Details of the Drug-Related molecule(s) Interaction Atlas

Ginsenoside Rb1 Drug Info

Arasaponin E1; Ginsenoside rb1; Gynosaponin C; Panax saponin E; Panaxsaponin E; Pseudoginsenoside D; Sanchinoside E1; ginsenoside-Rb1; (20S)-ginsenoside Rb1; 2-O-beta-Glucopyranosyl-(3beta,12beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside; 20(S)-ginsenoside Rb1; 41753-43-9; 7413S0WMH6; BIDD:ER0108; C54H92O23; CHEBI:67989; CHEMBL501515; GRb 1; GS-Rb1; GSRb1; GZYPWOGIYAIIPV-JBDTYSNRSA-N; Gypenoside III; NSC 310103; UNII-7413S0WMH6

Cross-matching ID

PubChem CID

9898279

ChEBI ID

CHEBI:67989

CAS Number

CAS 41753-43-9

TTD Drug ID

DMF70AB

INTEDE Drug ID

DR2669

General Information of Drug (ID: DMF70AB)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Metabolized By Beta-glucosidase (bglA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SC-46553	DM6XNJR	N. A.	N. A.	Phase 3	[3]
HY-N0040	DM349AM	N. A.	N. A.	Preclinical	[3]
SC-46553	DM6XNJR	N. A.	N. A.	Phase 3	[3]
HY-N0040	DM349AM	N. A.	N. A.	Preclinical	[3]
SC-46553	DM6XNJR	N. A.	N. A.	Phase 3	[4] , [3]
HY-N0040	DM349AM	N. A.	N. A.	Preclinical	[3]
SC-46553	DM6XNJR	N. A.	N. A.	Phase 3	[5]
Ginsenoside Re	DM46FVD	N. A.	N. A.	Investigative	[5]
Ginsenoside Rg1	DMYE2SR	N. A.	N. A.	Investigative	[5]
HY-N0040	DM349AM	N. A.	N. A.	Preclinical	[1]
Ginsenoside Rc	DMES9Q2	N. A.	N. A.	Investigative	[1]
Glucopyranosyl oleanolate	DMRHYU8	N. A.	N. A.	Investigative	[3]
Gypenoside XVII	DM8ENQZ	N. A.	N. A.	Investigative	[3]
HY-N0040	DM349AM	N. A.	N. A.	Preclinical	[1]
CCG-208408	DMCFEUG	N. A.	N. A.	Preclinical	[13]
Ginsenoside Rc	DMES9Q2	N. A.	N. A.	Investigative	[1]
DB-041901	DM7JV4O	N. A.	N. A.	Phase 2	[14]
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Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[15]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[18]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[19]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[20]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[21]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[22]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[28]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Selenium	DM25CGV	N. A.	N. A.	Approved	[31]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
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Drug(s) Affected By Potassium voltage-gated channel subfamily E member 1 (KCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Pentobarbital	DMFNH7L	Brain ischaemia	8B1Z	Approved	[37]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[38]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[38]
Diltiazem	DMAI7ZV	Angina pectoris	BA40	Approved	[38]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[38]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[38]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[38]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[38]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[39]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[42]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[45]
Selenium	DM25CGV	N. A.	N. A.	Approved	[46]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[47]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[48]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[49]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[50]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[51]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[52]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[52]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[53]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[54]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[55]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[56]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[52]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[61]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[28]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Selenium	DM25CGV	N. A.	N. A.	Approved	[46]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[69]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[70]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[72]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-glucosidase (bglA)	DEUQTKA	A0A249DCH3_LACRH	Substrate	[1]
Beta-glucosidase (bglA)	DEE8WXK	A0A076JJU4_BIFAD	Substrate	[2]
Beta-glucosidase (bglA)	DEUO7V8	A0A509DD13_9STRE	Substrate	[3]
Beta-glucosidase (bglA)	DE4LKZ9	A0A3D1ZWL4_9BIFI	Substrate	[3]
Beta-glucosidase (bglA)	DEM6GYO	A0A351PC96_9FIRM	Substrate	[4] , [3]
Beta-glucosidase (bglA)	DE9N4OU	C6WCL5_ACTMD	Substrate	[5]
Beta-glucosidase (bglA)	DERPJZ6	A0A4Q4LS82_BIFAN	Substrate	[1]
Beta-glucosidase (bglA)	DEVLXCG	R7LVY8_9FUSO	Substrate	[3]
Beta-glucosidase (bglA)	DEXRUS1	A0A267WL33_9BIFI	Substrate	[2]
Beta-glucosidase (bglA)	DERX7ML	A0A3B8TKP6_9FIRM	Substrate	[2]
Beta-glucosidase (bglA)	DEOHI3U	A0A0P0FEZ9_BACT4	Substrate	[2]
Beta-glucosidase (bglA)	DE46IH1	A0A1T4QCU7_9PROT	Substrate	[6]
Beta-glucosidase (bglA)	DECBSVP	A0A126SWK8_9BIFI	Substrate	[2]
Beta-glucosidase (bglA)	DEAVLU4	BGLFU_BIFBR	Substrate	[2]
Beta-glucosidase (bglA)	DEPBQES	BGLS_BUTFI	Substrate	[2]
Beta-glucosidase (bglA)	DEGVUWH	A0A174JG46_9FIRM	Substrate	[2]
Beta-glucosidase (bglA)	DEE8RS0	A0A174GPV4_9FIRM	Substrate	[2]
Beta-glucosidase (bglA)	DEC0M8H	A0A174ZK85_9FIRM	Substrate	[2]
Beta-glucosidase (bglA)	DE2OMS0	A0A173UNF6_9FIRM	Substrate	[2]
Beta-glucosidase (bglA)	DEPUNVR	A0A395V8H8_9FIRM	Substrate	[2]
Beta-glucosidase (bglA)	DEX7SAW	A0A3R6A2W5_9FIRM	Substrate	[2]
Beta-glucosidase (bglA)	DEE3I1P	A0A412BAD0_9FIRM	Substrate	[2]
Beta-glucosidase (bglA)	DEASJG5	A5ZMW4_9FIRM	Substrate	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Gene/Protein Processing	[7]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Gene/Protein Processing	[8]
Potassium voltage-gated channel subfamily E member 1 (KCNE1)	OTZNQUW9	KCNE1_HUMAN	Gene/Protein Processing	[9]
Potassium voltage-gated channel subfamily H member 2 (KCNH2)	OTZX881H	KCNH2_HUMAN	Gene/Protein Processing	[10]
Progesterone receptor (PGR)	OT0FZ3QE	PRGR_HUMAN	Gene/Protein Processing	[11]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Post-Translational Modifications	[7]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Gene/Protein Processing	[12]

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