Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFNH7L)

Drug Name
Pentobarbital Drug Info
Synonyms
Aethaminalum; Dorsital; Etaminal; Ethaminal; Mebubarbital; Mebumal; Nebralin; Nembutal; Neodorm; Pentabarbital; Pentabarbitone; Pentobarbitale; Pentobarbitalum; Pentobarbitone; Pentobarbiturate; Rivadorm; Pentobarbital calcium; Pentobarbital suppository dosage form; Pentobarbitale [DCIT]; Pentobarbituric acid; Ethyl-propylmethylcarbinylbarbituric acid; Nembutal (TN); Nembutal (VAN); Neodorm (VAN); Neodorm (new); Pentobarbital (VAN); Pentobarbital [USP:INN]; Pentobarbital, Monosodium Salt; Pentobarbitalum [INN-Latin]; Pentobarbitone (VAN); Pentobarbital (USP/INN); (+-)-5-Ethyl-5-(1-methylbutyl)barbituric acid; 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Ethyl-5-(1-methylbutyl)barbituric acid; 5-Ethyl-5-(1-methylbutyl)malonylurea; 5-Ethyl-5-(sec-pentyl)barbituric acid; 5-ethyl-2-hydroxy-5-(1-methylbutyl)pyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione;5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione
Indication
Disease Entry ICD 11 Status REF
Brain ischaemia 8B1Z Approved [1]
Epilepsy 8A60-8A68 Approved [1]
Insomnia 7A00-7A0Z Approved [2]
Therapeutic Class
Hypnotics and Sedatives
Cross-matching ID
PubChem CID
4737
ChEBI ID
CHEBI:7983
CAS Number
CAS 76-74-4
TTD Drug ID
DMFNH7L
INTEDE Drug ID
DR1254
ACDINA Drug ID
D01333

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [3]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [10]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [3]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [3]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [11]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [3]
Hexobarbital DMQ314B Anaesthesia 9A78.6 Approved [3]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [12]
Meprobamate DMHM93Y Anxiety Approved [3]
Zaleplon DMGFWSM Insomnia 7A00-7A0Z Approved [13]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [14]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [15]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [16]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [17]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [19]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [22]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [23]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [24]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [25]
Fructose DM43AN2 Vomiting MD90 Approved [26]
Ketoprofen DMRKXPT Bursitis Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [29]
Gefitinib DM15F0X Colon adenocarcinoma Approved [30]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
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Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [33]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [35]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [37]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [39]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
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Drug(s) Affected By Potassium voltage-gated channel subfamily E member 1 (KCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [43]
Verapamil DMA7PEW Angina pectoris BA40 Approved [26]
Propranolol DM79NTF Angina pectoris BA40 Approved [26]
Diltiazem DMAI7ZV Angina pectoris BA40 Approved [26]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [26]
Quinidine DMLPICK N. A. N. A. Approved [26]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [26]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [26]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [26]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [44]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [45]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [46]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [47]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [48]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [6]
Gefitinib DM15F0X Colon adenocarcinoma Approved [49]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [52]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [45]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [53]
Paclitaxel DMLB81S Breast carcinoma Approved [54]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [44]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [28]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [47]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [57]
Quinidine DMLPICK N. A. N. A. Approved [58]
Verapamil DMA7PEW Angina pectoris BA40 Approved [59]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [60]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [60]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [61]
Propranolol DM79NTF Angina pectoris BA40 Approved [62]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [63]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [64]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [60]
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Drug(s) Affected By Glutamate carboxypeptidase 2 (FOLH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [65]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [68]
ACYLINE DM9GRTK Prostate cancer 2C82.0 Phase 2 [69]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [65]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [70]
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane DMDJYHK Discovery agent N.A. Investigative [71]
NAAG DMFGOW0 Discovery agent N.A. Investigative [72]
[3H]methyltrienolone DMTSGOW Discovery agent N.A. Investigative [68]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Antagonist [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Mephenytoin 4-hydroxylase (CYP2C19) Main DME DEGTFWK CP2CJ_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Glutamate carboxypeptidase 2 (FOLH1) OTQ9Z6QK FOLH1_HUMAN Drug Response [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [6]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [6]
Potassium voltage-gated channel subfamily E member 1 (KCNE1) OTZNQUW9 KCNE1_HUMAN Gene/Protein Processing [7]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [7]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Gene/Protein Processing [8]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Gene/Protein Processing [9]

References

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72 Synthesis and biological evaluation of copper-64 radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2], a novel bivalent targeting vector having affinity for two distinct biomarkers (GRPr/PSMA) of prostate cancer. Nucl Med Biol. 2014 Apr;41(4):355-63. doi: 10.1016/j.nucmedbio.2014.01.001. Epub 2014 Jan 10.