Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB920Z)

• Drug Name: Ceritinib Drug Info
• Synonyms: ceritinib; LDK378; 1032900-25-6; ZYKADIA; NVP-LDK378-NX; LDK-378; UNII-K418KG2GET; LDK378(Ceritinib); LDK 378; Eritinib (LDK378); 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine; K418KG2GET; CHEMBL2403108; CHEBI:78432; AK174337; ceritinib; C28H36ClN5O3S; 5-Chloro-N2-[2-isopropoxy-5-Methyl-4-(4-piperidyl)phenyl]-N4-(2-isopropylsulfonylphenyl)pyriMidine-2,4-diaMine; 5-Chloro-N2-(5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl)-N4-(2-(propane-2-sulfonyl)phenyl)pyrim

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25.Y	Approved	[1]

• Cross-matching ID:
  PubChem CID: 57379345
  ChEBI ID: CHEBI:78432
  CAS Number: CAS 1032900-25-6
  TTD Drug ID: DMB920Z
  VARIDT Drug ID: DR00228
  ACDINA Drug ID: D00115

Molecule-Related Drug Atlas

Drug(s) Targeting ALK tyrosine kinase receptor (ALK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[5]
Lorlatinib	DMICDLV	Non-small-cell lung cancer	2C25.Y	Approved	[6]
Entrectinib	DMMPTLH	Non-small-cell lung cancer	2C25	Approved	[7]
Brigatinib	DM7W94S	Anaplastic large cell lymphoma	2A90.A	Approved	[8]
Repotrectinib	DM9FB2T	Non-small-cell lung cancer	2C25	Approved	[9]
Alectinib	DMP1I6Y	Lung cancer	2C25.0	Approved	[10]
Ensartinib	DMIKDCQ	Non-small-cell lung cancer	2C25.Y	Phase 3	[9]
PF-06463922	DMKM7EW	Non-small-cell lung cancer	2C25.Y	Phase 2	[11]
AP26113	DMYBQEF	Solid tumour/cancer	2A00-2F9Z	Phase 2	[12]
TSR-011	DMFOR9Y	Non-small-cell lung cancer	2C25.Y	Phase 1/2	[13]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[21]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[22]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[24]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[25]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[27]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[28]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[29]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[14]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[16]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[17]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[16]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[18]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[30]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[32]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[33]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[34]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[36]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[37]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[38]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[39]

Drug(s) Affected By Alanine aminotransferase 1 (GPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[34]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[34]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[34]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[34]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[3]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[3]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[3]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[45]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[46]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[47]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[51]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[52]

Drug(s) Affected By Tyrosine-protein kinase JAK3 (JAK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[56]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[57]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[61]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[62]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[37]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[65]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[66]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[67]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[68]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[70]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[71]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[75]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[76]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[39]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[79]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[83]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[30]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[52]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[36]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[84]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[63]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[87]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[88]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[38]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[84]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[94]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[95]

Drug(s) Affected By TNF receptor-associated factor 2 (TRAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[101]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[104]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]

Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[112]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ALK tyrosine kinase receptor (ALK)	TTPMQSO	ALK_HUMAN	Modulator	[1]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alanine aminotransferase 1 (GPT)	OTOXOA0Q	ALAT1_HUMAN	Protein Interaction/Cellular Processes	[3]
ALK tyrosine kinase receptor (ALK)	OTV3P4V8	ALK_HUMAN	Post-Translational Modifications	[4]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[4]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Protein Interaction/Cellular Processes	[4]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Protein Interaction/Cellular Processes	[4]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Gene/Protein Processing	[4]
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)	OTLUM9L7	PK3C3_HUMAN	Gene/Protein Processing	[4]
TNF receptor-associated factor 2 (TRAF2)	OT1MEZZN	TRAF2_HUMAN	Gene/Protein Processing	[4]

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