Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVMIK2)

Drug Name
Roxithromycin Drug Info
Synonyms
Assoral; Overall; RXM; Rossitrol; Roxithromycine; Roxithromycinum; Roxitromicina; Rulid; Rulide; Surlid; Roxithromycine [French]; Roxithromycinum [Latin]; Roxitromicina [Spanish]; RC2952; RU 28965; RU 965; Biaxsig (TN); Coroxin (TN); RU-28965; RU-965; Roxar (TN); Roximycin (TN); Roxithromycin & Tumor Necrosis Factor; Roxo (TN); Rulide (TN); Surlid (TN); Tirabicin (TN); Roxithromycin [USAN:INN:JAN]; Roxl-150 (TN); Roxithromycin (JP15/USAN/INN); Erythromycin 9-(-O-[2-methoxyethoxy]methyloxime);Erythromycin 9-(O-((2-methoxyethoxy)methyl)oxime); Erythromycin, 9-(O-((2-methoxyethoxy)methyl)oxime); 9-(O-((2-Methoxyethoxy)methyl)oxime)erythromycin; 9-[O-(2-methoxyethoxymethyl)-oxime] of erythromycin
Indication
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Withdrawn from market [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
6915744
ChEBI ID
CHEBI:48935
CAS Number
CAS 80214-83-1
TTD Drug ID
DMVMIK2
VARIDT Drug ID
DR00708
INTEDE Drug ID
DR1448

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial 50S ribosomal RNA (Bact 50S rRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [10]
Telithromycin DMZ4P3A Bacterial infection 1A00-1C4Z Approved [11]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [12]
Dirithromycin DM0D9YJ Bacterial infection 1A00-1C4Z Approved [13]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [12]
Zithromax DMN4H2O Syphilis infection 1A6Z Approved [14]
Troleandomycin DMUZNIG Bacterial infection 1A00-1C4Z Approved [15]
Retapamulin DM9JXB7 Impetigo 1B72 Approved [16]
Dalfopristin DM4LTKV Bacterial infection 1A00-1C4Z Approved [17]
Tedizolid DMG2SKR Skin infection 1F28-1G0Z Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [19]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [33]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [27]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [35]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [38]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [39]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [39]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [40]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [41]
Capsaicin DMGMF6V Back pain ME84.Z Approved [42]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [43]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [46]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [47]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [53]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [54]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [55]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [56]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [58]
Verapamil DMA7PEW Angina pectoris BA40 Approved [59]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [60]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [61]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [62]
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Drug(s) Affected By Integrin beta-4 (ITGB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [63]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [8]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [66]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [67]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
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Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [70]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [71]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [72]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [73]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [74]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [75]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [76]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [77]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [78]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Epinephrine DM3KJBC Acute asthma CA23 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [85]
Fructose DM43AN2 Vomiting MD90 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [88]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Laminin subunit gamma-2 (LAMC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [92]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [93]
Panobinostat DM58WKG Chronic graft versus host disease Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [97]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [98]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial 50S ribosomal RNA (Bact 50S rRNA) TTUWYEA NOUNIPROTAC Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [5]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Gene/Protein Processing [6]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [7]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Gene/Protein Processing [8]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Gene/Protein Processing [8]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Gene/Protein Processing [9]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Gene/Protein Processing [5]

References

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68 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
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84 Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep. 2011 Feb;25(2):583-91. doi: 10.3892/or.2010.1097. Epub 2010 Dec 10.
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