Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTY169)

Drug Name
Norethindrone Drug Info
Synonyms
Activella; Anhydrohydroxynorprogesterone; Anovulatorio; Anovule; Brevicon; Brevinor; Camila; Ciclovulan; Conceplan;Conludaf; Conludag; Demulen; Errin; Estrinor; Ethinylnortestosterone; Ethynylmortestosterone; Ethynylnortestosterone; Gencept; Genora; Gestest; Jenest; Loestrin; Menzol; Microneth; Micronett; Micronor; Micronovum; Milli; Minovlar; Nelova; Nodiol; Noraethisteronum; Noralutin; Norcept; Norcolut; Norcolute; Noresthisterone; Norethadrone; Norethin; Norethindirone; Norethisteron; Norethisterone; Norethisteronum; Norethyndron; Norethynodron; Norethynodrone; Noretisterona; Noretisterone; Norfor; Norgestin; Noriday; Norluten; Norlutin; Norluton; Normapause; Norpregneninlone; Norpregneninolone; Norpregneninotone; Orlest; Proluteasi; Synphase; Triella; Utovlan; Utovlar; Component of Noriday; Norethindrone Norethisterone; Norethindrone [USAN]; Norethisterone [Progestins]; Noretisterone [DCIT]; Primolut N; Brevinor 21; Brevinor 28; Noriday 28; Ortho 1 35; Ortho 7 7 7; Ovysmen 1 35; SC 4640; Synphasic 28; Trinovum 21; Brevinor-1 21; Brevinor-1 28; Camila (TN); Jenest-28; Micronor (TN); Mini-Pe; Mini-pill; Nor-QD; Nora-BE; Norcept-E; Norethin 1/35 E; Norethin 1/50 M; Norethindrone (USP); Norethisterone (JP15); Norethisteronum [INN-Latin]; Noretisterona [INN-Spanish]; Ortho-Novum 1 35; Ortho-Novum 1 50; Ortho-Novum 7 7 7; Ovysmen 0.5 35; Primolut-N; Tri-Norinyl; Ethinyl-19-nortestosterone; Nor-Q.D; Primolut-N (TN); Nor-Q.D.; 17-Ethinyl-19-nortestosterone; 17-Ethynyl-17-hydroxyestr-4-en-3-one; 17-alpha-Ethynyl-19-nortestosterone; 17-alpha-Ethynyl-4-estren-17-ol-3-one; 17-ethynyl-17beta-hydroxyestr-4-en-3-one; 17.alpha.-Ethinyl-19-nortestosterone; 17.alpha.-Ethynyl-19-nortestosterone; 17.alpha.-Ethynyl-4-estren-17-ol-3-one; 17alpha-Ethinyl-19-nortestosterone; 17alpha-Ethynyl-19-nortestosterone; 17alpha-Ethynyl-4-estren-17-ol-3-one; 19-Nor-17-alpha-ethynyltestosterone; 19-Nor-17-ethinyltestosterone; 19-Nor-17.alpha.-ethynyltestosterone; 19-Nor-17alpa-ethynyltestosterone; 19-Nor-17alpha-ethynyltestosterone; 19-Nor-ethindrone; 19-Nor-ethinyl-4,5-testosterone; 19-Norethindrone; 19-Norethinyltestosterone; 19-Norethisterone; 4-Estren-17alpha-ethynyl-17beta-ol-3-one
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Advanced cancer 2A00-2F9Z Approved [1]
Hot flushes GA30 Approved [1]
Menorrhagia GA20.50 Approved [1]
Obsolete atrophic vulva Approved [1]
Solid tumour/cancer 2A00-2F9Z Approved [2]
Endometriosis GA10 Investigative [1]
Therapeutic Class
Contraceptive Agents
Cross-matching ID
PubChem CID
6230
ChEBI ID
CHEBI:7627
CAS Number
CAS 68-22-4
TTD Drug ID
DMTY169
ACDINA Drug ID
D00478

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Progesterone receptor (PGR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [12]
Desogestrel DM27U4Y Contraception QA21 Approved [13]
Ulipristal DMBNI20 Contraception QA21 Approved [14]
Etonogestrel DMKA8J4 Contraception QA21 Approved [15]
Megestrol DMDH9KX Breast cancer 2C60-2C65 Approved [16]
Segesterone acetate; ethinyl estradiol DMFEGB0 Contraception QA21 Approved [17]
Norgestimate DMYP4XC Acne vulgaris ED80 Approved [15]
Dydrogesterone DMAKIDV Menstrual disorder GA20.3 Approved [18]
Medroxyprogesterone DMBGWPH Solid tumour/cancer 2A00-2F9Z Approved [18]
Ethynodiol Diacetate DMZM84R Contraception QA21 Approved [19]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [20]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [21]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [22]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [23]
Cepharanthine DM9Y5JB N. A. N. A. Approved [24]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [25]
Clozapine DMFC71L Schizophrenia 6A20 Approved [26]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [27]
Trifluoperazine DMKBYWI Anxiety Approved [28]
Olanzapine DMPFN6Y Bipolar depression Approved [26]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [6]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [29]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [29]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [30]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [6]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [29]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [6]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [32]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [6]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [33]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [34]
Diazepam DM08E9O Alcohol withdrawal Approved [35]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [4]
Desogestrel DM27U4Y Contraception QA21 Approved [4]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [34]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [34]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [39]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [34]
Diazepam DM08E9O Alcohol withdrawal Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [34]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [34]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [41]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [42]
Ethacrynic acid DM60QMR Edema MG29 Approved [40]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [34]
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Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [10]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [47]
Estrone DM5T6US Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [48]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [49]
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Drug(s) Affected By Osteocalcin (BGLAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [54]
Pamidronate DMB4AVP Bone Paget disease Approved [55]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [56]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
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Drug(s) Affected By Myb-related protein A (MYBL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [43]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [10]
Quercetin DM3NC4M Obesity 5B81 Approved [46]
Panobinostat DM58WKG Chronic graft versus host disease Approved [59]
Estrone DM5T6US Acne vulgaris ED80 Approved [43]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [10]
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Drug(s) Affected By Microtubule-associated protein tau (MAPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [9]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Testosterone enanthate DMB6871 N. A. N. A. Approved [71]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [74]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [75]
Etretinate DM2CZFA Keratosis ED56 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [78]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [79]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
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Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [82]
Selenium DM25CGV N. A. N. A. Approved [74]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [83]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [84]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [86]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [89]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [90]
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Drug(s) Affected By Protein GREB1 (GREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [91]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [10]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
Testosterone DM7HUNW Hot flushes GA30 Approved [93]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [10]
Nandrolone DMFWKG1 Osteoporosis FB83.0 Approved [97]
Mestranol DMG3F94 Contraception QA21 Approved [10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Progesterone receptor (PGR) TTUV8G9 PRGR_HUMAN Agonist [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [4]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [4]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [5]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [6]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Gene/Protein Processing [7]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Post-Translational Modifications [8]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Gene/Protein Processing [9]
Myb-related protein A (MYBL1) OTBJMC2P MYBA_HUMAN Gene/Protein Processing [10]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Protein Interaction/Cellular Processes [11]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Gene/Protein Processing [10]

References

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