Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9Y6X7)

• Drug Name: Clodronate Drug Info
• Synonyms: Bonefos; Clodronsaeure; Dichloromethanediphosphonate; Dichloromethylenebisphosphonate; Methanedichlorodiphosphonate; Acide clodronique; Acido clodronico; Acidum clodronicum; Clodronic Acid; Dichloromethanediphosphonic acid; Dichloromethylene Biphosphonate; Dichloromethylene Diphosphonate; Dichloromethylidene diphosphonate; Liposomes containing clodronic acid; Methanedichlorodiphosphonic acid; Acid, Clodronic; Acid, Dichloromethanediphosphonic; Acide clodronique [INN-French]; Acido clodronico [INN-Spanish]; Acidum clodronicum [INN-Latin]; Biphosphonate, Dichloromethylene; Bonefos (TN); Clodron (TN); Diphosphonate, Dichloromethane; Diphosphonate, Dichloromethylene; Disodium, Clodronate; Loron (TN); Sodium, Clodronate; [dichloro(phosphono)methyl]phosphonic acid; Clodronic acid (USAN/INN); Clodronic acid [USAN:BAN:INN]; Dichlormethylen-bis(phosphonsaeure); Dichloromethylene-1,1-bisphosphonic acid; Dichloromethylene-1,1-diphosphonic acid; Phosphonic acid, (dichloromethylene)di-(8CI); (Dichloro-phosphono-methyl)-phosphonic acid; (Dichloromethylene)bisphosphonic acid; (Dichloromethylene)diphosphonic acid; (Lip-C); (dichloromethanediyl)bis(phosphonic acid)

Indication

Disease Entry	ICD 11	Status	REF
Hypercalcaemia	5B91.0	Approved	[1]

• Therapeutic Class: Antihypocalcemic Agents
• Cross-matching ID:
  PubChem CID: 25419
  ChEBI ID: CHEBI:110423
  CAS Number: CAS 10596-23-3
  TTD Drug ID: DM9Y6X7
  VARIDT Drug ID: DR00994

Molecule-Related Drug Atlas

Drug(s) Targeting Adenine nucleotide translocator 1 (SLC25A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Di-Stearoyl-3-Sn-Phosphatidylcholine	DM0GQJ2	Discovery agent	N.A.	Investigative	[4]
bongkrek acid	DMWALXQ	Discovery agent	N.A.	Investigative	[5]
Cardiolipin	DMCSMX4	Discovery agent	N.A.	Investigative	[6]
Carboxyatractyloside	DMEORTQ	Discovery agent	N.A.	Investigative	[4]

Drug(s) Affected By Solute carrier family 12 member 8 (SLC12A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]

Drug(s) Affected By PDZ and LIM domain protein 1 (PDLIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[17]

Drug(s) Affected By Golgi integral membrane protein 4 (GOLIM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]

Drug(s) Affected By Agrin (AGRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[24]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[17]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[25]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By TRAF-type zinc finger domain-containing protein 1 (TRAFD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[35]
Bortezomib	DMNO38U	Leukemia		Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[37]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[39]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Selenium	DM25CGV	N. A.	N. A.	Approved	[42]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[43]

Drug(s) Affected By Rho guanine nucleotide exchange factor 10 (ARHGEF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[3]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[47]

Drug(s) Affected By Secretory carrier-associated membrane protein 1 (SCAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[51]

Drug(s) Affected By Protein phosphatase 1D (PPM1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[54]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By Apoptosis regulatory protein Siva (SIVA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Bortezomib	DMNO38U	Leukemia		Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]

Drug(s) Affected By Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Haloperidol	DM96SE0	Delirium		Approved	[61]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[62]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[65]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[66]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[69]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By E3 ubiquitin-protein ligase SIAH2 (SIAH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[77]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By Protein sprouty homolog 1 (SPRY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[25]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-2 (PRKAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[85]

Drug(s) Affected By Asparagine--tRNA ligase, cytoplasmic (NARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[86]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]

Drug(s) Affected By NUAK family SNF1-like kinase 1 (NUAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[88]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[89]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[90]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[91]

Drug(s) Affected By High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Astrotactin-2 (ASTN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By PR domain zinc finger protein 1 (PRDM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[100]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[97]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]

Drug(s) Affected By E3 ubiquitin-protein ligase listerin (LTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[107]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By Tetraspanin-12 (TSPAN12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[51]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[111]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[89]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[116]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Ketoprofen	DMRKXPT	Bursitis		Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[126]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[129]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[137]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[141]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[142]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[143]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[145]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[147]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[147]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[147]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[148]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[149]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[150]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[151]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[152]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[153]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[118]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[157]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]

Drug(s) Affected By Bifunctional glutamate/proline--tRNA ligase (EPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[158]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[159]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[83]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[164]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[165]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[165]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[166]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[168]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[169]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[173]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[174]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Selenium	DM25CGV	N. A.	N. A.	Approved	[177]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]

Drug(s) Affected By RNA-binding protein RO60 (RO60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[182]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[183]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[184]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[187]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]

Drug(s) Affected By Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[189]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[72]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[194]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]

Drug(s) Affected By Fos-related antigen 2 (FOSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[195]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[196]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[197]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[199]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[127]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[200]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[203]

Drug(s) Affected By Protein SON (SON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[205]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[102]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[93]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[208]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[209]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[72]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]

Drug(s) Affected By Transcription factor E3 (TFE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[79]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[214]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[215]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[214]

Drug(s) Affected By B-cell lymphoma 3 protein (BCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[218]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]

Drug(s) Affected By Ephrin-A1 (EFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[157]

Drug(s) Affected By Iduronate 2-sulfatase (IDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]

Drug(s) Affected By Ferrochelatase, mitochondrial (FECH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[220]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[100]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]

Drug(s) Affected By Diacylglycerol kinase alpha (DGKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]

Drug(s) Affected By Thromboxane-A synthase (TBXAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[223]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]

Drug(s) Affected By Bromodomain-containing protein 2 (BRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[162]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[226]
Fructose	DM43AN2	Vomiting	MD90	Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[164]

Drug(s) Affected By Threonine--tRNA ligase 1, cytoplasmic (TARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]

Drug(s) Affected By ETS domain-containing protein Elk-4 (ELK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[51]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]

Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[229]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[230]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[231]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[232]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[233]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[229]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[235]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[236]

Drug(s) Affected By Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[61]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[97]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[239]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[240]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[241]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[102]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[40]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[243]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[244]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[245]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[246]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[247]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[249]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[251]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[252]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[257]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[259]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[260]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[262]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[263]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[265]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[266]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[267]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]

Drug(s) Affected By ADP-ribosylation factor-like protein 1 (ARL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[107]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[268]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[269]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[270]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[271]

Drug(s) Affected By Glycine--tRNA ligase (GARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[273]

Drug(s) Affected By Isoleucine--tRNA ligase, cytoplasmic (IARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[274]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[93]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[195]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]

Drug(s) Affected By Eukaryotic translation initiation factor 1 (EIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[273]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]

Drug(s) Affected By Neutral amino acid transporter A (SLC1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[83]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[109]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[276]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[277]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[278]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[118]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]

Drug(s) Affected By Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[17]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[282]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[121]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]

Drug(s) Affected By Alanine--tRNA ligase, cytoplasmic (AARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]

Drug(s) Affected By Cysteine--tRNA ligase, cytoplasmic (CARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[204]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[290]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[292]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[290]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]

Drug(s) Affected By Dipeptidyl peptidase 1 (CTSC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[295]

Drug(s) Affected By Ataxin-1 (ATXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[105]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]

Drug(s) Affected By Rho-related GTP-binding protein RhoE (RND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[297]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[298]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[299]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[300]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[301]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[302]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[303]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]

Drug(s) Affected By Runt-related transcription factor 1 (RUNX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[305]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[235]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[77]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[306]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[307]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[308]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[309]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[183]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[310]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[311]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[267]

Drug(s) Affected By Transmembrane protein 94 (TMEM94)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[312]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[90]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[90]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[315]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase G (PPIG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[79]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]

Drug(s) Affected By Ras-related protein Rab-31 (RAB31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[318]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[320]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[322]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]

Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[324]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[327]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[328]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[329]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[330]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[331]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[332]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By Dihydropyrimidinase-related protein 3 (DPYSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[333]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[61]

Drug(s) Affected By Src substrate cortactin (CTTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[334]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[61]

Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]

Drug(s) Affected By Protein disulfide-isomerase A5 (PDIA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[3]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]

Drug(s) Affected By Transmembrane glycoprotein NMB (GPNMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[100]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[275]

Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[336]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[337]

Drug(s) Affected By Plectin (PLEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[338]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[340]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]

Drug(s) Affected By Disks large-associated protein 5 (DLGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 2 (MAPRE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[203]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[203]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[90]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[341]

Drug(s) Affected By Neutral amino acid transporter B(0) (SLC1A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[37]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[342]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[174]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[344]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[200]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[345]

Drug(s) Affected By Basic leucine zipper transcriptional factor ATF-like (BATF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[89]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[346]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[164]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[164]

Drug(s) Affected By Neuronal regeneration-related protein (NREP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[295]

Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[347]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[349]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[85]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[351]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[352]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[352]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[353]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[354]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[162]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[356]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[357]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[358]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[359]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[360]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[361]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[362]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[363]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[364]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[365]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[173]

Drug(s) Affected By Laminin subunit alpha-3 (LAMA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[157]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[366]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[367]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[109]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[100]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[17]

Drug(s) Affected By Tumor protein D53 (TPD52L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]

Drug(s) Affected By Atos homolog protein A (ATOSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[368]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[369]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[89]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[97]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[370]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[371]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[372]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[373]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]

Drug(s) Affected By RRP12-like protein (RRP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[97]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[374]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]

Drug(s) Affected By FRAS1-related extracellular matrix protein 2 (FREM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[375]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[346]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By ALS2 C-terminal-like protein (ALS2CL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[100]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]

Drug(s) Affected By Endogenous Bornavirus-like nucleoprotein 2 (EBLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[376]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[17]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[377]

Drug(s) Affected By ATPase family AAA domain-containing protein 2 (ATAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[275]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[212]

Drug(s) Affected By Arginine/serine-rich coiled-coil protein 2 (RSRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[378]

Drug(s) Affected By BEN domain-containing protein 5 (BEND5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[28]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[100]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[379]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[380]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[15]

Drug(s) Affected By Serine/threonine-protein kinase TAO1 (TAOK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[107]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[381]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[382]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[382]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[278]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By Probable helicase senataxin (SETX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[268]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[90]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]

Drug(s) Affected By Protein LYRIC (MTDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[82]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[376]

Drug(s) Affected By Liprin-beta-1 (PPFIBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]

Drug(s) Affected By Dynein axonemal intermediate chain 3 (DNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[384]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[385]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[386]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[376]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[190]

Drug(s) Affected By Extracellular sulfatase Sulf-2 (SULF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[387]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[388]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[47]

Drug(s) Affected By Probable ATP-dependent RNA helicase DHX37 (DHX37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[368]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[389]

Drug(s) Affected By Stromal membrane-associated protein 1 (SMAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[390]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[82]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[369]

Drug(s) Affected By Mucolipin-2 (MCOLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[368]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[391]

Drug(s) Affected By CAP-Gly domain-containing linker protein 4 (CLIP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Bortezomib	DMNO38U	Leukemia		Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[312]

Drug(s) Affected By Ninein (NIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[392]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[15]

Drug(s) Affected By Ceramide synthase 5 (CERS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[393]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By F-box only protein 22 (FBXO22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[51]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[47]

Drug(s) Affected By (Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[275]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]

Drug(s) Affected By F-box only protein 30 (FBXO30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[370]

Drug(s) Affected By Secreted and transmembrane protein 1 (SECTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[394]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[385]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[89]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[107]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[395]

Drug(s) Affected By Paraspeckle component 1 (PSPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[396]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[397]

Drug(s) Affected By E3 ubiquitin-protein ligase rififylin (RFFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[273]

Drug(s) Affected By DNA damage-binding protein 2 (DDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[398]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By Sortilin-related receptor (SORL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By GTP-binding protein Rit1 (RIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[3]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[212]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[35]
Bortezomib	DMNO38U	Leukemia		Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]

Drug(s) Affected By Protein TMEPAI (PMEPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[157]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[400]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[17]

Drug(s) Affected By Protein FAM162A (FAM162A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[109]

Drug(s) Affected By Tumor protein p53-inducible nuclear protein 1 (TP53INP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By Transmembrane protein 45B (TMEM45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[97]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[388]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[12]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[89]

Drug(s) Affected By Carboxymethylenebutenolidase homolog (CMBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[402]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]

Drug(s) Affected By Protein FAM89A (FAM89A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[15]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[403]

Drug(s) Affected By E1A-binding protein p400 (EP400)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[368]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[107]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[268]

Drug(s) Affected By Protein FAM210A (FAM210A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[376]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[377]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[404]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[405]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[406]

Drug(s) Affected By ETS-related transcription factor Elf-4 (ELF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[79]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[95]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit C (EIF3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[18]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[214]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[407]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[409]

Drug(s) Affected By Protein orai-3 (ORAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[37]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[3]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]

Drug(s) Affected By Ferroptosis suppressor protein 1 (AIFM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[93]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[97]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[17]
Bortezomib	DMNO38U	Leukemia		Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]

Drug(s) Affected By Cancer-related nucleoside-triphosphatase (NTPCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]

Drug(s) Affected By G-protein coupled receptor 87 (GPR87)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[11]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[410]

Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[85]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[411]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[412]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Fructose	DM43AN2	Vomiting	MD90	Approved	[413]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[413]

Drug(s) Affected By Coiled-coil domain-containing protein 90B, mitochondrial (CCDC90B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[414]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[415]

Drug(s) Affected By Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[62]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[275]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[379]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[394]

Drug(s) Affected By Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[416]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[278]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[100]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]

Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC6 (POLR3F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[368]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[268]

Drug(s) Affected By Serine/threonine-protein kinase PLK3 (PLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[388]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[17]

Drug(s) Affected By Polyprenol reductase (SRD5A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[312]

Drug(s) Affected By Ankyrin repeat family A protein 2 (ANKRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]

Drug(s) Affected By ABC-type oligopeptide transporter ABCB9 (ABCB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[83]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[417]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[13]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[89]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[418]

Drug(s) Affected By Suppressor of SWI4 1 homolog (PPAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[111]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[89]

Drug(s) Affected By Fructose-2,6-bisphosphatase TIGAR (TIGAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]

Drug(s) Affected By Dual specificity protein phosphatase 22 (DUSP22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[360]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[419]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[376]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[12]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[420]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]

Drug(s) Affected By Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Indomethacin	DMSC4A7	Bursitis		Approved	[421]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[75]

Drug(s) Affected By Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[422]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[17]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[423]

Drug(s) Affected By Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[17]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[72]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[62]

Drug(s) Affected By SERTA domain-containing protein 1 (SERTAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]

Drug(s) Affected By GTP:AMP phosphotransferase AK3, mitochondrial (AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]

Drug(s) Affected By Oxidative stress-induced growth inhibitor 1 (OSGIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[3]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]

Drug(s) Affected By Two pore channel protein 1 (TPCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[111]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[204]

Drug(s) Affected By Ras-related protein Rab-26 (RAB26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[3]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[10]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[368]

Drug(s) Affected By Heme transporter FLVCR2 (FLVCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[3]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[424]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[37]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[425]

Drug(s) Affected By Lysine-specific demethylase 3A (KDM3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[426]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[19]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[3]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[47]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[274]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[3]

Drug(s) Affected By Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[16]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[3]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[3]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[376]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[90]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[427]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[428]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[429]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[141]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[430]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[431]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[433]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[434]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[307]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenine nucleotide translocator 1 (SLC25A4)	TTU5A6Q	ADT1_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
(E3-independent) E2 ubiquitin-conjugating enzyme	OTHGS2VA	UBE2O_HUMAN	Gene/Protein Processing	[3]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)	OTQK3M9X	ABHD4_HUMAN	Gene/Protein Processing	[3]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[3]
3'-5' RNA helicase YTHDC2	OTYDYKDY	YTDC2_HUMAN	Gene/Protein Processing	[3]
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)	OT1OG4QZ	AAKB1_HUMAN	Gene/Protein Processing	[3]
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2)	OTLVN68B	AAKB2_HUMAN	Gene/Protein Processing	[3]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)	OTQYEXL2	F264_HUMAN	Gene/Protein Processing	[3]
ABC-type oligopeptide transporter ABCB9 (ABCB9)	OTSOBOL5	ABCB9_HUMAN	Gene/Protein Processing	[3]
ADP-ribosylation factor-like protein 1 (ARL1)	OTB6N6BR	ARL1_HUMAN	Gene/Protein Processing	[3]
Agrin (AGRN)	OTWJENAZ	AGRIN_HUMAN	Gene/Protein Processing	[3]

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