Details of the Drug

General Information of Drug (ID: DMFNH7L)

Drug Name
Pentobarbital
Synonyms
Aethaminalum; Dorsital; Etaminal; Ethaminal; Mebubarbital; Mebumal; Nebralin; Nembutal; Neodorm; Pentabarbital; Pentabarbitone; Pentobarbitale; Pentobarbitalum; Pentobarbitone; Pentobarbiturate; Rivadorm; Pentobarbital calcium; Pentobarbital suppository dosage form; Pentobarbitale [DCIT]; Pentobarbituric acid; Ethyl-propylmethylcarbinylbarbituric acid; Nembutal (TN); Nembutal (VAN); Neodorm (VAN); Neodorm (new); Pentobarbital (VAN); Pentobarbital [USP:INN]; Pentobarbital, Monosodium Salt; Pentobarbitalum [INN-Latin]; Pentobarbitone (VAN); Pentobarbital (USP/INN); (+-)-5-Ethyl-5-(1-methylbutyl)barbituric acid; 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Ethyl-5-(1-methylbutyl)barbituric acid; 5-Ethyl-5-(1-methylbutyl)malonylurea; 5-Ethyl-5-(sec-pentyl)barbituric acid; 5-ethyl-2-hydroxy-5-(1-methylbutyl)pyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione;5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione
Indication
Disease Entry ICD 11 Status REF
Brain ischaemia 8B1Z Approved [1]
Epilepsy 8A60-8A68 Approved [1]
Insomnia 7A00-7A0Z Approved [2]
Therapeutic Class
Hypnotics and Sedatives
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 226.27
Logarithm of the Partition Coefficient (xlogp) 2.1
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
Bioavailability
80% of drug becomes completely available to its intended biological destination(s) [3]
Clearance
The drug present in the plasma can be removed from the body at the rate of 0.47 mL/min/kg [4]
Half-life
The concentration or amount of drug in body reduced by one-half in 5 - 50 hours [4]
Metabolism
The drug is metabolized via the hepatic microsomal enzyme system []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 12.61439 micromolar/kg/day [5]
Unbound Fraction
The unbound fraction of drug in plasma is 0.39% [4]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 0.91 L/kg [4]
Chemical Identifiers
Formula
C11H18N2O3
IUPAC Name
5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione
Canonical SMILES
CCCC(C)C1(C(=O)NC(=O)NC1=O)CC
InChI
InChI=1S/C11H18N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
InChIKey
WEXRUCMBJFQVBZ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4737
ChEBI ID
CHEBI:7983
CAS Number
76-74-4
DrugBank ID
DB00312
TTD ID
D0F0YZ
INTEDE ID
DR1254
ACDINA ID
D01333
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Antagonist [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Mephenytoin 4-hydroxylase (CYP2C19)
Main DME 		DEGTFWK CP2CJ_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Glutamate carboxypeptidase 2 (FOLH1) OTQ9Z6QK FOLH1_HUMAN Drug Response [8]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [9]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [9]
Potassium voltage-gated channel subfamily E member 1 (KCNE1) OTZNQUW9 KCNE1_HUMAN Gene/Protein Processing [10]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [10]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Gene/Protein Processing [11]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Gene/Protein Processing [12]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Brain ischaemia
ICD Disease Classification 8B1Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
GABA(A) receptor alpha-1 (GABRA1) DTT GABRA1 9.57E-01 -0.12 -0.18
Mephenytoin 4-hydroxylase (CYP2C19) DME CYP2C19 7.66E-01 9.19E-03 4.88E-02
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Pentobarbital
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Suvorexant DM0E6S3 Moderate Increased metabolism of Pentobarbital caused by Suvorexant mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [13]
Eszopiclone DM8RZ9H Moderate Increased metabolism of Pentobarbital caused by Eszopiclone mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [14]
Tasimelteon DMLOQ1V Moderate Increased metabolism of Pentobarbital caused by Tasimelteon mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [15]
ITI-007 DMUQ1DO Major Increased metabolism of Pentobarbital caused by ITI-007 mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [16]
Coadministration of a Drug Treating the Disease Different from Pentobarbital (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Methylergonovine DMBEX4O Moderate Increased metabolism of Pentobarbital caused by Methylergonovine mediated induction of CYP450 enzyme. Abortion [JA00] [17]
Repaglinide DM5SXUV Moderate Increased metabolism of Pentobarbital caused by Repaglinide mediated induction of CYP450 enzyme. Acute diabete complication [5A2Y] [18]
Midostaurin DMI6E0R Moderate Increased metabolism of Pentobarbital caused by Midostaurin mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [19]
Gilteritinib DMTI0ZO Moderate Increased metabolism of Pentobarbital caused by Gilteritinib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [20]
Oliceridine DM6MDCF Major Increased metabolism of Pentobarbital caused by Oliceridine mediated induction of CYP450 enzyme. Acute pain [MG31] [21]
Mitotane DMU1GX0 Minor Increased metabolism of Pentobarbital caused by Mitotane mediated induction of CYP450 enzyme. Adrenal cancer [2D11] [22]
Donepezil DMIYG7Z Moderate Increased metabolism of Pentobarbital caused by Donepezil mediated induction of CYP450 enzyme. Alzheimer disease [8A20] [23]
Metronidazole DMTIVEN Moderate Increased metabolism of Pentobarbital caused by Metronidazole mediated induction of CYP450 enzyme. Amoebiasis [1A36] [24]
Ivabradine DM0L594 Moderate Increased metabolism of Pentobarbital caused by Ivabradine mediated induction of CYP450 enzyme. Angina pectoris [BA40] [25]
Dronedarone DMA8FS5 Moderate Increased metabolism of Pentobarbital caused by Dronedarone mediated induction of CYP450 enzyme. Angina pectoris [BA40] [26]
Nifedipine DMSVOZT Moderate Increased metabolism of Pentobarbital caused by Nifedipine mediated induction of CYP450 enzyme. Angina pectoris [BA40] [27]
Bedaquiline DM3906J Moderate Increased metabolism of Pentobarbital caused by Bedaquiline mediated induction of CYP450 enzyme. Antimicrobial drug resistance [MG50-MG52] [28]
Buspirone DMBS632 Moderate Increased metabolism of Pentobarbital caused by Buspirone mediated induction of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [29]
Voriconazole DMAOL2S Moderate Increased metabolism of Pentobarbital caused by Voriconazole mediated induction of CYP450 enzyme. Aspergillosis [1F20] [30]
Montelukast DMD157S Moderate Increased metabolism of Pentobarbital caused by Montelukast mediated induction of CYP450 enzyme. Asthma [CA23] [31]
Aminophylline DML2NIB Moderate Increased metabolism of Pentobarbital caused by Aminophylline mediated induction of CYP450 enzyme. Asthma [CA23] [32]
Tindamax DM3OWT4 Moderate Increased metabolism of Pentobarbital caused by Tindamax mediated induction of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [24]
Chloramphenicol DMFXEWT Moderate Increased metabolism of Pentobarbital caused by Chloramphenicol mediated induction of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [33]
Cariprazine DMJYDVK Moderate Increased metabolism of Pentobarbital caused by Cariprazine mediated induction of CYP450 enzyme. Bipolar disorder [6A60] [25]
Lapatinib DM3BH1Y Moderate Increased metabolism of Pentobarbital caused by Lapatinib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [17]
LY2835219 DM93VBZ Moderate Increased metabolism of Pentobarbital caused by LY2835219 mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [34]
Exemestane DM9HPW3 Moderate Increased metabolism of Pentobarbital caused by Exemestane mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [35]
Esterified estrogens DM9KZDO Moderate Increased metabolism of Pentobarbital caused by Esterified estrogens mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [36]
Tucatinib DMBESUA Moderate Increased metabolism of Pentobarbital caused by Tucatinib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [37]
Alpelisib DMEXMYK Moderate Increased metabolism of Pentobarbital caused by Alpelisib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [38]
Quinestrol DMJ6H1Z Moderate Increased metabolism of Pentobarbital caused by Quinestrol mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [36]
Tamoxifen DMLB0EZ Moderate Increased metabolism of Pentobarbital caused by Tamoxifen mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [39]
Cabazitaxel DMPAZHC Moderate Increased metabolism of Pentobarbital caused by Cabazitaxel mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [40]
Toremifene DMQYUWG Moderate Increased metabolism of Pentobarbital caused by Toremifene mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [41]
Bosutinib DMTI8YE Moderate Increased metabolism of Pentobarbital caused by Bosutinib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [42]
Estradiol DMUNTE3 Moderate Increased metabolism of Pentobarbital caused by Estradiol mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [36]
Atorvastatin DMF28YC Moderate Increased metabolism of Pentobarbital caused by Atorvastatin mediated induction of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [43]
Macitentan DMP79A1 Moderate Increased metabolism of Pentobarbital caused by Macitentan mediated induction of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [44]
Doxercalciferol DM6FG1P Moderate Increased metabolism of Pentobarbital caused by Doxercalciferol mediated induction of CYP450 enzyme. Chronic kidney disease [GB61] [45]
Corticotropin DMP9TWZ Moderate Increased metabolism of Pentobarbital caused by Corticotropin mediated induction of CYP450 enzyme. Chronic kidney disease [GB61] [46]
PF-04449913 DMSB068 Moderate Increased metabolism of Pentobarbital caused by PF-04449913 mediated induction of CYP450 enzyme. Chronic myelomonocytic leukaemia [2A40] [47]
Dihydrocodeine DMB0FWL Major Additive CNS depression effects by the combination of Pentobarbital and Dihydrocodeine. Chronic pain [MG30] [48]
Irinotecan DMP6SC2 Moderate Increased metabolism of Pentobarbital caused by Irinotecan mediated induction of CYP450 enzyme. Colorectal cancer [2B91] [49]
Olopatadine DMKMWQG Moderate Additive CNS depression effects by the combination of Pentobarbital and Olopatadine. Conjunctiva disorder [9A60] [50]
Drospirenone DM1A9W3 Moderate Increased metabolism of Pentobarbital caused by Drospirenone mediated induction of CYP450 enzyme. Contraceptive management [QA21] [36]
Levonorgestrel DM1DP7T Moderate Increased metabolism of Pentobarbital caused by Levonorgestrel mediated induction of CYP450 enzyme. Contraceptive management [QA21] [36]
Ulipristal DMBNI20 Moderate Increased metabolism of Pentobarbital caused by Ulipristal mediated induction of CYP450 enzyme. Contraceptive management [QA21] [25]
Levobupivacaine DM783CH Minor Increased metabolism of Pentobarbital caused by Levobupivacaine mediated induction of CYP450 enzyme. Corneal disease [9A76-9A78] [51]
Propofol DMB4OLE Moderate Additive CNS depression effects by the combination of Pentobarbital and Propofol. Corneal disease [9A76-9A78] [52]
Methoxyflurane DML0RAE Moderate Increased metabolism of Pentobarbital caused by Methoxyflurane mediated induction of CYP450 enzyme. Corneal disease [9A76-9A78] [53]
Alfentanil DMVO0UB Major Additive CNS depression effects by the combination of Pentobarbital and Alfentanil. Corneal disease [9A76-9A78] [54]
Remifentanil DMZTXCH Major Additive CNS depression effects by the combination of Pentobarbital and Remifentanil. Corneal disease [9A76-9A78] [54]
Oxtriphylline DMLHSE3 Moderate Increased metabolism of Pentobarbital caused by Oxtriphylline mediated induction of CYP450 enzyme. Cough [MD12] [32]
Methadone DMTW6IU Major Additive CNS depression effects by the combination of Pentobarbital and Methadone. Cough [MD12] [55]
Mifepristone DMGZQEF Moderate Increased metabolism of Pentobarbital caused by Mifepristone mediated induction of CYP450 enzyme. Cushing syndrome [5A70] [56]
Osilodrostat DMIJC9X Moderate Increased metabolism of Pentobarbital caused by Osilodrostat mediated induction of CYP450 enzyme. Cushing syndrome [5A70] [57]
Ivacaftor DMZC1HS Moderate Increased metabolism of Pentobarbital caused by Ivacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [58]
Ethanol DMDRQZU Major Additive CNS depression effects by the combination of Pentobarbital and Ethanol. Cystitis [GC00] [59]
Rivaroxaban DMQMBZ1 Moderate Increased metabolism of Pentobarbital caused by Rivaroxaban mediated induction of CYP450 enzyme. Deep vein thrombosis [BD71] [60]
Fluoxetine DM3PD2C Minor Decreased metabolism of Pentobarbital caused by Fluoxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [61]
Vilazodone DM4LECQ Moderate Increased metabolism of Pentobarbital caused by Vilazodone mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [62]
Paroxetine DM5PVQE Minor Increased metabolism of Pentobarbital caused by Paroxetine mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [63]
Vortioxetine DM6F1PU Moderate Increased metabolism of Pentobarbital caused by Vortioxetine mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [64]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Pentobarbital and Esketamine. Depression [6A70-6A7Z] [17]
Griseofulvin DMK54YG Moderate Altered absorption of Pentobarbital caused by Griseofulvin. Dermatophytosis [1F28] [65]
[3H]estrone-3-sulphate DMGPF0N Moderate Increased metabolism of Pentobarbital caused by [3H]estrone-3-sulphate mediated induction of CYP450 enzyme. Discovery agent [N.A.] [66]
Trihexyphenidyl DMB19L8 Moderate Additive CNS depression effects by the combination of Pentobarbital and Trihexyphenidyl. Dystonic disorder [8A02] [67]
Zonisamide DM0DTF7 Moderate Increased metabolism of Pentobarbital caused by Zonisamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [68]
Fosphenytoin DMOX3LB Moderate Increased metabolism of Pentobarbital caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [69]
Carbamazepine DMZOLBI Minor Increased metabolism of Pentobarbital caused by Carbamazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [70]
Timolol DM3NXRU Moderate Increased metabolism of Pentobarbital caused by Timolol mediated induction of CYP450 enzyme. Essential hypertension [BA00] [71]
Nicardipine DMCDYW7 Moderate Increased metabolism of Pentobarbital caused by Nicardipine mediated induction of CYP450 enzyme. Essential hypertension [BA00] [27]
Praziquantel DMOU1PK Moderate Increased metabolism of Pentobarbital caused by Praziquantel mediated induction of CYP450 enzyme. Flatworm infection [1F70-1F86] [72]
Bay 80-6946 DMLOS5R Moderate Increased metabolism of Pentobarbital caused by Bay 80-6946 mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [73]
Tazemetostat DMWP1BH Major Increased metabolism of Pentobarbital caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [74]
Solifenacin DMG592Q Moderate Increased metabolism of Pentobarbital caused by Solifenacin mediated induction of CYP450 enzyme. Functional bladder disorder [GC50] [75]
Mirabegron DMS1GYT Minor Increased metabolism of Pentobarbital caused by Mirabegron mediated induction of CYP450 enzyme. Functional bladder disorder [GC50] [76]
Darifenacin DMWXLYZ Moderate Increased metabolism of Pentobarbital caused by Darifenacin mediated induction of CYP450 enzyme. Functional bladder disorder [GC50] [77]
Caspofungin DMGQIPT Moderate Increased metabolism of Pentobarbital caused by Caspofungin mediated induction of CYP450 enzyme. Fungal infection [1F29-1F2F] [78]
Cimetidine DMH61ZB Minor Altered absorption of Pentobarbital caused by Cimetidine. Gastro-oesophageal reflux disease [DA22] [79]
Ripretinib DM958QB Moderate Increased metabolism of Pentobarbital caused by Ripretinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [17]
Sunitinib DMCBJSR Moderate Increased metabolism of Pentobarbital caused by Sunitinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [17]
Avapritinib DMK2GZX Moderate Increased metabolism of Pentobarbital caused by Avapritinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [25]
Brimonidine DMQLT4N Moderate Additive CNS depression effects by the combination of Pentobarbital and Brimonidine. Glaucoma [9C61] [80]
Ergotamine DMKR3C5 Moderate Increased metabolism of Pentobarbital caused by Ergotamine mediated induction of CYP450 enzyme. Headache [8A80-8A84] [17]
Carvedilol DMHTEAO Moderate Increased metabolism of Pentobarbital caused by Carvedilol mediated induction of CYP450 enzyme. Heart failure [BD10-BD1Z] [71]
Digitoxin DMWVIGP Moderate Increased metabolism of Pentobarbital caused by Digitoxin mediated induction of CYP450 enzyme. Heart failure [BD10-BD1Z] [81]
Boceprevir DMBSHMF Moderate Increased metabolism of Pentobarbital caused by Boceprevir mediated induction of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [82]
Telaprevir DMMRV29 Moderate Increased metabolism of Pentobarbital caused by Telaprevir mediated induction of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [82]
Rifampin DMA8J1G Minor Increased metabolism of Pentobarbital caused by Rifampin mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [83]
MK-1439 DM215WE Moderate Increased metabolism of Pentobarbital caused by MK-1439 mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [84]
Delavirdine DM3NF5G Moderate Increased metabolism of Pentobarbital caused by Delavirdine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [85]
Fosamprenavir DM4W9B3 Moderate Increased metabolism of Pentobarbital caused by Fosamprenavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [86]
Fostemsavir DM50ILT Minor Increased metabolism of Pentobarbital caused by Fostemsavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [87]
Tipranavir DM8HJX6 Moderate Increased metabolism of Pentobarbital caused by Tipranavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [86]
Efavirenz DMC0GSJ Moderate Increased metabolism of Pentobarbital caused by Efavirenz mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [88]
Dolutegravir DMCZGRE Minor Increased metabolism of Pentobarbital caused by Dolutegravir mediated induction of UGT. Human immunodeficiency virus disease [1C60-1C62] [89]
Saquinavir DMG814N Moderate Increased metabolism of Pentobarbital caused by Saquinavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [86]
Etravirine DMGV8QU Moderate Increased metabolism of Pentobarbital caused by Etravirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [90]
Rilpivirine DMJ0QOW Moderate Increased metabolism of Pentobarbital caused by Rilpivirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [17]
Amprenavir DMLMXE0 Moderate Increased metabolism of Pentobarbital caused by Amprenavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [86]
Darunavir DMN3GCH Moderate Increased metabolism of Pentobarbital caused by Darunavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [86]
Atazanavir DMSYRBX Moderate Increased metabolism of Pentobarbital caused by Atazanavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [86]
Maraviroc DMTL94F Moderate Increased metabolism of Pentobarbital caused by Maraviroc mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [17]
Ritonavir DMU764S Moderate Increased metabolism of Pentobarbital caused by Ritonavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [86]
Paricalcitol DMYBV3G Moderate Increased metabolism of Pentobarbital caused by Paricalcitol mediated induction of CYP450 enzyme. Hyper-parathyroidism [5A51] [45]
Acebutolol DM0TI4U Moderate Increased metabolism of Pentobarbital caused by Acebutolol mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [71]
Penbutolol DM4ES8F Moderate Increased metabolism of Pentobarbital caused by Penbutolol mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [71]
Losartan DM72JXH Minor Increased metabolism of Pentobarbital caused by Losartan mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [91]
Nebivolol DM7F1PA Moderate Increased metabolism of Pentobarbital caused by Nebivolol mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [71]
Nisoldipine DM7ISKJ Moderate Increased metabolism of Pentobarbital caused by Nisoldipine mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [27]
Levamlodipine DM92S6N Moderate Increased metabolism of Pentobarbital caused by Levamlodipine mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [27]
Verapamil DMA7PEW Moderate Increased metabolism of Pentobarbital caused by Verapamil mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [92]
Diltiazem DMAI7ZV Moderate Increased metabolism of Pentobarbital caused by Diltiazem mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [93]
Amlodipine DMBDAZV Moderate Increased metabolism of Pentobarbital caused by Amlodipine mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [27]
Felodipine DMOSW35 Moderate Increased metabolism of Pentobarbital caused by Felodipine mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [94]
Tolvaptan DMIWFRL Moderate Increased metabolism of Pentobarbital caused by Tolvaptan mediated induction of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [25]
Fludrocortisone DMUDIR8 Moderate Increased metabolism of Pentobarbital caused by Fludrocortisone mediated induction of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [46]
Levothyroxine DMHN027 Moderate Increased metabolism of Pentobarbital caused by Levothyroxine mediated induction of CYP450 enzyme. Hypo-thyroidism [5A00] [25]
Lesinurad DMUR64T Moderate Increased metabolism of Pentobarbital caused by Lesinurad mediated induction of CYP450 enzyme. Inborn purine/pyrimidine/nucleotide metabolism error [5C55] [95]
Naloxegol DML0B41 Moderate Increased metabolism of Pentobarbital caused by Naloxegol mediated induction of CYP450 enzyme. Large intestine motility disorder [DB32] [96]
Pemigatinib DM819JF Moderate Increased metabolism of Pentobarbital caused by Pemigatinib mediated induction of CYP450 enzyme. Liver cancer [2C12] [25]
Crizotinib DM4F29C Moderate Increased metabolism of Pentobarbital caused by Crizotinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [97]
Ceritinib DMB920Z Moderate Increased metabolism of Pentobarbital caused by Ceritinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [98]
Erlotinib DMCMBHA Moderate Increased metabolism of Pentobarbital caused by Erlotinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [99]
Lurbinectedin DMEFRTZ Moderate Increased metabolism of Pentobarbital caused by Lurbinectedin mediated induction of CYP450 enzyme. Lung cancer [2C25] [100]
Osimertinib DMRJLAT Moderate Increased metabolism of Pentobarbital caused by Osimertinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [101]
Capmatinib DMYCXKL Moderate Increased metabolism of Pentobarbital caused by Capmatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [102]
Selpercatinib DMZR15V Moderate Increased metabolism of Pentobarbital caused by Selpercatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [25]
Artemether DM48QOT Moderate Increased metabolism of Pentobarbital caused by Artemether mediated induction of CYP450 enzyme. Malaria [1F40-1F45] [17]
Quinine DMSWYF5 Moderate Increased metabolism of Pentobarbital caused by Quinine mediated induction of CYP450 enzyme. Malaria [1F40-1F45] [103]
Mefloquine DMWT905 Moderate Increased metabolism of Pentobarbital caused by Mefloquine mediated induction of CYP450 enzyme. Malaria [1F40-1F45] [104]
Idelalisib DM602WT Moderate Increased metabolism of Pentobarbital caused by Idelalisib mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [105]
GDC-0199 DMH0QKA Moderate Increased metabolism of Pentobarbital caused by GDC-0199 mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [106]
IPI-145 DMWA24P Moderate Increased metabolism of Pentobarbital caused by IPI-145 mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [107]
Acalabrutinib DM7GCVW Moderate Increased metabolism of Pentobarbital caused by Acalabrutinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [108]
Ibrutinib DMHZCPO Moderate Increased metabolism of Pentobarbital caused by Ibrutinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [109]
Ponatinib DMYGJQO Moderate Increased metabolism of Pentobarbital caused by Ponatinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [17]
Vemurafenib DM62UG5 Moderate Increased metabolism of Pentobarbital caused by Vemurafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [110]
Selumetinib DMC7W6R Moderate Increased metabolism of Pentobarbital caused by Selumetinib mediated induction of CYP450 enzyme. Melanoma [2C30] [111]
LGX818 DMNQXV8 Moderate Increased metabolism of Pentobarbital caused by LGX818 mediated induction of CYP450 enzyme. Melanoma [2C30] [112]
Estrone DM5T6US Moderate Increased metabolism of Pentobarbital caused by Estrone mediated induction of CYP450 enzyme. Menopausal disorder [GA30] [36]
Ethinyl estradiol DMODJ40 Moderate Increased metabolism of Pentobarbital caused by Ethinyl estradiol mediated induction of CYP450 enzyme. Menopausal disorder [GA30] [66]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Pentobarbital and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [113]
Dihydroergotamine DM5IKUF Moderate Increased metabolism of Pentobarbital caused by Dihydroergotamine mediated induction of CYP450 enzyme. Migraine [8A80] [17]
Ubrogepant DM749I3 Moderate Increased metabolism of Pentobarbital caused by Ubrogepant mediated induction of CYP450 enzyme. Migraine [8A80] [114]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Pentobarbital and Lasmiditan. Migraine [8A80] [115]
Dihydrotachysterol DMFB97P Moderate Increased metabolism of Pentobarbital caused by Dihydrotachysterol mediated induction of CYP450 enzyme. Mineral deficiency [5B5K] [45]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Pentobarbital and Flibanserin. Mood disorder [6A60-6E23] [116]
Panobinostat DM58WKG Moderate Increased metabolism of Pentobarbital caused by Panobinostat mediated induction of CYP450 enzyme. Multiple myeloma [2A83] [117]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Pentobarbital and Thalidomide. Multiple myeloma [2A83] [118]
Nilotinib DM7HXWT Moderate Increased metabolism of Pentobarbital caused by Nilotinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [119]
Ruxolitinib DM7Q98D Moderate Increased metabolism of Pentobarbital caused by Ruxolitinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [120]
Imatinib DM7RJXL Moderate Increased metabolism of Pentobarbital caused by Imatinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [121]
Dasatinib DMJV2EK Moderate Increased metabolism of Pentobarbital caused by Dasatinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [17]
Modafinil DMYILBE Moderate Increased metabolism of Pentobarbital caused by Modafinil mediated induction of CYP450 enzyme. Narcolepsy [7A20] [122]
Rolapitant DM8XP26 Moderate Increased metabolism of Pentobarbital caused by Rolapitant mediated induction of CYP450 enzyme. Nausea/vomiting [MD90] [123]
Bupropion DM5PCS7 Moderate Increased metabolism of Pentobarbital caused by Bupropion mediated induction of CYP450 enzyme. Nicotine use disorder [6C4A] [124]
Entrectinib DMMPTLH Moderate Increased metabolism of Pentobarbital caused by Entrectinib mediated induction of CYP450 enzyme. Non-small cell lung cancer [2C25] [125]
Levomethadyl Acetate DM06HG5 Major Additive CNS depression effects by the combination of Pentobarbital and Levomethadyl Acetate. Opioid use disorder [6C43] [48]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Pentobarbital and Apraclonidine. Optic nerve disorder [9C40] [80]
Olaparib DM8QB1D Moderate Increased metabolism of Pentobarbital caused by Olaparib mediated induction of CYP450 enzyme. Ovarian cancer [2C73] [17]
Altretamine DMKLAYG Moderate Increased metabolism of Pentobarbital caused by Altretamine mediated induction of CYP450 enzyme. Ovarian cancer [2C73] [126]
Pentazocine DM1XBHS Major Additive CNS depression effects by the combination of Pentobarbital and Pentazocine. Pain [MG30-MG3Z] [54]
Dextropropoxyphene DM23HCX Major Additive CNS depression effects by the combination of Pentobarbital and Dextropropoxyphene. Pain [MG30-MG3Z] [127]
Butorphanol DM5KYPJ Major Increased metabolism of Pentobarbital caused by Butorphanol mediated induction of CYP450 enzyme. Pain [MG30-MG3Z] [21]
Oxymorphone DM65AGJ Major Additive CNS depression effects by the combination of Pentobarbital and Oxymorphone. Pain [MG30-MG3Z] [54]
Hydromorphone DMHP21E Major Additive CNS depression effects by the combination of Pentobarbital and Hydromorphone. Pain [MG30-MG3Z] [54]
Dezocine DMJDB0Y Major Additive CNS depression effects by the combination of Pentobarbital and Dezocine. Pain [MG30-MG3Z] [54]
Codeine DMJX6ZG Major Additive CNS depression effects by the combination of Pentobarbital and Codeine. Pain [MG30-MG3Z] [54]
Nalbuphine DMOSQGU Major Additive CNS depression effects by the combination of Pentobarbital and Nalbuphine. Pain [MG30-MG3Z] [54]
Buprenorphine DMPRI8G Major Additive CNS depression effects by the combination of Pentobarbital and Buprenorphine. Pain [MG30-MG3Z] [128]
Hydrocodone DMQ2JO5 Major Additive CNS depression effects by the combination of Pentobarbital and Hydrocodone. Pain [MG30-MG3Z] [55]
Acetaminophen DMUIE76 Moderate Increased metabolism of Pentobarbital caused by Acetaminophen mediated induction of CYP450 enzyme. Pain [MG30-MG3Z] [129]
Meperidine DMX4GND Major Increased metabolism of Pentobarbital caused by Meperidine mediated induction of CYP450 enzyme. Pain [MG30-MG3Z] [25]
Oxycodone DMXLKHV Major Additive CNS depression effects by the combination of Pentobarbital and Oxycodone. Pain [MG30-MG3Z] [21]
Biperiden DME78OA Moderate Additive CNS depression effects by the combination of Pentobarbital and Biperiden. Parkinsonism [8A00] [67]
Procyclidine DMHFJDT Moderate Additive CNS depression effects by the combination of Pentobarbital and Procyclidine. Parkinsonism [8A00] [67]
Pimavanserin DMR7IVC Moderate Increased metabolism of Pentobarbital caused by Pimavanserin mediated induction of CYP450 enzyme. Parkinsonism [8A00] [130]
Macimorelin DMQYJIR Moderate Increased metabolism of Pentobarbital caused by Macimorelin mediated induction of CYP450 enzyme. Pituitary gland disorder [5A60-5A61] [131]
Lefamulin DME6G97 Moderate Increased metabolism of Pentobarbital caused by Lefamulin mediated induction of CYP450 enzyme. Pneumonia [CA40] [132]
Betamethasone DMAHJEF Moderate Increased metabolism of Pentobarbital caused by Betamethasone mediated induction of CYP450 enzyme. Postoperative inflammation [1A00-CA43] [46]
Hydrocortisone DMGEMB7 Moderate Increased metabolism of Pentobarbital caused by Hydrocortisone mediated induction of CYP450 enzyme. Postoperative inflammation [1A00-CA43] [46]
Ergonovine DM0VEC1 Moderate Increased metabolism of Pentobarbital caused by Ergonovine mediated induction of CYP450 enzyme. Postpartum haemorrhage [JA43] [17]
Lonafarnib DMGM2Z6 Moderate Increased metabolism of Pentobarbital caused by Lonafarnib mediated induction of CYP450 enzyme. Premature ageing appearance [LD2B] [133]
Progesterone DMUY35B Moderate Increased metabolism of Pentobarbital caused by Progesterone mediated induction of CYP450 enzyme. Preterm labour/delivery [JB00] [36]
Enzalutamide DMGL19D Moderate Increased metabolism of Pentobarbital caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [134]
Darolutamide DMV7YFT Moderate Increased metabolism of Pentobarbital caused by Darolutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [135]
Apremilast DMTWS9E Moderate Increased metabolism of Pentobarbital caused by Apremilast mediated induction of CYP450 enzyme. Psoriasis [EA90] [136]
Riociguat DMXBLMP Moderate Increased metabolism of Pentobarbital caused by Riociguat mediated induction of CYP450 enzyme. Pulmonary hypertension [BB01] [137]
Everolimus DM8X2EH Moderate Increased metabolism of Pentobarbital caused by Everolimus mediated induction of CYP450 enzyme. Renal cell carcinoma [2C90] [17]
Axitinib DMGVH6N Moderate Increased metabolism of Pentobarbital caused by Axitinib mediated induction of CYP450 enzyme. Renal cell carcinoma [2C90] [138]
Tofacitinib DMBS370 Moderate Increased metabolism of Pentobarbital caused by Tofacitinib mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [17]
Fenoprofen DML5VQ0 Minor Increased metabolism of Pentobarbital caused by Fenoprofen mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [139]
Dexamethasone DMMWZET Moderate Increased metabolism of Pentobarbital caused by Dexamethasone mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [46]
Quetiapine DM1N62C Moderate Increased metabolism of Pentobarbital caused by Quetiapine mediated induction of CYP450 enzyme. Schizophrenia [6A20] [17]
Aripiprazole DM3NUMH Moderate Increased metabolism of Pentobarbital caused by Aripiprazole mediated induction of CYP450 enzyme. Schizophrenia [6A20] [140]
Sufentanil DMU7YEL Major Additive CNS depression effects by the combination of Pentobarbital and Sufentanil. Sensation disturbance [MB40] [54]
Avanafil DM75CXN Moderate Increased metabolism of Pentobarbital caused by Avanafil mediated induction of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [141]
Tadalafil DMJZHT1 Moderate Increased metabolism of Pentobarbital caused by Tadalafil mediated induction of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [25]
LDE225 DMM9F25 Moderate Increased metabolism of Pentobarbital caused by LDE225 mediated induction of CYP450 enzyme. Skin cancer [2C30-2C37] [142]
Gefitinib DM15F0X Moderate Increased metabolism of Pentobarbital caused by Gefitinib mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [99]
Larotrectinib DM26CQR Moderate Increased metabolism of Pentobarbital caused by Larotrectinib mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [17]
Methylprednisolone DM4BDON Moderate Increased metabolism of Pentobarbital caused by Methylprednisolone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [46]
Docetaxel DMDI269 Moderate Increased metabolism of Pentobarbital caused by Docetaxel mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [143]
Trabectedin DMG3Y89 Moderate Increased metabolism of Pentobarbital caused by Trabectedin mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [25]
Armodafinil DMGB035 Moderate Increased metabolism of Pentobarbital caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [122]
Prednisolone DMQ8FR2 Moderate Increased metabolism of Pentobarbital caused by Prednisolone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [46]
Norethindrone DMTY169 Moderate Increased metabolism of Pentobarbital caused by Norethindrone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [66]
Taxol DMUOT9V Moderate Increased metabolism of Pentobarbital caused by Taxol mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [144]
Doxorubicin DMVP5YE Moderate Increased metabolism of Pentobarbital caused by Doxorubicin mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [25]
Warfarin DMJYCVW Major Increased metabolism of Pentobarbital caused by Warfarin mediated induction of CYP450 enzyme. Supraventricular tachyarrhythmia [BC81] [145]
Fostamatinib DM6AUHV Moderate Increased metabolism of Pentobarbital caused by Fostamatinib mediated induction of CYP450 enzyme. Thrombocytopenia [3B64] [146]
Apixaban DM89JLN Moderate Increased metabolism of Pentobarbital caused by Apixaban mediated induction of CYP450 enzyme. Thrombosis [DB61-GB90] [147]
Brilinta DMBR01X Moderate Increased metabolism of Pentobarbital caused by Brilinta mediated induction of CYP450 enzyme. Thrombosis [DB61-GB90] [148]
Cabozantinib DMIYDT4 Moderate Increased metabolism of Pentobarbital caused by Cabozantinib mediated induction of CYP450 enzyme. Thyroid cancer [2D10] [149]
Tizanidine DMR2IQ4 Moderate Additive CNS depression effects by the combination of Pentobarbital and Tizanidine. Tonus and reflex abnormality [MB47] [150]
Tacrolimus DMZ7XNQ Moderate Increased metabolism of Pentobarbital caused by Tacrolimus mediated induction of CYP450 enzyme. Transplant rejection [NE84] [17]
Canagliflozin DMFRM1I Moderate Increased metabolism of Pentobarbital caused by Canagliflozin mediated induction of UGT. Type 2 diabetes mellitus [5A11] [17]
Saxagliptin DMGXENV Moderate Increased metabolism of Pentobarbital caused by Saxagliptin mediated induction of CYP450 enzyme. Type 2 diabetes mellitus [5A11] [151]
Linagliptin DMWFJTR Moderate Increased metabolism of Pentobarbital caused by Linagliptin mediated induction of CYP450 enzyme. Type 2 diabetes mellitus [5A11] [152]
Elagolix DMB2C0E Moderate Increased metabolism of Pentobarbital caused by Elagolix mediated induction of CYP450 enzyme. Uterine fibroid [2E86] [153]
Triamcinolone DM98IXF Moderate Increased metabolism of Pentobarbital caused by Triamcinolone mediated induction of CYP450 enzyme. Vasomotor/allergic rhinitis [CA08] [46]
Cetirizine DMOMP9U Moderate Additive CNS depression effects by the combination of Pentobarbital and Cetirizine. Vasomotor/allergic rhinitis [CA08] [154]
Propafenone DMPIBJK Minor Increased metabolism of Pentobarbital caused by Propafenone. Ventricular tachyarrhythmia [BC71] [155]
⏷ Show the Full List of 220 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Hydrochloric acid E00015 313 Acidulant
Ethanol E00023 702 Antimicrobial preservative; Penetration agent; Solvent
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Sodium hydroxide E00234 14798 Alkalizing agent
Water E00035 962 Solvent
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Pentobarbital 50mg/ml solution 50mg/ml Solution Intravenous; Intramuscular
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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106 Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
107 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
108 Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
109 Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
110 Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
111 Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
112 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
113 Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
114 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
115 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
116 Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
117 Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
118 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
119 Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
120 Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
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131 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
132 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
133 Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
134 Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
135 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
136 Product Information. Otezla (apremilast). Celgene Corporation, Summit, NJ.
137 Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
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141 Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
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149 Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
150 Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
151 Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
152 Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
153 Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
154 Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.
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