Details of the Drug Combination

General Information of Drug Combination (ID: DCNG89M)

Drug Combination Name
AHPN Ruxolitinib
Indication
Disease Entry Status REF
T-cell leukemia/lymphoma Investigative [1]
Component Drugs AHPN   DM8G6O4 Ruxolitinib   DM7Q98D
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL
High-throughput Screening Result Testing Cell Line: ED-40515
Zero Interaction Potency (ZIP) Score: 9.823
Bliss Independence Score: 7.999
Loewe Additivity Score: 37.443
LHighest Single Agent (HSA) Score: 7.999

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of AHPN
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [2]
AHPN Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Retinoic acid receptor gamma (RARG) TT1Q3IE RARG_HUMAN Agonist [10]
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AHPN Interacts with 193 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 26A1 (CYP26A1) OTL1DFWV CP26A_HUMAN Increases Expression [11]
Menin (MEN1) OTN6U6V0 MEN1_HUMAN Decreases Expression [9]
Chloride intracellular channel protein 1 (CLIC1) OTYLFWNG CLIC1_HUMAN Decreases Expression [9]
Histone deacetylase complex subunit SAP18 (SAP18) OTJAZWOL SAP18_HUMAN Decreases Expression [9]
Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L) OTY21FKV COX7R_HUMAN Decreases Expression [9]
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) OTUG4BWA PAHX_HUMAN Decreases Expression [9]
Actin-related protein 2/3 complex subunit 2 (ARPC2) OTSOKOMY ARPC2_HUMAN Decreases Expression [9]
Actin-related protein 2/3 complex subunit 3 (ARPC3) OTKWVF8P ARPC3_HUMAN Decreases Expression [9]
Eukaryotic translation initiation factor 3 subunit D (EIF3D) OTDOMP80 EIF3D_HUMAN Decreases Expression [9]
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) OT585WY8 PSMD3_HUMAN Decreases Expression [9]
Asparagine--tRNA ligase, cytoplasmic (NARS1) OTFS4J1W SYNC_HUMAN Decreases Expression [9]
NADH dehydrogenase iron-sulfur protein 5 (NDUFS5) OTF40UYJ NDUS5_HUMAN Decreases Expression [9]
Selenoprotein F (SELENOF) OT2JFB3S SEP15_HUMAN Decreases Expression [9]
Barrier-to-autointegration factor (BANF1) OTP7Z38L BAF_HUMAN Decreases Expression [9]
Eukaryotic translation initiation factor 3 subunit G (EIF3G) OT5L1SRY EIF3G_HUMAN Decreases Expression [9]
ATP synthase subunit g, mitochondrial (ATP5MG) OTD569IJ ATP5L_HUMAN Decreases Expression [9]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Decreases Expression [9]
Adenomatous polyposis coli protein 2 (APC2) OTRH91CX APCL_HUMAN Decreases Expression [9]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Decreases Expression [9]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Decreases Expression [9]
Muellerian-inhibiting factor (AMH) OT5FH4BD MIS_HUMAN Decreases Expression [9]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Decreases Expression [9]
ADP/ATP translocase 2 (SLC25A5) OT1XIBMN ADT2_HUMAN Decreases Expression [9]
Large ribosomal subunit protein P1 (RPLP1) OT7B0SIB RLA1_HUMAN Decreases Expression [9]
Large ribosomal subunit protein P2 (RPLP2) OT2YBK3W RLA2_HUMAN Decreases Expression [9]
ATP synthase subunit beta, mitochondrial (ATP5F1B) OTLFZUQK ATPB_HUMAN Decreases Expression [9]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Decreases Expression [9]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Decreases Expression [9]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Decreases Expression [9]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Decreases Expression [9]
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) OT47AK4C HNRPC_HUMAN Decreases Expression [9]
Small ribosomal subunit protein eS17 (RPS17) OTWHZ2JQ RS17_HUMAN Decreases Expression [9]
Galectin-1 (LGALS1) OT8LDFWR LEG1_HUMAN Decreases Expression [9]
High mobility group protein B1 (HMGB1) OT4B7CPF HMGB1_HUMAN Decreases Expression [9]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Decreases Expression [9]
Cytochrome c oxidase subunit 6C (COX6C) OT3V7JE5 COX6C_HUMAN Decreases Expression [9]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [9]
HLA class I histocompatibility antigen, C alpha chain (HLA-C) OTV38BUJ HLAC_HUMAN Decreases Expression [9]
Microsomal glutathione S-transferase 1 (MGST1) OTGN1KVZ MGST1_HUMAN Decreases Expression [9]
Heat shock cognate 71 kDa protein (HSPA8) OTJI2RCI HSP7C_HUMAN Decreases Expression [9]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [9]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Decreases Expression [9]
Polyadenylate-binding protein 1 (PABPC1) OT54LG0P PABP1_HUMAN Decreases Expression [9]
ADP/ATP translocase 3 (SLC25A6) OT9KAJP7 ADT3_HUMAN Decreases Expression [9]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [9]
Elongation factor 2 (EEF2) OTZ7SZ39 EF2_HUMAN Decreases Expression [9]
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) OTVT146E CX7A2_HUMAN Decreases Expression [9]
Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB) OT3UJ4ZU RSMB_HUMAN Decreases Expression [9]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Decreases Expression [9]
Arylsulfatase A (ARSA) OT1CU8VR ARSA_HUMAN Decreases Expression [9]
Nucleoside diphosphate kinase A (NME1) OT0NELQ1 NDKA_HUMAN Decreases Expression [9]
Small ribosomal subunit protein uS5 (RPS2) OTSMTZVB RS2_HUMAN Decreases Expression [9]
Cytochrome c oxidase subunit 7C, mitochondrial (COX7C) OTREWSBF COX7C_HUMAN Decreases Expression [9]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [9]
Phosphoglycerate mutase 1 (PGAM1) OTZ5DB06 PGAM1_HUMAN Decreases Expression [9]
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) OTDAE8FP ATP5J_HUMAN Decreases Expression [9]
Proteasome subunit beta type-1 (PSMB1) OTYRFBAH PSB1_HUMAN Decreases Expression [9]
Eukaryotic translation initiation factor 4B (EIF4B) OTE8TXA8 IF4B_HUMAN Decreases Expression [9]
Cytochrome c oxidase subunit 7B, mitochondrial (COX7B) OT67PIDP COX7B_HUMAN Decreases Expression [9]
ATP synthase subunit alpha, mitochondrial (ATP5F1A) OT3FZDLX ATPA_HUMAN Decreases Expression [9]
Proteasome subunit alpha type-4 (PSMA4) OTAD2XXI PSA4_HUMAN Decreases Expression [9]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Decreases Expression [9]
Large ribosomal subunit protein eL13 (RPL13) OTFKNTD6 RL13_HUMAN Decreases Expression [9]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) OTKPL09B VATL_HUMAN Decreases Expression [9]
Large ribosomal subunit protein uL16 (RPL10) OTBHOZGC RL10_HUMAN Decreases Expression [9]
Protein disulfide-isomerase A3 (PDIA3) OTHPQ0Q3 PDIA3_HUMAN Decreases Expression [9]
Coronin-1A (CORO1A) OTVAZOHC COR1A_HUMAN Increases Expression [9]
DnaJ homolog subfamily A member 1 (DNAJA1) OT38BZQQ DNJA1_HUMAN Decreases Expression [9]
Transcription factor SOX-11 (SOX11) OT4LG7LA SOX11_HUMAN Decreases Expression [9]
ADP-ribosylation factor-like protein 2 (ARL2) OTICNK0O ARL2_HUMAN Decreases Expression [9]
ATP synthase subunit gamma, mitochondrial (ATP5F1C) OTV5GZK5 ATPG_HUMAN Decreases Expression [9]
RNA-binding motif protein, X chromosome (RBMX) OTFZN66E RBMX_HUMAN Decreases Expression [9]
T-complex protein 1 subunit zeta (CCT6A) OTCYWL5F TCPZ_HUMAN Decreases Expression [9]
Large ribosomal subunit protein uL13 (RPL13A) OTME3VXN RL13A_HUMAN Decreases Expression [9]
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) OTO557N2 ECHA_HUMAN Decreases Expression [9]
Small ribosomal subunit protein eS27 (RPS27) OTFXKY7P RS27_HUMAN Decreases Expression [9]
Large ribosomal subunit protein uL29 (RPL35) OTFZX52Q RL35_HUMAN Increases Expression [9]
Translocon-associated protein subunit beta (SSR2) OTQJSL7M SSRB_HUMAN Decreases Expression [9]
G-protein coupled receptor 6 (GPR6) OTBF9YGT GPR6_HUMAN Decreases Expression [9]
Small ribosomal subunit protein eS10 (RPS10) OTE3VSAH RS10_HUMAN Decreases Expression [9]
ATP synthase subunit O, mitochondrial (ATP5PO) OTU3MCTN ATPO_HUMAN Decreases Expression [9]
ATP synthase F(0) complex subunit C3, mitochondrial (ATP5MC3) OTX674BU AT5G3_HUMAN Decreases Expression [9]
T-complex protein 1 subunit gamma (CCT3) OTL6EOS1 TCPG_HUMAN Decreases Expression [9]
Fms-related tyrosine kinase 3 ligand (FLT3LG) OTU0YGC4 FLT3L_HUMAN Decreases Expression [9]
Hsc70-interacting protein (ST13) OTNML6UP F10A1_HUMAN Decreases Expression [9]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Decreases Expression [9]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Decreases Expression [9]
Homeobox protein Nkx-2.5 (NKX2-5) OTS1SAWM NKX25_HUMAN Decreases Expression [9]
AP-2 complex subunit sigma (AP2S1) OTEV2XGW AP2S1_HUMAN Decreases Expression [9]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1) OTK71JYU TCP4_HUMAN Increases Expression [9]
Adenylate kinase 2, mitochondrial (AK2) OTZG3X2H KAD2_HUMAN Decreases Expression [9]
Eukaryotic initiation factor 4A-I (EIF4A1) OTMTBX6N IF4A1_HUMAN Decreases Expression [9]
26S proteasome complex subunit SEM1 (SEM1) OTASLBM1 SEM1_HUMAN Decreases Expression [9]
Transmembrane protein 258 (TMEM258) OTXSDU14 TM258_HUMAN Decreases Expression [9]
Small ribosomal subunit protein uS9 (RPS16) OTVGZOB5 RS16_HUMAN Decreases Expression [9]
Small nuclear ribonucleoprotein F (SNRPF) OTZE5W6G RUXF_HUMAN Decreases Expression [9]
Small nuclear ribonucleoprotein G (SNRPG) OTWX4XK1 RUXG_HUMAN Decreases Expression [9]
U6 snRNA-associated Sm-like protein LSm3 (LSM3) OTBHPD8H LSM3_HUMAN Decreases Expression [9]
Small nuclear ribonucleoprotein Sm D2 (SNRPD2) OT5ZGKU5 SMD2_HUMAN Decreases Expression [9]
DNA-directed RNA polymerase II subunit RPB7 (POLR2G) OTVYWCGN RPB7_HUMAN Decreases Expression [9]
Small ribosomal subunit protein uS19 (RPS15) OT0WYZYG RS15_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase RBX1 (RBX1) OTYA1UIO RBX1_HUMAN Decreases Expression [9]
Large ribosomal subunit protein eL39 (RPL39) OTL8TZHQ RL39_HUMAN Decreases Expression [9]
Large ribosomal subunit protein uL5 (RPL11) OT3VZ6OE RL11_HUMAN Decreases Expression [9]
Large ribosomal subunit protein uL2 (RPL8) OTHMZ1R9 RL8_HUMAN Decreases Expression [9]
Small ubiquitin-related modifier 1 (SUMO1) OTJFD4P5 SUMO1_HUMAN Decreases Expression [9]
S-phase kinase-associated protein 1 (SKP1) OT5BPAZ4 SKP1_HUMAN Decreases Expression [9]
Eukaryotic translation initiation factor 5A-1 (EIF5A) OTQ8DJX5 IF5A1_HUMAN Decreases Expression [9]
Thymosin beta-10 (TMSB10) OTLVZ13T TYB10_HUMAN Decreases Expression [9]
T-complex protein 1 subunit beta (CCT2) OTW1VV4E TCPB_HUMAN Decreases Expression [9]
Large ribosomal subunit protein eL24 (RPL24) OTCY9DEB RL24_HUMAN Decreases Expression [9]
Large ribosomal subunit protein eL42 (RPL36A) OT1LYV85 RL36A_HUMAN Decreases Expression [9]
ADP-ribosylation factor 1 (ARF1) OT5C4C3L ARF1_HUMAN Decreases Expression [9]
Enhancer of rudimentary homolog (ERH) OTJDWX99 ERH_HUMAN Decreases Expression [9]
Large ribosomal subunit protein eL19 (RPL19) OT33LM66 RL19_HUMAN Decreases Expression [9]
Serine/arginine-rich splicing factor 3 (SRSF3) OTOFT707 SRSF3_HUMAN Decreases Expression [9]
Solute carrier family 25 member 3 (SLC25A3) OTAWGR4K S25A3_HUMAN Decreases Expression [9]
Protein SET (SET) OTGYYQJO SET_HUMAN Decreases Expression [9]
POU domain, class 3, transcription factor 1 (POU3F1) OTYARA94 PO3F1_HUMAN Decreases Expression [9]
Single-stranded DNA-binding protein, mitochondrial (SSBP1) OTH2PZWH SSBP_HUMAN Decreases Expression [9]
Proteolipid protein 2 (PLP2) OTEZ4LOV PLP2_HUMAN Decreases Expression [9]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Decreases Expression [9]
Interleukin enhancer-binding factor 2 (ILF2) OTWWVM9X ILF2_HUMAN Decreases Expression [9]
Peroxiredoxin-4 (PRDX4) OTT4OR8G PRDX4_HUMAN Increases Expression [9]
Serine/threonine-protein kinase 3 (STK3) OTLNSCQD STK3_HUMAN Increases Expression [9]
Eukaryotic translation initiation factor 3 subunit I (EIF3I) OTE07WND EIF3I_HUMAN Decreases Expression [9]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Decreases Expression [9]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) OTDS5WAU PIN1_HUMAN Decreases Expression [9]
Nascent polypeptide-associated complex subunit alpha (NACA) OTLP1KR3 NACA_HUMAN Decreases Expression [9]
Eukaryotic initiation factor 4A-II (EIF4A2) OT08H03R IF4A2_HUMAN Decreases Expression [9]
Hypermethylated in cancer 1 protein (HIC1) OTI9TWY4 HIC1_HUMAN Decreases Expression [9]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [9]
Lysine--tRNA ligase (KARS1) OT0EU4SV SYK_HUMAN Decreases Expression [9]
Poly(rC)-binding protein 1 (PCBP1) OTHN0TD7 PCBP1_HUMAN Decreases Expression [9]
Poly(rC)-binding protein 2 (PCBP2) OTXCN9CG PCBP2_HUMAN Decreases Expression [9]
Septin-7 (SEPTIN7) OTJI08YX SEPT7_HUMAN Decreases Expression [9]
Fascin (FSCN1) OTTGIHTM FSCN1_HUMAN Decreases Expression [9]
Prickle-like protein 4 (PRICKLE4) OT19NLJR PRIC4_HUMAN Decreases Expression [9]
Patatin-like phospholipase domain-containing protein 6 (PNPLA6) OTT5T45Q PLPL6_HUMAN Decreases Expression [9]
RING1 and YY1-binding protein (RYBP) OTZZ4P2Z RYBP_HUMAN Decreases Expression [9]
Proton-coupled zinc antiporter SLC30A5 (SLC30A5) OTOWD75R ZNT5_HUMAN Decreases Expression [9]
Roundabout homolog 4 (ROBO4) OT2Q29L9 ROBO4_HUMAN Decreases Expression [9]
Proteasome inhibitor PI31 subunit (PSMF1) OTX84WLQ PSMF1_HUMAN Decreases Expression [9]
DNA topoisomerase 2-binding protein 1 (TOPBP1) OT6UPZPD TOPB1_HUMAN Decreases Expression [9]
Growth hormone secretagogue receptor type 1 (GHSR) OT1Y8ARK GHSR_HUMAN Decreases Expression [9]
Ribosomal protein eL42-like (RPL36AL) OTH8NHO7 RL36L_HUMAN Decreases Expression [9]
AP-2 complex subunit mu (AP2M1) OTQCOSFN AP2M1_HUMAN Decreases Expression [9]
Transcriptional regulator protein Pur-beta (PURB) OTCDDKYB PURB_HUMAN Decreases Expression [9]
Ras-like protein family member 10B (RASL10B) OT0A5YKR RSLAB_HUMAN Decreases Expression [9]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Decreases Expression [9]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) OTM3B3OA TBL1R_HUMAN Decreases Expression [9]
Apoptosis inhibitor 5 (API5) OTYX9YCZ API5_HUMAN Decreases Expression [9]
INO80 complex subunit B (INO80B) OTSHV8JF IN80B_HUMAN Decreases Expression [9]
Histone-lysine N-methyltransferase SETD5 (SETD5) OTRPAVEO SETD5_HUMAN Increases Expression [9]
SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP) OT2M7VH6 SLIRP_HUMAN Decreases Expression [9]
SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) OTKMW34I SH3L3_HUMAN Decreases Expression [9]
MOB kinase activator 1A (MOB1A) OTSPBZ4Z MOB1A_HUMAN Decreases Expression [9]
U3 small nucleolar ribonucleoprotein protein IMP3 (IMP3) OTHN25MF IMP3_HUMAN Decreases Expression [9]
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) OT9ZAY6U S38A7_HUMAN Decreases Expression [9]
Mitoferrin-1 (SLC25A37) OTJ9F01S MFRN1_HUMAN Decreases Expression [9]
Transmembrane protein 14C (TMEM14C) OTHYTMLC TM14C_HUMAN Decreases Expression [9]
Mitochondrial import receptor subunit TOM7 homolog (TOMM7) OTJJOI2B TOM7_HUMAN Decreases Expression [9]
Stomatin-like protein 2, mitochondrial (STOML2) OTJ55M30 STML2_HUMAN Decreases Expression [9]
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (MAN1B1) OTI780UB MA1B1_HUMAN Decreases Expression [9]
Integrin alpha-11 (ITGA11) OTBWSRA1 ITA11_HUMAN Decreases Expression [9]
Integral membrane protein 2B (ITM2B) OTMXEPXB ITM2B_HUMAN Decreases Expression [9]
Kinesin-like protein KIF3A (KIF3A) OTMUBSSK KIF3A_HUMAN Decreases Expression [9]
Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) OTGZO1MT TIM8B_HUMAN Decreases Expression [9]
Mitochondrial carrier homolog 2 (MTCH2) OTV3E4GU MTCH2_HUMAN Decreases Expression [9]
NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) OTO3WI7S NDUB9_HUMAN Decreases Expression [9]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [12]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [13]
PRA1 family protein 3 (ARL6IP5) OTYZ6BEQ PRAF3_HUMAN Affects Expression [14]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Expression [14]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [15]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Increases Localization [16]
Procathepsin L (CTSL) OTYTUW29 CATL1_HUMAN Decreases Expression [15]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Increases Expression [15]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [17]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [15]
ADP/ATP translocase 1 (SLC25A4) OTKYLK2J ADT1_HUMAN Decreases Activity [18]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [13]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Expression [12]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [19]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [17]
Double-strand break repair protein MRE11 (MRE11) OTGU8TZM MRE11_HUMAN Decreases Expression [15]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [19]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [19]
Retinoblastoma-like protein 2 (RBL2) OTBQSOE6 RBL2_HUMAN Increases Expression [15]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [19]
Syntaxin-binding protein 5 (STXBP5) OTE3M7QB STXB5_HUMAN Increases Expression [15]
ADP/ATP translocase 4 (SLC25A31) OTX8N6YO ADT4_HUMAN Decreases Activity [18]
DNA-directed RNA polymerase III subunit RPC5 (POLR3E) OT69PWBM RPC5_HUMAN Increases Expression [15]
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⏷ Show the Full List of 193 DOT(s)
Indication(s) of Ruxolitinib
Disease Entry ICD 11 Status REF
Essential thrombocythemia 3B63.1Z Approved [3]
High-risk myelofibrosis 2A20.2 Approved [4]
Myelofibrosis 2A22 Approved [5]
Myeloproliferative neoplasm 2A20 Approved [6]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [7]
Pancreatic cancer 2C10 Phase 3 [4]
Atopic dermatitis EA80 Phase 1/2 [8]
Vitiligo ED63.0 Phase 1/2 [8]
Ruxolitinib Interacts with 5 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Janus kinase 2 (JAK-2) TTRMX3V JAK2_HUMAN Modulator [20]
Janus kinase 1 (JAK-1) TT6DM01 JAK1_HUMAN Modulator [20]
Urokinase plasminogen activator surface receptor (PLAUR) TTPRL03 UPAR_HUMAN Inhibitor [21]
HUMAN janus kinase 1 (JAK-1) TTWKB01 JAK1_HUMAN Inhibitor [22]
HUMAN janus kinase 2 (JAK-2) TT0F5HE JAK2_HUMAN Inhibitor [22]
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Ruxolitinib Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Increases ADR [23]
------------------------------------------------------------------------------------

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3431).
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5688).
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 Ruxolitinib FDA Label
7 Incyte begins Phase III trial of ruxolitinib to treat Covid-19. 20.April.2020.
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
10 Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. J Med Chem. 1995 Dec 22;38(26):4993-5006.
11 Induction of the cytochrome P450 gene CYP26 during mucous cell differentiation of normal human tracheobronchial epithelial cells. Mol Pharmacol. 2000 Sep;58(3):483-90.
12 Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res. 2005 Jul 15;65(14):6354-63. doi: 10.1158/0008-5472.CAN-04-4061.
13 GADD45A is a mediator of CD437 induced apoptosis in ovarian carcinoma cells. J Cell Physiol. 2007 Sep;212(3):771-9. doi: 10.1002/jcp.21073.
14 Comparing the effect of ATRA, 4-HPR, and CD437 in bladder cancer cells. Front Biosci. 2006 Sep 1;11:2007-16. doi: 10.2741/1942.
15 Identification of retinoid-modulated proteins in squamous carcinoma cells using high-throughput immunoblotting. Cancer Res. 2004 Apr 1;64(7):2439-48. doi: 10.1158/0008-5472.can-03-2643.
16 Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells. Cell Death Differ. 2001 May;8(5):477-85. doi: 10.1038/sj.cdd.4400843.
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