Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6A4NW)

Drug Name
Etoricoxib Drug Info
Synonyms
Algix; Arcoxia; Etoricoxibe; Nucoxia; Tauxib; L791456; MK 0663; MK 663; Algix (TN); Arcoxia (TN); L-791456; MK-0663; MK-663; Merck Sharp & Dohme brand of etoricoxib; Tauxib (TN); Etoricoxib (USAN/INN); Etoricoxib [USAN:INN:BAN]; 5-Chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine; 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine; 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine; 5CH
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Approved [1]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
123619
ChEBI ID
CHEBI:6339
CAS Number
CAS 202409-33-4
TTD Drug ID
DM6A4NW
VARIDT Drug ID
DR01183
INTEDE Drug ID
DR0670

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [9]
Naproxen DMZ5RGV Bursitis Approved [10]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [11]
Indomethacin DMSC4A7 Bursitis Approved [12]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [13]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [14]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [15]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [16]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [17]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [19]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [20]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [21]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [22]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [23]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [24]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [25]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [19]
Verapamil DMA7PEW Angina pectoris BA40 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [27]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [24]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [33]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [35]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [6]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [6]
Capsaicin DMGMF6V Back pain ME84.Z Approved [45]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [46]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [47]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [48]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [49]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [50]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [51]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [52]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [37]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [38]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [39]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [40]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [39]
Verapamil DMA7PEW Angina pectoris BA40 Approved [41]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [42]
Estrone DM5T6US Acne vulgaris ED80 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [53]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [54]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [57]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [58]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [60]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [4]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [63]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [63]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [64]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [4]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [63]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [65]
Gefitinib DM15F0X Colon adenocarcinoma Approved [4]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [66]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [4]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [67]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [68]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [69]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [70]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [71]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [72]
Ethacrynic acid DM60QMR Edema MG29 Approved [73]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [74]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [75]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [76]
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Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [77]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [77]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [51]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [79]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [82]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [83]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [84]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [3]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [4]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [5]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [6]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Gene/Protein Processing [7]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Gene/Protein Processing [8]

References

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