Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWVIGP)

Drug Name
Digitoxin Drug Info
Synonyms
Acedoxin; Asthenthilo; Cardidigin; Cardigin; Cardiolanata; Carditalin; Carditoxin; Coramedan; Cristapurat; Crystodigin; Digicor; Digilanid; Digilong; Digimed; Digimerck; Digipural; Digisidin; Digitoksim; Digitoksin; Digitophyllin; Digitossina; Digitoxina; Digitoxine; Digitoxinum; Digitoxoside; Digitoxosidum; Digitrin; Ditaven; Glucodigin; Lanatoxin; Lanostabil; Monodigitoxoside; Myodigin; Natigal; Pandigal; Panlanat; Purodigin; Purpurid; Tardigal; Unidigin; Crystalline digitalin; Digitaline cristallisee; Digitaline nativelle; Digitalinum verum; Digitossina [DCIT]; Digitoxigenin tridigitoxoside; LT00244784; Crystodigin (TN); De-Tone; Digitalin, crystalline; Digitaline (TN); Digitoxigenin-tridigitoxosid; Digitoxigenin-tridigitoxosid [German]; Digitoxina [INN-Spanish]; Digitoxine [INN-French]; Digitoxinum [INN-Latin]; Mono-digitoxid; Mono-digitoxid [German]; Mono-glycocard; Purodigin, crystalline; Tri-digitoxoside; Tri-digitoxoside [German]; Digitoxin [INN:BAN:JAN]; Digitoxin (JP15/USP/INN); Inhibits Na+/K+ ATPase; 5.beta.-Card-20(22)-enolide, 3.beta.,14-dihydroxy-, 3-[tris-(digitoxoside)]
Indication
Disease Entry ICD 11 Status REF
Arrhythmia BC9Z Approved [1]
Congestive cardiac insufficiency BD1Z Approved [1]
Heart failure BD10-BD13 Approved [1]
Therapeutic Class
Antiarrhythmic Agents
Cross-matching ID
PubChem CID
441207
ChEBI ID
CHEBI:28544
CAS Number
CAS 71-63-6
TTD Drug ID
DMWVIGP
VARIDT Drug ID
DR00239
INTEDE Drug ID
DR0497

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Sodium/potassium-transporting ATPase (SPT ATPase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Digoxin DMQCTIH Arrhythmia BC9Z Approved [9]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [10]
Rostafuroxin DMKQXDB Hypertension BA00-BA04 Phase 2 [11]
PBI-05204 DM05WIU Pancreatic cancer 2C10 Phase 2 [12]
RX108 DM4XETK Solid tumour/cancer 2A00-2F9Z Phase 1 [13]
Istaroxime DMWN09H Cardiac disease BA00-BE2Z Discontinued in Phase 2 [14]
Cordil DMQESM7 Heart arrhythmia BC65 Terminated [15]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [16]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Folic Acid DMEMBJC Colorectal carcinoma Approved [19]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [18]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [18]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [18]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [25]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [26]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [38]
Metronidazole DMTIVEN Abscess Approved [39]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [40]
Ethanol DMDRQZU Chronic pain MG30 Approved [41]
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Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [46]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [47]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [48]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [49]
Epinephrine DM3KJBC Acute asthma CA23 Approved [50]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [51]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [52]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [53]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [54]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [55]
Cepharanthine DM9Y5JB N. A. N. A. Approved [56]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [57]
Clozapine DMFC71L Schizophrenia 6A20 Approved [58]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [59]
Trifluoperazine DMKBYWI Anxiety Approved [60]
Olanzapine DMPFN6Y Bipolar depression Approved [58]
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Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [65]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [68]
Fructose DM43AN2 Vomiting MD90 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [75]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [76]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [77]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [79]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [80]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Gefitinib DM15F0X Colon adenocarcinoma Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [84]
Etretinate DM2CZFA Keratosis ED56 Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [87]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [90]
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Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [92]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [93]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [94]
Testosterone DM7HUNW Hot flushes GA30 Approved [95]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Capsaicin DMGMF6V Back pain ME84.Z Approved [97]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [100]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [101]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [102]
Paclitaxel DMLB81S Breast carcinoma Approved [103]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [104]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [106]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [107]
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Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Selenium DM25CGV N. A. N. A. Approved [110]
Etretinate DM2CZFA Keratosis ED56 Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [112]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [115]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [116]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [117]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [118]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [119]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [120]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [121]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [122]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [123]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [121]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [71]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [124]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Selenium DM25CGV N. A. N. A. Approved [110]
Etretinate DM2CZFA Keratosis ED56 Approved [85]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [125]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [126]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
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Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [128]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [129]
Gefitinib DM15F0X Colon adenocarcinoma Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [136]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [138]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [139]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [140]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [141]
Gefitinib DM15F0X Colon adenocarcinoma Approved [142]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Selenium DM25CGV N. A. N. A. Approved [145]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [146]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [147]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [63]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [148]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [149]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [120]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [151]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [152]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [153]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [155]
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Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Selenium DM25CGV N. A. N. A. Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [156]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [157]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [158]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [159]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [160]
Bortezomib DMNO38U Leukemia Approved [161]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [162]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [163]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [164]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [124]
Gefitinib DM15F0X Colon adenocarcinoma Approved [82]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Etretinate DM2CZFA Keratosis ED56 Approved [85]
Prednisone DM2HG4X Acute asthma CA23 Approved [165]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [125]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [166]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [167]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [168]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [169]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [102]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [170]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [171]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [172]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [173]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [174]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [148]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [175]
Gefitinib DM15F0X Colon adenocarcinoma Approved [142]
Prednisone DM2HG4X Acute asthma CA23 Approved [165]
Methotrexate DM2TEOL Anterior urethra cancer Approved [176]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [177]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [179]
Fluoxetine DM3PD2C Bipolar depression Approved [180]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [181]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [182]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [183]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [184]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [185]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [186]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [187]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [84]
Meloxicam DM2AR7L Arthritis FA20 Approved [189]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [190]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [191]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [192]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [194]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [196]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [197]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [198]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [149]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Gefitinib DM15F0X Colon adenocarcinoma Approved [201]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [187]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [202]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [203]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Quercetin DM3NC4M Obesity 5B81 Approved [155]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [205]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [206]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [146]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [207]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [208]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [209]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [210]
Testosterone DM7HUNW Hot flushes GA30 Approved [211]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [212]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [159]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [213]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [214]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [216]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [149]
Gefitinib DM15F0X Colon adenocarcinoma Approved [217]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [84]
Selenium DM25CGV N. A. N. A. Approved [145]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [190]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
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Drug(s) Affected By E3 SUMO-protein ligase PIAS3 (PIAS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [156]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [220]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [162]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [221]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [222]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [223]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [224]
Urethane DM7NSI0 N. A. N. A. Phase 4 [225]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [226]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium/potassium-transporting ATPase (SPT ATPase) TTQ38E9 AT1A1_HUMAN; AT1A2_HUMAN; AT1A3_HUMAN; AT1B1_HUMAN; AT1B2_HUMAN; AT1B3_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [5]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [7]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [8]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [8]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Protein Interaction/Cellular Processes [8]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [8]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [8]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Gene/Protein Processing [8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [8]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [8]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Gene/Protein Processing [8]

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130 EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
131 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
132 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
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