Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8QB1D)

Drug Name
Olaparib Drug Info
Synonyms
AZD 2281; AZD2281; AZD-2281; Acylpiperazine analogue, 47; KU-0059436; KU-59436; Olaparib, KU-0059436, AZD2281,KU0059436, AZD2281; 4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one; 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
Indication
Disease Entry ICD 11 Status REF
Ovarian cancer 2C73 Approved [1]
Pancreatic cancer 2C10 Phase 3 [2]
Prostate cancer 2C82.0 Phase 3 [2]
Cross-matching ID
PubChem CID
23725625
ChEBI ID
CHEBI:83766
CAS Number
CAS 763113-22-0
TTD Drug ID
DM8QB1D
VARIDT Drug ID
DR00221
INTEDE Drug ID
DR1188
ACDINA Drug ID
D00485

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Poly [ADP-ribose] polymerase (PARP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rucaparib DM9PVX8 Ovarian cancer 2C73 Approved [10]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [11]
MK-4827 DMLYGH4 Ovarian cancer 2C73 Phase 3 [12]
BSI-201 DMM0VO3 Solid tumour/cancer 2A00-2F9Z Phase 3 [13]
Rubraca rucaparib DM25TMP Ovarian cancer 2C73 Phase 3 [2]
ABT-888 DM4HYMS Breast cancer 2C60-2C65 Phase 3 [12]
INO-1001 DM5L8QT Brain cancer 2A00 Phase 3 [14]
BGP-15 DMYDM68 Type-2 diabetes 5A11 Phase 2 [15]
BGB-290 DMRO6XT Ovarian cancer 2C73 Phase 2 [2]
2X-121 DMX9MSL Breast cancer 2C60-2C65 Phase 2 [2]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [16]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Folic Acid DMEMBJC Colorectal carcinoma Approved [19]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [18]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [18]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Methotrexate DM2TEOL Anterior urethra cancer Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [35]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [39]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [41]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [44]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [48]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [48]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [50]
Gefitinib DM15F0X Colon adenocarcinoma Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Etretinate DM2CZFA Keratosis ED56 Approved [54]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [55]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [56]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [64]
Paclitaxel DMLB81S Breast carcinoma Approved [65]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [68]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Gefitinib DM15F0X Colon adenocarcinoma Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [73]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [73]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [75]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [78]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [80]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [81]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [82]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Verapamil DMA7PEW Angina pectoris BA40 Approved [83]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [84]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [85]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [86]
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Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Selenium DM25CGV N. A. N. A. Approved [89]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [90]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [91]
Meloxicam DM2AR7L Arthritis FA20 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [94]
Epinephrine DM3KJBC Acute asthma CA23 Approved [95]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Selenium DM25CGV N. A. N. A. Approved [98]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [99]
Etretinate DM2CZFA Keratosis ED56 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [102]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [103]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [104]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [106]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [107]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [108]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [45]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [110]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [113]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [114]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [116]
Gefitinib DM15F0X Colon adenocarcinoma Approved [51]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Etretinate DM2CZFA Keratosis ED56 Approved [54]
Prednisone DM2HG4X Acute asthma CA23 Approved [118]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [42]
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Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [119]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [120]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [122]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [123]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [124]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [125]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [126]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [78]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [127]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Verapamil DMA7PEW Angina pectoris BA40 Approved [83]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [128]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [129]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Meloxicam DM2AR7L Arthritis FA20 Approved [92]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [74]
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Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Selenium DM25CGV N. A. N. A. Approved [98]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [132]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [133]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [134]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [135]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [136]
Testosterone DM7HUNW Hot flushes GA30 Approved [137]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [138]
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Drug(s) Affected By Bromodomain-containing protein 4 (BRD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [55]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [55]
Leflunomide DMR8ONJ Arthritis FA20 Approved [139]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [138]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [140]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [141]
Folic Acid DMEMBJC Colorectal carcinoma Approved [142]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [143]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [144]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [145]
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Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [70]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [146]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [147]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [148]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [149]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [150]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [151]
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Drug(s) Affected By DNA mismatch repair protein Msh3 (MSH3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [153]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [154]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [155]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [156]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [145]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [9]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [157]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [158]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [159]
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Drug(s) Affected By Fumarate hydratase, mitochondrial (FH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [160]
Quercetin DM3NC4M Obesity 5B81 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [162]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [163]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [164]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [140]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [165]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [141]
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Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [166]
Quercetin DM3NC4M Obesity 5B81 Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [150]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [126]
Testosterone DM7HUNW Hot flushes GA30 Approved [168]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [140]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [165]
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Drug(s) Affected By Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [169]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [171]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [126]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [153]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [141]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [172]
Menthol DMG2KW7 Back pain ME84.Z Approved [173]
Arsenic DMTL2Y1 N. A. N. A. Approved [174]
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Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [175]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [176]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [177]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [153]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [145]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [178]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [98]
APR-246 DMNFADH Ovarian cancer 2C73 Phase 2 [179]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [180]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Poly [ADP-ribose] polymerase (PARP) TTEBCY8 NOUNIPROTAC Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [6]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [7]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [7]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Drug Response [8]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Drug Response [8]
Bromodomain-containing protein 4 (BRD4) OT2Y2TCW BRD4_HUMAN Drug Response [6]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Post-Translational Modifications [7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [6]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [7]
DNA mismatch repair protein Msh3 (MSH3) OTD3YPVL MSH3_HUMAN Drug Response [9]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7519).
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
4 Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer. Transl Oncol. 2019 May 7;12(7):871-878.
5 Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiother Oncol. 2015 Sep;116(3):358-65.
6 The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer. Gynecol Oncol. 2018 Jun;149(3):575-584. doi: 10.1016/j.ygyno.2018.03.049. Epub 2018 Mar 20.
7 PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma. PLoS One. 2014 Dec 22;9(12):e114583. doi: 10.1371/journal.pone.0114583. eCollection 2014.
8 Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest. 2011 Jul;121(7):2750-67. doi: 10.1172/JCI45014.
9 MSH3 mediates sensitization of colorectal cancer cells to cisplatin, oxaliplatin, and a poly(ADP-ribose) polymerase inhibitor. J Biol Chem. 2011 Apr 8;286(14):12157-65. doi: 10.1074/jbc.M110.198804. Epub 2011 Feb 1.
10 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
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