Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9BS50)

Drug Name
Plumbagin Drug Info
Synonyms
Plumbagin; 481-42-5; Plumbagine; 5-Hydroxy-2-methyl-1,4-naphthoquinone; Plumbaein; Plumbagone; 2-Methyljuglone; 5-hydroxy-2-methylnaphthalene-1,4-dione; 5-Hydroxy-2-methyl-1,4-naphthalenedione; 5-Hydroxy-2-methyl-[1,4]naphthoquinone; 1,4-Naphthalenedione, 5-hydroxy-2-methyl-; 2-Methyl-5-hydroxy-1,4-naphthoquinone; UNII-YAS4TBQ4OQ; NSC 688284; NSC 236613; CCRIS 6671; YAS4TBQ4OQ; EINECS 207-569-6; BRN 1870475; AI3-38055; CHEBI:8273; CHEMBL295316; VCMMXZQDRFWYSE-UHFFFAOYSA-N; 1,4-NAPHTHOQUINONE, 5-HYDROXY-2-METHYL-; NSC688284
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10205
ChEBI ID
CHEBI:8273
CAS Number
CAS 481-42-5
TTD Drug ID
DM9BS50
VARIDT Drug ID
DR01476

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [6]
Leflunomide DMR8ONJ Arthritis FA20 Approved [7]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [8]
Atovaquone DMY4UMW Fungal infection 1F29-1F2F Approved [9]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [2]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [10]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [10]
Orotate DMMB29S Discovery agent N.A. Investigative [11]
Lauryl Dimethylamine-N-Oxide DM3W2OE Discovery agent N.A. Investigative [10]
1,4-Naphthoquinone DMTCMH7 Discovery agent N.A. Investigative [2]
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Drug(s) Affected By Dihydroorotate dehydrogenase (DHODH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [12]
Leflunomide DMR8ONJ Arthritis FA20 Approved [13]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [14]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [15]
Arsenic DMTL2Y1 N. A. N. A. Approved [16]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Atovaquone DMY4UMW Fungal infection 1F29-1F2F Approved [2]
Urethane DM7NSI0 N. A. N. A. Phase 4 [19]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [2]
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Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [20]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [22]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [23]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [26]
Etretinate DM2CZFA Keratosis ED56 Approved [27]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [28]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [29]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [33]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Selenium DM25CGV N. A. N. A. Approved [35]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [42]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [43]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [44]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [47]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [49]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [50]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [51]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [53]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [54]
Gefitinib DM15F0X Colon adenocarcinoma Approved [55]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [58]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [49]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [59]
Paclitaxel DMLB81S Breast carcinoma Approved [60]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [61]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [62]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [51]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
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Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [68]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [69]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [72]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [80]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [81]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Gefitinib DM15F0X Colon adenocarcinoma Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [85]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [86]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [87]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [86]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [88]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Etretinate DM2CZFA Keratosis ED56 Approved [27]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [94]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [95]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [96]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [97]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [99]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [101]
Gefitinib DM15F0X Colon adenocarcinoma Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Selenium DM25CGV N. A. N. A. Approved [74]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [104]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [88]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [106]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [107]
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Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [109]
Selenium DM25CGV N. A. N. A. Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [112]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [115]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [116]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [117]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [119]
Gefitinib DM15F0X Colon adenocarcinoma Approved [120]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [121]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [122]
Selenium DM25CGV N. A. N. A. Approved [26]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [123]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [124]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [125]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [126]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [127]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [94]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [129]
Methotrexate DM2TEOL Anterior urethra cancer Approved [130]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [131]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [132]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [133]
Gefitinib DM15F0X Colon adenocarcinoma Approved [134]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [135]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Etretinate DM2CZFA Keratosis ED56 Approved [136]
Prednisone DM2HG4X Acute asthma CA23 Approved [137]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [87]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [138]
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Drug(s) Affected By Chymotrypsin-like protease CTRL-1 (CTRL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [139]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [140]
Urethane DM7NSI0 N. A. N. A. Phase 4 [19]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [141]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [142]
PMID28870136-Compound-48 DMPIM9L N. A. N. A. Patented [64]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [143]
CH-223191 DMMJZYC Solid tumour/cancer 2A00-2F9Z Investigative [144]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [145]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [146]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [147]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [85]
Meloxicam DM2AR7L Arthritis FA20 Approved [150]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [151]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [152]
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Drug(s) Affected By Transcription factor E2F1 (E2F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [153]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [154]
Gefitinib DM15F0X Colon adenocarcinoma Approved [155]
Selenium DM25CGV N. A. N. A. Approved [26]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [138]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [156]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [157]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [158]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [159]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [160]
Gefitinib DM15F0X Colon adenocarcinoma Approved [161]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [163]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [165]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [166]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Selenium DM25CGV N. A. N. A. Approved [26]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [167]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [44]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [98]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [168]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) TT3PQ2Y PYRD_PLAF7 Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [3]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [3]
Chymotrypsin-like protease CTRL-1 (CTRL) OTB6NA5O CTRL_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]
Dihydroorotate dehydrogenase (DHODH) OTAKFN78 PYRD_HUMAN Gene/Protein Processing [2]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [4]
E3 ubiquitin-protein ligase UHRF1 OTBNJUF2 UHRF1_HUMAN Gene/Protein Processing [3]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Gene/Protein Processing [4]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Gene/Protein Processing [5]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Gene/Protein Processing [5]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7003).
2 Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76.
3 Plumbagin downregulates UHRF1, p-Akt, MMP-2 and suppresses survival, growth and migration of cervical cancer CaSki cells. Toxicol In Vitro. 2023 Feb;86:105512. doi: 10.1016/j.tiv.2022.105512. Epub 2022 Nov 4.
4 Plumbagin induces paraptosis in cancer cells by disrupting the sulfhydryl homeostasis and proteasomal function. Chem Biol Interact. 2019 Sep 1;310:108733. doi: 10.1016/j.cbi.2019.108733. Epub 2019 Jul 2.
5 Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia. J Neurochem. 2010 Mar;112(5):1316-26.
6 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
7 Identification and characterization of potential new therapeutic targets in inflammatory and autoimmune diseases. Eur J Biochem. 1999 Dec;266(3):1184-91.
8 Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression. J Mol Microbiol Biotechnol. 1999 Aug;1(1):183-8.
9 Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Protein Sci. 2004 Apr;13(4):1031-42.
10 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
11 Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.
12 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
13 Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives. Biochem Pharmacol. 1998 Nov 1;56(9):1259-64. doi: 10.1016/s0006-2952(98)00145-2.
14 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
15 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
16 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
17 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
18 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
19 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
20 Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2010 Dec 1;55(6):1172-9. doi: 10.1002/pbc.22739.
21 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
22 The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance. J Pharmacol Exp Ther. 2000 Aug;294(2):480-7.
23 Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
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