Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6CHNJ)

• Drug Name: Camptothecin Drug Info
• Synonyms: camptothecin; Camptothecine; 7689-03-4; (S)-(+)-Camptothecin; Campathecin; d-Camptothecin; (+)-Camptothecine; (+)-Camptothecin; 20(S)-Camptothecine; 21,22-Secocamptothecin-21-oic acid lactone; NSC94600; (S)-Camptothecin; Camptothecine (8CI); 20(S)-Camptothecin; Camptothecine (S,+); CHEMBL65; UNII-XT3Z54Z28A; MLS000766223; (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; XT3Z54Z28A; CHEBI:27656; VSJKWCGYPAHWDS-FQEVSTJZSA-N; Camptothecin, Camptotheca acuminata; NSC-94600; Camptothecin derivat

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 24360
  ChEBI ID: CHEMBL27656
  CAS Number: CAS 7689-03-4
  TTD Drug ID: DM6CHNJ
  VARIDT Drug ID: DR01383

Molecule-Related Drug Atlas

Drug(s) Targeting DNA topoisomerase I (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[10]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[10]
B-Lactams	DMR8YD6	Bacterial infection	1A00-1C4Z	Approved	[11]
Belotecan hydrocholoride	DM3SRJZ	Small-cell lung cancer	2C25.Y	Approved	[12]
Topetecan	DMAE6LK	Small-cell lung cancer	2C25.Y	Approved	[13]
Karenitecin	DMCRGY4	Lung cancer	2C25.0	Phase 3	[14]
Exatecan	DMCA7FN	Solid tumour/cancer	2A00-2F9Z	Phase 3	[15]
Edotecarin	DM3ZL7D	Gastric adenocarcinoma	2B72	Phase 3	[16]
Rubitecan	DMDWU1S	Human immunodeficiency virus infection	1C62	Phase 3	[17]
Etirinotecan pegol	DMQHX1Y	Breast cancer	2C60-2C65	Phase 3	[18]

Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[20]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[21]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[22]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[26]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[27]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[28]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[31]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[33]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[34]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[36]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[37]

Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[39]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[40]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[41]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[3]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[42]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[43]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[45]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[3]

Drug(s) Affected By Frataxin, mitochondrial (FXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Molsidomine	DM9MA8O	Angina pectoris	BA40	Approved	[47]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[51]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Deferiprone	DMS2M7O	Beta thalassemia	3A50.2	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[62]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[63]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[64]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[65]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[66]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[67]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[68]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[69]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[70]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[71]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[69]

Drug(s) Affected By Transcription factor SOX-12 (SOX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Selenium	DM25CGV	N. A.	N. A.	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[84]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[87]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]

Drug(s) Affected By Adenomatous polyposis coli protein (APC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[97]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[98]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[99]

Drug(s) Affected By Transcription factor SOX-11 (SOX11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[104]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[105]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Transcription factor SOX-3 (SOX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[107]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[109]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Transcription factor SOX-8 (SOX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[75]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[112]

Drug(s) Affected By Transcription factor SOX-4 (SOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]

Drug(s) Affected By Centrosomal protein of 85 kDa-like (CEP85L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[112]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[100]

Drug(s) Affected By Centrosome-associated protein ALMS1 (ALMS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[112]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[123]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[75]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[111]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]

Drug(s) Affected By AMSH-like protease (STAMBPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[127]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[112]

Drug(s) Affected By Frizzled-8 (FZD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[96]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[100]

Drug(s) Affected By Transcription factor SOX-17 (SOX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[129]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[129]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[129]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[129]
Ziprasidone	DMM58JY	Bipolar disorder	6A60	Approved	[129]

Drug(s) Affected By Frizzled-1 (FZD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[133]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[135]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[133]

Drug(s) Affected By Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]

Drug(s) Affected By Transcription factor E2F8 (E2F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[120]

Drug(s) Affected By Transmembrane protein 250 (TMEM250)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[6]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[136]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[142]

Drug(s) Affected By Agrin (AGRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[143]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[143]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[145]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[146]

Drug(s) Affected By Etoposide-induced protein 2.4 homolog (EI24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[139]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[98]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]

Drug(s) Affected By Tax1-binding protein 3 (TAX1BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[148]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[149]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[153]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[154]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[155]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[156]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[158]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]

Drug(s) Affected By SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[160]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[160]

Drug(s) Affected By Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[164]
Bortezomib	DMNO38U	Leukemia		Approved	[165]

Drug(s) Affected By Cytoplasmic protein NCK2 (NCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[143]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]

Drug(s) Affected By A-kinase anchor protein 8 (AKAP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[149]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[167]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[168]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[169]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[136]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[174]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[179]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[180]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[178]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[182]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[183]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[184]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[185]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[188]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[189]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[190]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[193]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[194]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[195]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[196]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[197]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[198]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[184]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[202]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[207]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[208]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[209]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[210]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Fructose	DM43AN2	Vomiting	MD90	Approved	[193]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[213]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[184]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[215]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[217]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[218]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[220]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[190]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[226]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[227]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[228]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[229]

Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[230]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[233]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[234]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[228]

Drug(s) Affected By Annexin A4 (ANXA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[236]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[146]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[153]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[239]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[240]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[239]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[244]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[245]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[247]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[213]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[248]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[251]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[249]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[252]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[253]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[254]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[233]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[120]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[255]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[166]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[257]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[258]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[259]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[260]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[263]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[265]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[266]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[253]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[267]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[268]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[139]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[269]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[272]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[275]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[276]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[278]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[279]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[280]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[282]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[283]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[284]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[285]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[286]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[184]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[287]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[155]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[207]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[288]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[178]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[289]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[290]

Drug(s) Affected By NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[292]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[293]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[184]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[294]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[295]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[298]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[299]

Drug(s) Affected By Retinoblastoma-like protein 1 (RBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[293]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[303]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[184]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[287]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[305]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]

Drug(s) Affected By Coilin (COIL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[168]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[307]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[308]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[214]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[151]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[154]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[309]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[240]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[133]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[296]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[311]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[312]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[81]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[208]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[313]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[216]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[314]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[320]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]

Drug(s) Affected By Double-strand break repair protein MRE11 (MRE11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[322]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[323]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[324]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[325]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[237]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[327]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[328]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[329]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[330]

Drug(s) Affected By Transcription factor Sp3 (SP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[331]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[332]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[333]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[334]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[336]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[337]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]

Drug(s) Affected By CCAAT/enhancer-binding protein zeta (CEBPZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[112]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]

Drug(s) Affected By Unconventional myosin-Ie (MYO1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[6]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[6]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[6]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]

Drug(s) Affected By Vesicle transport protein SEC20 (BNIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[141]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[6]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[6]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[338]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[338]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[339]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[340]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[344]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[347]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[348]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[349]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[350]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]

Drug(s) Affected By Cyclin-dependent kinase 5 activator 1 (CDK5R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[353]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[354]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[355]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[355]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[356]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[357]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[359]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[361]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[181]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[364]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[143]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]

Drug(s) Affected By EPM2A-interacting protein 1 (EPM2AIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[365]

Drug(s) Affected By tRNA-uridine aminocarboxypropyltransferase 1 (DTWD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[6]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]

Drug(s) Affected By TBC1 domain family member 16 (TBC1D16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[366]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[6]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[365]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[367]

Drug(s) Affected By Protein Jumonji (JARID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[368]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[141]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]

Drug(s) Affected By Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[96]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[370]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[371]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[372]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[373]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[320]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[374]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[375]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[376]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[377]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]

Drug(s) Affected By Serine/threonine-protein kinase PLK3 (PLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[117]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[143]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[378]

Drug(s) Affected By Sphingomyelin phosphodiesterase 3 (SMPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[379]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[337]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[337]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]

Drug(s) Affected By PH and SEC7 domain-containing protein 3 (PSD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[380]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[120]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[99]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[292]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[381]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[184]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[304]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[382]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[304]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[207]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[288]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[289]

Drug(s) Affected By Kelch-like protein 42 (KLHL42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[6]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[6]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[127]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[105]

Drug(s) Affected By Calcium-binding protein 39 (CAB39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[8]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[383]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[140]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[384]

Drug(s) Affected By RWD domain-containing protein 3 (RWDD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[385]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[6]
Pracinostat	DMTD7AB	Acute myeloid leukaemia	2A60	Phase 3	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[386]

Drug(s) Affected By Integrin-binding sialoprotein (IBSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[387]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[388]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[387]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[389]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[390]
GSK2816126	DMJDVW4	Solid tumour/cancer	2A00-2F9Z	Phase 1	[391]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[392]
alpha-ketoglutaric acid	DM5LFYN	Discovery agent	N.A.	Investigative	[393]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF31 (RNF31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[394]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[395]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[396]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[397]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[398]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[383]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[169]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[99]
Bortezomib	DMNO38U	Leukemia		Approved	[399]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[400]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[401]

Drug(s) Affected By Cytochrome P450 26B1 (CYP26B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[402]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[403]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[404]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[107]

Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[406]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[407]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]

Drug(s) Affected By Protein sel-1 homolog 1 (SEL1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[409]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[124]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[236]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[410]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[105]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[96]

Drug(s) Affected By Protein prenyltransferase alpha subunit repeat-containing protein 1 (PTAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[386]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[411]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[140]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[100]

Drug(s) Affected By Lipid scramblase CLPTM1L (CLPTM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[412]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[386]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[413]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[414]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[415]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[400]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[400]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[416]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[398]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[125]

Drug(s) Affected By DNA repair endonuclease XPF (ERCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[417]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[418]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[419]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Bortezomib	DMNO38U	Leukemia		Approved	[420]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[421]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase O (PTPRO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[422]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[92]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[423]

Drug(s) Affected By Cone-rod homeobox protein (CRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[424]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[425]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[426]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[103]

Drug(s) Affected By Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[427]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[141]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[428]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[429]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[169]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By Homeobox protein Hox-A1 (HOXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[430]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[120]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[431]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[126]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[432]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[96]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[109]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[416]

Drug(s) Affected By Myotubularin-related protein 2 (MTMR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[433]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[168]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[169]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By Olfactory receptor 7C2 (OR7C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By A-kinase anchor protein 13 (AKAP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[434]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[435]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[436]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]

Drug(s) Affected By TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[399]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[386]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[169]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[435]

Drug(s) Affected By ARF GTPase-activating protein GIT2 (GIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[400]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[400]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[437]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[169]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[411]

Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[438]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[439]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[440]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[441]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[442]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[443]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[444]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[445]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[446]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[447]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[252]

Drug(s) Affected By MTRF1L release factor glutamine methyltransferase (HEMK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[386]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[448]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 1B (PPP1R1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[385]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[449]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[449]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[449]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[385]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[423]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Serine/threonine/tyrosine-interacting-like protein 1 (STYXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[92]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[414]

Drug(s) Affected By Apoptosis-inducing factor 3 (AIFM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[450]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[423]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[450]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[232]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[397]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[451]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[452]

Drug(s) Affected By DNA repair protein RAD51 homolog 3 (RAD51C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[454]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[60]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[454]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[324]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[455]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[396]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[456]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[457]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[458]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[459]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[461]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[462]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[120]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[463]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[400]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[400]

Drug(s) Affected By Olfactory receptor 1A2 (OR1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Artemin (ARTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[464]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[465]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[428]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[109]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[465]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[50]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[466]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[467]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[468]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[78]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[92]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[386]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[469]

Drug(s) Affected By Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[139]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[137]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[470]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[469]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[136]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[471]

Drug(s) Affected By Ataxin-3-like protein (ATXN3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase I (TOP1)	TTGTQHC	TOP1_HUMAN	Modulator	[1]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[2]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[3]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
A-kinase anchor protein 13 (AKAP13)	OTOZAR14	AKP13_HUMAN	Drug Response	[5]
A-kinase anchor protein 8 (AKAP8)	OTK3EQAI	AKAP8_HUMAN	Gene/Protein Processing	[6]
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Post-Translational Modifications	[7]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Gene/Protein Processing	[8]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[9]
AMSH-like protease (STAMBPL1)	OTI4CYTF	STALP_HUMAN	Post-Translational Modifications	[7]
Annexin A4 (ANXA4)	OTUCRYXL	ANXA4_HUMAN	Gene/Protein Processing	[8]
Apoptosis-inducing factor 3 (AIFM3)	OTSWKCAO	AIFM3_HUMAN	Drug Response	[5]
ARF GTPase-activating protein GIT2 (GIT2)	OTQ2EQJ1	GIT2_HUMAN	Drug Response	[5]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP1)	OTVX8835	AGAP1_HUMAN	Post-Translational Modifications	[7]

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