]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[30]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[38]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[39]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[40]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[40]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[38]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[44]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[38]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[38]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[38]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[45]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[38]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[47]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[48]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[48]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[49]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[51]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[48]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[48]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[48]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[53]
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Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Fructose	DM43AN2	Vomiting	MD90	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[60]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[63]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[67]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[68]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[69]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[71]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
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Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[74]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[82]
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Drug(s) Affected By Calpain-2 catalytic subunit (CAPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
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Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain G (HLA-G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[74]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[91]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[89]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[89]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[89]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[94]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[67]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[95]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[99]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[100]
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Drug(s) Affected By Calpain-10 (CAPN10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[104]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[105]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[106]
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Drug(s) Affected By ATP-binding cassette sub-family C member 8 (ABCC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[106]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative
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Drug(s) Affected By ATP-binding cassette sub-family C member 9 (ABCC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[82]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[116]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[117]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ATP-binding cassette transporter C8 (ABCC8)	TTP835K	ABCC8_HUMAN	Blocker	[2]
ATP-binding cassette transporter C9 (ABCC9)	TTEF5MJ	ABCC9_HUMAN	Blocker	[2]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Bile salt export pump (ABCB11)	DTJ0EW4	ABCBB_HUMAN	Substrate	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)^{Main DME}	DE5IED8	CP2C9_HUMAN	Substrate	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[5]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[5]
ATP-binding cassette sub-family C member 8 (ABCC8)	OTCWQ54I	ABCC8_HUMAN	Drug Response	[6]
ATP-binding cassette sub-family C member 9 (ABCC9)	OTGAXLQN	ABCC9_HUMAN	Drug Response	[6]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Gene/Protein Processing	[7]
Calpain-1 catalytic subunit (CAPN1)	OTK6OQZR	CAN1_HUMAN	Gene/Protein Processing	[8]
Calpain-10 (CAPN10)	OTS9LJW4	CAN10_HUMAN	Gene/Protein Processing	[8]
Calpain-2 catalytic subunit (CAPN2)	OTIAPE5J	CAN2_HUMAN	Gene/Protein Processing	[8]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[8]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[8]

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References

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2	Mechanism of disopyramide-induced hypoglycaemia in a patient with Type 2 diabetes. Diabet Med. 2009 Jan;26(1):76-8.
3	Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
4	Effect of CYP2C9 genetic polymorphisms on the efficacy and pharmacokinetics of glimepiride in subjects with type 2 diabetes. Diabetes Res Clin Pract. 2006 May;72(2):148-54.
5	Initro inhibition of AKR1Cs by sulphonylureas and the structural basis. Chem Biol Interact. 2015 Oct 5;240:310-5.
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8	A potential role of calpains in sulfonylureas (SUs) -mediated death of human pancreatic cancer cells (1.2B4). Toxicol In Vitro. 2021 Jun;73:105128. doi: 10.1016/j.tiv.2021.105128. Epub 2021 Feb 27.
9	Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest. 2009 Jan;119(1):80-90.
10	Metformin/Repaglinide (PrandiMet) for type 2 diabetes. Med Lett Drugs Ther. 2009 Jun 1;51(1313):41-3.
11	A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K(+) chann... J Mol Cell Cardiol. 2005 Jul;39(1):1-6.
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14	Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides. J Physiol. 2003 Feb 15;547(Pt 1):159-68.
15	The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats.J Cereb Blood Flow Metab.2007 Feb;27(2):348-55.
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18	Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 2001 Oct;50(10):2253-9.
19	Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.Metabolism.2004 Apr;53(4):441-7.
20	Cardioselective K(ATP) channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas. J Med Chem. 2001 Mar 29;44(7):1085-98.
21	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2944).
22	Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther. 2005 Aug;314(2):876-82.
23	Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8.
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26	Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
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