Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKP6BM)

• Drug Name: 2-Methylamino-succinic acid(NMDA) Drug Info
• Synonyms: N-Methyl-D-aspartic acid; N-methyl-D-aspartic acid; NMDA; 6384-92-5; N-Methyl-D-aspartate; N-Methylaspartate; D-Aspartic acid, N-methyl-; N-Me-D-Asp-OH; (R)-2-(Methylamino)succinic acid; NMDA (N-Methyl-D-aspartic acid); Methyl aspartic acid; n-methyl-d-aspartic acid (nmda); UNII-1903B9Q6PI; N-Methyl aspartic acid; (2R)-2-(methylamino)butanedioic acid; 2-Methylamino-succinic acid; BRN 1724431; CHEMBL291278; CHEBI:31882; HOKKHZGPKSLGJE-GSVOUGTGSA-N; 1903B9Q6PI; N-Methyl-D-aspartic Acid, Hydrate; AK-44365; W-203368; N-Methyl-D-aspartic acid, 98%

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 22880
  ChEBI ID: CHEBI:31882
  CAS Number: CAS 6384-92-5
  TTD Drug ID: DMKP6BM

Molecule-Related Drug Atlas

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2A (NMDAR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[10]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[11]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[12]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[13]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[3]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[14]
DIZOCILPINE	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[15]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[16]
L-698532	DMO9HM7	Neurological disorder	6B60	Terminated	[17]
L-695902	DMT1DNS	N. A.	N. A.	Terminated	[14]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2D (GluN2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[6]
D-aspartic acid	DM7Z892	Discovery agent	N.A.	Investigative	[6]
[3H]CPP	DMR5UBF	Discovery agent	N.A.	Investigative	[6]
[3H]MDL105519	DMPKGHB	Discovery agent	N.A.	Investigative	[6]
[3H]CGP39653	DMITR7A	Discovery agent	N.A.	Investigative	[6]
homoquinolinic acid	DMBW5DU	Discovery agent	N.A.	Investigative	[6]
[3H]dizocilpine	DMEC2PF	Discovery agent	N.A.	Investigative	[6]
CGP61594	DM8KFZH	Discovery agent	N.A.	Investigative	[6]
(RS)-(tetrazol-5-yl)glycine	DMYZCRF	Discovery agent	N.A.	Investigative	[6]
[3H]CGS19755	DM7H3JN	Discovery agent	N.A.	Investigative	[6]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 1 (NMDAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[18]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[19]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[20]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[11]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[12]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[13]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[2]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[14]
DIZOCILPINE	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[15]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[16]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2C (GluN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[5]
D-aspartic acid	DM7Z892	Discovery agent	N.A.	Investigative	[5]
[3H]CPP	DMR5UBF	Discovery agent	N.A.	Investigative	[5]
[3H]MDL105519	DMPKGHB	Discovery agent	N.A.	Investigative	[5]
[3H]CGP39653	DMITR7A	Discovery agent	N.A.	Investigative	[5]
homoquinolinic acid	DMBW5DU	Discovery agent	N.A.	Investigative	[5]
[3H]dizocilpine	DMEC2PF	Discovery agent	N.A.	Investigative	[5]
CGP61594	DM8KFZH	Discovery agent	N.A.	Investigative	[5]
(RS)-(tetrazol-5-yl)glycine	DMYZCRF	Discovery agent	N.A.	Investigative	[5]
[3H]CGS19755	DM7H3JN	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2B (NMDAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha 1-PI	DMXC1K9	Alpha-1 antitrypsin deficiency	5C5A	Approved	[21]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[20]
CP-101,606	DMIU19E	Parkinson disease	8A00.0	Phase 2	[22]
CERC-301	DMSABRI	Major depressive disorder	6A70.3	Phase 2	[23]
RGH-896	DMCHZAN	Peripheral neuropathy	8C0Z	Phase 2	[24]
MIJ821	DMN45RI	Major depressive disorder	6A70.3	Phase 2	[25]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[11]
Neu-2000	DMNJTLC	Cardiac arrest	MC82	Phase 1	[26]
EVT100	DMAKWQD	Major depressive disorder	6A70.3	Phase 1	[27]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[12]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[28]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[31]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[32]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[34]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[35]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[36]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[37]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[47]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[50]
Selenium	DM25CGV	N. A.	N. A.	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[54]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[56]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[36]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[60]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[61]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[62]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[65]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[58]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[66]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[67]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[68]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[32]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[36]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[70]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[71]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[37]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[75]
Selenium	DM25CGV	N. A.	N. A.	Approved	[51]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[76]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[77]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[37]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[80]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[93]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[94]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[28]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[34]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[97]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[99]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[100]

Drug(s) Affected By ELAV-like protein 1 (ELAVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[102]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[105]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[107]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[108]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[51]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[113]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[114]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[116]

Drug(s) Affected By SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[51]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[118]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[105]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor ionotropic NMDA 1 (NMDAR1)	TTLD29N	NMDZ1_HUMAN	Inhibitor	[2]
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	TTKJEMQ	NMDE1_HUMAN	Inhibitor	[3]
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	TTN9D8E	NMDE2_HUMAN	Inhibitor	[4]
Glutamate receptor ionotropic NMDA 2C (GluN2C)	TT1M8OW	NMDE3_HUMAN	Agonist	[5]
Glutamate receptor ionotropic NMDA 2D (GluN2D)	TT5POTG	NMDE4_HUMAN	Agonist	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[7]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[7]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Post-Translational Modifications	[8]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Post-Translational Modifications	[7]
ELAV-like protein 1 (ELAVL1)	OTY55PLY	ELAV1_HUMAN	Post-Translational Modifications	[9]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[7]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[7]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	OTAYZMOY	SIR1_HUMAN	Gene/Protein Processing	[9]
Neutrophil cytosol factor 1 (NCF1)	OTMHT3G6	NCF1_HUMAN	Protein Interaction/Cellular Processes	[7]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Post-Translational Modifications	[7]

References

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